2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:Tb12,Close social relationships are linked to improved individual health and even longevity. These effects are hypothesized to be mediated through improved neuroendocrine and immune functioning, particularly in individuals who engage in positive and affectionate interactions. However, systematic data examining these factors in humans are currently lacking. To investigate the interacting effects of repeated intranasal oxytocin administration, a behavioral microintervention, and daily physical intimacy on neuroendocrine stress responses and dermatological wound healing. This randomized clinical trial was a double-blind, randomized, placebo-controlled study whereby participants completed 3 laboratory visits and a 5-day ecological momentary assessment (EMA). During the first laboratory visit, participants received 4 small suction-blister wounds applied to their forearms. Data were collected from November 20, 2011, to July 25, 2013; final analyses were conducted from December 2023 to February 2025. Over the following 7 days, participants were instructed to self-administer either oxytocin or a placebo twice daily and to engage in structured positive interaction (Partner Appreciation Task [PAT]) up to 3 times in total or not. Wound healing was assessed at 24 hours and 7 days after wounding. Throughout the week, participants collected saliva samples for cortisol analyses and reported their stress levels and experiences of partner interaction 6 times per day (5760 measurement points in total). The volunteer sample was 80 healthy, heterosexual couples (N = 160 participants, mean [SD] age, 27.6 [5.0] years). Couples in the PAT condition who received daily oxytocin showed improved wound healing (b = -0.125, t286 = -1.983; P = .048). However, these effects were not consistently robust in sensitivity analyses (b = -0.090, t282 = -1.643; P = .10). Notably, the administration of oxytocin combined with daily affectionate touch (b = -0.038, t137 = -2.091; P = .04) and sexual activity (b = -0.145, t137 = -2.122; P = .04) was linked to a reduction in wound severity. These associations remained largely consistent in sensitivity analyses (affectionate touch: b = -0.037, t135 = -2.057; P = .04; sexual activity: b = -0.131, t135 = -1.900; P = .06). Additionally, greater sexual activity was associated with reduced daily cortisol levels (b = -373.084, t488 = -2.813; P = .005). This study found that intimate physical contact can reduce cortisol responses and, along with oxytocin administration, promote wound healing. These findings provide a foundation for future interventions that integrate relationship dynamics and neurohormonal modulation to improve health and recovery from illness. ClinicalTrials.gov Identifier: NCT01594775.31:T183f, Importance Close social relationships are linked to improved individual health and even longevity. These effects are hypothesized to be mediated through improved neuroendocrine and immune functioning, particularly in individuals who engage in positive and affectionate interactions. However, systematic data examining these factors in humans are currently lacking. Objective To investigate the interacting effects of repeated intranasal oxytocin administration, a behavioral microintervention, and daily physical intimacy on neuroendocrine stress responses and dermatological wound healing. Design, Setting, and Participants This randomized clinical trial was a double-blind, randomized, placebo-controlled study whereby participants completed 3 laboratory visits and a 5-day ecological momentary assessment (EMA). During the first laboratory visit, participants received 4 small suction-blister wounds applied to their forearms. Data were collected from November 20, 2011, to July 25, 2013; final analyses were conducted from December 2023 to February 2025. Interventions Over the following 7 days, participants were instructed to self-administer either oxytocin or a placebo twice daily and to engage in structured positive interaction (Partner Appreciation Task [PAT]) up to 3 times in total or not. Main Outcomes and Measures Wound healing was assessed at 24 hours and 7 days after wounding. Throughout the week, participants collected saliva samples for cortisol analyses and reported their stress levels and experiences of partner interaction 6 times per day (5760 measurement points in total). Results The volunteer sample was 80 healthy, heterosexual couples (N = 160 participants, mean [SD] age, 27.6 [5.0] years). Couples in the PAT condition who received daily oxytocin showed improved wound healing ( b = −0.125, t 286 = −1.983; P = .048). However, these effects were not consistently robust in sensitivity analyses ( b = −0.090, t 282 = −1.643; P = .10). Notably, the administration of oxytocin combined with daily affectionate touch ( b = −0.038, t 137 = −2.091; P = .04) and sexual activity ( b = −0.145, t 137 = −2.122; P = .04) was linked to a reduction in wound severity. These associations remained largely consistent in sensitivity analyses (affectionate touch: b = –0.037, t 135 = –2.057; P = .04; sexual activity: b = –0.131, t 135 = –1.900; P = .06). Additionally, greater sexual activity was associated with reduced daily cortisol levels ( b = −373.084, t 488 = −2.813; P = .005). Conclusions and Relevance This study found that intimate physical contact can reduce cortisol responses and, along with oxytocin administration, promote wound healing. These findings provide a foundation for future interventions that integrate relationship dynamics and neurohormonal modulation to improve health and recovery from illness. Trial Registration ClinicalTrials.gov Identifier: NCT01594775 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Psychological Stress: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Psychological Stress (condition). Clinician-written summaries and actionable practice insights. 