2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T86c,To theoretically evaluate the efficacy and safety of large-spot (i.e., > 4 mm) picosecond laser treatment for pigmented lesions in Asian skin using a melanosome disruption threshold fluence (MDTF) model. The MDTF model was applied to calculate the required fluence for melanosome disruption with 532, 730, 755, 785, and 1064 nm picosecond lasers. To assess potential complication risks, energy deposition in surrounding tissues was simulated. Additionally, a clinical case series was conducted using a 1064 nm picosecond laser with a large spot size to evaluate its feasibility for treating an ectopic Mongolian spot and a nevus of Ota. At 532 nm, spot size had minimal impact on the required fluence for epidermal melanosome disruption and on collateral energy deposition. For 730-1064 nm wavelengths, the optimal spot size depended on the lesion depth. When targeting epidermal melanosomes, smaller spot sizes confined energy deposition to superficial layers, reducing collateral exposure. In contrast, for dermal melanosomes, larger spot sizes reduced the required fluence by 39%-65% and lowered collateral energy deposition, while also decreasing variation in required fluence across lesion depths. In the clinical validation, both dermal cases showed good clearance without adverse events, supporting the feasibility of this approach. However, increasing the energy output of laser devices may be necessary to achieve sufficient efficacy. The theoretical analysis shows that at 532 nm, both small and large spot sizes can be effective for treating epidermal lesions. In contrast, at near-infrared wavelengths, smaller spot sizes are preferable for epidermal lesions, whereas larger spot sizes are advantageous for dermal lesions, potentially lowering the risk of complications while maintaining effective target disruption. These findings provide practical clinical guidance by clarifying wavelength- and spot-size-specific strategies according to target depth. Furthermore, the present results may help optimize treatment parameters and device specifications and inform future clinical studies using large-spot picosecond laser systems.31:Tb09,ABSTRACT Objectives To theoretically evaluate the efficacy and safety of large‐spot (i.e., > 4 mm) picosecond laser treatment for pigmented lesions in Asian skin using a melanosome disruption threshold fluence (MDTF) model. Materials and Methods The MDTF model was applied to calculate the required fluence for melanosome disruption with 532, 730, 755, 785, and 1064 nm picosecond lasers. To assess potential complication risks, energy deposition in surrounding tissues was simulated. Additionally, a clinical case series was conducted using a 1064 nm picosecond laser with a large spot size to evaluate its feasibility for treating an ectopic Mongolian spot and a nevus of Ota. Results At 532 nm, spot size had minimal impact on the required fluence for epidermal melanosome disruption and on collateral energy deposition. For 730–1064 nm wavelengths, the optimal spot size depended on the lesion depth. When targeting epidermal melanosomes, smaller spot sizes confined energy deposition to superficial layers, reducing collateral exposure. In contrast, for dermal melanosomes, larger spot sizes reduced the required fluence by 39%–65% and lowered collateral energy deposition, while also decreasing variation in required fluence across lesion depths. In the clinical validation, both dermal cases showed good clearance without adverse events, supporting the feasibility of this approach. However, increasing the energy output of laser devices may be necessary to achieve sufficient efficacy. Conclusion The theoretical analysis shows that at 532 nm, both small and large spot sizes can be effective for treating epidermal lesions. In contrast, at near‐infrared wavelengths, smaller spot sizes are preferable for epidermal lesions, whereas larger spot sizes are advantageous for dermal lesions, potentially lowering the risk of complications while maintaining effective target disruption. These findings provide practical clinical guidance by clarifying wavelength‐ and spot‐size‐specific strategies according to target depth. Furthermore, the present results may help optimize treatment parameters and device specifications and inform future clinical studies using large‐spot picosecond laser systems. