2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T7f4,Skin aging is driven by intrinsic and extrinsic factors. Epigenetic alterations are one primary hallmark of aging and powerful biomarkers of biological skin age. To investigate epigenetic skin aging mechanisms and their regulation as a skin longevity approach across diverse ethnicities and phototypes, we assessed epidermal methylomes from white, African, and Asian donors. We collected epidermis samples from 17 multi-ethnic donors with diverse phototypes using a newly established tape-stripping method followed by array-based DNA methylation profiling to investigate the robustness of DNA methylation clocks across diverse ethnic backgrounds. Additionally, we conducted a clinical study with 60 participants representing Fitzpatrick phototypes I-VI. Diverse clinical parameters and biological skin age of the volunteers were determined at baseline and after applying a serum containing the natural epigenetic inhibitor dihydromyricetin (DHM) for 8 weeks to investigate skin longevity effects across phototypes. Data analysis revealed that age-dependent DNA hypermethylation is conserved across populations and affects genes essential for keratinocyte vitality and longevity. A newly developed epidermal methylation clock accurately predicted biological age in multi-ethnic cohorts, confirming the robustness of epigenetic age estimation across phototypes. Topical application of a DHM-containing serum significantly reduced epidermal DNA methylation age. Epigenetic rejuvenation was associated with clinical improvements, including reduced skin roughness and wrinkle visibility and occupancy, and increased dermal echogenicity. Together, these findings establish that epigenetic aging signatures are conserved across ethnicities and that targeted modulation using a DHM-containing topical formulation can reverse biological skin age while improving structural and visible signs of aging. This work provides the clinical evidence supporting epigenetic rejuvenation as a viable strategy for skin longevity across diverse populations.31:T470,Both studies were conducted in accordance with ethics requirements. The pilot study was approved by the Ethics Committee of the Faculty of Medicine at the University of Heidelberg (ref. S-783/2024), and all participants provided written, informed consent. Specifically, consent was obtained for the storage and processing of biosamples at the German Cancer Research Center (DKFZ) and for the processing and use of data for biomedical research, including publication. The product-use study was conducted in accordance with the principles of the Declaration of Helsinki, applicable regulatory requirements, including Resolution CNS no. 466/12, and ICH E6: Good Clinical Practices and Document of the Americas. This study was approved by the Independent Ethics Committee (IEC) of Investiga-Institutos de Pesquisa, registered by the National Research Ethics Commission (CONEP) (CEP approval no. CAAE 90155525.9.0000.5599). All participants provided written, informed consent for the collection of clinical data, biological samples, and facial images, as well as consent for the publication of anonymized data and images in scientific media.32:T58c,Lips are prone to dehydration and aging. Effective noninvasive hyaluronic acid (HA) delivery remains challenging. To evaluate topical Replenishing Lip Filler-Tiered Release Vesicles (RLF-TRV) in filler-naïve and previously-augmented lips. Two single-center trials evaluated efficacy and tolerability of RLF-TRV Serum. Study 1 included filler-naïve subjects or those without lip filler for 12 months. Study 2 enrolled subjects with prior HA lip augmentation (3-9 months earlier) in a double-blind, placebo-controlled design. Participants applied RLF-TRV or placebo twice daily for 3 weeks, followed by a 2-week regression period. Outcomes included grading of shine, texture, and vermilion border, Investigator and Subject Global Aesthetic Improvement Scale (I-GAIS, S-GAIS), and satisfaction. Imaging and tolerability assessments were conducted throughout the study. RLF-TRV significantly improved lip aesthetics (shine, texture, and vermilion border), with high satisfaction across both studies. In Study 1, 94% of treated participants were "Improved" on I-GAIS (p < 0.001), and 81% were "Much-Improved" on S-GAIS (p < 0.05). In Study 2, 88% of treated participants were "Improved" on both I-GAIS and S-GAIS. RLF-TRV was well tolerated, with no recorded adverse events. RLF-TRV significantly improved lip aesthetics, offering a noninvasive alternative or complementary treatment to injectable procedures.33:T996,ABSTRACT Background Lips are prone to dehydration and aging. Effective noninvasive hyaluronic acid (HA) delivery remains challenging. Aim To evaluate topical Replenishing Lip Filler‐Tiered Release Vesicles (RLF‐TRV) in filler‐naïve and previously‐augmented lips. Methods Two single‐center trials evaluated efficacy and tolerability of RLF‐TRV Serum. Study 1 included filler‐naïve subjects or those without lip filler for 12 months. Study 2 enrolled subjects with prior HA lip augmentation (3–9 months earlier) in a double‐blind, placebo‐controlled design. Participants applied RLF‐TRV or placebo twice daily for 3 weeks, followed by a 2‐week regression period. Outcomes included grading of shine, texture, and vermilion border, Investigator and Subject Global Aesthetic Improvement Scale (I‐GAIS, S‐GAIS), and satisfaction. Imaging and tolerability assessments were conducted throughout the study. Results RLF‐TRV significantly improved lip aesthetics (shine, texture, and vermilion border), with high satisfaction across both studies. In Study 1, 94% of treated participants were “Improved” on I‐GAIS ( p < 0.001), and 81% were “Much‐Improved” on S‐GAIS ( p < 0.05). In Study 2, 88% of treated participants were “Improved” on both I‐GAIS and S‐GAIS. RLF‐TRV was well tolerated, with no recorded adverse events. Conclusions RLF‐TRV significantly improved lip aesthetics, offering a noninvasive alternative or complementary treatment to injectable procedures. 34:T652,Mast cells (MCs) are innate immune cells primarily located in the papillary layer of the dermis that play a crucial role in the skin immune response by secreting mediators and recruiting effector cells. Increasing laboratory and clinical evidence indicates that MCs are not only passive participants but also key regulators of skin aging. MCs act as sensors and amplifiers of aging-related signals, integrating various stimuli, including the nature of the triggering factor, microenvironmental cues such as senescence-associated secretory phenotype (SASP) factors, and specific activation pathways. Upon activation, MCs release diverse mediators that engage signalling pathways including Fc epsilon RI (FcεRI), c-KIT, Toll-like receptors (TLRs) and Mas-related G-protein-coupled receptor X2 (MRGPRX2) thereby eliciting broad target cell responses. MCs engage in pathological crosstalk with fibroblasts, keratinocytes, melanocytes and immune cells, establishing self-perpetuating feedback loops that amplify aging-related processes. Collectively, these findings highlight the dual and context-dependent roles of MCs as not only protectors but also accelerators of skin aging, positioning them as promising therapeutic targets. The use of novel MC stabilisers such as ketotifen or luteolin, as well as phototherapy and other treatments, shows potential in mitigating skin aging and may offer valuable insights into novel therapeutic targets. Nonetheless, additional studies are required to dissect the underlying mechanisms and optimise targeted therapies to facilitate the development of precision medicine strategies.35:T6ab,ABSTRACT Mast cells (MCs) are innate immune cells primarily located in the papillary layer of the dermis that play a crucial role in the skin immune response by secreting mediators and recruiting effector cells. Increasing laboratory and clinical evidence indicates that MCs are not only passive participants but also key