2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T667,Our aim was to evaluate the diagnostic and safety performance of shape-sensing robotic-assisted bronchoscopy (ssRAB) with cone beam CT (CBCT) for the biopsy of pulmonary nodules. Additional analysis was performed to assess outcomes for small nodules and those close to the fissure, pleura or mediastinum. This single arm, multicentre prospective study enrolled 200 subjects with suspicious pulmonary nodules. Each subject underwent a ssRAB procedure with CBCT and was subsequently followed up. The primary outcome was tool-in-lesion (TIL) confirmed with CBCT. Further endpoints included diagnostic outcomes and rate of adverse events. Of 200 subjects recruited, 198 subjects had a successful biopsy (whereby lesion was reached and sample was taken) and 97% completed the required follow-up. The median size of the nodules was 13 mm; 26.8% (60/224) have a positive bronchus sign and 181 (80.8%) were located in the outer two-thirds of the lung. TIL was obtained in 99.0% (198/200). The strict diagnostic yield was 85% (170/200) with diagnostic accuracy of 92.0% (184/200) and sensitivity for malignancy of 95.5% (147/154). Diagnostic accuracy for nodules under 20 mm size, within 5 mm from a critical structure (eg, heart, aorta or main pulmonary artery) or from the pleura was 88.2% (172/195), 100% (11/11) and 93.3% (56/60), respectively. There were four (2%) serious procedure-related adverse events, with one patient (0.5%) suffering a pneumothorax. ssRAB with CBCT can effectively reach and biopsy small pulmonary nodules, including perifissural, peripleural and paramediastinal lesions with a strong safety profile. NCT05867953.31:Ta1b, Introduction Our aim was to evaluate the diagnostic and safety performance of shape-sensing robotic-assisted bronchoscopy (ssRAB) with cone beam CT (CBCT) for the biopsy of pulmonary nodules. Additional analysis was performed to assess outcomes for small nodules and those close to the fissure, pleura or mediastinum. Methods This single arm, multicentre prospective study enrolled 200 subjects with suspicious pulmonary nodules. Each subject underwent a ssRAB procedure with CBCT and was subsequently followed up. The primary outcome was tool-in-lesion (TIL) confirmed with CBCT. Further endpoints included diagnostic outcomes and rate of adverse events. Results Of 200 subjects recruited, 198 subjects had a successful biopsy (whereby lesion was reached and sample was taken) and 97% completed the required follow-up. The median size of the nodules was 13 mm; 26.8% (60/224) have a positive bronchus sign and 181 (80.8%) were located in the outer two-thirds of the lung. TIL was obtained in 99.0% (198/200). The strict diagnostic yield was 85% (170/200) with diagnostic accuracy of 92.0% (184/200) and sensitivity for malignancy of 95.5% (147/154). Diagnostic accuracy for nodules under 20 mm size, within 5 mm from a critical structure (eg, heart, aorta or main pulmonary artery) or from the pleura was 88.2% (172/195), 100% (11/11) and 93.3% (56/60), respectively. There were four (2%) serious procedure-related adverse events, with one patient (0.5%) suffering a pneumothorax. Conclusion ssRAB with CBCT can effectively reach and biopsy small pulmonary nodules, including perifissural, peripleural and paramediastinal lesions with a strong safety profile. Trial registration number NCT05867953 . 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Pulmonary Nodule: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Pulmonary Nodule (condition). Clinician-written summaries and actionable practice insights. 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Level of evidence assigned as 5 (expert review/narrative review).","value_numeric":null},{"paper_doi":"10.1002/resp.70301","tag_type":"warning","value":"Sex of study populations is not reported, as this is a review article.","value_numeric":null},{"paper_doi":"10.1002/resp.70301","tag_type":"warning","value":"The paper does not specify which robotic bronchoscopy platforms were reviewed; comparative performance between platforms is not addressed.","value_numeric":null}],"summaries":{"what_studied":"This review evaluates lung lesion marking techniques used to guide sublobar (parenchyma-preserving) resection of early-stage lung cancers via thoracoscopy, comparing CT-guided transthoracic methods (dye injection, fiducials, hook wires) against conventional and robotic bronchoscopic approaches.","key_result":"Transthoracic marking is widely used but carries risks including pneumothorax, air embolism, dye dissipation/extravasation, and hook-wire dislodgement; robotic bronchoscopy is characterized as a safe and accurate alternative that can mark lesions in the same procedural setting as resection, though availability and learning curve are limiting factors.","limitations":"This is a narrative review without a systematic search strategy or meta-analysis, so no comparative efficacy or complication-rate data are pooled. Robotic bronchoscopy access is limited globally, and evidence on long-term oncologic outcomes tied to marking technique choice is not addressed.","practice_takeaway":"For thoracoscopic sublobar resection of small, subsolid, or deep lung lesions, preprocedural marking is essential — robotic bronchoscopy offers a same-session, lower-complication alternative to transthoracic methods where available. Modality choice should be driven by local expertise and resources, as no single technique is universally superior."