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Retention was high (87%), and 83% of participants endorsed government action on smartphone use.","limitations":"Small pilot sample (n=82) limits statistical power to detect true effects. Positive changes were not sustained at 2-month follow-up, raising questions about durability. Participant self-selection and reliance on self-report surveys alongside wearables may introduce bias.","practice_takeaway":"A 21-day S/SM detox is feasible and acceptable in adolescents, with short-term signals for better sleep and mood, but the lack of lasting benefit suggests full-scale trials should test more targeted approaches — such as disabling internet access at bedtime rather than total abstinence."}},{"doi":"10.1161/jaha.125.047311","pmid":"42294783","title":"Randomized Controlled Trial of Internet‐Delivered Cognitive Behavioral Therapy After Myocardial Infarction With Nonobstructive Coronary Arteries or Takotsubo Syndrome","journal_title":"Journal of the American Heart Association","journal_issn":"2047-9980","published_at":"2026-06-15T00:00:00.000Z","url":"https://doi.org/10.1161/jaha.125.047311","source_score":50,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-21T13:29:55.218Z","updated_at":"2026-06-21T13:29:55.218Z","tags":[{"paper_doi":"10.1161/jaha.125.047311","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"category","value":"Cardiac & Cardiovascular Systems","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"condition","value":"Anxiety","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"condition","value":"Myocardial Infarction With Nonobstructive Coronary Arteries","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"condition","value":"Psychological Stress","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"condition","value":"Takotsubo Syndrome","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"modality","value":"Cognitive Behavioral Therapy","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"sample_size","value":"n=88","value_numeric":88},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"warning","value":"Sex distribution of the sample is not explicitly reported in the abstract; 'mixed' sex tag is inferred given the known female predominance of both MINOCA and TS populations.","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"warning","value":"The primary outcome was not statistically significant (P=0.09); positive secondary findings should be interpreted with caution given the risk of type I error from multiple comparisons.","value_numeric":null},{"paper_doi":"10.1161/jaha.125.047311","tag_type":"warning","value":"The TS subgroup interaction (P=0.016) is an exploratory finding from a small sample and should not be used to change practice without replication.","value_numeric":null}],"summaries":{"what_studied":"A parallel, multicenter RCT evaluated an internet-delivered CBT (iCBT) program versus wait-list control in 88 patients with MINOCA or Takotsubo syndrome (TS) who had elevated stress (PSS-14 ≥25) or anxiety (HADS-A ≥8), with follow-up at 10–12 weeks post-randomization.","key_result":"The primary composite outcome (normalized stress and anxiety) did not reach statistical significance (OR 2.37, 95% CI 0.88–6.38, P=0.09); however, secondary outcomes showed significant anxiety normalization and symptom improvement on continuous measures (effect sizes d=0.44–0.67), with a stronger treatment effect in TS patients vs. non-TS (interaction P=0.016).","limitations":"Small sample size (n=88) likely underpowered the primary endpoint; wait-list control does not blind participants; exploratory TS subgroup finding requires replication in a dedicated trial.","practice_takeaway":"Consider iCBT as a low-barrier mental health intervention for MINOCA or TS patients with elevated stress or anxiety, particularly those with TS who may benefit most. Formal evidence is still emerging, so shared decision-making and close follow-up remain essential."}},{"doi":"10.1007/s10862-026-10295-3","pmid":null,"title":"Extraversion and Conscientiousness: Personality Profiles and their Links to Mental Health","journal_title":"Journal of Psychopathology and Behavioral Assessment","journal_issn":"0882-2689","published_at":"2026-06-02T00:00:00.000Z","url":"https://doi.org/10.1007/s10862-026-10295-3","source_score":10,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-06-10T14:24:03.119Z","updated_at":"2026-06-11T13:42:25.333Z","tags":[{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"category","value":"Psychology, Clinical","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"condition","value":"Anxiety","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"condition","value":"Depression","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"condition","value":"Loneliness","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"condition","value":"Psychological