2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T715,Intraductal papillary mucinous neoplasms with low-grade dysplasia (IPMNs w/LGD) and benign cysts, including serous cystadenomas (SCAs), are common pancreatic cystic lesions (PCLs) that are better managed conservatively. The burden of patients who undergo surgical resection for these cysts is unknown. Our study aims to estimate the global prevalence of surgical resections for IPMNs w/LGD and benign cysts, as well as the pre-operative misclassification rate among all resected PCLs. We searched the literature through September 2023 to identify full-text articles that reported the surgical histopathology of resected PCLs. A proportional meta-analysis was performed using a random-effects model, with prevalence estimates reported as pooled proportions. Subgroup analysis and meta-regression were performed based on use of endoscopic ultrasound (EUS), years of enrollment, and geographic location. Sixteen studies (n = 5830) were identified. Among all surgically resected PCLs, 24% were IPMNs w/LGD (95% CI: 18%-32%), 16% were SCAs (95% CI 13%-19%), 4% were other benign cysts (95% CI: 3%-6%), and 24% were pre-operatively misclassified (95% CI: 16%-34%). Of the resected IPMNs, 62% had LGD (95% CI: 51%-71%). An increasing use of pre-operative EUS is associated with a lower prevalence of resected SCAs (p < 0.05) but has not impacted the rate of resections for IPMNs w/LGD. The pre-operative misclassification of PCLs has significantly decreased over time (p < 0.01), although not significantly influenced by increasing EUS utilization or geographic location. One quarter of PCLs are pre-operatively misclassified and ∼44% are surgically resected for benign cysts or IPMNs w/LGD. Implementation of advanced diagnostic tools might improve pre-operative classification and reduce overtreatment of PCLs.31:Tabe,ABSTRACT Background Intraductal papillary mucinous neoplasms with low‐grade dysplasia (IPMNs w/LGD) and benign cysts, including serous cystadenomas (SCAs), are common pancreatic cystic lesions (PCLs) that are better managed conservatively. The burden of patients who undergo surgical resection for these cysts is unknown. Our study aims to estimate the global prevalence of surgical resections for IPMNs w/LGD and benign cysts, as well as the pre‐operative misclassification rate among all resected PCLs. Methods We searched the literature through September 2023 to identify full‐text articles that reported the surgical histopathology of resected PCLs. A proportional meta‐analysis was performed using a random‐effects model, with prevalence estimates reported as pooled proportions. Subgroup analysis and meta‐regression were performed based on use of endoscopic ultrasound (EUS), years of enrollment, and geographic location. Results Sixteen studies ( n = 5830) were identified. Among all surgically resected PCLs, 24% were IPMNs w/LGD (95% CI: 18%–32%), 16% were SCAs (95% CI 13%–19%), 4% were other benign cysts (95% CI: 3%–6%), and 24% were pre‐operatively misclassified (95% CI: 16%–34%). Of the resected IPMNs, 62% had LGD (95% CI: 51%–71%). An increasing use of pre‐operative EUS is associated with a lower prevalence of resected SCAs ( p < 0.05) but has not impacted the rate of resections for IPMNs w/LGD. The pre‐operative misclassification of PCLs has significantly decreased over time ( p < 0.01), although not significantly influenced by increasing EUS utilization or geographic location. Conclusion One quarter of PCLs are pre‐operatively misclassified and ∼44% are surgically resected for benign cysts or IPMNs w/LGD. Implementation of advanced diagnostic tools might improve pre‐operative classification and reduce overtreatment of PCLs. