2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T6d5,Postacute sequelae of COVID-19 (PASC), also known as long COVID, and postacute COVID-19 vaccination syndrome (PACVS) present overlapping but distinct clinical challenges. We hypothesize that PASC and PACVS share clinical features but differ in symptom patterns and biomarker profiles. This study aims to identify differences in presentation and distinguish immunologic biomarkers relevant to general clinical practice. This cross-sectional study analyzed 181 patients from a PASC clinic at Columbia University Irving Medical Center. Patients were divided into PASC with myalgic encephalomyelitis/chronic fatigue syndrome (MECFS), PASC without MECFS (LC), and PACVS groups. Prevalence and severity of self-reported symptoms, as well as immunologic abnormalities, were compared across groups. Fatigue was the most common symptom (Total: 88.95%; MECFS: 100.00%; PACVS: 92.86%; LC: 78.05%). The MECFS group generally reported more symptoms across all organ systems. The PACVS group reported higher rates of atypical chief complaints such as peripheral neuropathy (17.9%), tinnitus (7.1%), and rash (10.7%) compared to the other groups (P = <.01). Functional impairment was comparable between the MECFS and PACVS groups and less severe in the LC group. All groups had high rates of autoantibody positivity and cytokine elevation. The PACVS group showed significantly higher rates of anticardiolipin IgM (PACVS 42.9%, LC 11.6%; P = .02) and anti-U1-RNP (PACVS 21.4%, LC 2.3%; P = .04) positivity compared to the LC group. PASC and PACVS share symptom overlap but exhibit distinct biomarker patterns, particularly elevated autoantibody levels in PACVS. These findings suggest autoimmune involvement, warranting further investigation for targeted therapies.31:T959,Abstract Background Postacute sequelae of COVID-19 (PASC), also known as long COVID, and postacute COVID-19 vaccination syndrome (PACVS) present overlapping but distinct clinical challenges. We hypothesize that PASC and PACVS share clinical features but differ in symptom patterns and biomarker profiles. This study aims to identify differences in presentation and distinguish immunologic biomarkers relevant to general clinical practice. Methods This cross-sectional study analyzed 181 patients from a PASC clinic at Columbia University Irving Medical Center. Patients were divided into PASC with myalgic encephalomyelitis/chronic fatigue syndrome (MECFS), PASC without MECFS (LC), and PACVS groups. Prevalence and severity of self-reported symptoms, as well as immunologic abnormalities, were compared across groups. Results Fatigue was the most common symptom (Total: 88.95%; MECFS: 100.00%; PACVS: 92.86%; LC: 78.05%). The MECFS group generally reported more symptoms across all organ systems. The PACVS group reported higher rates of atypical chief complaints such as peripheral neuropathy (17.9%), tinnitus (7.1%), and rash (10.7%) compared to the other groups (P = <.01). Functional impairment was comparable between the MECFS and PACVS groups and less severe in the LC group. All groups had high rates of autoantibody positivity and cytokine elevation. The PACVS group showed significantly higher rates of anticardiolipin IgM (PACVS 42.9%, LC 11.6%; P = .02) and anti-U1-RNP (PACVS 21.4%, LC 2.3%; P = .04) positivity compared to the LC group. Conclusions PASC and PACVS share symptom overlap but exhibit distinct biomarker patterns, particularly elevated autoantibody levels in PACVS. These findings suggest autoimmune involvement, warranting further investigation for targeted therapies. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Postacute COVID-19 Vaccination Syndrome: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Postacute COVID-19 Vaccination Syndrome (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Postacute%20COVID-19%20Vaccination%20Syndrome\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Postacute COVID-19 Vaccination Syndrome\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Postacute%20COVID-19%20Vaccination%20Syndrome\"}]}}"}}]],["$","$L2f",null,{"title":"Postacute COVID-19 Vaccination Syndrome: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Postacute COVID-19 Vaccination Syndrome with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1093/cid/ciaf624","pmid":"41510565","title":"Overlapping Clinical Presentation of Long COVID and Postacute COVID-19 Vaccination Syndrome: Phenotypes, Severity, and Biomarkers","journal_title":"Clinical Infectious Diseases","journal_issn":"1058-4838","published_at":"2026-01-09T00:00:00.000Z","url":"https://doi.org/10.1093/cid/ciaf624","source_score":20,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-14","doi":"10.1093/cid/ciaf624","days":"7","issn":"1058-4838","rank":"5","field":"Clinical Medicine","score":"20","category":"Immunology","categories":["Immunology","Infectious Diseases"],"_categories":["Immunology","Infectious Diseases"]},"pubmed":{"doi":"10.1093/cid/ciaf624","title":"Overlapping Clinical Presentation of Long COVID and Postacute