2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T698,Recurrent acute pancreatitis (RAP) or acute-on-chronic flares in chronic pancreatitis (CP) have limited preventive options beyond addressing the underlying aetiology. Statins, due to their anti-inflammatory properties, have been proposed as a potential prophylactic treatment. We aimed to evaluate whether simvastatin could reduce the recurrence of pancreatitis. At 23 centres, we conducted a triple-blind, randomised, controlled, superiority trial enrolling patients with at least two episodes of RAP or CP flares in the previous 12 months. Participants were randomly assigned to receive simvastatin or placebo for 1 year. The primary endpoint was the recurrence of pancreatitis. The target sample size was 144 patients; however, an interim analysis was planned in the event of slow recruitment. A total of 85 patients (42.1% women) were included in the interim analysis. In the intention-to-treat analysis, no significant differences were observed regarding recurrence: 46.2% simvastatin versus 44.4% placebo; OR 1.07, 95% CI 0.43 to 2.66; p=0.88, or time to recurrence. No statistically significant differences were observed in recurrence in per-protocol analysis (35.5% simvastatin vs 41.9% placebo; OR 0.76, 95% CI 0.27 to 2.12; p=0.60). Development of diabetes mellitus was more frequent in the simvastatin group (4 vs 0 patients; OR not calculable, p=0.04). This trial, evaluating simvastatin versus placebo for the prevention of pancreatitis, did not demonstrate a reduction in recurrence rate, although results might be underpowered due to early termination. The relationship between statins in these patients and new-onset diabetes requires further investigation. NCT04021498.31:Tae0, Background Recurrent acute pancreatitis (RAP) or acute-on-chronic flares in chronic pancreatitis (CP) have limited preventive options beyond addressing the underlying aetiology. Statins, due to their anti-inflammatory properties, have been proposed as a potential prophylactic treatment. Objective We aimed to evaluate whether simvastatin could reduce the recurrence of pancreatitis. Design At 23 centres, we conducted a triple-blind, randomised, controlled, superiority trial enrolling patients with at least two episodes of RAP or CP flares in the previous 12 months. Participants were randomly assigned to receive simvastatin or placebo for 1 year. The primary endpoint was the recurrence of pancreatitis. The target sample size was 144 patients; however, an interim analysis was planned in the event of slow recruitment. Results A total of 85 patients (42.1% women) were included in the interim analysis. In the intention-to-treat analysis, no significant differences were observed regarding recurrence: 46.2% simvastatin versus 44.4% placebo; OR 1.07, 95% CI 0.43 to 2.66; p=0.88, or time to recurrence. No statistically significant differences were observed in recurrence in per-protocol analysis (35.5% simvastatin vs 41.9% placebo; OR 0.76, 95% CI 0.27 to 2.12; p=0.60). Development of diabetes mellitus was more frequent in the simvastatin group (4 vs 0 patients; OR not calculable, p=0.04). Conclusion This trial, evaluating simvastatin versus placebo for the prevention of pancreatitis, did not demonstrate a reduction in recurrence rate, although results might be underpowered due to early termination. The relationship between statins in these patients and new-onset diabetes requires further investigation. Trial registration number NCT04021498 . 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Recurrent Acute Pancreatitis: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Recurrent Acute Pancreatitis (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Recurrent%20Acute%20Pancreatitis\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Recurrent Acute Pancreatitis\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Recurrent%20Acute%20Pancreatitis\"}]}}"}}]],["$","$L2f",null,{"title":"Recurrent Acute Pancreatitis: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Recurrent Acute Pancreatitis with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1136/gutjnl-2025-337154","pmid":"41482454","title":"Simvastatin in the prevention of recurrent pancreatitis: a triple-blinded randomised clinical trial (the SIMBA