2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T76d,This case describes a 29-year-old man with Morbihan disease, characterized by a 5-year history of recurrent facial erythema, papules, and pustules, followed by persistent right face edema. Initially misdiagnosed as lupus erythematosus, he received multiple treatments with only transient relief. Clinical manifestations combined with pathological findings confirmed a diagnosis of Morbihan disease associated with rosacea. Notably, the patient developed erythema and papules on the inner thighs, along with small papules on the trunk and upper limbs for 3 months. A biopsy revealed nonspecific inflammation. Since the morphology of these lesions differed from any known skin disease and no other cause could be identified, we believe this may be a manifestation of the disease. Extra-facial manifestation not previously reported. Various therapies were attempted: doxycycline and azelaic acid improved erythema; baricitinib was ineffective; while omalizumab and intense pulsed light (IPL) achieved partial improvement in erythema and edema. Long-term isotretinoin therapy provided sustained remission without relapse during tapering, confirming its efficacy and safety. This case expands the clinical spectrum of Morbihan disease by documenting extra-facial involvement and reported isotretinoin as an effective long-term therapy, with omalizumab and IPL as promising adjuncts. Furthermore, the literature review (2004-2025) summarizes the clinical features, pathology, and treatment responses of reported cases, showing a male-to-female ratio of 2.81:1. Lymphatic or vascular dilation was significantly correlated with a favorable outcome. Conversely, dermal edema and granuloma were inversely associated with treatment efficacy, indicating poorer prognosis. However, based on uncontrolled data, these findings are strictly hypothesis-generating and do not establish a definitive treatment hierarchy.31:T83a,Emerging evidence suggests rosacea as a recognizable adverse event during dupilumab therapy. This study aimed to investigate the potential association between dupilumab and rosacea using pharmacovigilance data and to characterize the clinical features of dupilumab-associated rosacea (DAR) through a review of reported cases. We utilized the FDA Adverse Event Reporting System (FAERS) database (2017-2024) to identify disproportionality signals using four methods: Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Information Component (IC), and Empirical Bayesian Geometric Mean (EBGM). To contextualize these findings, we performed a focused narrative review of 8 publications comprising 10 DAR cases with extractable individual data. A significant disproportionality signal was identified across all four methods (ROR 3.873; PRR 3.872; IC 1.865 with IC025 1.653; EBGM 3.642), with reports predominantly in adults and females. In the case review, a consistent phenotype emerged: papulopustules on persistent centrofacial erythema with frequent burning; facial predominance with occasional extension to neck, scalp, or upper trunk; frequent Demodex detection by scraping, KOH, or in vivo imaging; and occasional granulomatous histology. Onset ranged from approximately 2 weeks to 21 months, including one post-discontinuation case. Most patients improved with rosacea-directed therapy (topical ivermectin or metronidazole; anti-inflammatory-dose doxycycline). However, dechallenge or rechallenge patterns and the need for dose-interval extension, temporary interruption, or switching biologic (e.g., lebrikizumab, upadacitinib) in a subset support a drug-related pattern at the reporting level. DAR represents a distinct clinical entity from dupilumab-associated head and neck dermatitis, which is eczematous and typically responds to antifungals or calcineurin inhibitors. While disproportionality signals indicate association rather than incidence or causality and are subject to reporting bias, clinicians should be aware of this potential adverse event to ensure appropriate management.32:Td6c,Several plant-based dietary foods are associated with the rosacea risk, but the associations between plant-based dietary patterns and the risk of rosacea remain unclear. We aimed to examine the associations of plant-based dietary patterns, represented by three plant-based diet indices (PDIs), with the risk of rosacea. This prospective cohort study included 198,557 participants free of rosacea at baseline from the UK Biobank. Three PDIs (the overall plant-based diet index, PDI; the healthful plant-based diet index, hPDI; and the unhealthful plant-based diet index, uPDI) were calculated from 24-h dietary recalls based on 17 food groups. The primary outcome was the risk of rosacea. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During a median follow-up of 13.46 years, 1075 new-onset rosacea cases were recorded. Each 10-point increase in the PDI and hPDI was associated with a 16% (95% CI: 0.76, 0.94) and 9% (95% CI: 0.82, 1.00) decrease in the risk of rosacea, respectively, whereas each 10-point increase in the uPDI was associated with a 12% (95% CI: 1.02, 1.24) increase in the risk. Compared with participants in the lowest PDI quintile, those in the highest PDI quintile had a lower risk of rosacea, with a HR of 0.78 (95% CI: 0.63, 0.95; p for trend = 0.004). In contrast, compared with participants in the lowest uPDI quintile, participants in the highest uPDI quintile had a higher risk of rosacea, with a HR of 1.23 (95% CI: 1.02, 1.48; p for trend = 0.046). A higher PDI or hPDI decreased the risk of rosacea, whereas a higher uPDI increased the rosacea risk. These findings suggest that adhering to an overall or a healthful plant-based pattern while avoiding an unhealthful plant-based pattern should be recommended as preventive strategies for rosacea. What is the disease? Rosacea is a chronic inflammatory dermatosis that is also psychologically burdensome, characterized by various skin lesions predominantly on the face including erythema, papulopustules, telangiectasia and/or ophthalmic involvement. It affects approximately 1% to 3% of people worldwide. The condition is often refractory to treatment, with frequent relapses. The identification of risk factors is crucial for the primary prevention of rosacea Location of the study: United Kingdom. To examine the associations of plant‐based dietary patterns represented by three plant‐based diet indices (PDIs) with the risk of rosacea. This study was based on a large population‐based prospective cohort of 198,557 participants from the UK Biobank, with a median follow‐up of 13.46 years. Three PDIs (the overall plant‐based diet index, PDI; the healthful plant‐based diet index, hPDI; and the unhealthful plant‐based diet index, uPDI) were calculated. The primary outcome was the risk of rosacea. Cox proportional hazards models were used to assess the associations between the three PDIs and the risk of rosacea. A higher PDI or hPDI was associated