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Serous Cystadenoma: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Serous Cystadenoma (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Serous%20Cystadenoma\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Serous Cystadenoma\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Serous%20Cystadenoma\"}]}}"}}]],["$","$L2f",null,{"title":"Serous Cystadenoma: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Serous Cystadenoma with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1002/ueg2.70145","pmid":"41284225","title":"High Burden of Pancreatic Surgery for Intraductal Papillary Mucinous Neoplasia With Low‐Grade Dysplasia and Benign Cysts: A Systematic Review and Meta‐Analysis","journal_title":"United European Gastroenterology Journal","journal_issn":"2050-6406","published_at":"2025-11-24T00:00:00.000Z","url":"https://doi.org/10.1002/ueg2.70145","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-11-27","doi":"10.1002/ueg2.70145","days":"7","issn":"2050-6406","rank":"5","field":"Clinical Medicine","score":"7","category":"Gastroenterology & Hepatology","categories":["Gastroenterology & Hepatology"],"_categories":["Gastroenterology & Hepatology"]},"pubmed":{"doi":"10.1002/ueg2.70145","title":"High Burden of Pancreatic Surgery for Intraductal Papillary Mucinous Neoplasia With Low-Grade Dysplasia and Benign Cysts: A Systematic Review and Meta-Analysis.","journal":"United European gastroenterology journal","methods":"","results":"Sixteen studies (n = 5830) were identified. Among all surgically resected PCLs, 24% were IPMNs w/LGD (95% CI: 18%-32%), 16% were SCAs (95% CI 13%-19%), 4% were other benign cysts (95% CI: 3%-6%), and 24% were pre-operatively misclassified (95% CI: 16%-34%). Of the resected IPMNs, 62% had LGD (95% CI: 51%-71%). An increasing use of pre-operative EUS is associated with a lower prevalence of resected SCAs (p < 0.05) but has not impacted the rate of resections for IPMNs w/LGD. The pre-operative misclassification of PCLs has significantly decreased over time (p < 0.01), although not significantly influenced by increasing EUS utilization or geographic location.","abstract":"$30","keywords":["IPMN","benign cyst","low‐grade dysplasia","pancreas cyst","pancreas surgery","pancreatectomy","serous cystadenoma"],"pubmed_id":"41284225","conclusions":"One quarter of PCLs are pre-operatively misclassified and ∼44% are surgically resected for benign cysts or IPMNs w/LGD. Implementation of advanced diagnostic tools might improve pre-operative classification and reduce overtreatment of PCLs.","publication_date":"2025-11-24T00:00:00"},"crossref":{"DOI":"10.1002/ueg2.70145","URL":"https://doi.org/10.1002/ueg2.70145","ISSN":["2050-6406","2050-6414"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ueg2.70145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["High Burden of Pancreatic Surgery for Intraductal Papillary Mucinous Neoplasia With Low‐Grade Dysplasia and Benign Cysts: A Systematic Review and Meta‐Analysis"],"author":[{"given":"Samuel","family":"Tanner","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan Ann Arbor Michigan USA"}]},{"given":"Priyata","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Trinity Health Ann Arbor Michigan USA"}]},{"given":"Elit","family":"Quingalahua","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Central Michigan University Saginaw Michigan USA"}]},{"given":"Jean M.","family":"Chalhoub","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Staten Island University Hospital Northwell Health Staten Island New York USA"}]},{"given":"Fadi","family":"Hawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Ohio State University Wexner Medical Center Columbus Ohio USA"}]},{"given":"Antonio","family":"Facciorusso","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Experimental Medicine Università del Salento Lecce Italy"},{"name":"Clinical Effectiveness Research Group University of Oslo Oslo Norway"}]},{"given":"Gabriele","family":"Capurso","sequence":"additional","affiliation":[{"name":"Pancreato‐Biliary Endoscopy and Endosonography Division Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, and “Vita‐Salute” San Raffaele University Milan Italy"}]},{"given":"Un‐Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Office of Academic Affairs Northwell Health New Hyde Park New York USA"}]},{"given":"Jorge D.","family":"Machicado","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan Ann Arbor Michigan