}},{"doi":"10.1016/j.lungcan.2026.109558","pmid":null,"title":"Biology, detection, and management of incidental pulmonary nodules: the emerging role of targeted treatments. A review of the current literature and future perspectives","journal_title":"Lung Cancer","journal_issn":"0169-5002","published_at":"2026-08-03T00:00:00.000Z","url":"https://doi.org/10.1016/j.lungcan.2026.109558","source_score":5,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-08-08T13:23:33.481Z","updated_at":"2026-08-08T13:23:33.481Z","tags":[{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"brand","value":"Tagrisso","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"category","value":"Respiratory System","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"condition","value":"Lung Adenocarcinoma","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"condition","value":"Non-Small Cell Lung Cancer","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"condition","value":"Pulmonary Nodule","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"generic","value":"aumolertinib","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"generic","value":"osimertinib","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"modality","value":"EGFR Tyrosine Kinase Inhibitor","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"study_design","value":"Narrative Review","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"warning","value":"Aumolertinib is referenced via a conference abstract (Huang CB, JTHO 2024) — clinical data on its use for residual GGN lesions should be interpreted with caution.","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"warning","value":"Full text was not accessible; structured data was extracted from the abstract, highlights, keywords, and reference list only — quantitative outcomes cannot be confirmed.","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"warning","value":"Sample size is not applicable for this review article and has been omitted.","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"warning","value":"Sex of the studied population is not reported in the available text.","value_numeric":null},{"paper_doi":"10.1016/j.lungcan.2026.109558","tag_type":"warning","value":"Study design tagged as 'Narrative Review' based on the article type designation and methodology described; no systematic search protocol was reported.","value_numeric":null}],"summaries":{"what_studied":"This narrative review covers the classification, prevalence, detection, risk stratification, and management of incidental pulmonary nodules (IPNs), with a focus on oncogenic driver mutations (especially EGFR) and the emerging role of targeted therapies such as EGFR-TKIs in managing oncogene-driven IPNs.","key_result":"Most IPNs are benign, but a subset represent early-stage lung cancer. EGFR mutations are enriched in ground-glass nodules (GGNs), and early evidence suggests EGFR-TKIs (e.g., osimertinib, aumolertinib) may suppress progression of residual GGN lesions after resection. Immunotherapy shows limited activity in GGN-type lesions, particularly those with EGFR/ALK alterations.","limitations":"- Full text was not available; conclusions are based on the abstract, highlights, and reference list only.\n- As a narrative review, it is subject to selection bias and does not provide pooled quantitative estimates.\n- Most cited treatment data come from small case series, single-arm phase II trials, or retrospective studies rather than completed randomized controlled trials.","practice_takeaway":"When managing patients with residual or synchronous GGNs after lung resection, test for EGFR mutations — EGFR-TKIs are an emerging option for EGFR-mutant nodules and are under active investigation in ongoing phase II trials. Immunotherapy is unlikely to benefit GGN lesions, especially in EGFR/ALK-positive cases."}},{"doi":"10.1136/thorax-2025-223631","pmid":"41391887","title":"Tool in lesion verification of shape-sensing robotic-assisted bronchoscopy with cone beam CT in sampling peripheral pulmonary nodules","journal_title":"Thorax","journal_issn":"0040-6376","published_at":"2025-12-15T00:00:00.000Z","url":"https://doi.org/10.1136/thorax-2025-223631","source_score":1062,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-12-15","doi":"10.1136/thorax-2025-223631","days":"30","issn":"0040-6376","rank":"1","field":"Clinical Medicine","score":"1062","category":"Respiratory System","categories":["Respiratory System"],"_categories":["Respiratory System"]},"pubmed":{"doi":"10.1136/thorax-2025-223631","title":"Tool in lesion verification of shape-sensing robotic-assisted bronchoscopy with cone beam CT in sampling peripheral pulmonary nodules.","journal":"Thorax","methods":"","results":"Of 200 subjects recruited, 198 subjects had a successful biopsy (whereby lesion was reached and sample was taken) and 97% completed the required follow-up. The median size of the nodules was 13 mm; 26.8% (60/224) have a positive bronchus sign and 181 (80.8%) were located in the outer two-thirds of the lung. TIL was obtained in 99.0% (198/200). The strict diagnostic yield was 85% (170/200) with diagnostic accuracy of 92.0% (184/200) and sensitivity for malignancy of 95.5% (147/154). Diagnostic accuracy for nodules under 20 mm size, within 5 mm from a critical structure (eg, heart, aorta or main pulmonary artery) or from the pleura was 88.2% (172/195), 100% (11/11) and 93.3% (56/60), respectively. 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this was a single-arm diagnostic performance study.","value_numeric":null},{"paper_doi":"10.1136/thorax-2025-223631","tag_type":"warning","value":"Follow-up completion was 97%, which could affect accuracy estimates if losses were non-random.","value_numeric":null}],"summaries":{"what_studied":"A single-arm, multicentre prospective study evaluated shape-sensing robotic-assisted bronchoscopy (ssRAB) with cone beam CT (CBCT) for biopsy of suspicious pulmonary nodules; the primary outcome was tool-in-lesion (TIL) by CBCT, with diagnostic performance, safety, and subgroup outcomes (small and near pleura/fissure/mediastinum) also assessed.","key_result":"TIL was achieved in 99.0% (198/200); strict diagnostic yield was 85% (170/200), diagnostic accuracy 92.0% (184/200), and sensitivity for malignancy 95.5% (147/154). Subgroup diagnostic accuracy was 88.2% (172/195) for nodules <20 mm, 100% (11/11) within 5 mm of critical structures, and 93.3% (56/60) within 5 mm of the pleura; serious procedure-related adverse events occurred in 2% (4/200), including pneumothorax in 0.5% (1/200).","limitations":"Single-arm design without a comparator limits inference against alternative biopsy approaches; 3% did not complete follow-up; some subgroups were small (e.g., 11 near critical structures).","practice_takeaway":"In this multicentre series, ssRAB with CBCT achieved high lesion confirmation and diagnostic performance with low serious adverse event rates, including in small and challenging nodule locations. Consider this approach when planning bronchoscopic sampling of small, peripheral, or near-critical-structure pulmonary nodules."}}],"initialOffset":3,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Pulmonary Nodule"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Pulmonary Nodule"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Pulmonary Nodule"}}}]]

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