2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T727,Management of complex hard-to-heal (chronic) wounds presents a substantial challenge in various healthcare settings where logistical constraints and patient-related factors can impede wound closure. This retrospective study evaluates outcomes associated with the use of a dehydrated, full-thickness placental allograft (CompleteFT; ExtremityCare, LLC, US) composed of the amnion, chorion and intermediate layers, when applied to complex hard-to-heal wounds in a mobile care environment. A retrospective analysis reviewed data collected between February 2024 and July 2025 from patients (aged ≥18 years) with complex hard-to-heal wounds. Data were retrieved from a single mobile wound care service provider team (Compassionate Care Concierge, US). Prior to allograft application, all wounds exhibited stalled healing for at least 30 days with standard of care (SoC). The allograft was applied to all wounds as an adjunct to SoC. Trend changes in wound surface area and percentage area reduction (PAR) across various wound aetiologies were assessed, with additional endpoints including the number of allograft applications and relevant patient parameters. The patient cohort (n=114, with a total of 184 hard-to-heal wounds), included 51 males and 63 females, with a mean age of 73.1 years. Analysis revealed statistically significant PAR values for various wound aetiologies, such that: p<0.0001 for diabetic foot ulcers (n=11); venous leg ulcers (n=48); pressure ulcers (n=73); and wounds classified as 'other' (n=39). Surgical wounds (n=13) demonstrated a p<0.0007. The study allograft was well-tolerated, with no adverse events directly attributable to the product. Application of the full-thickness allograft as an adjunct to SoC presents a promising option for supporting wound size regression in complex, hard-to-heal wounds.31:T97b, Objective: Management of complex hard-to-heal (chronic) wounds presents a substantial challenge in various healthcare settings where logistical constraints and patient-related factors can impede wound closure. This retrospective study evaluates outcomes associated with the use of a dehydrated, full-thickness placental allograft (CompleteFT; ExtremityCare, LLC, US) composed of the amnion, chorion and intermediate layers, when applied to complex hard-to-heal wounds in a mobile care environment. Method: A retrospective analysis reviewed data collected between February 2024 and July 2025 from patients (aged ≥18 years) with complex hard-to-heal wounds. Data were retrieved from a single mobile wound care service provider team (Compassionate Care Concierge, US). Prior to allograft application, all wounds exhibited stalled healing for at least 30 days with standard of care (SoC). The allograft was applied to all wounds as an adjunct to SoC. Trend changes in wound surface area and percentage area reduction (PAR) across various wound aetiologies were assessed, with additional endpoints including the number of allograft applications and relevant patient parameters. Results: The patient cohort (n=114, with a total of 184 hard-to-heal wounds), included 51 males and 63 females, with a mean age of 73.1 years. Analysis revealed statistically significant PAR values for various wound aetiologies, such that: p<0.0001 for diabetic foot ulcers (n=11); venous leg ulcers (n=48); pressure ulcers (n=73); and wounds classified as ‘other’ (n=39). Surgical wounds (n=13) demonstrated a p<0.0007. The study allograft was well-tolerated, with no adverse events directly attributable to the product. Conclusion: Application of the full-thickness allograft as an adjunct to SoC presents a promising option for supporting wound size regression in complex, hard-to-heal wounds. 32:T663,Soft silicone multi-layer dressings are commonly used for pressure ulcer (pressure injury) prevention, yet their effectiveness varies based on design, construct, and material properties. This study evaluated the protective efficacy of a new multi-layer dressing, ALLEVYN COMPLETE CARE (ACC, Smith & Nephew Limited), which incorporates an advanced structure facilitating the dissipation of shear forces through internal layer-on-layer frictional sliding within the dressing. Using a combination of experimental frictional energy absorber effectiveness (FEAE) testing and computational finite element modelling, we quantified the capacity of this dressing to mitigate strain and stress concentrations in the soft tissues of the supported posterior heel. The dressing demonstrated considerable