Stress","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"condition","value":"Somatization","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"sample_size","value":"n=469","value_numeric":469},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"warning","value":"Full text was not available; summary is based on the abstract and reference list only. Specific effect sizes, statistical fit indices, and full demographic details could not be verified.","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"warning","value":"Latent profile analysis assigns probabilistic membership; profile labels (e.g., 'introverted and impulsive') are interpretive and may not map cleanly onto clinical constructs.","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"warning","value":"Only the paper title, DOI, journal, and publication date were provided — no abstract, methods, results, or full text. All summary fields have been set to null because no study content could be verified. Tags and summaries cannot be populated without source data.","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"warning","value":"Sample is from a single university context (Canada); cultural and institutional generalizability is uncertain.","value_numeric":null},{"paper_doi":"10.1007/s10862-026-10295-3","tag_type":"warning","value":"The study excluded emotionality/neuroticism by design; this limits comparability with studies using full Big Five or HEXACO models.","value_numeric":null}],"summaries":{"what_studied":"Latent profile analysis (LPA) was used to identify personality profiles based on extraversion and conscientiousness (measured via HEXACO-60) in 469 emerging adults (mean age 20.2 years, 58.4% women), then examined how profile membership related to anxiety, depression, somatization, loneliness, and stress.","key_result":"Five profiles emerged; the two introverted profiles (low extraversion ± high conscientiousness; combined ~9.8% of sample) showed the highest levels of anxiety, depression, somatization, loneliness, and stress. The extraverted profiles (high extraversion ± high or low conscientiousness; combined ~28.8%) had the most favorable mental health outcomes. No demographic variables predicted profile membership.","limitations":"- Cross-sectional design prevents causal inference about personality-mental health links.\n- Sample was limited to emerging adults at one timepoint, restricting generalizability across age groups.\n- Emotionality/neuroticism was intentionally excluded to avoid criterion contamination, so its moderating role in these profiles is unknown.","practice_takeaway":"Clinicians working with college-age patients should screen for introversion as a risk marker for internalizing symptoms—anxiety, depression, loneliness, and somatic complaints—regardless of conscientiousness level. Interventions targeting social engagement and approach motivation may benefit this subgroup."}},{"doi":"10.1007/s12671-026-02874-y","pmid":null,"title":"A Daily Digital Mindfulness Meditation to Reduce Stress from Discrimination Among Racially Diverse Sexual and Gender Minorities: Preparation Phase of the Multi-Phase Optimization Strategy (MOST)","journal_title":"Mindfulness","journal_issn":"1868-8527","published_at":"2026-05-21T00:00:00.000Z","url":"https://doi.org/10.1007/s12671-026-02874-y","source_score":5,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-05-22T13:22:19.954Z","updated_at":"2026-05-22T13:22:19.954Z","tags":[{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"age_group","value":"adolescent","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"category","value":"Psychology, Clinical","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"condition","value":"Minority Stress","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"condition","value":"Psychological Stress","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"modality","value":"Digital Mindfulness Meditation","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"modality","value":"mHealth Application","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"sample_size","value":"n=72","value_numeric":72},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"study_design","value":"Factorial Experiment (Preparation Phase, MOST Framework)","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"warning","value":"No brand name for the meditation app is mentioned in the available text; the app appears to be a custom research tool, not a commercial product.","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"warning","value":"The Connection component p-value (p=0.04) was flagged as a preliminary signal only; the authors explicitly caution against interpreting it as a confirmed effect given the non-significant omnibus test.","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"warning","value":"The study_design tag reflects a MOST preparation-phase factorial experiment, which is neither a standard RCT nor a classic observational study — level of evidence assigned as 3 (controlled trial without full randomization to final treatment) but this is approximate given the optimization framework context.","value_numeric":null},{"paper_doi":"10.1007/s12671-026-02874-y","tag_type":"warning","value":"The 'young' SGM population spans adolescents and adults; exact age range is not reported in the available text, so age_group is listed as mixed adolescent/adult.","value_numeric":null}],"summaries":{"what_studied":"This preparation-phase study used a 2³ (8-condition) factorial design to test the feasibility, acceptability, and preliminary efficacy of three app-based mindfulness components (Awareness, Connection, Purpose) for reducing stress and improving well-being in young sexual and gender minorities (YSGM; n=72, 95.65% people of color) over 5 days.","key_result":"Omnibus factorial tests were non-significant for both perceived stress (F[7,64]=1.44, p=0.20, η²p=0.136) and satisfaction with life (F[7,64]=0.98, p=0.45, η²p=0.097). The Connection component showed a preliminary signal for stress reduction (b=−5.21, p=0.04, η²p=0.064), but this should be interpreted cautiously given the non-significant omnibus test.","limitations":"- Very small sample (n=72) with only 5 days of follow-up, underpowered to confirm component effects.