trial)","journal_title":"Gut","journal_issn":"0017-5749","published_at":"2026-01-03T00:00:00.000Z","url":"https://doi.org/10.1136/gutjnl-2025-337154","source_score":25,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-06","doi":"10.1136/gutjnl-2025-337154","days":"14","issn":"0017-5749","rank":"10","field":"Clinical Medicine","score":"25","category":"Gastroenterology & Hepatology","categories":["Gastroenterology & Hepatology"],"_categories":["Gastroenterology & Hepatology"]},"pubmed":{"doi":"10.1136/gutjnl-2025-337154","title":"Simvastatin in the prevention of recurrent pancreatitis: a triple-blinded randomised clinical trial (the SIMBA trial).","journal":"Gut","methods":"","results":"A total of 85 patients (42.1% women) were included in the interim analysis. In the intention-to-treat analysis, no significant differences were observed regarding recurrence: 46.2% simvastatin versus 44.4% placebo; OR 1.07, 95% CI 0.43 to 2.66; p=0.88, or time to recurrence. No statistically significant differences were observed in recurrence in per-protocol analysis (35.5% simvastatin vs 41.9% placebo; OR 0.76, 95% CI 0.27 to 2.12; p=0.60). Development of diabetes mellitus was more frequent in the simvastatin group (4 vs 0 patients; OR not calculable, p=0.04).","abstract":"$30","keywords":["CHRONIC PANCREATITIS","Hydroxymethylglutaryl-CoA Reductase Inhibitors","RANDOMIZED CONTROLLED TRIAL"],"pubmed_id":"41482454","conclusions":"This trial, evaluating simvastatin versus placebo for the prevention of pancreatitis, did not demonstrate a reduction in recurrence rate, although results might be underpowered due to early termination. The relationship between statins in these patients and new-onset diabetes requires further investigation.","publication_date":"2026-01-03T00:00:00"},"crossref":{"DOI":"10.1136/gutjnl-2025-337154","URL":"https://doi.org/10.1136/gutjnl-2025-337154","ISSN":["0017-5749","1468-3288"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1136/gutjnl-2025-337154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"gutjnl-2025-337154","type":"journal-article","issue":null,"score":1,"title":["Simvastatin in the prevention of recurrent pancreatitis: a triple-blinded randomised clinical trial (the SIMBA trial)"],"author":[{"given":"Lucía","family":"Guilabert","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Dr. Balmis General University Hospital-Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, 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cautiously.","value_numeric":null},{"paper_doi":"10.1136/gutjnl-2025-337154","tag_type":"warning","value":"Interim analysis with early termination; estimates may be imprecise due to small sample size.","value_numeric":null},{"paper_doi":"10.1136/gutjnl-2025-337154","tag_type":"warning","value":"Population details (age range, etiologies) were not provided in the excerpt.","value_numeric":null}],"summaries":{"what_studied":"A triple-blind randomized controlled superiority trial at 23 centres tested simvastatin versus placebo for 1 year to prevent recurrence in patients with ≥2 episodes of recurrent acute pancreatitis or chronic pancreatitis flares in the prior 12 months. The primary endpoint was recurrence of pancreatitis; an interim analysis was done due to slow recruitment.","key_result":"Among 85 patients, recurrence did not differ: intention-to-treat 46.2% with simvastatin vs 44.4% with placebo (OR 1.07, 95% CI 0.43–2.66; p=0.88); per-protocol 35.5% vs 41.9% (OR 0.76, 95% CI 0.27–2.12; p=0.60). New-onset diabetes occurred more often with simvastatin (4 vs 0; p=0.04).","limitations":"Early termination with an interim sample of 85 versus a planned 144 likely left the study underpowered. The mixed population (recurrent acute pancreatitis and chronic pancreatitis flares) and sparse diabetes events (4 vs 0) limit precision.","practice_takeaway":"Simvastatin did not reduce recurrent pancreatitis over 1 year versus placebo in this trial. If using statins in this population for other indications, be alert to a possible increase in new-onset diabetes, pending further data."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Recurrent Acute Pancreatitis"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Recurrent Acute Pancreatitis"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Recurrent Acute Pancreatitis"}}}]]

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