with a decreased risk of rosacea, while a higher uPDI was associated with an increased risk. These findings suggest that for individuals of European ancestry, adherence to an overall plant‐based diet, particularly one rich in whole grains, fruits, and vegetables, may lower the risk of rosacea, whereas a diet high in sugary beverages, snacks, desserts, refined grains, and fruit juices might increase the risk.33:Tb24,Abstract Background Several plant‐based dietary foods are associated with the rosacea risk, but the associations between plant‐based dietary patterns and the risk of rosacea remain unclear. Objectives We aimed to examine the associations of plant‐based dietary patterns, represented by three plant‐based diet indices (PDIs), with the risk of rosacea. Methods This prospective cohort study included 198,557 participants free of rosacea at baseline from the UK Biobank. Three PDIs (the overall plant‐based diet index, PDI; the healthful plant‐based diet index, hPDI; and the unhealthful plant‐based diet index, uPDI) were calculated from 24‐h dietary recalls based on 17 food groups. The primary outcome was the risk of rosacea. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results During a median follow‐up of 13.46 years, 1075 new‐onset rosacea cases were recorded. Each 10‐point increase in the PDI and hPDI was associated with a 16% (95% CI: 0.76, 0.94) and 9% (95% CI: 0.82, 1.00) decrease in the risk of rosacea, respectively, whereas each 10‐point increase in the uPDI was associated with a 12% (95% CI: 1.02, 1.24) increase in the risk. Compared with participants in the lowest PDI quintile, those in the highest PDI quintile had a lower risk of rosacea, with a HR of 0.78 (95% CI: 0.63, 0.95; p for trend = 0.004). In contrast, compared with participants in the lowest uPDI quintile, participants in the highest uPDI quintile had a higher risk of rosacea, with a HR of 1.23 (95% CI: 1.02, 1.48; p for trend = 0.046). Conclusions A higher PDI or hPDI decreased the risk of rosacea, whereas a higher uPDI increased the rosacea risk. These findings suggest that adhering to an overall or a healthful plant‐based pattern while avoiding an unhealthful plant‐based pattern should be recommended as preventive strategies for rosacea. 34:T79c,Patients with skin of color (SOC) face unique dermatologic challenges that are often underrepresented in research and in dermatological education, creating critical gaps in care. We aimed to identify and explore key gaps in research and clinical management for SOC across four domains: skin diseases, hair disorders, photoprotection, and aesthetic procedures. An international panel reviewed articles retrieved from PubMed using the search terms "skin of color" or "skin of colour" in titles and abstracts from September 2019 to September 2024. Inflammatory skin diseases, including acne, atopic dermatitis, psoriasis, and rosacea, are common in SOC subjects, necessitating tailored diagnostic and therapeutic approaches due to unique clinical presentations and specific challenges such as post-inflammatory hyperpigmentation and erythema detection. Pigmentary disorders such as melasma and acne-induced hyperpigmentation significantly impact quality of life in SOC, requiring cautious treatment to avoid exacerbation, while the unregulated use of skin bleaching agents containing high-potency corticosteroids can pose serious health risks. Skin cancer in SOC often presents at advanced stages with poorer outcomes due to lower awareness and unique clinical manifestations, resulting in delayed diagnosis. Hair disorders in SOC populations require tailored diagnostic and therapeutic approaches due to unique hair properties. Gaps in photoprotection education on SOC exacerbate pigmentary disorders and other dermatologic conditions, with limited research on effective sunscreens for this population. In aesthetic dermatology, misconceptions and knowledge gaps regarding the prevention of complications hinder access to safe and effective procedures for SOC subjects, compounded by inadequate diversity in clinical trials. Inclusive research, improved diagnostic accuracy, and customized procedures are needed to ensure equitable dermatologic care.35:T7ef,ABSTRACT Patients with skin of color (SOC) face unique dermatologic challenges that are often underrepresented in research and in dermatological education, creating critical gaps in care. We aimed to identify and explore key gaps in research and clinical management for SOC across four domains: skin diseases, hair disorders, photoprotection, and aesthetic procedures. An international panel reviewed articles retrieved from PubMed using the search terms “skin of color” or “skin of colour” in titles and abstracts from September 2019 to September 2024. Inflammatory skin diseases, including acne, atopic dermatitis, psoriasis, and rosacea, are common in SOC subjects, necessitating tailored diagnostic and therapeutic approaches due to unique clinical presentations and specific challenges such as post‐inflammatory hyperpigmentation and erythema detection. Pigmentary disorders such as melasma and acne‐induced hyperpigmentation significantly impact quality of life in SOC, requiring cautious treatment to avoid exacerbation, while the unregulated use of skin bleaching agents containing high‐potency corticosteroids can pose serious health risks. Skin cancer in SOC often presents at advanced stages with poorer outcomes due to lower awareness and unique clinical manifestations, resulting in delayed diagnosis. Hair disorders in SOC populations require tailored diagnostic and therapeutic approaches due to unique hair properties. Gaps in photoprotection education on SOC exacerbate pigmentary disorders and other dermatologic conditions, with limited research on effective sunscreens for this population. In aesthetic dermatology, misconceptions and knowledge gaps regarding the prevention of complications hinder access to safe and effective procedures for SOC subjects, compounded by inadequate diversity in clinical trials. Inclusive research, improved diagnostic accuracy, and customized procedures are needed to ensure equitable dermatologic care.36:T598,Dapsone (4,4'-Diamino diphenyl sulfone) has been utilized in managing a wide variety of mucocutaneous conditions, usually as a systemic product. Topical dapsone is commercially available as 5% and 7.5% gel and is FDA-approved for acne vulgaris. These topical formulations have shown less systemic absorption and fewer adverse events. Considering this, topical dapsone might benefit localized disease, immunosuppressed individuals, and those who avoid exposure to systemic therapies. Following PRISMA guidelines, a comprehensive literature search was conducted across PubMed, Web of Science, and Scopus databases for published papers up to April 2025. Then, eligible studies are included, and we summarize the findings of different clinical studies concerning the use, efficacy, and side effects of topical dapsone in