2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T68e,Patients with severe pulmonary embolism (PE) may experience hemodynamic instability with intubation and mechanical ventilation. However, the characteristics and outcomes of intubated PE patients have not been previously described in the literature. We conducted a retrospective cohort study of patients requiring activation of our hospital's Pulmonary Embolism Response Team (PERT) from 2012 to 2021 who were intubated within 24 h of their acute PE diagnosis. Our primary outcome was peri-intubation hemodynamic instability and death occurring within 30 min. Our secondary outcome was peri-intubation hemodynamic instability and death within 3 h of intubation. We included 51 patients. Within 30 min of intubation, seven (14%) patients had a new or increased vasopressor requirement, four (8%) suffered cardiac arrest, and 1 (2%) required ECMO. Within 3 h, 26 (51%) patients had a new or increased vasopressor requirement, six (12%) suffered cardiac arrest, and five (10%) required ECMO. Patients with a central PE (n = 29, 57%) were more likely to experience peri-intubation hemodynamic instability (OR 3.4, 95% CI [0.95, 13], p = 0.048). Patients who had right ventricular strain on CT (OR 3.7, 95% CI [1.01, 15], p = 0.043) or echocardiogram (OR 8.0, 95% CI [1.9, 42], p = 0.0014) were also more likely to experience hemodynamic instability. Peri-intubation hemodynamic deterioration occurs in more than half of patients with acute PE, and severe events, like cardiac arrest, are common. Physicians should be cautious when intubating PE patients. Further research is needed to identify optimal strategies to treat PE patients who require intubation.31:Ta5f,ABSTRACT Background Patients with severe pulmonary embolism (PE) may experience hemodynamic instability with intubation and mechanical ventilation. However, the characteristics and outcomes of intubated PE patients have not been previously described in the literature. Methods We conducted a retrospective cohort study of patients requiring activation of our hospital's Pulmonary Embolism Response Team (PERT) from 2012 to 2021 who were intubated within 24 h of their acute PE diagnosis. Our primary outcome was peri‐intubation hemodynamic instability and death occurring within 30 min. Our secondary outcome was peri‐intubation hemodynamic instability and death within 3 h of intubation. Results We included 51 patients. Within 30 min of intubation, seven (14%) patients had a new or increased vasopressor requirement, four (8%) suffered cardiac arrest, and 1 (2%) required ECMO. Within 3 h, 26 (51%) patients had a new or increased vasopressor requirement, six (12%) suffered cardiac arrest, and five (10%) required ECMO. Patients with a central PE ( n = 29, 57%) were more likely to experience peri‐intubation hemodynamic instability (OR 3.4, 95% CI [0.95, 13], p = 0.048). Patients who had right ventricular strain on CT (OR 3.7, 95% CI [1.01, 15], p = 0.043) or echocardiogram (OR 8.0, 95% CI [1.9, 42], p = 0.0014) were also more likely to experience hemodynamic instability. Conclusion Peri‐intubation hemodynamic deterioration occurs in more than half of patients with acute PE, and severe events, like cardiac arrest, are common. Physicians should be cautious when intubating PE patients. Further research is needed to identify optimal strategies to treat PE patients who require intubation. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Right Ventricular Strain: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Right Ventricular Strain (condition). Clinician-written summaries and actionable practice insights. 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Within 30 min of intubation, seven (14%) patients had a new or increased vasopressor requirement, four (8%) suffered cardiac arrest, and 1 (2%) required ECMO. Within 3 h, 26 (51%) patients had a new or increased vasopressor requirement, six (12%) suffered cardiac arrest, and five (10%) required ECMO. Patients with a central PE (n = 29, 57%) were more likely to experience peri-intubation hemodynamic instability (OR 3.4, 95% CI [0.95, 13], p = 0.048). Patients who had right ventricular strain on CT (OR 3.7, 95% CI [1.01, 15], p = 0.043) or echocardiogram (OR 8.0, 95% CI [1.9, 42], p = 0.0014) were also more likely to experience hemodynamic instability.","abstract":"$30","keywords":["intubation","mechanical ventilation","outcomes","pulmonary embolism","venous thromboembolism"],"pubmed_id":"42084455","conclusions":"Peri-intubation hemodynamic deterioration occurs in more than half of patients with acute PE, and severe events, like cardiac arrest, are common. Physicians should be cautious when intubating PE patients. Further research is needed to identify optimal strategies to treat PE patients who require intubation.","publication_date":"2026-05-05T00:00:00"},"crossref":{"DOI":"10.1111/acem.70317","URL":"https://doi.org/10.1111/acem.70317","ISSN":["1069-6563","1553-2712"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/acem.70317","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/acem.70317","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/acem.70317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"5","score":1,"title":["Characteristics and Short‐Term Outcomes of Patients With Acute Pulmonary Embolism Requiring Intubation"],"author":[{"given":"Isabel 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may overestimate complication rates compared to all-comer intubated PE patients.","value_numeric":null},{"paper_doi":"10.1111/acem.70317","tag_type":"warning","value":"Sex distribution is reported as mixed but specific breakdown is not provided in the abstract.","value_numeric":null},{"paper_doi":"10.1111/acem.70317","tag_type":"warning","value":"Small sample size (n=51) means confidence intervals are wide — especially for ECMO outcomes — and findings should be interpreted cautiously.","value_numeric":null}],"summaries":{"what_studied":"Retrospective cohort study of 51 intubated acute PE patients activated through a hospital PERT (2012–2021), examining peri-intubation hemodynamic instability and death within 30 min and 3 h of intubation.","key_result":"Within 30 min: 14% had new/increased vasopressor need, 8% had cardiac arrest, 2% required ECMO. Within 3 h: 51% had new/increased vasopressor need, 12% had cardiac arrest, 10% required ECMO. Central PE (OR 3.4), RV strain on CT (OR 3.7), and RV strain on echo (OR 8.0) were each associated with higher odds of hemodynamic instability.","limitations":"Single-center retrospective design with only 51 patients limits generalizability and statistical power. PERT activation as inclusion criterion may select for higher-acuity cases, introducing selection bias. No control group of non-intubated PE patients for comparison.","practice_takeaway":"Clinicians should anticipate hemodynamic collapse when intubating PE patients — especially those with central clot or RV strain on imaging — and prepare vasopressors, resuscitation resources, and ECMO backup in advance. Over half of intubated PE patients deteriorated within 3 hours."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Right Ventricular Strain"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Right Ventricular Strain"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Right Ventricular Strain"}}}]]

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