2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T4ab,This manuscript provides expert recommendations on the role of allogeneic haematopoietic cell transplantation (allo-HCT) for cutaneous T-cell lymphoma (CTCL), specifically mycosis fungoides (MF) and Sezary syndrome (SS). Critical aspects such as patient selection, timing, and bridging therapy are addressed, as well as donor source, conditioning regimens and post-transplant management. These consensus guidelines are based on a thorough literature review and discussions among leading dermatologists and haematologists. These recommendations aim to harmonize clinical practice towards improving patient outcomes in these rare but aggressive lymphomas. It is of critical importance to consider allo-HCT early in the management of eligible patients with high-risk disease. Advanced stage, large-cell transformation, relapsed or refractory disease following systemic treatment, and N3-stage lymph node involvement are indicators that should trigger consultation with a transplant haematologist in parallel with a donor search. Early interaction between dermatologists and transplant haematologists is vital to avoiding delays, which can significantly impact post-transplant outcomes and survival.31:T4ed,AbstractThis manuscript provides expert recommendations on the role of allogeneic haematopoietic cell transplantation (allo‐HCT) for cutaneous T‐cell lymphoma (CTCL), specifically mycosis fungoides (MF) and Sezary syndrome (SS). Critical aspects such as patient selection, timing, and bridging therapy are addressed, as well as donor source, conditioning regimens and post‐transplant management. These consensus guidelines are based on a thorough literature review and discussions among leading dermatologists and haematologists. These recommendations aim to harmonize clinical practice towards improving patient outcomes in these rare but aggressive lymphomas. It is of critical importance to consider allo‐HCT early in the management of eligible patients with high‐risk disease. Advanced stage, large‐cell transformation, relapsed or refractory disease following systemic treatment, and N3‐stage lymph node involvement are indicators that should trigger consultation with a transplant haematologist in parallel with a donor search. Early interaction between dermatologists and transplant haematologists is vital to avoiding delays, which can significantly impact post‐transplant outcomes and survival.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Sezary Syndrome: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Sezary Syndrome (condition). Clinician-written summaries and actionable practice insights. 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Syndrome","value_numeric":null},{"paper_doi":"10.1111/jdv.70042","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1111/jdv.70042","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1111/jdv.70042","tag_type":"modality","value":"Allogeneic Hematopoietic Cell Transplantation","value_numeric":null},{"paper_doi":"10.1111/jdv.70042","tag_type":"study_design","value":"Guideline","value_numeric":null},{"paper_doi":"10.1111/jdv.70042","tag_type":"warning","value":"Recommendations against routine MRD monitoring or maintenance reflect insufficient evidence, not proof of no benefit.","value_numeric":null},{"paper_doi":"10.1111/jdv.70042","tag_type":"warning","value":"Some donor-source comparisons (especially haploidentical) derive from small cohorts and may not generalize.","value_numeric":null},{"paper_doi":"10.1111/jdv.70042","tag_type":"warning","value":"This is a consensus guideline synthesizing heterogeneous studies rather than a single trial.","value_numeric":null}],"summaries":{"what_studied":"Expert consensus guidance from the EBMT PH&G Committee on when and how to use allogeneic haematopoietic cell transplantation for cutaneous T‑cell lymphomas (mycosis fungoides and Sézary syndrome), covering referral criteria, timing/bridging, donor selection, conditioning/GVHD prophylaxis, and post‑transplant care.","key_result":"In the CUTALLO propensity‑matched prospective study (n=99), allo‑HCT prolonged PFS to 9.0 months vs 3.0 months with conventional therapy (HR 0.38, 95% CI 0.21–0.69; p<0.0001). Historical/pooled benchmarks for allo‑HCT show 5‑year OS 38% and PFS 26% (EBMT registry), and OS 51% at 1 year and 40% at 3 years with PFS 42% at 1 year and 33% at 3 years (meta‑analysis).","limitations":"Recommendations rest largely on retrospective series, registry analyses, and small prospective cohorts, with heterogeneous conditioning, donor sources, and peri‑transplant practices. Evidence for haploidentical donors, modern GVHD prophylaxis (e.g., PTCy), MRD monitoring, and maintenance strategies remains limited or inconclusive.","practice_takeaway":"Refer high‑risk MF/SS early; aim for CR or deep response (VGPR or mSWAT <10) before RIC allo‑HCT, prefer MRD/MUD donors, and observe a 6‑week washout after pre‑HCT mogamulizumab. Manage relapse with immunosuppression taper and DLI, adding site‑directed therapy or TSEB as indicated; routine post‑HCT MRD monitoring or maintenance is not recommended."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Sezary Syndrome"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Sezary Syndrome"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Sezary Syndrome"}}}]]

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