regulators of skin aging. MCs act as sensors and amplifiers of aging‐related signals, integrating various stimuli, including the nature of the triggering factor, microenvironmental cues such as senescence‐associated secretory phenotype (SASP) factors, and specific activation pathways. Upon activation, MCs release diverse mediators that engage signalling pathways including Fc epsilon RI (FcεRI), c‐KIT, Toll‐like receptors (TLRs) and Mas‐related G‐protein‐coupled receptor X2 (MRGPRX2) thereby eliciting broad target cell responses. MCs engage in pathological crosstalk with fibroblasts, keratinocytes, melanocytes and immune cells, establishing self‐perpetuating feedback loops that amplify aging‐related processes. Collectively, these findings highlight the dual and context‐dependent roles of MCs as not only protectors but also accelerators of skin aging, positioning them as promising therapeutic targets. The use of novel MC stabilisers such as ketotifen or luteolin, as well as phototherapy and other treatments, shows potential in mitigating skin aging and may offer valuable insights into novel therapeutic targets. Nonetheless, additional studies are required to dissect the underlying mechanisms and optimise targeted therapies to facilitate the development of precision medicine strategies.36:Tc74,This research presents a novel, scientifically validated facial aging simulator. It integrates two published methodologies for personalized aging predictions, particularly concerning the impact of tobacco. This contrasts with widespread simulations on social network and gaming applications, often lacking scientific rigor and transparent methodology. This simulator combines elicited knowledge from 28 expert dermatologists with an AI-powered image generation system. Based on this knowledge, the model predicts 15-year facial aging signs according to various intrinsic and extrinsic factors, providing personalized probabilities of reaching specific aging stages (e.g., wrinkles, pigmentation). This work couples these 15-year predictions with a machine learning model (AMGAN) that generates personalized facial aging simulation images. The AMGAN was initially trained on a dataset of 600 individuals with sign scores averaged from 15 expert graders. We present predicted independent probabilities of reaching grades for different facial aging signs as a function of cumulative tobacco consumption. A simulation was performed using a 43-year-old subject's facial image to demonstrate the tool's capabilities in illustrating the impact of tobacco consumption. Confounding variables such as sun exposure, sunscreen use, and body mass index (BMI) were controlled, while cumulative smoking (less than 10 or greater than 20 pack-years) was varied. This tool effectively visualizes the known effects of smoking on aging and provides personalized quantification of its impact on specific facial wrinkles. Recognizing that individuals prioritize different facial signs, the simulator allows users to focus on areas of personal concern. By focusing on preserving skin longevity and preventing premature aging, the simulator, which can quantify the impact of smoking on individual aging trajectories, effectively motivates positive lifestyle changes. This personalized approach offers a promising preventative messaging strategy, particularly for audiences resistant to traditional methods, and strengthens the scientific rationale regarding the impact of tobacco on specific aging signs. This work introduces a novel, scientifically robust facial aging simulator, addressing the lack of scientific and dermatological validation in most existing aging simulators, especially those used in social networks and gaming applications. Integrating two published research and leveraging dermatologist knowledge, the simulator generates personalized aging predictions (visualized as images and probabilities). This personalized, quantified, and visual approach, focused on the impact of tobacco, empowers informed decisions through probability comparisons of individual facial signs, motivating behavior change. Consequently, by focusing on preserving skin longevity and preventing premature aging, it offers a novel preventative messaging tool, particularly effective for those unresponsive to traditional campaigns, by promoting healthier behaviors. The synergy between expert dermatological knowledge and AI-generated imagery reinforces the scientific basis for the impact of smoking on facial aging.37:Td28,Porphyrins are ubiquitous metabolites and are constitutive of the bacterial metabolome of healthy skin. Their consideration has until now been limited to their pro-inflammatory activity in acne vulgaris. The present work suggests a new role for these molecules in the onset of skin ageing. A mixture of coproporphyrin III and protoporphyrin IX, representative of skin microbiota metabolites, was defined and applied in different skin models. Finally, an in vivo study was conducted to determine the association between porphyrin's abundance and ageing signs. Bacterial porphyrins penetrated stratum corneum and reached living epidermal cells. The porphyrin mixture increased IL-8, ROS and melanin contents. Porphyrin-induced melanin synthesis appeared to be regulated by translocator protein TSPO/PBR. In fibroblasts, bacterial metabolites down-regulated a set of transcripts involved in extracellular matrix architecture and associated with ageing, which was confirmed by a decrease of type I pro-collagen. Finally, the clinical study established positive and significant correlations between porphyrin abundance and the severity of ageing signs, including invisible spots, brown spots and wrinkles length. In summary, porphyrins could play unexpected roles in skin's premature ageing process, a phenomenon we propose to call Porphyr'ageing, that promotes hyperpigmentation, inflammation, oxidative stress and fibroblast cell ageing, leading to dermal matrix weakening. Les porphyrines sont des métabolites omniprésents et constituent le métabolome bactérien de la peau saine. Leur prise en compte a jusqu’à présent été limitée à leur activité pro‐inflammatoire dans l’acné vulgaire. Le présent travail suggère un nouveau rôle pour ces molécules dans l’apparition du vieillissement cutané. MÉTHODES: Un mélange de coproporphyrine III et de protoporphyrine IX, représentatif des métabolites du microbiote cutané, a été défini et appliqué dans différents modèles cutanés. Enfin, une étude in vivo a été réalisée pour déterminer l’association entre l’abondance des porphyrines et les signes de vieillissement. RÉSULTATS: Les porphyrines bactériennes ont pénétré dans la couche cornée et atteint les cellules épidermiques vivantes. Le mélange de porphyrines a augmenté les contenus en IL‐8, ROS et mélanine. La synthèse de mélanine induite par les porphyrines semble être régulée par la protéine translocatrice TSPO/PBR. Dans les fibroblastes, les métabolites bactériens ont régulé à la baisse un ensemble de transcrits impliqués dans l’architecture de la matrice extracellulaire et associés au vieillissement, ce qui a été confirmé par une diminution du pro‐collagène de type I. Enfin, l’étude clinique a établi des corrélations positives et significatives entre l’abondance des porphyrines et la gravité des signes de vieillissement, y compris les taches invisibles, les taches brunes et la longueur des rides. En résumé, les porphyrines pourraient jouer des rôles inattendus dans le processus de vieillissement prématuré de la peau, un phénomène que nous proposons d’appeler Porphyr’ageing, qui favorise l’hyperpigmentation, l’inflammation, le stress oxydatif et le vieillissement des cellules fibroblastes, conduisant à un affaiblissement de la matrice dermique.38:T73a,AbstractObjectivePorphyrins are ubiquitous metabolites and are constitutive of the bacterial metabolome of healthy skin. Their consideration has until now been limited to their pro‐inflammatory activity in acne vulgaris. The present work suggests a new role for these molecules in the onset of