frictional sliding between its adjacent layers, resulting in FEAE = 93% under simulated, clinically relevant usage conditions. This was associated with the dissipation of shear forces and alleviation of strain/stress concentrations in the skin and underlying soft tissues below the dressing. The dressing completely eliminated the stress and strain peaks at the top quartiles of the strain/stress domain (with reference to a no-dressing case). This work provided valuable insights into advanced testing methods and beneficial design principles for pressure ulcer prevention dressings. Earlier investigations concluded that a previous-generation ALLEVYN LIFE dressing achieved high levels of FEAE and thus provided protection. Our findings here establish that the next-generation dressing, ACC, demonstrates even greater protective capacity.33:T6ba,ABSTRACT Soft silicone multi‐layer dressings are commonly used for pressure ulcer (pressure injury) prevention, yet their effectiveness varies based on design, construct, and material properties. This study evaluated the protective efficacy of a new multi‐layer dressing, ALLEVYN COMPLETE CARE (ACC, Smith & Nephew Limited), which incorporates an advanced structure facilitating the dissipation of shear forces through internal layer‐on‐layer frictional sliding within the dressing. Using a combination of experimental frictional energy absorber effectiveness (FEAE) testing and computational finite element modelling, we quantified the capacity of this dressing to mitigate strain and stress concentrations in the soft tissues of the supported posterior heel. The dressing demonstrated considerable frictional sliding between its adjacent layers, resulting in FEAE = 93% under simulated, clinically relevant usage conditions. This was associated with the dissipation of shear forces and alleviation of strain/stress concentrations in the skin and underlying soft tissues below the dressing. The dressing completely eliminated the stress and strain peaks at the top quartiles of the strain/stress domain (with reference to a no‐dressing case). This work provided valuable insights into advanced testing methods and beneficial design principles for pressure ulcer prevention dressings. Earlier investigations concluded that a previous‐generation ALLEVYN LIFE dressing achieved high levels of FEAE and thus provided protection. Our findings here establish that the next‐generation dressing, ACC, demonstrates even greater protective capacity.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Pressure Ulcer: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Pressure Ulcer (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Pressure%20Ulcer\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Pressure Ulcer\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Pressure%20Ulcer\"}]}}"}}]],["$","$L2f",null,{"title":"Pressure Ulcer: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Pressure Ulcer with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.2340/actadv.v106.adv-2025-0159","pmid":"42670983","title":"Temporal Inflammatory Profile in Skin Surface after Oronasal Mask Application","journal_title":"Acta Dermato-Venereologica","journal_issn":"1651-2057","published_at":"2026-08-31T00:00:00.000Z","url":"https://doi.org/10.2340/actadv.v106.adv-2025-0159","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-07T06:30:48.750Z","updated_at":"2026-09-07T06:30:48.750Z","tags":[{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"condition","value":"Device-Related Pressure Injury","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"condition","value":"Pressure Ulcer","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"condition","value":"Skin Inflammation","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"modality","value":"Non-Invasive Ventilation","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"sample_size","value":"n=11","value_numeric":11},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"study_design","value":"Prospective Observational Study","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"warning","value":"Eight of 11 patients wore a preventive gel pad, which may have modulated the inflammatory response and confounded comparisons.