various mucocutaneous conditions, excluding acne vulgaris. Finally, 56 articles were selected based on the eligibility criteria. We summarized and categorized them into two general entities, including applications of the topical dapsone and side effects of the topical dapsone. The first entity has six subheadings consisting of acne vulgaris and acneiform eruptions, Rosacea, neutrophilic dermatosis, vesiculobullous diseases, vasculitis, and others. In conclusion, topical dapsone appears to have therapeutic advantages in several mucocutaneous conditions, especially in minimal, localized, and chronic eruptions.37:T6da,ABSTRACTBackgroundDapsone (4,4′‐Diamino diphenyl sulfone) has been utilized in managing a wide variety of mucocutaneous conditions, usually as a systemic product. Topical dapsone is commercially available as 5% and 7.5% gel and is FDA‐approved for acne vulgaris. These topical formulations have shown less systemic absorption and fewer adverse events. Considering this, topical dapsone might benefit localized disease, immunosuppressed individuals, and those who avoid exposure to systemic therapies.MethodsFollowing PRISMA guidelines, a comprehensive literature search was conducted across PubMed, Web of Science, and Scopus databases for published papers up to April 2025. Then, eligible studies are included, and we summarize the findings of different clinical studies concerning the use, efficacy, and side effects of topical dapsone in various mucocutaneous conditions, excluding acne vulgaris.ResultsFinally, 56 articles were selected based on the eligibility criteria. We summarized and categorized them into two general entities, including applications of the topical dapsone and side effects of the topical dapsone. The first entity has six subheadings consisting of acne vulgaris and acneiform eruptions, Rosacea, neutrophilic dermatosis, vesiculobullous diseases, vasculitis, and others.ConclusionIn conclusion, topical dapsone appears to have therapeutic advantages in several mucocutaneous conditions, especially in minimal, localized, and chronic eruptions.38:Ta32,Rosacea is a highly prevalent dermatosis affecting 5% of the world's population. Its impact is not only physical but also psychological, as over 60% of patients with rosacea also suffer from depression, anxiety, and other psychological comorbidities. Currently, topical treatments yield low or unsatisfactory success rates, and rosacea complications such as disfigurement, burning sensation, and pain can greatly affect patients' well-being. Intra-dermotherapy with high molecular weight non-cross-linked hyaluronic acid plus succinic acid has shown anti-inflammatory, regenerative, and vascular modulatory effects. To evaluate the efficacy and effectiveness of high molecular weight non-cross-linked hyaluronic acid (HMWNCHA) plus succinic acid (SA) mesotherapy in rosacea patients who are not responding to topical treatments. To determine the degree of improvement in general parameters such as erythema, telangiectasia, and skin laxity and hydration. To compare the cost of this treatment with that of laser therapy, a widely used modality. We performed a non-randomized, controlled interventional study, and we evaluated the results after three sessions (once monthly) as the primary endpoint of this mesotherapy, using a product containing 1.1% of high molecular weight non-cross-linked hyaluronic acid plus 1.6% succinic acid (full face, 2 mL per session, administered using the papule technique) in a group of 20 male and female patients, aged 40-45 years, Fitzpatrick skin types I-III, without comorbidities. All patients were already undergoing topical treatment with Ivermectin 1%, Metronidazole 0.75%, and photoprotection, but without good results or clear improvement, quantified as a reduction in the Investigator's Global Assessment (IGA) severity score of at least 1 point. Erythema, hydration, and facial telangiectasia were evaluated at every session for proper quantification. Our study group was compared with a control group that only continued their topical treatment, and the study lasted 4 months, with a prospective follow-up at 6 months. Our results showed a reduction of 80% in the baseline erythema, an improvement of 30% in skin hydration, and a reduction of 20% in facial telangiectasia after three sessions, compared with patients who used only topical treatment. In addition, the costs were significantly lower than those of three sessions of laser therapy in a private healthcare setting. We demonstrated that using this acid combination in mesotherapy is an efficient, safe, and cost-effective adjunct therapy for patients already using a particular topical treatment.39:Tbd2,ABSTRACTBackgroundRosacea is a highly prevalent dermatosis affecting 5% of the world's population. Its impact is not only physical but also psychological, as over 60% of patients with rosacea also suffer from depression, anxiety, and other psychological comorbidities. Currently, topical treatments yield low or unsatisfactory success rates, and rosacea complications such as disfigurement, burning sensation, and pain can greatly affect patients' well‐being. Intra‐dermotherapy with high molecular weight non‐cross‐linked hyaluronic acid plus succinic acid has shown anti‐inflammatory, regenerative, and vascular modulatory effects.ObjectivesTo evaluate the efficacy and effectiveness of high molecular weight non‐cross‐linked hyaluronic acid (HMWNCHA) plus succinic acid (SA) mesotherapy in rosacea patients who are not responding to topical treatments. To determine the degree of improvement in general parameters such as erythema, telangiectasia, and skin laxity and hydration. To compare the cost of this treatment with that of laser therapy, a widely used modality.MethodsWe performed a non‐randomized, controlled interventional study, and we evaluated the results after three sessions (once monthly) as the primary endpoint of this mesotherapy, using a product containing 1.1% of high molecular weight non‐cross‐linked hyaluronic acid plus 1.6% succinic acid (full face, 2 mL per session, administered using the papule technique) in a group of 20 male and female patients, aged 40–45 years, Fitzpatrick skin types I–III, without comorbidities. All patients were already undergoing topical treatment with Ivermectin 1%, Metronidazole 0.75%, and photoprotection, but without good results or clear improvement, quantified as a reduction in the Investigator's Global Assessment (IGA) severity score of at least 1 point. Erythema, hydration, and facial telangiectasia were evaluated at every session for proper quantification. Our study group was compared with a control group that only continued their topical treatment, and the study lasted 4 months, with a prospective follow‐up at 6 months.ResultsOur results showed a reduction of 80% in the baseline erythema, an improvement of 30% in skin hydration, and a reduction of 20% in facial telangiectasia after three sessions, compared with patients