skin ageing.MethodsA mixture of coproporphyrin III and protoporphyrin IX, representative of skin microbiota metabolites, was defined and applied in different skin models. Finally, an in vivo study was conducted to determine the association between porphyrin's abundance and ageing signs.ResultsBacterial porphyrins penetrated stratum corneum and reached living epidermal cells. The porphyrin mixture increased IL‐8, ROS and melanin contents. Porphyrin‐induced melanin synthesis appeared to be regulated by translocator protein TSPO/PBR. In fibroblasts, bacterial metabolites down‐regulated a set of transcripts involved in extracellular matrix architecture and associated with ageing, which was confirmed by a decrease of type I pro‐collagen. Finally, the clinical study established positive and significant correlations between porphyrin abundance and the severity of ageing signs, including invisible spots, brown spots and wrinkles length.ConclusionIn summary, porphyrins could play unexpected roles in skin's premature ageing process, a phenomenon we propose to call Porphyr'ageing, that promotes hyperpigmentation, inflammation, oxidative stress and fibroblast cell ageing, leading to dermal matrix weakening.39:T533,Improvement of skin barrier strength could lead to healthy and youthful appearance. "Beauty inside-out" approach using nutraceuticals such as tomato derived carotenoids to support skin barrier strength could be of benefit to the ageing population. A panel of 60 female subjects were provided with the Lumenato capsules (containing carotenoids) or placebo capsules as nutritional supplements for 3 months. Skin health and barrier function were observed using evaporimeter which measures trans epidermal water loss (TEWL). Barrier strength was determined by study of the number of strippings required to disrupt skin barrier and barrier repair was observed in terms of TEWL a few hours after barrier disruption. Cutometer was used to observe skin firmness and elasticity. Measurements were obtained before treatment and after 4 and 12 weeks of use. Results indicated a statistically significant improvement (p < 0.05) in skin barrier strength; a higher number of strippings were required to disrupt skin barrier after 12 weeks of supplement use. There was also a significant improvement in skin firmness and elasticity as observed with a cutometer. Based on the confines and conditions of this study, oral supplementation with Lumenato resulted in significant improvement in skin barrier as well as skin firmness and elasticity.3a:T694,AbstractIntroductionImprovement of skin barrier strength could lead to healthy and youthful appearance. “Beauty inside‐out” approach using nutraceuticals such as tomato derived carotenoids to support skin barrier strength could be of benefit to the ageing population.MethodA panel of 60 female subjects were provided with the Lumenato capsules (containing carotenoids) or placebo capsules as nutritional supplements for 3 months. Skin health and barrier function were observed using evaporimeter which measures trans epidermal water loss (TEWL). Barrier strength was determined by study of the number of strippings required to disrupt skin barrier and barrier repair was observed in terms of TEWL a few hours after barrier disruption. Cutometer was used to observe skin firmness and elasticity. Measurements were obtained before treatment and after 4 and 12 weeks of use.ResultsResults indicated a statistically significant improvement (p < 0.05) in skin barrier strength; a higher number of strippings were required to disrupt skin barrier after 12 weeks of supplement use. There was also a significant improvement in skin firmness and elasticity as observed with a cutometer.ConclusionBased on the confines and conditions of this study, oral supplementation with Lumenato resulted in significant improvement in skin barrier as well as skin firmness and elasticity.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Skin Aging: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Skin Aging (condition). Clinician-written summaries and actionable practice insights. 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Clinicians should watch for emerging therapies aimed at reducing dermal IgG accumulation or blocking its downstream immune signaling to slow skin aging."}},{"doi":"10.1111/1346-8138.70471","pmid":"42638272","title":"SIRT1\n Activator Resveratrol Attenuates Age‐Related Skin Thinning in Mice","journal_title":"The Journal of Dermatology","journal_issn":"0385-2407","published_at":"2026-08-24T00:00:00.000Z","url":"https://doi.org/10.1111/1346-8138.70471","source_score":6,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-29T06:19:18.446Z","updated_at":"2026-08-29T06:19:18.446Z","tags":[{"paper_doi":"10.1111/1346-8138.70471","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"condition","value":"Epidermal Thinning","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"condition","value":"Skin Aging","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"generic","value":"resveratrol","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"level_of_evidence","value":"6","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"modality","value":"SIRT1 Activator","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"sample_size","value":"n=3 groups (20-wo, 60-wo, 60-wo+RSV mice)","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"study_design","value":"Animal Study","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"warning","value":"Sample size (exact n per group) is not reported in the abstract — the sample_size tag reflects group structure only, not a total N.","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"warning","value":"Study design is preclinical (murine + in vitro); no human subjects were enrolled, so level of evidence is rated 6 (animal/lab study).","value_numeric":null},{"paper_doi":"10.1111/1346-8138.70471","tag_type":"warning","value":"The age_group tag reflects the aged mouse model; direct human age-group equivalence is approximate.","value_numeric":null}],"summaries":{"what_studied":"This mouse study evaluated whether dietary resveratrol (RSV, 0.4 g/kg diet), a SIRT1 activator, could mitigate age-related skin thinning when administered from 28 weeks of age for 32 weeks, comparing 60-week-old treated vs. untreated mice against 20-week-old controls.","key_result":"RSV attenuated age-related reductions in epidermal and dermal thickness; it restored Ki67-positive (proliferating) epidermal cells, reduced acetyl-lysine positivity (indicating enhanced SIRT1 activity), and blunted age-associated increases in dermal MMP-9 and MMP-13 without affecting phosphorylated SMAD2 levels. In vitro, SIRT1 knockdown in HaCaT keratinocytes raised p21 expression and senescence-associated β-galactosidase activity.","limitations":"Findings are from a mouse model only — human skin translation is uncertain. The study used a single RSV dose (0.4 g/kg diet) with no dose-response data. No functional skin barrier outcomes (e.g., TEWL, clinical wrinkle scores) were measured.","practice_takeaway":"Dietary resveratrol shows preclinical promise for slowing skin aging via SIRT1 activation, but clinical evidence in humans is lacking. Clinicians should not recommend RSV specifically for skin thinning until human trials confirm these findings."