2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T744,Physical inactivity constitutes a pressing societal problem. To realize physical activity's (PA) potential as a key health resource, mechanisms of PA engagement need to be understood. Laboratory and interventional studies documented that exercise relates to affective well-being (AWB) and suggested that AWB may shape PA behaviour. Digitalization enabled the investigation of how PA relates to AWB in everyday life, but findings from individual studies are ambiguous. Here we compiled 67 datasets (55.2% of eligible records) including 321,345 smartphone-based AWB ratings and nearly 1,000,000 h of accelerometer-measured PA (N = 8,223 participants) until December 2023 to clarify the nature and extent of PA-AWB associations. One- and two-stage individual participant data meta-analyses reveal that momentary AWB is associated with both prior (within, r = 0.05, 99.2% confidence intervals (CI) 0.03 to 0.06; between, r = 0.08, 99.2% CI 0.04 to 0.12) and subsequent (within, r = 0.04, 99.2% CI 0.03 to 0.05; between, r = 0.08, 99.2% CI 0.04 to 0.13) short-term PA in everyday life. Within persons, PA displays a positive association with energetic arousal, positive affective states and valence, yet a negative relation to calmness. The practical effect sizes are comparable to other daily life activities, with energetic arousal evincing the strongest relation to PA. Considerable heterogeneity in associations across individuals can be partially explained by sociodemographic moderators. Between participants, PA relates to positive affective states. The results document the critical relevance of PA-AWB relations in everyday life. They can contribute to the revision and development of health behaviour models and establish a starting point to approach behavioural, physiological and neuronal mechanisms underlying PA-AWB associations.31:T90e,Abstract Physical inactivity constitutes a pressing societal problem. To realize physical activity’s (PA) potential as a key health resource, mechanisms of PA engagement need to be understood. Laboratory and interventional studies documented that exercise relates to affective well-being (AWB) and suggested that AWB may shape PA behaviour. Digitalization enabled the investigation of how PA relates to AWB in everyday life, but findings from individual studies are ambiguous. Here we compiled 67 datasets (55.2% of eligible records) including 321,345 smartphone-based AWB ratings and nearly 1,000,000 h of accelerometer-measured PA ( N = 8,223 participants) until December 2023 to clarify the nature and extent of PA–AWB associations. One- and two-stage individual participant data meta-analyses reveal that momentary AWB is associated with both prior (within, r = 0.05, 99.2% confidence intervals (CI) 0.03 to 0.06; between, r = 0.08, 99.2% CI 0.04 to 0.12) and subsequent (within, r = 0.04, 99.2% CI 0.03 to 0.05; between, r = 0.08, 99.2% CI 0.04 to 0.13) short-term PA in everyday life. Within persons, PA displays a positive association with energetic arousal, positive affective states and valence, yet a negative relation to calmness. The practical effect sizes are comparable to other daily life activities, with energetic arousal evincing the strongest relation to PA. Considerable heterogeneity in associations across individuals can be partially explained by sociodemographic moderators. Between participants, PA relates to positive affective states. The results document the critical relevance of PA–AWB relations in everyday life. They can contribute to the revision and development of health behaviour models and establish a starting point to approach behavioural, physiological and neuronal mechanisms underlying PA–AWB associations. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Physical Inactivity: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Physical Inactivity (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Physical%20Inactivity\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Physical Inactivity\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Physical%20Inactivity\"}]}}"}}]],["$","$L2f",null,{"title":"Physical Inactivity: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Physical Inactivity with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1007/s12529-026-10480-4","pmid":"42477287","title":"Sleep as an Effect Modifier for Physical Activity Intervention Efficacy: Secondary Analysis of Data from Two Randomized Controlled Trials","journal_title":"International Journal of Behavioral Medicine","journal_issn":"1070-5503","published_at":"2026-07-20T00:00:00.000Z","url":"https://doi.org/10.1007/s12529-026-10480-4","source_score":5,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-23T13:33:17.271Z","updated_at":"2026-07-23T13:33:17.271Z","tags":[{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"category","value":"Psychology, Clinical","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"condition","value":"Physical Inactivity","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"condition","value":"Sleep Insufficiency","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"modality","value":"Behavioral Physical Activity Intervention","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"study_design","value":"Secondary Analysis of Randomized Controlled Trials","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"warning","value":"Sample size (total N) was not reported in the abstract or available full text; the tag has been omitted.","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"warning","value":"Study population is exclusively sedentary Latinas; findings may not apply to other ethnic groups or men.","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"warning","value":"The 'practice_changing' impact flag reflects the novelty claim (first study to examine sleep as an effect modifier of PA intervention) but should be interpreted cautiously given the secondary, observational nature of the moderation analysis.","value_numeric":null},{"paper_doi":"10.1007/s12529-026-10480-4","tag_type":"warning","value":"The study is a secondary analysis with an unregistered analysis plan, which increases the risk of type I error despite use of two separate datasets for consistency.","value_numeric":null}],"summaries":{"what_studied":"This secondary analysis examined whether time in bed (a proxy for nighttime sleep duration) moderates the effect of physical activity (PA) interventions in sedentary Latinas, using data from two separate RCTs (Pasos Hacia La Salud I and II; NCT01834287 and NCT03491592).","key_result":"Time in bed was a significant moderator of PA intervention outcomes (p < 0.05 across both studies). Women with more time in bed showed greater PA gains: in Study 1, intervention vs. control; in Study 2, enhanced vs. original intervention.","limitations":"- Time in bed was self-reported and used only as a proxy for sleep duration, not a validated measure of sleep quality or actual sleep time.\n- The analysis plan was not pre-registered, raising risk of post-hoc inference.\n- Both RCTs enrolled only sedentary Latinas, limiting generalizability to other populations.","practice_takeaway":"Clinicians designing PA interventions for Latinas should screen for insufficient sleep, as women with adequate time in bed appear to benefit more from these programs. 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Moderator analyses, subgroup breakdowns, and secondary outcomes could not be independently verified from the full text.","value_numeric":null},{"paper_doi":"10.1038/s41562-026-02427-2","tag_type":"warning","value":"The study covers data up to December 2023; the publication date of May 2026 suggests a substantial lag that may affect currency of included datasets.","value_numeric":null}],"summaries":{"what_studied":"This individual participant data (IPD) meta-analysis examined how accelerometer-measured physical activity (PA) relates to smartphone-based affective well-being (AWB) in daily life, pooling 67 datasets (N = 8,223 participants, ~321,345 AWB ratings, ~1,000,000 h of PA data) collected up to December 2023.","key_result":"PA showed small but consistent positive associations with momentary AWB both before (within-person r = 0.05, between-person r = 0.08) and after (within-person r = 0.04, between-person r = 0.08) PA episodes. 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The negative link to calmness suggests PA may transiently increase arousal, which is worth discussing with patients who exercise for relaxation."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Physical Inactivity"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Physical Inactivity"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Physical Inactivity"}}}]]

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