who used only topical treatment. In addition, the costs were significantly lower than those of three sessions of laser therapy in a private healthcare setting.ConclusionWe demonstrated that using this acid combination in mesotherapy is an efficient, safe, and cost‐effective adjunct therapy for patients already using a particular topical treatment.3a:T55c,The potent carcinogen, benzene, is a known degradation product of benzoyl peroxide (BPO) and was recently reported to form when BPO drug products, used for acne and rosacea treatment, are incubated at body temperature and elevated temperatures expected during storage and transportation. This study provides evidence for a wide range of benzene concentrations (0.16-35.30 ppm) detected by gas chromatography-mass spectrometry in 111 over-the-counter BPO drug products tested and maintained at room temperature. A prescription-encapsulated BPO drug product was stability tested at cold (2 °C) and elevated (50 °C) temperature, resulting in no apparent benzene formation at 2 °C and high levels of benzene formation at 50 °C, suggesting that encapsulation technology may not stabilize BPO drug products but that cold storage may greatly reduce benzene formation. Face model experiments where BPO drug product was applied to polymethyl methacrylate photoprotection test skin plates and benzene was detected in surrounding air by selected ion flow tube-mass spectrometry showed detectable benzene through evaporation and substantial benzene formation when exposed to UV light at levels below peak sunlight. Results suggest that potential benzene exposure from formation during BPO drug product use poses significant risks independent of the starting benzene concentration.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Rosacea: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Rosacea (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Rosacea\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Rosacea\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Rosacea\"}]}}"}}]],["$","$L2f",null,{"title":"Rosacea: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Rosacea with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.2340/actadv.v106.adv-2026-0668","pmid":"42658205","title":"Patient Expectations and Perceived Treatment Benefit in Dermatology: A Sex-specific Analysis in Routine Dermatological Care","journal_title":"Acta Dermato-Venereologica","journal_issn":"1651-2057","published_at":"2026-08-27T00:00:00.000Z","url":"https://doi.org/10.2340/actadv.v106.adv-2026-0668","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-05T06:20:19.612Z","updated_at":"2026-09-05T06:20:19.612Z","tags":[{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"condition","value":"Acne","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"condition","value":"Allergic Skin Disease","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"condition","value":"Hidradenitis Suppurativa","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"condition","value":"Inflammatory Skin Disease","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"condition","value":"Rosacea","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"condition","value":"Skin Cancer","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"sample_size","value":"n=460","value_numeric":460},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"warning","value":"Sex was recorded as a binary self-reported variable; the paper explicitly notes it refers to biological sex, so findings may not apply to gender-diverse populations.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"warning","value":"The study is described as 'hypothesis-generating' by the authors themselves; results should not be used to change practice without confirmatory multivariable evidence.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"warning","value":"The study used a convenience sample with no a-priori power calculation, so effect estimates may be imprecise. The convenience sample design and single-center setting limit generalizability.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0668","tag_type":"warning","value":"Univariable sex comparisons were not adjusted for age (mean difference ~4 years between groups), disease severity, or diagnosis mix, which could confound the observed differences.","value_numeric":null}],"summaries":{"what_studied":"This cross-sectional study examined sex differences in treatment expectations (PNQ), perceived treatment benefit (PBQ), and the expectation–benefit gap using the Patient Benefit Index (PBI) in 460 adult dermatology outpatients (232 male, 228 female; mean age 52.1 years) at a single German academic center between February 2024 and February 2026.","key_result":"Women reported higher treatment expectations than men across all 25 items (13/25 significant after Bonferroni correction), with the largest gaps for lower treatment costs (male 3.21 vs female 3.96, p<0.001) and fewer side-effects (3.66 vs 4.28, p<0.001). Despite comparable perceived benefit between sexes, the expectation–benefit gap was significant for 24/25 items in women (effect sizes r=0.69–0.82) versus only 10/25 in men, with women's largest gaps for healed skin (Δ=1.43) and regaining control (Δ=1.08).","limitations":"- The expectation–benefit gap was derived cross-sectionally (not a prospective disconfirmation design), so it reflects a retrospective discrepancy score, not a validated longitudinal measure.\n- Sex comparisons were univariable and unadjusted for confounders such as age, disease severity, or diagnosis.\n- The cohort was dominated by inflammatory skin diseases (65.1%), limiting generalizability to non-inflammatory or more homogeneous dermatological populations.","practice_takeaway":"Women in dermatology consistently enter treatment with higher expectations than men but perceive similar benefit, creating a large unmet-expectations gap — clinicians should proactively discuss realistic treatment goals with female patients at the start of care. Addressing this gap explicitly may improve satisfaction and adherence, since unmet expectations — not just insufficient efficacy — can drive perceived treatment failure."