}},{"doi":"10.1111/jocd.70930","pmid":null,"title":"Regeneration of an Extracellular Matrix Ecosystem Following Subcutaneous Injection With Different Radiesse Dilutions: A Histologic and Ultrasound Study","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2026-05-26T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70930","source_score":30,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-05-28T13:24:24.391Z","updated_at":"2026-05-28T13:24:24.391Z","tags":[{"paper_doi":"10.1111/jocd.70930","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"brand","value":"Radiesse","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"condition","value":"Extracellular Matrix Remodeling","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"condition","value":"Skin Aging","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"generic","value":"calcium hydroxylapatite","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"modality","value":"Dermal Filler / Biostimulator","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"sample_size","value":"n=10","value_numeric":10},{"paper_doi":"10.1111/jocd.70930","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"study_design","value":"Prospective Controlled Study","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"warning","value":"Injections were limited to the abdominal pannus (abdominoplasty patients); results may not generalize to facial or other anatomical sites commonly treated in aesthetic practice.","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"warning","value":"Sample size is very small (n=10), making all effect estimates exploratory and prone to type I/II error.","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"warning","value":"Sex breakdown of participants is not reported in the abstract; the 'mixed' sex tag is an assumption.","value_numeric":null},{"paper_doi":"10.1111/jocd.70930","tag_type":"warning","value":"Study design is prospective but not randomized; treatment sites were assigned within-subject, which may introduce local tissue variability as a confounder.","value_numeric":null}],"summaries":{"what_studied":"This prospective study in 10 adults (scheduled abdominoplasty) evaluated subcutaneous CaHA-CMC (Radiesse) at three dilutions—undiluted, 1:1, and 1:2—versus saline control, injected at 6 months, 3 months, and 14 days before surgery, assessing collagen, elastin, proteoglycans, elastosis, microcirculation, and skin thickness via histology, immunohistochemistry, and ultrasound.","key_result":"CaHA-CMC 1:1 showed the most consistent overall improvements: highest collagen deposition at 3 months (significant vs. saline at all time points for all dilutions), improved elastosis and increased skin thickness at both 3 and 6 months, and strongest microcirculation gains; fibulin-5 rose at 6 months especially for CaHA-CMC 1:2, while decorin and versican peaked at 3 months.","limitations":"Very small sample size (n=10) limits statistical power and generalizability; injections were made into the abdominal pannus only, which may not reflect facial or other treatment sites; no long-term follow-up beyond 6 months.","practice_takeaway":"A 1:1 dilution of CaHA-CMC appears to offer the most balanced and sustained ECM regenerative response—including collagen, skin thickness, and microcirculation—supporting its use as a biostimulator for skin quality improvement. Clinicians using Radiesse for bioregenerative indications may favor the 1:1 dilution over undiluted or more dilute preparations."}},{"doi":"10.1111/jocd.70919","pmid":"42175651","title":"Chlorella\n Polysaccharide Extract Attenuates Skin Aging via\n MAPK\n Pathway Suppression: Implications for Cosmetic Dermatology","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2026-05-23T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70919","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-30T13:22:49.022Z","updated_at":"2026-05-30T13:22:49.022Z","tags":[{"paper_doi":"10.1111/jocd.70919","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"condition","value":"Oxidative Stress","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"condition","value":"Skin Aging","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"generic","value":"Chlorella polysaccharide extract","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"level_of_evidence","value":"6","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"modality","value":"Botanical Polysaccharide Extract","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"study_design","value":"Preclinical Study (In Vivo / In Vitro)","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"warning","value":"No human clinical data are presented; all results come from zebrafish and HaCaT cell models — direct clinical applicability is speculative.","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"warning","value":"Sample size (N) is not reported in the abstract for either the zebrafish or cell-line experiments; a sample_size tag could not be assigned.","value_numeric":null},{"paper_doi":"10.1111/jocd.70919","tag_type":"warning","value":"Study design label 'Preclinical Study' is used as no standard RCT or observational design applies; the paper combines in vivo animal and in vitro cell work with network pharmacology.","value_numeric":null}],"summaries":{"what_studied":"This study evaluated the anti-aging effects of *Chlorella* polysaccharide extract (CPE) using an oxidative stress-induced zebrafish model (in vivo) and HaCaT keratinocyte cells (in vitro), with network pharmacology to identify mechanistic pathways.","key_result":"CPE reduced ROS, MDA, neutrophil infiltration, and pro-inflammatory factors while boosting SOD, CAT, and IL-10 in zebrafish; it suppressed SA-β-galactosidase activity (anti-senescence marker), and in HaCaT cells downregulated P53, c-JUN, STAT3, and NF-κB while inhibiting Jnk and p38 phosphorylation within the MAPK pathway.","limitations":"- No human or mammalian in vivo data; findings rely on zebrafish and cell-line models with uncertain clinical translatability.\n- No quantitative dose-response or safety data relevant to topical cosmetic use.\n- Network pharmacology pathway identification is hypothesis-generating, not experimentally validated at the pathway level.","practice_takeaway":"CPE shows preclinical anti-oxidative and anti-senescence activity via MAPK suppression, but human clinical evidence is absent—clinicians should not yet recommend CPE-based products for skin aging based on this data alone."}},{"doi":"10.1111/jocd.70888","pmid":"42087444","title":"Study on the Multiple Efficacies of Vitamin C Serum in Anti‐Glycation, Anti‐Carbonylation, Antioxidation, and Anti‐Inflammation of Human Skin Based on In Vivo Tests","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2026-05-05T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70888","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-16T13:22:33.007Z","updated_at":"2026-05-16T13:22:33.007Z","tags":[{"paper_doi":"10.1111/jocd.70888","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"condition","value":"Skin Aging","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"condition","value":"Skin Glycation","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"condition","value":"Skin Hyperpigmentation","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"generic","value":"ascorbic acid","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"modality","value":"Topical Antioxidant","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"sample_size","value":"n=66","value_numeric":66},{"paper_doi":"10.1111/jocd.70888","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"warning","value":"All participants were healthy Chinese females; findings may not generalize to males, other ethnicities, or patients with skin disease.","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"warning","value":"Macro-structural outcomes (elasticity, wrinkle depth) were not assessed; clinical anti-aging benefits beyond colorimetric and molecular markers remain to be confirmed.","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"warning","value":"The blank control group was not a vehicle-only placebo — it received no treatment at all, which limits the ability to separate active vitamin C effects from vehicle effects.","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"warning","value":"The study was partly industry-affiliated (Amway Shanghai); no external funding conflicts were declared, but sponsor involvement in trial design is not fully detailed.","value_numeric":null}],"summaries":{"what_studied":"A 12-week randomized, double-blind, controlled trial in 66 healthy Chinese females (n=35 topical 10% vitamin C serum; n=31 blank control) evaluated in vivo effects of topical vitamin C on skin glycation (AGEs), carbonylation, inflammation (IL-1α), antioxidant capacity (ABTS), and skin color (a*, b* values).","key_result":"After 12 weeks, the vitamin C group showed: AGEs −17.65%, carbonylated protein fluorescence −49.22%, IL-1α −58.73%, ABTS free radical scavenging rate +12.14%, skin yellowness (b*) −6.13%, and skin redness (a*) −16.46% (all p < 0.001 vs. baseline and vs. blank control).","limitations":"- Study enrolled only healthy Chinese females aged 18–60, limiting generalizability to males, other ethnicities, or those with skin disease.