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"warning","value":"Study design is observational with repeated measures but no control group without mask use, making it difficult to isolate mask-specific effects from post-surgical systemic inflammation (mean CRP 120 mg/L).","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2025-0159","tag_type":"warning","value":"Very small sample size (n=11 patients, 1 outlier removed) from a single ICU center limits statistical power and generalizability; findings should be considered hypothesis-generating only.","value_numeric":null}],"summaries":{"what_studied":"This study tracked the temporal inflammatory cytokine profile in skin sebum at the nasal bridge of 11 adult ICU patients after oronasal (NIV) facemask removal, collecting Sebutape® samples at 0, 20, 40, 60, 120, and 180 minutes post-removal and analyzing 71 inflammatory proteins using OPLS-DA, protein network analysis, and ODE-based mathematical modeling.","key_result":"Two distinct cytokine response phases emerged: an early phase (0–20 min) with 9 fast-declining proteins and a delayed phase (40–180 min) with 8 proteins that continued to rise after mask removal—17 cytokines drove this separation (OPLS-DA R²=0.685, Q²=0.391, p<0.0001). Delayed-phase inflammation persisted without visible erythema in most patients, and network analysis flagged pathways for angiogenesis, tissue remodelling, haemopoiesis, and cell death regulation.","limitations":"- Very small sample (n=11), limiting generalizability.\n- Sebutape® captures only skin-surface proteins; deeper tissue physiology is not reflected.\n- NIV mask duration varied widely (9–41 min), introducing variability in inflammatory stimulus.","practice_takeaway":"Clinicians should be aware that subclinical inflammatory and microvascular stress at the nasal bridge can persist well beyond mask removal—even without visible erythema—suggesting a monitoring window up to at least 180 minutes post-mask use. Early preventive measures (e.g., gel pads) and attention to mask fit and duration may help avert device-related pressure ulcer progression before it becomes visible."}},{"doi":"10.12968/jowc.2025.0459","pmid":"41205152","title":"Application of a full-thickness placental allograft in complex wound management: a case series across diverse aetiologies","journal_title":"Journal of Wound Care","journal_issn":"0969-0700","published_at":"2025-11-08T00:00:00.000Z","url":"https://doi.org/10.12968/jowc.2025.0459","source_score":38,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-11-30","doi":"10.12968/jowc.2025.0459","days":"7","issn":"0969-0700","rank":"2","field":"Clinical Medicine","score":"38","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.12968/jowc.2025.0459","title":"Application of a full-thickness placental allograft in complex wound management: a case series across diverse aetiologies.","journal":"Journal of wound care","methods":"A retrospective analysis reviewed data collected between February 2024 and July 2025 from patients (aged ≥18 years) with complex hard-to-heal wounds. Data were retrieved from a single mobile wound care service provider team (Compassionate Care Concierge, US). Prior to allograft application, all wounds exhibited stalled healing for at least 30 days with standard of care (SoC). The allograft was applied to all wounds as an adjunct to SoC. Trend changes in wound surface area and percentage area reduction (PAR) across various wound aetiologies were assessed, with additional endpoints including the number of allograft applications and relevant patient parameters.","results":"The patient cohort (n=114, with a total of 184 hard-to-heal wounds), included 51 males and 63 females, with a mean age of 73.1 years. Analysis revealed statistically significant PAR values for various wound aetiologies, such that: p<0.0001 for diabetic foot ulcers (n=11); venous leg ulcers (n=48); pressure ulcers (n=73); and wounds classified as 'other' (n=39). Surgical wounds (n=13) demonstrated a p<0.0007. The study allograft was well-tolerated, with no adverse events directly attributable to the product.","abstract":"$30","keywords":["CompleteFT","amniotic membrane","chronic wounds","complex wounds","full-thickness membrane","hard-to-heal","placental allograft","wound","wound care","wound closure","wound covering","wound dressing"],"pubmed_id":"41205152","conclusions":"Application of the full-thickness allograft as an adjunct to SoC presents a promising option for supporting wound size regression in complex, hard-to-heal wounds.","publication_date":"2025-11-08T00:00:00"},"crossref":{"DOI":"10.12968/jowc.2025.0459","URL":"https://doi.org/10.12968/jowc.2025.0459","ISSN":["0969-0700","2052-2916"],"link":[{"URL":"http://www.magonlinelibrary.com/doi/pdf/10.12968/jowc.2025.0459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"S15-S24","type":"journal-article","issue":"S11a","score":1,"title":["Application