\n- Highest attrition in the all-three-components condition, which may bias estimates.\n- Single-site, predominantly young people of color; generalizability to broader SGM populations is limited.","practice_takeaway":"App-based mindfulness appears feasible and acceptable for racially diverse YSGM, but no components showed confirmed efficacy at this stage. Clinicians should await larger optimization trials before recommending this specific intervention format."}},{"doi":"10.1001/jamapsychiatry.2025.3705","pmid":"41222549","title":"Intranasal Oxytocin and Physical Intimacy for Dermatological Wound Healing and Neuroendocrine Stress","journal_title":"JAMA Psychiatry","journal_issn":"2168-622X","published_at":"2025-11-12T00:00:00.000Z","url":"https://doi.org/10.1001/jamapsychiatry.2025.3705","source_score":260,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-11-16","doi":"10.1001/jamapsychiatry.2025.3705","days":"30","issn":"2168-622X","rank":"6","field":"Clinical Medicine","score":"260","category":"Psychiatry","categories":["Psychiatry"],"_categories":["Psychiatry"]},"pubmed":{"doi":"10.1001/jamapsychiatry.2025.3705","title":"Intranasal Oxytocin and Physical Intimacy for Dermatological Wound Healing and Neuroendocrine Stress: A Randomized Clinical Trial.","journal":"JAMA psychiatry","methods":"","results":"The volunteer sample was 80 healthy, heterosexual couples (N = 160 participants, mean [SD] age, 27.6 [5.0] years). Couples in the PAT condition who received daily oxytocin showed improved wound healing (b = -0.125, t286 = -1.983; P = .048). However, these effects were not consistently robust in sensitivity analyses (b = -0.090, t282 = -1.643; P = .10). Notably, the administration of oxytocin combined with daily affectionate touch (b = -0.038, t137 = -2.091; P = .04) and sexual activity (b = -0.145, t137 = -2.122; P = .04) was linked to a reduction in wound severity. These associations remained largely consistent in sensitivity analyses (affectionate touch: b = -0.037, t135 = -2.057; P = .04; sexual activity: b = -0.131, t135 = -1.900; P = .06). Additionally, greater sexual activity was associated with reduced daily cortisol levels (b = -373.084, t488 = -2.813; P = .005).","abstract":"$30","keywords":[],"pubmed_id":"41222549","conclusions":"","publication_date":"2025-11-12T00:00:00"},"crossref":{"DOI":"10.1001/jamapsychiatry.2025.3705","URL":"https://doi.org/10.1001/jamapsychiatry.2025.3705","ISSN":["2168-622X"],"link":[{"URL":"https://jamanetwork.com/journals/jamapsychiatry/articlepdf/2841268/jamapsychiatry_schneider_2025_oi_250064_1762374564.65751.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Intranasal Oxytocin and Physical Intimacy for Dermatological Wound Healing and Neuroendocrine Stress"],"author":[{"given":"Ekaterina","family":"Schneider","sequence":"first","affiliation":[{"name":"Institute of Medical Psychology, University Hospital, Heidelberg, Germany"},{"name":"Ruprecht-Karls University 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Wound healing was assessed at 24 hours and 7 days after four forearm suction-blister wounds.","key_result":"In the Partner Appreciation Task condition, daily oxytocin was linked to improved wound healing (b=-0.125; t286=-1.983; P=.048), but this was not robust in sensitivity analyses (b=-0.090; t282=-1.643; P=.10). Oxytocin combined with daily affectionate touch (b=-0.038; t137=-2.091; P=.04) and sexual activity (b=-0.145; t137=-2.122; P=.04) correlated with reduced wound severity, with similar sensitivity results (touch: b=-0.037; t135=-2.057; P=.04; sex: b=-0.131; t135=-1.900; P=.06); greater sexual activity was also associated with lower daily cortisol (b=-373.084; t488=-2.813; P=.005).","limitations":"Key wound-healing effects lost significance in sensitivity analyses; intimacy behaviors (affectionate touch, sexual activity) were not randomized and may be confounded. The sample was healthy, young, heterosexual couples, and the suction-blister model may limit generalizability to clinical wounds.","practice_takeaway":"In healthy couples, intranasal oxytocin paired with positive, affectionate contact showed small, analysis-sensitive improvements in suction-blister healing and lower cortisol with sexual activity; this is hypothesis-generating rather than practice-changing. Consider these findings preliminary and not yet applicable to routine wound care or stress management."}}],"initialOffset":5,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Psychological Stress"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Psychological Stress"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Psychological Stress"}}}]]

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