\n- No omics-level mechanistic data (lipidomics, proteomics).\n- Macro-structural anti-aging endpoints (e.g., wrinkle depth, skin elasticity) were not measured, so molecular improvements cannot yet be directly linked to visible structural rejuvenation.","practice_takeaway":"Topical 10% vitamin C serum applied twice daily for 12 weeks significantly reduced skin glycation, carbonylation, and inflammation while improving skin tone in healthy adult women. Clinicians recommending vitamin C for anti-aging or brightening can point to this in vivo trial as supporting evidence, noting the use of a dual-chamber powder/vehicle system to maintain stability."}},{"doi":"10.1007/s13555-026-01764-4","pmid":"42034839","title":"Epigenetic Skin Aging and Its Reversal to Improve Skin Longevity across Ethnicities and Phototypes Using a Dihydromyricetin-Containing Serum: Results from a Prospective, Single-Cohort Study","journal_title":"Dermatology and Therapy","journal_issn":"2193-8210","published_at":"2026-04-26T00:00:00.000Z","url":"https://doi.org/10.1007/s13555-026-01764-4","source_score":12,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-04-30","doi":"10.1007/s13555-026-01764-4","days":"14","issn":"2193-8210","rank":"5","field":"Clinical Medicine","score":"12","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1007/s13555-026-01764-4","title":"Epigenetic Skin Aging and Its Reversal to Improve Skin Longevity across Ethnicities and Phototypes Using a Dihydromyricetin-Containing Serum: Results from a Prospective, Single-Cohort Study.","journal":"Dermatology and therapy","methods":"","results":"Data analysis revealed that age-dependent DNA hypermethylation is conserved across populations and affects genes essential for keratinocyte vitality and longevity. A newly developed epidermal methylation clock accurately predicted biological age in multi-ethnic cohorts, confirming the robustness of epigenetic age estimation across phototypes. Topical application of a DHM-containing serum significantly reduced epidermal DNA methylation age. Epigenetic rejuvenation was associated with clinical improvements, including reduced skin roughness and wrinkle visibility and occupancy, and increased dermal echogenicity.","abstract":"$30","keywords":["DNA methylation","Dihydromyricetin","Epigenetic age clock","Rejuvenation","Skin of color"],"pubmed_id":"42034839","conclusions":"","publication_date":"2026-04-26T00:00:00"},"crossref":{"DOI":"10.1007/s13555-026-01764-4","URL":"https://doi.org/10.1007/s13555-026-01764-4","ISSN":["2193-8210","2190-9172"],"link":[{"URL":"https://link.springer.com/content/pdf/10.1007/s13555-026-01764-4.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/article/10.1007/s13555-026-01764-4","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/content/pdf/10.1007/s13555-026-01764-4.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Epigenetic Skin Aging and Its Reversal to Improve Skin Longevity across Ethnicities and Phototypes Using a Dihydromyricetin-Containing Serum: Results from a Prospective, Single-Cohort Study"],"author":[{"given":"Minyue","family":"Qi","sequence":"first","affiliation":[]},{"given":"Paula","family":"Pitta","sequence":"additional","affiliation":[]},{"given":"Katrin","family":"Wegner","sequence":"additional","affiliation":[]},{"given":"Boris","family":"Kristof","sequence":"additional","affiliation":[]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[]},{"given":"Günter","family":"Raddatz","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Rodríguez-Paredes","sequence":"additional","affiliation":[]},{"given":"Julia","family":"Gallinger","sequence":"additional","affiliation":[]},{"given":"Rungsima","family":"Wanitphakdeedecha","sequence":"additional","affiliation":[]},{"given":"Marc","family":"Winnefeld","sequence":"additional","affiliation":[]},{"given":"Lilia","family":"Guadanhim","sequence":"additional","affiliation":[]},{"given":"Cheri","family":"Frey","sequence":"additional","affiliation":[]},{"given":"Frank","family":"Lyko","sequence":"additional","affiliation":[]},{"given":"Cassandra","family":"Falckenhayn","sequence":"additional","affiliation":[]},{"given":"Elke","family":"Grönniger","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,4,25]]},"member":"297","prefix":"10.1007","source":"Crossref","volume":null,"created":{"date-time":"2026-04-25T18:29:18Z","timestamp":1777141758000,"date-parts":[[2026,4,25]]},"indexed":{"date-time":"2026-04-25T18:40:13Z","timestamp":1777142413517,"date-parts":[[2026,4,25]]},"license":[{"URL":"https://creativecommons.org/licenses/by-nc/4.0","start":{"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000,"date-parts":[[2026,4,25]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by-nc/4.0","start":{"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000,"date-parts":[[2026,4,25]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1007/s13555-026-01764-4"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"25 February 2026"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"7 April 2026"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"25 April 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"},"order":2,"value":"Authors Minyue Qi, Paula Pitta, Katrin Wegner, Boris Kristof, Julia Gallinger, Marc Winnefeld, Cassandra Falckenhayn, and Elke Grönniger were employed by the company Beiersdorf AG. Lilia Guadanhim, Cheri Frey, and Frank Lyko received consultation fees from Beiersdorf AG. Manuel Rodríguez-Paredes received speaker fees from Beiersdorf SA. The remaining authors Günter Raddatz, Yan Feng, and Rungsima Wanitphakdeedecha declare that the research was conducted in the absence of any commercial or financial relationship that could be construed as a potential conflict of interest."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"},"order":3,"value":"$31"}],"deposited":{"date-time":"2026-04-25T18:29:20Z","timestamp":1777141760000,"date-parts":[[2026,4,25]]},"issn-type":[{"type":"print","value":"2193-8210"},{"type":"electronic","value":"2190-9172"}],"published":{"date-parts":[[2026,4,25]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":"10.3390/ijms222212489","key":"1764_CR1","year":"2021","issue":null,"author":"H Lee","volume":null,"first-page":null,"unstructured":"Lee H, Hong Y, Kim M. 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The epidermal methylation clock showed robust age prediction across all phototypes (MAE reported; phototype bias not detected).","limitations":"Single-cohort design with no placebo or vehicle control arm for the 60-participant clinical study, limiting causal inference. Sunscreen use was assessed as a confounder but correlation was non-significant and only modestly negative (R=−0.14), leaving residual confounding possible. The study was industry-sponsored (Beiersdorf AG), and several authors are employees.","practice_takeaway":"A DHM-containing topical serum reduced biological skin age by epigenetic measurement and improved visible aging signs across all skin phototypes after 8 weeks — but the lack of a parallel vehicle control group means clinicians should interpret efficacy claims cautiously until RCT data are available."