COVID-19 Vaccination Syndrome: Phenotypes, Severity, and Biomarkers.","journal":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","methods":"","results":"Fatigue was the most common symptom (Total: 88.95%; MECFS: 100.00%; PACVS: 92.86%; LC: 78.05%). The MECFS group generally reported more symptoms across all organ systems. The PACVS group reported higher rates of atypical chief complaints such as peripheral neuropathy (17.9%), tinnitus (7.1%), and rash (10.7%) compared to the other groups (P = <.01). Functional impairment was comparable between the MECFS and PACVS groups and less severe in the LC group. All groups had high rates of autoantibody positivity and cytokine elevation. The PACVS group showed significantly higher rates of anticardiolipin IgM (PACVS 42.9%, LC 11.6%; P = .02) and anti-U1-RNP (PACVS 21.4%, LC 2.3%; P = .04) positivity compared to the LC group.","abstract":"$30","keywords":["autoimmunity","long COVID","myalgic encephalomyelitis/chronic fatigue syndrome (ME-CFS)","postacute COVID-19 vaccination syndrome (PACVS)","postacute sequelae of COVID-19 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inhibitory factor regulates U1 small nuclear RNP immune complex-mediated activation of the NLRP3 inflammasome","journal-title":"Arthritis Rheumatol","doi-asserted-by":"crossref"},{"DOI":null,"key":"2026010905014549100_ciaf624-B40","year":"2023","issue":null,"author":"Son","volume":"61","first-page":"2200970","unstructured":null,"article-title":"Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long COVID symptoms","journal-title":"Eur Respir J","doi-asserted-by":null}],"short-title":[],"article-number":"ciaf624","content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["Clinical Infectious Diseases"],"reference-count":40,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,9]]},"references-count":40,"short-container-title":[],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1093/cid/ciaf624","is_oa":false,"title":"Overlapping Clinical Presentation of Long COVID and Postacute COVID-19 Vaccination Syndrome: Phenotypes, Severity, and Biomarkers","updated":"2026-01-11T01:49:12+00:00","published_date":"2025-12-17","best_oa_location":null}},"created_at":"2026-01-15T20:51:27.064Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1093/cid/ciaf624","tag_type":"category","value":"Immunology","value_numeric":null},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"category","value":"Infectious Diseases","value_numeric":null},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"condition","value":"Long COVID","value_numeric":null},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"condition","value":"Myalgic Encephalomyelitis/Chronic Fatigue Syndrome","value_numeric":null},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"condition","value":"Postacute COVID-19 Vaccination Syndrome","value_numeric":null},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"sample_size","value":"n=181","value_numeric":181},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"warning","value":"Cross-sectional design limits causal inference.","value_numeric":null},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"warning","value":"Group sizes for MECFS, LC, and PACVS are not reported; percentages may reflect small subgroups.","value_numeric":null},{"paper_doi":"10.1093/cid/ciaf624","tag_type":"warning","value":"Primary outcomes and statistical adjustments are not specified in the abstract.","value_numeric":null}],"summaries":{"what_studied":"A cross-sectional analysis of 181 patients from a PASC clinic compared three groups—PASC with ME/CFS, PASC without ME/CFS (LC), and postacute COVID-19 vaccination syndrome (PACVS)—for self-reported symptom prevalence/severity and immunologic abnormalities.","key_result":"Fatigue predominated (Total 88.95%; MECFS 100%; PACVS 92.86%; LC 78.05%). PACVS showed higher rates of peripheral neuropathy (17.9%), tinnitus (7.1%), and rash (10.7%) versus other groups (P<.01), comparable functional impairment to MECFS and greater than LC, and higher autoantibody positivity than LC for anticardiolipin IgM (42.9% vs 11.6%; P=.02) and anti-U1-RNP (21.4% vs 2.3%; P=.04); all groups had high autoantibody and cytokine elevations.","limitations":"Single-center, cross-sectional study from a PASC clinic relying on self-reported symptoms. Group sizes and absolute event counts per cohort are not provided in the abstract.","practice_takeaway":"PACVS can mirror the functional impairment seen in PASC with ME/CFS and may present more neuropathy, tinnitus, or rash. Anticardiolipin IgM and anti-U1-RNP positivity appear more frequent in PACVS than LC, which may help phenotype patients while awaiting confirmatory studies."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Postacute COVID-19 Vaccination Syndrome"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Postacute COVID-19 Vaccination Syndrome"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Postacute COVID-19 Vaccination Syndrome"}}}]]

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