}},{"doi":"10.1001/jamadermatol.2026.2062","pmid":"42384418","title":"Topical Preparations for Moderate to Severe Rosacea Treatment","journal_title":"JAMA Dermatology","journal_issn":"2168-6068","published_at":"2026-07-01T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13324944/","source_score":31,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-08T13:26:23.135Z","updated_at":"2026-07-08T13:26:23.135Z","tags":[{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"brand","value":"Soolantra","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"condition","value":"Rosacea","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"generic","value":"benzoyl peroxide","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"generic","value":"ivermectin","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"generic","value":"metronidazole","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"level_of_evidence","value":"1","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"modality","value":"Topical Antimicrobial","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"modality","value":"Topical Antiparasitic","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"modality","value":"Topical Benzoyl Peroxide","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"sample_size","value":"n=11399","value_numeric":11399},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"study_design","value":"Systematic Review and Network Meta-Analysis","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"warning","value":"'Encapsulated benzoyl peroxide' is a novel formulation; it may not yet have a widely recognized brand name confirmed in this paper.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"warning","value":"Full text is under PMC embargo until July 1, 2027; structured data is based solely on the abstract and results summary provided.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"warning","value":"The brand name 'Soolantra' is inferred for topical ivermectin 1% cream — not explicitly stated in the abstract.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2062","tag_type":"warning","value":"The impact_flag 'practice_changing' is applied based on the finding that ivermectin and encapsulated BPO outperform the long-standing standard metronidazole, but certainty of evidence grades from GRADE were not extractable from the abstract alone.","value_numeric":null}],"summaries":{"what_studied":"A systematic review and network meta-analysis of 32 RCTs (n=11,399 adults) compared the efficacy and tolerability of 10 topical therapies for moderate to severe rosacea, with most studies spanning 8–16 weeks of follow-up.","key_result":"Compared with metronidazole, both ivermectin (MD −4.17 lesions; 95% CI, 1.85–6.48) and encapsulated benzoyl peroxide (MD −4.14 lesions; 95% CI, 0.62–7.66) reduced lesion counts more effectively and achieved higher IGA success rates (+10.31% and +15.51%, respectively). However, encapsulated benzoyl peroxide had significantly more discontinuations due to adverse events than metronidazole (MD +8.33%; 95% CI, 0.45–16.22).","limitations":"- Follow-up was mostly 8–16 weeks, leaving long-term efficacy and tolerability unknown.\n- Limited data prevented robust synthesis of patient-reported outcomes and erythema endpoints.\n- Network meta-analysis relies on indirect comparisons, which may introduce uncertainty.","practice_takeaway":"For moderate to severe rosacea, topical ivermectin offers better lesion reduction and IGA response than metronidazole with a similar tolerability profile, making it a strong first-line topical option. Encapsulated benzoyl peroxide is also more efficacious but carries a higher risk of treatment discontinuation due to side effects — counsel patients accordingly before prescribing."}},{"doi":"10.2340/actadv.v106.adv-2026-0599","pmid":"42374766","title":"Validation and Responsiveness of the Rosacea Area and Severity Index in a Chinese Cohort: A Comparative Study with the Investigator’s Global Assessment","journal_title":"Acta Dermato-Venereologica","journal_issn":"1651-2057","published_at":"2026-06-29T00:00:00.000Z","url":"https://doi.org/10.2340/actadv.v106.adv-2026-0599","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-06T13:36:21.854Z","updated_at":"2026-07-06T13:36:21.854Z","tags":[{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"condition","value":"Rosacea","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"modality","value":"Disease Severity Assessment Tool","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"sample_size","value":"n=230","value_numeric":230},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"study_design","value":"Prospective Cohort Study with Cross-Sectional and Longitudinal Components","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"warning","value":"All patients were Chinese adults (Fitzpatrick III–IV); findings may not apply to Caucasian or other non-East-Asian populations.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"warning","value":"Study design is primarily a validation/psychometric study using photo-based ratings, not a standard interventional cohort — 'level_of_evidence: 2' reflects diagnostic/instrument validation hierarchy; some may classify differently.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"warning","value":"The MCID for RASI is not yet defined, so the clinical significance of detected RASI changes in IGA-stable patients cannot be fully quantified.","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0599","tag_type":"warning","value":"The 'responsiveness' substudy used only 60 of 230 patients and lacked a control arm, limiting conclusions about treatment effect size.","value_numeric":null}],"summaries":{"what_studied":"This study validated the Rosacea Area and Severity Index (RASI) in 230 Chinese patients (Fitzpatrick skin types III–IV) by comparing it to the Investigator's Global Assessment (IGA), assessing reliability, validity, and responsiveness over a 1-month follow-up period using standardized VISIA photographs rated by 6 trained observers.","key_result":"RASI showed excellent interobserver reliability (ICC=0.923), comparable to IGA (ICC=0.935), and strong convergent validity (Spearman r=0.726 vs. IGA). RASI outperformed IGA in responsiveness (standardized response mean 0.43 vs. 0.37) and detected significant changes (p<0.001) in 35 patients deemed \"stable\" by IGA.","limitations":"- Photograph-based 2D assessment may miss physiological fluctuations in erythema and telangiectasia; no direct comparison with in-person scoring was done.\n- Cohort was exclusively Chinese; generalizability to other ethnicities is unconfirmed.\n- Minimal clinically important difference (MCID) for RASI remains undefined, limiting clinical interpretation of score changes.","practice_takeaway":"RASI detects subtle rosacea changes that IGA misses, making it better suited for tracking treatment response — especially in mild-to-moderate disease where IGA may not register meaningful improvements. Clinicians and trialists should consider adopting RASI with standardized photography and a brief training session to ensure reliable scoring."}},{"doi":"10.1001/jamadermatol.2026.1437","pmid":"42307911","title":"Systemic Proteomic Alterations and Predictive Biomarkers of Paroxetine Response in Refractory Rosacea","journal_title":"JAMA Dermatology","journal_issn":"2168-6068","published_at":"2026-06-17T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13276666/","source_score":12,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-25T13:25:13.805Z","updated_at":"2026-06-25T13:25:13.805Z","tags":[{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"condition","value":"Rosacea","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"generic","value":"paroxetine","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"modality","value":"Selective Serotonin Reuptake Inhibitor","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"sample_size","value":"n=24","value_numeric":24},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"study_design","value":"Secondary Analysis of Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"warning","value":"AUC confidence intervals for IGFBP2 are very wide (0.55–1.00), meaning clinical utility as a predictive biomarker is uncertain.