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Pigmented Lesion: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Pigmented Lesion (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Pigmented%20Lesion\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Pigmented Lesion\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Pigmented%20Lesion\"}]}}"}}]],["$","$L2f",null,{"title":"Pigmented Lesion: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Pigmented Lesion with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1002/lsm.70086","pmid":"41431236","title":"Theoretical Analysis of Large‐Spot Picosecond Laser Treatment for Pigmented Lesions in Asian Skin","journal_title":"Lasers in Surgery and Medicine","journal_issn":"0196-8092","published_at":"2025-12-23T00:00:00.000Z","url":"https://doi.org/10.1002/lsm.70086","source_score":10,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-12-27","doi":"10.1002/lsm.70086","days":"14","issn":"0196-8092","rank":"6","field":"Clinical Medicine","score":"10","category":"Dermatology","categories":["Dermatology","Surgery"],"_categories":["Dermatology","Surgery"]},"pubmed":{"doi":"10.1002/lsm.70086","title":"Theoretical Analysis of Large-Spot Picosecond Laser Treatment for Pigmented Lesions in Asian Skin.","journal":"Lasers in surgery and medicine","methods":"","results":"At 532 nm, spot size had minimal impact on the required fluence for epidermal melanosome disruption and on collateral energy deposition. For 730-1064 nm wavelengths, the optimal spot size depended on the lesion depth. When targeting epidermal melanosomes, smaller spot sizes confined energy deposition to superficial layers, reducing collateral exposure. In contrast, for dermal melanosomes, larger spot sizes reduced the required fluence by 39%-65% and lowered collateral energy deposition, while also decreasing variation in required fluence across lesion depths. In the clinical validation, both dermal cases showed good clearance without adverse events, supporting the feasibility of this approach. However, increasing the energy output of laser devices may be necessary to achieve sufficient efficacy.","abstract":"$30","keywords":["Asian skin","Monte Carlo light transport simulation","clinical endpoint","energy deposition","large‐spot irradiation","melanosome disruption threshold fluence","picosecond laser","pigmented lesions","treatment parameter optimization"],"pubmed_id":"41431236","conclusions":"The theoretical analysis shows that at 532 nm, both small and large spot sizes can be effective for treating epidermal lesions. In contrast, at near-infrared wavelengths, smaller spot sizes are preferable for epidermal lesions, whereas larger spot sizes are advantageous for dermal lesions, potentially lowering the risk of complications while maintaining effective target disruption. These findings provide practical clinical guidance by clarifying wavelength- and spot-size-specific strategies according to target depth. Furthermore, the present results may help optimize treatment parameters and device specifications and inform future clinical studies using large-spot picosecond laser systems.","publication_date":"2025-12-23T00:00:00"},"crossref":{"DOI":"10.1002/lsm.70086","URL":"https://doi.org/10.1002/lsm.70086","ISSN":["0196-8092","1096-9101"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/lsm.70086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Theoretical Analysis of Large‐Spot Picosecond Laser Treatment for Pigmented Lesions in Asian Skin"],"author":[{"given":"Yu","family":"Shimojo","sequence":"first","affiliation":[{"name":"Department of Dermatology, Graduate School of Medicine Osaka Metropolitan University Osaka Japan"},{"name":"Research Fellow of Japan Society for the Promotion of Science Tokyo 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In two dermal cases, both lesions cleared well without adverse events; higher device energy may be needed for adequate efficacy.","limitations":"The analysis is theoretical and the clinical validation includes only two cases without quantitative efficacy metrics or follow‑up details. Device energy may be inadequate with existing systems, as higher output was noted as potentially necessary.","practice_takeaway":"For near‑infrared picosecond treatments in Asian skin, use smaller spots for epidermal lesions and larger spots for dermal lesions to lower required fluence and collateral energy; at 532 nm, either spot size appears acceptable for epidermal targets. Early clinical use of a large‑spot 1064 nm laser for dermal lesions showed good clearance without adverse events, but adequate device energy is a practical constraint."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Pigmented Lesion"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Pigmented Lesion"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Pigmented Lesion"}}}]]

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