}},{"doi":"10.1111/jocd.70826","pmid":"41947480","title":"Hydroquinone‐Free, Tetrahexyldecyl Ascorbate Antioxidant Serum for Hyperpigmented and Photodamaged Skin to Achieve Skin Health","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2026-04-07T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70826","source_score":34,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-07T17:34:08.507Z","updated_at":"2026-05-07T17:34:08.507Z","tags":[{"paper_doi":"10.1111/jocd.70826","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"condition","value":"Hyperpigmentation","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"condition","value":"Photodamaged Skin","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"condition","value":"Skin Aging","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"generic","value":"tetrahexyldecyl ascorbate","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"modality","value":"Topical Antioxidant Serum","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"sample_size","value":"n=62","value_numeric":62},{"paper_doi":"10.1111/jocd.70826","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"warning","value":"A referenced key penetration study (Maloney et al.) is cited as 'under review' and was not published at the time of this paper, leaving a key comparative efficacy claim unverified.","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"warning","value":"Industry funding: Study was fully sponsored by Revision Skincare LLC, and multiple authors have direct financial ties (consultant, employee). Results should be interpreted with caution pending independent replication.","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"warning","value":"Study design is described as randomized and double-blind, but blinding details (e.g., who was blinded, how allocation was concealed) are not fully described in the available text.","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"warning","value":"The clinical trial enrolled only women, limiting applicability to male patients.","value_numeric":null},{"paper_doi":"10.1111/jocd.70826","tag_type":"warning","value":"The ex vivo collagen analysis was conducted on skin explants from a single 60-year-old female subject, making the 4-fold collagen increase finding very preliminary.","value_numeric":null}],"summaries":{"what_studied":"A 30% tetrahexyldecyl (THD) ascorbate antioxidant serum (THD-AA serum) was evaluated across in vitro, ex vivo, and a 12-week randomized double-blind clinical trial (n=62 women, ages 38–60, mostly Fitzpatrick Type III) for antioxidant, anti-melanogenic, and anti-aging efficacy vs. a 30% hexyldecanol control moisturizer.","key_result":"In vitro: 82–88% ROS reduction under blue light exposure; 24% reduction in melanin production. Ex vivo: 4-fold increase in collagen vs. control. Clinically at 12 weeks: 87% of subjects improved in facial lines and skin smoothness; 88% showed melanin improvement by week 8; 77% had reduced wrinkle volume (avg. 10% reduction). No adverse events were reported.","limitations":"- The ex vivo histopathology was performed on a single subject (60-year-old female), limiting generalizability.\n- Clinical trial participants were predominantly Fitzpatrick Skin Type III (56.5%), reducing diversity.\n- No direct head-to-head comparison with active depigmenting agents (e.g., 4% hydroquinone) was performed.\n- Study was industry-sponsored (Revision Skincare), with authors holding financial ties to the funder.","practice_takeaway":"THD ascorbate 30% serum may be a well-tolerated, hydroquinone-free option for patients with photodamage and hyperpigmentation, particularly relevant given current OTC hydroquinone restrictions. Clinicians can consider it as a frontline brightening and anti-aging agent, with effects measurable by 4–8 weeks."}},{"doi":"10.1111/jocd.70563","pmid":"41273141","title":"Efficacy and Tolerability of a Topical Peptide‐Hyaluronic Acid Lip Treatment Using a Novel Delivery System in Subjects With and Without Prior Lip Augmentation","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2025-11-22T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70563","source_score":8,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-11-26","doi":"10.1111/jocd.70563","days":"7","issn":"1473-2130","rank":"5","field":"Clinical Medicine","score":"8","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70563","title":"Efficacy and Tolerability of a Topical Peptide-Hyaluronic Acid Lip Treatment Using a Novel Delivery System in Subjects With and Without Prior Lip Augmentation.","journal":"Journal of cosmetic dermatology","methods":"","results":"RLF-TRV significantly improved lip aesthetics (shine, texture, and vermilion border), with high satisfaction across both studies. 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Dermatology Chicago Illinois USA"},{"name":"Northwestern Feinberg School of Medicine Chicago Illinois USA"}]},{"given":"Joy","family":"Tao","sequence":"additional","affiliation":[{"name":"Modern Skin Dermatology Hinsdale Illinois USA"}]},{"given":"Robert","family":"Love","sequence":"additional","affiliation":[{"name":"Ourself Carlsbad California USA"}]},{"given":"Stacy","family":"Osborne","sequence":"additional","affiliation":[{"name":"Ourself Carlsbad California USA"}]},{"given":"Tina","family":"Fleck","sequence":"additional","affiliation":[{"name":"Ourself Carlsbad California 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Board suggestions: Plinest for most areas (mid/lower face 0.5–1 mL per side), Plinest Fast/Eye for periorbital (table lists 1 mL per side); all other proposed PN HPT effects/indications achieved 84.2%–97.0% agreement. Reported combination use: microneedling 73.3%, MFU/HIFU 69.3%, botulinum toxin 66.3%, transdermal RF 52.5%, picosecond lasers 7.2%, and limited use with ablative CO2 lasers (42.6%). Injection‑site erythema typically resolved within 72 h (within 1 h in 30% and ≤12 h in 40%); bruising/hematomas had similar timeframes and were less common with cannulas.","limitations":"No stratification by age, skin aging severity, or sensitivity; self‑reported practice patterns without validated instruments or statistical estimates; limited consideration of intra‑Asian ethnic differences and potential sponsor/author conflicts.","practice_takeaway":"For Asian skin, consider PN HPT in 2–4 sessions spaced 4 weeks apart, using Plinest for most facial/neck areas (e.g., 0.5–1 mL per facial side; 2 mL for neck) and Plinest Fast/Eye for the periocular region, tailoring technique/plane to skin sensitivity and aging. Counsel patients on transient erythema/bruising (usually ≤72 h), avoid UV for 48 h, and hold makeup for at least 6–12 h post‑procedure."}},{"doi":"10.1111/exd.70173","pmid":"41159513","title":"The Role of Mast Cells in Skin Aging: Mechanisms and Therapeutic Advances","journal_title":"Experimental Dermatology","journal_issn":"0906-6705","published_at":"2025-10-29T00:00:00.000Z","url":"https://doi.org/10.1111/exd.70173","source_score":5,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-11-02","doi":"10.1111/exd.70173","days":"7","issn":"0906-6705","rank":"7","field":"Clinical Medicine","score":"5","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/exd.70173","title":"The Role of Mast Cells in Skin Aging: Mechanisms and Therapeutic Advances.","journal":"Experimental dermatology","methods":"","results":"","abstract":"$34","keywords":["SASP","UV","cellular crosstalk","mast cells","mediator release","signalling pathways","skin aging","therapeutic strategies"],"pubmed_id":"41159513","conclusions":"","publication_date":"2025-10-29T00:00:00"},"crossref":{"DOI":"10.1111/exd.70173","URL":"https://doi.org/10.1111/exd.70173","ISSN":["0906-6705","1600-0625"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/exd.70173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"11","score":1,"title":["The Role of Mast Cells in Skin Aging: Mechanisms and Therapeutic Advances"],"author":[{"given":"Liyuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]},{"given":"Zhi","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]},{"given":"Shuzhan","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]},{"given":"Yiting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]},{"given":"Xidie","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]},{"given":"Qingyu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]},{"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]},{"given":"Peiru","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]}],"funder":[{"id":[{"id":"10.13039/501100001809","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100001809","name":"National