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"warning","value":"Full text is under PMC embargo until June 17, 2027; this summary is based solely on the abstract and results excerpt.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.1437","tag_type":"warning","value":"Sample is exclusively female (n=24); results may not apply to male patients or broader rosacea populations.","value_numeric":null}],"summaries":{"limitations":"- Very small sample (n=24), all female, limiting generalizability to men and broader populations.\n- Wide confidence intervals for AUC estimates (e.g., IGFBP2 lower bound 0.55) signal substantial statistical uncertainty.\n- Exploratory/secondary proteomic analysis; findings are hypothesis-generating and require independent replication.","what_studied":"This secondary proteomic analysis, nested within a 12-week multicenter RCT (PRRERCT), investigated systemic plasma protein changes and predictive biomarkers of paroxetine (25 mg/day oral) response in 24 adult women with refractory erythematous rosacea (CEA score ≥3).","key_result":"Paroxetine significantly reduced mean CEA scores from 3.1 to 2.3 and Flushing Assessment Tool scores from 3.1 to 2.0 (P<.001). Proteomic analysis identified 497 differentially expressed proteins; candidate biomarkers OLFML3 (AUC 0.87, 95% CI 0.70–1.00) and IGFBP2 (AUC 0.80, 95% CI 0.55–1.00) showed the highest predictive value for clinical response.","practice_takeaway":"Paroxetine may improve erythema and flushing in refractory rosacea via neuro-vascular-immune pathways, but the sample is too small to change practice. OLFML3 and IGFBP2 are early candidate biomarkers worth tracking in future validation studies."}},{"doi":"10.1016/j.jaad.2026.04.1986","pmid":"42092611","title":"Pathophysiologic Distinctions Between Sensitive Skin Syndrome and Rosacea: Evidence from a Sensitive vs. Non-Sensitive Skin Pilot Study","journal_title":"Journal of the American Academy of Dermatology","journal_issn":"0190-9622","published_at":"2026-05-07T00:00:00.000Z","url":"https://doi.org/10.1016/j.jaad.2026.04.1986","source_score":38,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-05-07","doi":"10.1016/j.jaad.2026.04.1986","days":"7","issn":"0190-9622","rank":"1","field":"Clinical Medicine","score":"38","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1016/j.jaad.2026.04.1986","title":"Pathophysiologic Distinctions Between Sensitive Skin Syndrome and Rosacea: Evidence from a Sensitive vs. Non-Sensitive Skin Pilot 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Syndrome","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.04.1986","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.04.1986","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.04.1986","tag_type":"study_design","value":"Pilot Study","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.04.1986","tag_type":"warning","value":"Level of evidence set to 4 as a conservative estimate for a small pilot/observational study; may need revision once full text is reviewed.","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.04.1986","tag_type":"warning","value":"Only bibliographic metadata was provided for this paper — no abstract, methods, results, or conclusions were included. Summaries and tags are based solely on the title and journal context. Key results, sample size, sex, and specific mechanistic findings could not be extracted.","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.04.1986","tag_type":"warning","value":"Study design classified as 'Pilot Study' based on title; exact methodology (observational, cross-sectional, etc.) is unconfirmed.","value_numeric":null}],"summaries":{"what_studied":"This pilot study examined pathophysiologic differences between sensitive skin syndrome (SSS) and rosacea, comparing participants with sensitive versus non-sensitive skin to identify distinguishing mechanistic features.","limitations":"Pilot study design limits statistical power and generalizability; sample size is likely small; specific outcome measures and full results are not available from the provided abstract.","practice_takeaway":"Clinicians should be aware that sensitive skin syndrome and rosacea may have distinct underlying mechanisms, which could inform more targeted treatment approaches for each condition."}},{"doi":"10.2147/ccid.s596249","pmid":"42079476","title":"Morbihan Disease May Induce Nonspecific Inflammatory of Extra-Facial Region: A Case Report and Literature Review","journal_title":"Clinical, Cosmetic and Investigational Dermatology","journal_issn":"1178-7015","published_at":"2026-05-04T00:00:00.000Z","url":"https://doi.org/10.2147/ccid.s596249","source_score":32,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-04-28","doi":"10.2147/ccid.s596249","days":"30","issn":"1178-7015","rank":"9","field":"Clinical Medicine","score":"32","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.2147/CCID.S596249","title":"Morbihan Disease May Induce Nonspecific Inflammatory of Extra-Facial Region: A Case Report and Literature Review.","journal":"Clinical, cosmetic and investigational dermatology","methods":"","results":"","abstract":"$30","keywords":["Morbihan disease","case report","literature 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In the pooled literature cohort (n=80), lymphatic/vascular dilation on biopsy predicted favorable outcomes (OR 6.00, 95% CI 1.57–22.96, p=0.007), while dermal edema (OR 0.167, p=0.007) and granuloma (OR 0.321, p=0.037) predicted poorer response. Of 24 isotretinoin-treated patients, 15 improved; all 4 omalizumab-treated patients responded.","limitations":"- Evidence base is entirely retrospective case reports/series, precluding any definitive treatment hierarchy.\n- Literature search restricted to English-language publications, introducing potential language bias.\n- Extra-facial lesion attribution to Morbihan disease is presumptive (biopsy showed only nonspecific inflammation; no definitive causal link established).","practice_takeaway":"Consider long-term low-dose isotretinoin as a first-line option in refractory Morbihan disease; omalizumab and IPL may offer partial benefit as adjuncts. Histopathological findings (lymphatic/vascular dilation vs. dermal edema or granuloma) may help predict treatment response, though data are exploratory only."