USA"}]}],"issued":{"date-parts":[[2025,11,24]]},"member":"311","prefix":"10.1002","source":"Crossref","volume":null,"archive":["Portico"],"created":{"date-time":"2025-11-24T16:21:00Z","timestamp":1764001260000,"date-parts":[[2025,11,24]]},"indexed":{"date-time":"2025-11-24T16:24:05Z","timestamp":1764001445716,"date-parts":[[2025,11,24]]},"license":[{"URL":"http://creativecommons.org/licenses/by-nc-nd/4.0/","start":{"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000,"date-parts":[[2025,11,24]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1002/ueg2.70145"}},"subtitle":[],"deposited":{"date-time":"2025-11-24T16:21:04Z","timestamp":1764001264000,"date-parts":[[2025,11,24]]},"issn-type":[{"type":"print","value":"2050-6406"},{"type":"electronic","value":"2050-6414"}],"published":{"date-parts":[[2025,11,24]]},"publisher":"Wiley","reference":[{"DOI":"10.1016/J.CGH.2024.02.018","key":"e_1_2_9_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1053/j.gastro.2015.01.015","key":"e_1_2_9_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.pan.2017.07.007","key":"e_1_2_9_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/ajg.2018.14","key":"e_1_2_9_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1136/GUTJNL‐2018‐316027","key":"e_1_2_9_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.pan.2023.12.009","key":"e_1_2_9_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1053/j.gastro.2015.01.014","key":"e_1_2_9_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/J.SURG.2023.07.016","key":"e_1_2_9_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/J.SURG.2012.05.019","key":"e_1_2_9_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/J.PAN.2017.01.002","key":"e_1_2_9_11_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_9_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1136/BMJ.N71","key":"e_1_2_9_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_9_14_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"WellsG. 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Hepatology","value_numeric":null},{"paper_doi":"10.1002/ueg2.70145","tag_type":"condition","value":"Intraductal Papillary Mucinous Neoplasm","value_numeric":null},{"paper_doi":"10.1002/ueg2.70145","tag_type":"condition","value":"Pancreatic Cystic Lesions","value_numeric":null},{"paper_doi":"10.1002/ueg2.70145","tag_type":"condition","value":"Serous Cystadenoma","value_numeric":null},{"paper_doi":"10.1002/ueg2.70145","tag_type":"modality","value":"Endoscopic Ultrasound","value_numeric":null},{"paper_doi":"10.1002/ueg2.70145","tag_type":"sample_size","value":"n=5830","value_numeric":5830},{"paper_doi":"10.1002/ueg2.70145","tag_type":"study_design","value":"Systematic Review and Meta-Analysis","value_numeric":null},{"paper_doi":"10.1002/ueg2.70145","tag_type":"warning","value":"Associations from meta-regression (e.g., EUS use) do not establish causality.","value_numeric":null},{"paper_doi":"10.1002/ueg2.70145","tag_type":"warning","value":"Only abstract-level data provided; detailed methods, heterogeneity, and study quality are not available here.","value_numeric":null},{"paper_doi":"10.1002/ueg2.70145","tag_type":"warning","value":"Population demographics (age/sex) and operative details are not reported in the provided text.","value_numeric":null}],"summaries":{"what_studied":"Systematic review and proportional meta-analysis of 16 studies (n=5830) through September 2023 assessing how often resected pancreatic cystic lesions (PCLs) prove to be intraductal papillary mucinous neoplasms with low-grade dysplasia (IPMN-LGD) or benign cysts, and the rate of pre-operative misclassification; subgroup/meta-regression examined endoscopic ultrasound (EUS) use, enrollment years, and geography.","key_result":"Among resected PCLs, pooled proportions were: IPMN-LGD 24% (95% CI 18–32), serous cystadenomas 16% (13–19), other benign cysts 4% (3–6), and pre-operative misclassification 24% (16–34). Of resected IPMNs, 62% had LGD (51–71); greater pre-operative EUS use correlated with fewer SCA resections (p<0.05) but not with IPMN-LGD resections, and misclassification decreased over time (p<0.01) without significant influence from EUS use or geography.","practice_takeaway":"Roughly 44% of resected PCLs are benign or IPMN-LGD, and one quarter are misclassified before surgery; stronger pre-operative classification is needed to avoid overtreatment. Increasing EUS use appears to curb SCA resections, but advanced diagnostic tools may be required to further reduce unnecessary operations."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Serous Cystadenoma"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Serous Cystadenoma"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Serous Cystadenoma"}}}]]

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