Natural Science Foundation of China","award":["82303993","82573955"],"doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2025,10,29]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":"34","archive":["Portico"],"created":{"date-time":"2025-10-29T18:30:20Z","timestamp":1761762620000,"date-parts":[[2025,10,29]]},"indexed":{"date-time":"2025-10-29T18:39:08Z","timestamp":1761763148414,"date-parts":[[2025,10,29]]},"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","start":{"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000,"date-parts":[[2025,10,29]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$35","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/exd.70173"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-04-17"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-10-14"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2025-10-29"}],"deposited":{"date-time":"2025-10-29T18:30:41Z","timestamp":1761762641000,"date-parts":[[2025,10,29]]},"issn-type":[{"type":"print","value":"0906-6705"},{"type":"electronic","value":"1600-0625"}],"published":{"date-parts":[[2025,10,29]]},"publisher":"Wiley","reference":[{"DOI":"10.1111/bjd.17268","key":"e_1_2_10_2_1","year":"2019","issue":"4","author":"Pilkington S. 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The authors note that further studies are needed to define mechanisms and optimise targeted therapies."}},{"doi":"10.1007/s13555-025-01570-4","pmid":"41134452","title":"A Combined Approach to Predict Tobacco-Induced Facial Aging Using Dermatologist Knowledge Elicitation and Generative Models","journal_title":"Dermatology and Therapy","journal_issn":"2193-8210","published_at":"2025-10-24T00:00:00.000Z","url":"https://doi.org/10.1007/s13555-025-01570-4","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-10-24","doi":"10.1007/s13555-025-01570-4","days":"7","issn":"2193-8210","rank":"7","field":"Clinical Medicine","score":"7","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1007/s13555-025-01570-4","title":"A Combined Approach to Predict Tobacco-Induced Facial Aging Using Dermatologist Knowledge Elicitation and Generative Models.","journal":"Dermatology and therapy","methods":"","results":"We present predicted independent probabilities of reaching grades for different facial aging signs as a function of cumulative tobacco consumption. A simulation was performed using a 43-year-old subject's facial image to demonstrate the tool's capabilities in illustrating the impact of tobacco consumption. Confounding variables such as sun exposure, sunscreen use, and body mass index (BMI) were controlled, while cumulative smoking (less than 10 or greater than 20 pack-years) was varied. This tool effectively visualizes the known effects of smoking on aging and provides personalized quantification of its impact on specific facial wrinkles. Recognizing that individuals prioritize different facial signs, the simulator allows users to focus on areas of personal concern.","abstract":"$36","keywords":["AI","Artificial intelligence","Elicitation","Longevity","Predictive model","Skin aging","Smoking","Tobacco"],"pubmed_id":"41134452","conclusions":"By focusing on preserving skin longevity and preventing premature aging, the simulator, which can quantify the impact of smoking on individual aging trajectories, effectively motivates positive lifestyle changes. This personalized approach offers a promising preventative messaging strategy, particularly for audiences resistant to traditional methods, and strengthens the scientific rationale regarding the impact of tobacco on specific aging signs.","publication_date":"2025-10-24T00:00:00"},"crossref":{"DOI":"10.1007/s13555-025-01570-4","URL":"https://doi.org/10.1007/s13555-025-01570-4","ISSN":["2193-8210","2190-9172"],"link":[{"URL":"https://link.springer.com/content/pdf/10.1007/s13555-025-01570-4.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/article/10.1007/s13555-025-01570-4/fulltext.html","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/content/pdf/10.1007/s13555-025-01570-4.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["A Combined Approach to Predict Tobacco-Induced Facial Aging Using Dermatologist Knowledge Elicitation and Generative Models"],"author":[{"given":"Edouard","family":"Raynaud","sequence":"first","affiliation":[]},{"given":"Laudine","family":"Bertrand","sequence":"additional","affiliation":[]},{"given":"Frederic","family":"Flament","sequence":"additional","affiliation":[]},{"given":"Julien","family":"Despois","sequence":"additional","affiliation":[]},{"given":"Sileye","family":"Ba","sequence":"additional","affiliation":[]},{"given":"Emmanuelle","family":"Tancrède-Bohin","sequence":"additional","affiliation":[]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[]},{"given":"Hussein","family":"Jouni","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2025,10,24]]},"member":"297","prefix":"10.1007","source":"Crossref","volume":null,"created":{"date-time":"2025-10-24T14:19:18Z","timestamp":1761315558000,"date-parts":[[2025,10,24]]},"indexed":{"date-time":"2025-10-24T14:25:57Z","timestamp":1761315957671,"date-parts":[[2025,10,24]]},"license":[{"URL":"https://creativecommons.org/licenses/by-nc/4.0","start":{"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000,"date-parts":[[2025,10,24]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by-nc/4.0","start":{"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000,"date-parts":[[2025,10,24]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1007/s13555-025-01570-4"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"4 August 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"8 October 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"24 October 2025"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"},"order":2,"value":"Hussein Jouni, Laudine Bertrand, Frederic Flament, Sileye Ba, Emmanuelle Tancrede-Bohin, Tao Li are employees of L’Oréal. Julien Despois was employee of L’Oréal. Edouard Raynaud works as a consultant dermatologist for L’Oréal."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"},"order":3,"value":"The authors did not consider it necessary to submit this study to an ethics committee. 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it is demonstrated on a 43‑year‑old with sun exposure, sunscreen use, and BMI held constant while smoking (<10 vs >20 pack‑years) is varied.","key_result":"For nasolabial fold wrinkles, the probability of worsening by at least two grades by age 58 was 28.54% for a non‑smoker versus 57.92% for someone with >20 pack‑years; independent probabilities were produced across multiple wrinkle types.","limitations":"Findings are illustrated with a single 43‑year‑old case and probabilities derive from expert elicitation rather than longitudinal patient outcomes; image generation and validation rely on controlled Canfield imaging, limiting generalizability to smartphone or uncontrolled lighting; data are proprietary and the study did not undergo ethics committee review.","practice_takeaway":"Clinicians can use this simulator to visually and quantitatively communicate smoking‑related wrinkle progression over 15 years (e.g., nasolabial folds nearly doubling in risk with >20 pack‑years), while noting it is based on expert‑elicited models and controlled imaging conditions."