}},{"doi":"10.1007/s00266-026-05834-y","pmid":"42047762","title":"Effectiveness of Radiofrequency Microneedling in the Treatment of Dermatological Conditions: A Systematic Review","journal_title":"Aesthetic Plastic Surgery","journal_issn":"0364-216X","published_at":"2026-04-28T00:00:00.000Z","url":"https://doi.org/10.1007/s00266-026-05834-y","source_score":8,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-07T22:49:32.722Z","updated_at":"2026-05-07T22:49:32.722Z","tags":[{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"category","value":"Surgery","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Atrophic Acne Scars","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Melasma","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Photoaging","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Primary Axillary Hyperhidrosis","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Rosacea","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Skin Laxity","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"condition","value":"Striae","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"generic","value":"botulinum toxin A","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"modality","value":"Botulinum Toxin","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"modality","value":"Fractional Laser","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"modality","value":"Radiofrequency Microneedling","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"sample_size","value":"n=41 studies","value_numeric":41},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"study_design","value":"Systematic Review","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"warning","value":"Level of evidence is assigned as '2' based on systematic review of RCTs and cohort studies, but the journal's own assigned level was not explicitly stated in the provided text.","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"warning","value":"Sample size tag reflects number of included studies (n=41), not individual patients — total patient count is not reported in the abstract.","value_numeric":null},{"paper_doi":"10.1007/s00266-026-05834-y","tag_type":"warning","value":"The PROSPERO registration number (CRD420251089393) appears unusually formatted — may contain a typographic error in the source.","value_numeric":null}],"summaries":{"what_studied":"Systematic review evaluating the clinical effectiveness, safety, and patient-reported outcomes (PROs) of radiofrequency microneedling (RFMN) across multiple dermatological indications (acne scars, skin laxity/photoaging, rosacea, melasma, striae, axillary hyperhidrosis) in 41 studies published January 2015–July 2025.","key_result":"RFMN consistently reduced atrophic acne scar scores with efficacy comparable to fractional lasers, and improved wrinkle scales, dermal density, and submental volume for skin laxity/photoaging. Botulinum toxin A outperformed RFMN for primary axillary hyperhidrosis. Side effects were mostly transient (erythema, edema, pain); post-inflammatory hyperpigmentation was infrequent and self-limited. PROs showed high satisfaction and minimal downtime.","limitations":"- Heterogeneity in devices, technical parameters (temperature, pulse width, cooling), and outcome measures limits cross-study comparisons.\n- Inconsistent reporting of device settings prevents protocol standardization.\n- No meta-analysis performed; findings are narratively synthesized only.","practice_takeaway":"RFMN is a safe, well-tolerated option for atrophic acne scars, skin laxity, and photoaging across diverse Fitzpatrick skin types — consider it as a first-line or adjunct procedure with a favorable recovery profile. For primary axillary hyperhidrosis, botulinum toxin A remains the stronger choice over RFMN."}},{"doi":"10.1080/09546634.2025.2605426","pmid":"41486954","title":"From signal to strategy: a disproportionality analysis of dupilumab-associated rosacea in FAERS with a summary of reported clinical cases","journal_title":"Journal of Dermatological Treatment","journal_issn":"0954-6634","published_at":"2026-01-05T00:00:00.000Z","url":"https://doi.org/10.1080/09546634.2025.2605426","source_score":4,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-08","doi":"10.1080/09546634.2025.2605426","days":"7","issn":"0954-6634","rank":"8","field":"Clinical Medicine","score":"4","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1080/09546634.2025.2605426","title":"From signal to strategy: a disproportionality analysis of dupilumab-associated rosacea in FAERS with a summary of reported clinical cases.","journal":"The Journal of dermatological treatment","methods":"","results":"A significant disproportionality signal was identified across all four methods (ROR 3.873; PRR 3.872; IC 1.865 with IC025 1.653; EBGM 3.642), with reports predominantly in adults and females. In the case review, a consistent phenotype emerged: papulopustules on persistent centrofacial erythema with frequent burning; facial predominance with occasional extension to neck, scalp, or upper trunk; frequent Demodex detection by scraping, KOH, or in vivo imaging; and occasional granulomatous histology. Onset ranged from approximately 2 weeks to 21 months, including one post-discontinuation case. Most patients improved with rosacea-directed therapy (topical ivermectin or metronidazole; anti-inflammatory-dose doxycycline). However, dechallenge or rechallenge patterns and the need for dose-interval extension, temporary interruption, or switching biologic (e.g., lebrikizumab, upadacitinib) in a subset support a drug-related pattern at the reporting level.","abstract":"$31","keywords":["Dupilumab","FAERS","Rosacea","atopic dermatitis","disproportionality analysis","pharmacovigilance"],"pubmed_id":"41486954","conclusions":"","publication_date":"2026-01-05T00:00:00"},"crossref":{"DOI":"10.1080/09546634.2025.2605426","URL":"https://doi.org/10.1080/09546634.2025.2605426","ISSN":["0954-6634","1471-1753"],"link":[{"URL":"https://www.tandfonline.com/doi/pdf/10.1080/09546634.2025.2605426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"1","score":1,"title":["From signal to strategy: a disproportionality analysis of dupilumab-associated rosacea in FAERS with a summary of reported clinical 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formal consensus methodology is not detailed.","value_numeric":null}],"summaries":{"what_studied":"An international panel reviewed PubMed articles with “skin of color” or “skin of colour” in the title/abstract from September 2019 to September 2024 to map research and clinical care gaps for skin of color across skin diseases, hair disorders, photoprotection, and aesthetic procedures.","key_result":"The panel highlighted consistent gaps: inflammatory diseases in skin of color need tailored diagnosis and treatment due to unique presentations and challenges detecting erythema and managing post‑inflammatory hyperpigmentation; pigmentary disorders strongly affect quality of life and unsafe skin bleaching with high‑potency corticosteroids poses serious risks; skin cancer often presents late with poorer outcomes; and photoprotection and aesthetic care lack inclusive evidence and guidance.","limitations":"The search was limited to PubMed and to papers with “skin of color/colour” in the title or abstract, which may miss relevant studies. No quantitative outcomes or effect estimates are reported, and formal consensus methods are not described.","practice_takeaway":"In patients with skin of color, expect different visual cues and prioritize detection of erythema and post‑inflammatory hyperpigmentation; tailor treatment and counsel on photoprotection and the dangers of unregulated bleaching agents. Be vigilant for late‑presenting skin cancers and proceed cautiously with aesthetic procedures given sparse, non‑inclusive trial data."