2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T6bc,To assess maternal infection following prelabor rupture of membranes (PROM) at term in a setting where active management is recommended, and to identify associated risk factors. A retrospective cohort study was conducted including pregnant women admitted to a Portuguese tertiary care center where immediate induction of labor is recommended following term PROM. Women with singleton term pregnancies complicated by PROM, who delivered between January 2020 and July 2023, were included. The primary outcome was intrauterine maternal infection, defined as clinical chorioamnionitis and/or endometritis. A comparative analysis was conducted between groups, based on latency to delivery (≤12 h vs. >12 h). A multivariable logistic regression model was used to evaluate the influence of confounding factors on the association between latency and the primary outcome. A total of 759 patients with singleton term pregnancies complicated by PROM were included, corresponding to a prevalence of 9.7%. Chorioamnionitis and/or endometritis occurred in 40 patients (5.3%), with significantly different rates between the up to 12 h and the more than 12 h latency groups (0.9% vs. 7.3%, P < 0.001). Latency of more than 12 h was independently associated with maternal infection (odds ratio 9.0; 95% confidence interval 2.1-39.2). Group B streptococcus colonization status was not associated with increased maternal infection risk. Neonatal outcomes were similar between groups. This study demonstrates the increased risk of maternal infection when latency exceeds 12 h following term PROM, supporting the rationale for active management strategies and highlighting the need to evaluate additional prophylactic measures.31:T9b3,Abstract Objective To assess maternal infection following prelabor rupture of membranes (PROM) at term in a setting where active management is recommended, and to identify associated risk factors. Methods A retrospective cohort study was conducted including pregnant women admitted to a Portuguese tertiary care center where immediate induction of labor is recommended following term PROM. Women with singleton term pregnancies complicated by PROM, who delivered between January 2020 and July 2023, were included. The primary outcome was intrauterine maternal infection, defined as clinical chorioamnionitis and/or endometritis. A comparative analysis was conducted between groups, based on latency to delivery (≤12 h vs. >12 h). A multivariable logistic regression model was used to evaluate the influence of confounding factors on the association between latency and the primary outcome. Results A total of 759 patients with singleton term pregnancies complicated by PROM were included, corresponding to a prevalence of 9.7%. Chorioamnionitis and/or endometritis occurred in 40 patients (5.3%), with significantly different rates between the up to 12 h and the more than 12 h latency groups (0.9% vs. 7.3%, P < 0.001). Latency of more than 12 h was independently associated with maternal infection (odds ratio 9.0; 95% confidence interval 2.1–39.2). Group B streptococcus colonization status was not associated with increased maternal infection risk. Neonatal outcomes were similar between groups. Conclusion This study demonstrates the increased risk of maternal infection when latency exceeds 12 h following term PROM, supporting the rationale for active management strategies and highlighting the need to evaluate additional prophylactic measures. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Prelabor Rupture of Membranes: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Prelabor Rupture of Membranes (condition). Clinician-written summaries and actionable practice insights. 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Chorioamnionitis and/or endometritis occurred in 40 patients (5.3%), with significantly different rates between the up to 12 h and the more than 12 h latency groups (0.9% vs. 7.3%, P < 0.001). Latency of more than 12 h was independently associated with maternal infection (odds ratio 9.0; 95% confidence interval 2.1-39.2). Group B streptococcus colonization status was not associated with increased maternal infection risk. Neonatal outcomes were similar between groups.","abstract":"$30","keywords":["chorioamnionitis","endometritis","infection","prelabor rupture of membranes","term"],"pubmed_id":"41999150","conclusions":"This study demonstrates the increased risk of maternal infection when latency exceeds 12 h following term PROM, supporting the rationale for active management strategies and highlighting the need to evaluate additional prophylactic measures.","publication_date":"2026-04-18T00:00:00"},"crossref":{"DOI":"10.1002/ijgo.71018","URL":"https://doi.org/10.1002/ijgo.71018","ISSN":["0020-7292","1879-3479"],"link":[{"URL":"https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1002/ijgo.71018","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://obgyn.onlinelibrary.wiley.com/doi/full-xml/10.1002/ijgo.71018","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1002/ijgo.71018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Maternal infection in the context of actively managed prelabor rupture of membranes at term: An observational study"],"author":[{"given":"Inês","family":"Martins","sequence":"first","affiliation":[{"name":"Faculdade de Medicina 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Portuguese tertiary care center where immediate induction of labor is protocol, comparing women with latency ≤12 h vs. >12 h to delivery (January 2020–July 2023).","key_result":"Among 759 women with term PROM, maternal infection occurred in 5.3% overall; rates were 0.9% (≤12 h latency) vs. 7.3% (>12 h latency, P<0.001). Latency >12 h carried an OR of 9.0 (95% CI 2.1–39.2) for maternal infection; GBS colonization status was not associated with increased risk, and neonatal outcomes were similar between groups.","limitations":"Single-center retrospective design limits generalizability; confounding from unmeasured variables (e.g., reasons for prolonged latency) cannot be excluded; clinical infection definitions may introduce diagnostic variability.","practice_takeaway":"Aim to deliver within 12 hours of term PROM to minimize the risk of chorioamnionitis or endometritis — latency beyond this threshold carries a ~9-fold higher odds of maternal infection. GBS colonization alone should not drive infection risk stratification in this setting."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Prelabor Rupture of Membranes"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Prelabor Rupture of Membranes"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Prelabor Rupture of Membranes"}}}]]

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