of a full-thickness placental allograft in complex wound management: a case series across diverse aetiologies"],"author":[{"given":"Kirk","family":"Mitchell","sequence":"first","affiliation":[{"name":"Compassionate Concierge Physicians, Longmont, CO, US"}]}],"issued":{"date-parts":[[2025,11,1]]},"member":"5130","prefix":"10.12968","source":"Crossref","volume":"34","created":{"date-time":"2025-10-22T12:15:23Z","timestamp":1761135323000,"date-parts":[[2025,10,22]]},"indexed":{"date-time":"2025-11-11T11:43:29Z","timestamp":1762861409672,"date-parts":[[2025,11,11]]},"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"http://www.magonlinelibrary.com/doi/10.12968/jowc.2025.0459"}},"subtitle":[],"deposited":{"date-time":"2025-11-11T11:39:30Z","timestamp":1762861170000,"date-parts":[[2025,11,11]]},"issn-type":[{"type":"print","value":"0969-0700"},{"type":"electronic","value":"2052-2916"}],"published":{"date-parts":[[2025,11,1]]},"publisher":"Mark Allen 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Care"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.12968/jowc.2025.0459","is_oa":false,"title":"Application of a full-thickness placental allograft in complex wound management: a case series across diverse aetiologies","updated":"2025-10-27T16:35:26+00:00","published_date":"2025-10-22","best_oa_location":null}},"created_at":"2025-12-02T07:03:10.886Z","updated_at":"2025-12-08T12:24:58.509Z","tags":[{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"brand","value":"CompleteFT","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"condition","value":"Diabetic Foot Ulcer","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"condition","value":"Pressure Ulcer","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"condition","value":"Surgical Wound","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"condition","value":"Venous Leg Ulcer","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"level_of_evidence","value":"6","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"modality","value":"Placental Allograft","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"sample_size","value":"n=114","value_numeric":114},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"study_design","value":"Case Series","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"warning","value":"Effect sizes (PAR magnitudes) and time-to-healing are not reported in the abstract; only p-values by etiology.","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"warning","value":"Generalisability may be limited due to setting and a heterogeneous ‘other’ wound category.","value_numeric":null},{"paper_doi":"10.12968/jowc.2025.0459","tag_type":"warning","value":"Uncontrolled case series from a single mobile provider; no comparator described.","value_numeric":null}],"summaries":{"what_studied":"A retrospective case series (Feb 2024–July 2025) from a single US mobile wound care service evaluated a dehydrated, full-thickness placental allograft (CompleteFT) added to standard care in adults (≥18) with complex wounds stalled ≥30 days. Outcomes included trends in wound surface area and percentage area reduction (PAR) by wound etiology.","key_result":"Among 114 patients with 184 wounds (mean age 73.1; 51 male, 63 female), PAR was statistically significant for diabetic foot ulcers (n=11), venous leg ulcers (n=48), pressure ulcers (n=73), and ‘other’ wounds (n=39) with p<0.0001, and for surgical wounds (n=13) with p<0.0007; no adverse events were directly attributed to the product.","limitations":"Retrospective, single-provider case series without a control group and with heterogeneous wound types. The abstract reports p-values but not PAR magnitudes or time-to-closure.","practice_takeaway":"Adjunct use of a full-thickness placental allograft was associated with wound size regression across several chronic wound etiologies and appeared well tolerated, but the uncontrolled design and absent effect sizes limit clinical inference."}},{"doi":"10.1111/iwj.70764","pmid":"41028983","title":"The Protective Efficacy of a New Soft Silicone Multi‐Layer Dressing in Reducing the Heel Pressure Ulcer Risk","journal_title":"International Wound Journal","journal_issn":"1742-4801","published_at":"2025-10-01T00:00:00.000Z","url":"https://doi.org/10.1111/iwj.70764","source_score":54,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-10-07","doi":"10.1111/iwj.70764","days":"30","issn":"1742-4801","rank":"6","field":"Clinical 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