}},{"doi":"10.1111/jocd.70494","pmid":"41051026","title":"Efficacy and Safety of Topical Dapsone in Dermatology: A Scoping Review of Clinical Studies","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2025-10-06T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70494","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-10-12","doi":"10.1111/jocd.70494","days":"7","issn":"1473-2130","rank":"9","field":"Clinical Medicine","score":"7","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70494","title":"Efficacy and Safety of Topical Dapsone in Dermatology: A Scoping Review of Clinical Studies.","journal":"Journal of cosmetic dermatology","methods":"","results":"Finally, 56 articles were selected based on the eligibility criteria. We summarized and categorized them into two general entities, including applications of the topical dapsone and side effects of the topical dapsone. The first entity has six subheadings consisting of acne vulgaris and acneiform eruptions, Rosacea, neutrophilic dermatosis, vesiculobullous diseases, vasculitis, and others.","abstract":"$36","keywords":["dapsone","dermatology","skin","sulfones","topical"],"pubmed_id":"41051026","conclusions":"In conclusion, topical dapsone appears to have therapeutic advantages in several mucocutaneous conditions, especially in minimal, localized, and chronic eruptions.","publication_date":"2025-10-06T00:00:00"},"crossref":{"DOI":"10.1111/jocd.70494","URL":"https://doi.org/10.1111/jocd.70494","ISSN":["1473-2130","1473-2165"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"10","score":1,"title":["Efficacy and Safety of Topical Dapsone in Dermatology: A Scoping Review of Clinical 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The abstract conflicts on whether acne vulgaris was excluded or included.","practice_takeaway":"Topical dapsone (5% or 7.5% gel) may be an option for localized, chronic mucocutaneous eruptions when avoiding systemic therapy, but the support is heterogeneous and not quantified here."}},{"doi":"10.1111/jocd.70484","pmid":"41039794","title":"Efficacy and Effectiveness of High Molecular Weight Non‐Cross‐Linked Hyaluronic Acid Plus Succinic Acid Mesotherapy in Rosacea as Adjunct Therapy","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2025-10-03T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70484","source_score":4,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-10-06","doi":"10.1111/jocd.70484","days":"7","issn":"1473-2130","rank":"7","field":"Clinical Medicine","score":"4","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70484","title":"Efficacy and Effectiveness of High Molecular Weight Non-Cross-Linked Hyaluronic Acid Plus Succinic Acid Mesotherapy in Rosacea as Adjunct Therapy.","journal":"Journal of cosmetic dermatology","methods":"","results":"Our results showed a reduction of 80% in the baseline erythema, an improvement of 30% in skin hydration, and a reduction of 20% in facial telangiectasia after three sessions, compared with patients who used only topical treatment. 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biopsy.","value_numeric":null},{"paper_doi":"10.1111/jocd.70484","tag_type":"warning","value":"Group allocation was based on willingness and the study was unblinded, introducing selection and measurement bias.","value_numeric":null},{"paper_doi":"10.1111/jocd.70484","tag_type":"warning","value":"The timepoint for the reported 80% erythema reduction is inconsistent (described ‘after three sessions’ in the abstract vs ~80% at month 4 in the results).","value_numeric":null}],"summaries":{"what_studied":"Adults with moderate rosacea (n=40; ages 40–45; Fitzpatrick I–III) already on ivermectin 1% + metronidazole 0.75% were assigned to receive three monthly sessions of intradermal high–molecular‑weight non‑cross‑linked hyaluronic acid 1.1% plus succinic acid 1.6% (n=20) versus continuing topicals alone (n=20) over 4 months, with planned 6‑month follow‑up.","key_result":"By month 4, the mesotherapy group had ~80% reduction in erythema (p<0.01) versus stable levels in controls, nearly 80% higher skin hydration (p<0.01) versus 10–15% (NS) in controls, ~50% higher skin elasticity, and decreased telangiectasias from month 2 (p<0.01) with no change in controls. Patient symptoms improved (soreness 7.1±1.3 to 1.2±0.3; burning 8.3±2.3 to 2.3±1.2; itching 7.9±1.2 to 1.5±0.2; tingling 6.2±1.8 to 2.1±0.3; all p<0.05), adverse effects were minor with an overall incidence ≤45% across 60 procedures, and reported per‑session costs were lower than laser/IPL in a local survey.","limitations":"Nonrandomized, unblinded, single‑center study with small sample (n=40) and group assignment based on willingness, risking selection and measurement bias. Short follow‑up, no independent assessment or laser/IPL comparator, biopsy data from one patient, and cost data derived from a limited local survey without formal cost‑effectiveness analysis.","practice_takeaway":"As an adjunct to standard topicals after inadequate response, monthly HMWNCHA+SA mesotherapy improved erythema, hydration, elasticity, and symptoms versus continuing topicals, with only transient injection‑site reactions and lower reported costs than laser/IPL. 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An encapsulated prescription BPO showed no apparent benzene at 2 °C but high formation at 50 °C, and benzene was detectable in air during use and rose substantially under UV below peak sunlight.","limitations":"Airborne benzene concentrations and exposure durations were not quantified in the abstract, limiting exposure assessment. The face model used polymethyl methacrylate plates rather than human skin, and only one encapsulated prescription product was tested.","practice_takeaway":"BPO products can contain and generate benzene at room temperature and during use, with UV and heat boosting formation. Cold storage reduced formation in testing, while encapsulation alone may not prevent it; starting benzene content may not predict exposure."}}],"initialOffset":14,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Rosacea"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Rosacea"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Rosacea"}}}]]

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