}},{"doi":"10.1111/ics.70014","pmid":"40931435","title":"Bacterial porphyrins in healthy skin: Microbiota components impact melanogenesis and age‐related processes leading to Porphyr'ageing","journal_title":"International Journal of Cosmetic Science","journal_issn":"0142-5463","published_at":"2025-09-11T00:00:00.000Z","url":"https://doi.org/10.1111/ics.70014","source_score":32,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-09-22","doi":"10.1111/ics.70014","days":"30","issn":"0142-5463","rank":"9","field":"Clinical Medicine","score":"32","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/ics.70014","title":"Bacterial porphyrins in healthy skin: Microbiota components impact melanogenesis and age-related processes leading to Porphyr'ageing.","journal":"International journal of cosmetic science","methods":"","results":"Bacterial porphyrins penetrated stratum corneum and reached living epidermal cells. The porphyrin mixture increased IL-8, ROS and melanin contents. Porphyrin-induced melanin synthesis appeared to be regulated by translocator protein TSPO/PBR. In fibroblasts, bacterial metabolites down-regulated a set of transcripts involved in extracellular matrix architecture and associated with ageing, which was confirmed by a decrease of type I pro-collagen. Finally, the clinical study established positive and significant correlations between porphyrin abundance and the severity of ageing signs, including invisible spots, brown spots and wrinkles length.","abstract":"$37","keywords":["TSPO/PBR","hyperpigmentation","penetration","precursor spot","skin ageing","skin physiology/structure","statistics","wrinkle"],"pubmed_id":"40931435","conclusions":"In summary, porphyrins could play unexpected roles in skin's premature ageing process, a phenomenon we propose to call Porphyr'ageing, that promotes hyperpigmentation, inflammation, oxidative stress and fibroblast cell ageing, leading to dermal matrix weakening.\nEn résumé, les porphyrines pourraient jouer des rôles inattendus dans le processus de vieillissement prématuré de la peau, un phénomène que nous proposons d’appeler Porphyr’ageing, qui favorise l’hyperpigmentation, l’inflammation, le stress oxydatif et le vieillissement des cellules fibroblastes, conduisant à un affaiblissement de la 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and an in vivo study examined associations between porphyrin abundance and visible aging signs.","key_result":"Porphyrins penetrated the stratum corneum, reached living epidermal cells, and increased IL-8, reactive oxygen species, and melanin; melanogenesis appeared regulated by TSPO/PBR. In fibroblasts, they downregulated extracellular matrix–related transcripts with a decrease in type I pro-collagen, and an in vivo study found positive, significant correlations between porphyrin abundance and severity of invisible spots, brown spots, and wrinkle length.","limitations":"The clinical component is correlational, so causality cannot be inferred. The abstract provides no sample size, demographics, or effect sizes, limiting appraisal of magnitude and generalizability.","practice_takeaway":"Higher skin porphyrin levels were associated with greater pigmentation and wrinkle measures, suggesting porphyrins may be relevant markers in skin aging assessments; no treatment recommendations are supported by these data."}},{"doi":"10.1111/srt.13504","pmid":"38009018","title":"Effect of Lumenato a Tomato derived oral supplement on improving skin barrier strength","journal_title":"Skin Research and Technology","journal_issn":"0909-752X","published_at":"2023-11-27T00:00:00.000Z","url":"https://doi.org/10.1111/srt.13504","source_score":282,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2023-11-17","doi":"10.1111/srt.13504","days":"30","issn":"0909-752X","rank":"2","field":"Clinical Medicine","score":"282","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/srt.13504","title":"Effect of Lumenato a Tomato derived oral supplement on improving skin barrier strength.","journal":"Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)","methods":"A panel of 60 female subjects were provided with the Lumenato capsules (containing carotenoids) or placebo capsules as nutritional supplements for 3 months. Skin health and barrier function were observed using evaporimeter which measures trans epidermal water loss (TEWL). Barrier strength was determined by study of the number of strippings required to disrupt skin barrier and barrier repair was observed in terms of TEWL a few hours after barrier disruption. Cutometer was used to observe skin firmness and elasticity. Measurements were obtained before treatment and after 4 and 12 weeks of use.","results":"Results indicated a statistically significant improvement (p < 0.05) in skin barrier strength; a higher number of strippings were required to disrupt skin barrier after 12 weeks of supplement use. There was also a significant improvement in skin firmness and elasticity as observed with a cutometer.","abstract":"$39","keywords":["carotenes","facial ageing","oral supplement","skin barrier"],"pubmed_id":"38009018","conclusions":"Based on the confines and conditions of this study, oral supplementation with Lumenato resulted in significant improvement in skin barrier as well as skin firmness and elasticity.","publication_date":"2023-11-27T00:00:00"},"crossref":{"DOI":"10.1111/srt.13504","URL":"https://doi.org/10.1111/srt.13504","ISSN":["0909-752X","1600-0846"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/srt.13504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"11","score":1,"title":["Effect of Lumenato a Tomato derived oral supplement on improving skin barrier strength"],"author":[{"given":"Elizabeth","family":"Tarshish","sequence":"first","affiliation":[{"name":"Lycored Ltd Beer Sheva Israel"}]},{"given":"Karin","family":"Hermoni","sequence":"additional","affiliation":[{"name":"Lycored CORP Secaucus New Jersey USA"}]},{"given":"Neelam","family":"Muizzuddin","sequence":"additional","affiliation":[{"name":"Skin Clinical Research Consultants LLC Bethpage New York USA"}]}],"issued":{"date-parts":[[2023,11]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":"29","archive":["Portico"],"created":{"date-time":"2023-11-09T04:35:24Z","timestamp":1699504524000,"date-parts":[[2023,11,9]]},"indexed":{"date-time":"2025-08-26T06:43:48Z","timestamp":1756190628232,"date-parts":[[2025,8,26]]},"license":[{"URL":"http://creativecommons.org/licenses/by-nc-nd/4.0/","start":{"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000,"date-parts":[[2023,11,8]]},"delay-in-days":7,"content-version":"vor"}],"subject":[],"abstract":"$3a","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/srt.13504"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2023-10-02"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2023-10-09"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2023-11-08"}],"deposited":{"date-time":"2025-05-21T11:18:01Z","timestamp":1747826281000,"date-parts":[[2025,5,21]]},"issn-type":[{"type":"print","value":"0909-752X"},{"type":"electronic","value":"1600-0846"}],"published":{"date-parts":[[2023,11]]},"publisher":"Wiley","reference":[{"DOI":null,"key":"e_1_2_8_2_1","year":"2011","issue":"9","author":"Del Rosso JQ","volume":"4","first-page":"22","unstructured":null,"article-title":"The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease‐affected skin","journal-title":"J Clin Aesthet Dermatol","doi-asserted-by":null},{"DOI":"10.1111/j.1365-2133.1993.tb00222.x","key":"e_1_2_8_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1046/j.1523-1747.2003.12128.x","key":"e_1_2_8_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/jid.2012.43","key":"e_1_2_8_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_8_6_1","year":"2016","issue":"1","author":"Del Rosso J","volume":"9","first-page":"1","unstructured":null,"article-title":"Understanding the epidermal barrier in healthy and compromised skin: clinically relevant information for the dermatology practitioner proceedings of an expert panel roundtable meeting","journal-title":"Supp J Clin Aesthetic Derm","doi-asserted-by":null},{"DOI":"10.3390/ijms14046720","key":"e_1_2_8_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_8_8_1","year":"2010","issue":"1","author":"Robinson M","volume":"61","first-page":"13","unstructured":null,"article-title":"Natural moisturizing factors (NMF) in the stratum corneum (SC). 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