2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T59f,Skin laxity and crepiness of the arms is a cosmetic concern that before the advent of noninvasive skin tightening technologies could only be treated with surgery. Ultrasound-based technologies deliver energy to the dermis which causes neocollagenesis and neoelastogenesis to rejuvenate the skin. This study evaluates and compares the efficacy of a high-intensity, parallel beam ultrasound-based skin tightening (HIUS) device with microfocused ultrasound with visualization (MFU-V) for improvement of upper arm skin laxity and crepiness. A prospective, single-center, blinded, split-body, randomized clinical study investigated HIUS and MFU-V for improvement of upper arm skin laxity and crepiness. Subjects received a single treatment to the upper arms. Fourteen female subjects completed the study. Assessments compared Day 30 and Day 90 follow-up visits with baseline. HIUS was as effective as MFU-V in improving arm laxity and crepiness. Investigators and subjects rated improved arm laxity/crepiness at Day 90. Most subjects were satisfied with the improvement of arm laxity/crepiness. There was no statistically significant difference in pain scores observed between the HIUS and MFU-V. The MFU-V treatment took more time to perform than the HIUS treatment. High-intensity, parallel beam ultrasound-based skin tightening was effective and delivered results with high patient satisfaction for improving upper arm skin laxity/crepiness.31:T7f4, BACKGROUND Skin laxity and crepiness of the arms is a cosmetic concern that before the advent of noninvasive skin tightening technologies could only be treated with surgery. Ultrasound-based technologies deliver energy to the dermis which causes neocollagenesis and neoelastogenesis to rejuvenate the skin. OBJECTIVE This study evaluates and compares the efficacy of a high-intensity, parallel beam ultrasound-based skin tightening (HIUS) device with microfocused ultrasound with visualization (MFU-V) for improvement of upper arm skin laxity and crepiness. MATERIALS AND METHODS A prospective, single-center, blinded, split-body, randomized clinical study investigated HIUS and MFU-V for improvement of upper arm skin laxity and crepiness. Subjects received a single treatment to the upper arms. RESULTS Fourteen female subjects completed the study. Assessments compared Day 30 and Day 90 follow-up visits with baseline. HIUS was as effective as MFU-V in improving arm laxity and crepiness. Investigators and subjects rated improved arm laxity/crepiness at Day 90. Most subjects were satisfied with the improvement of arm laxity/crepiness. There was no statistically significant difference in pain scores observed between the HIUS and MFU-V. The MFU-V treatment took more time to perform than the HIUS treatment. CONCLUSION High-intensity, parallel beam ultrasound-based skin tightening was effective and delivered results with high patient satisfaction for improving upper arm skin laxity/crepiness. 32:T60e,Radiofrequency (RF) therapy is a popular noninvasive skin-tightening method, yet objective evaluations of its effectiveness remain limited. This study assesses RF therapy's impact on facial skin laxity and oiliness using a 3D skin analyzer, multi-parameter skin analysis, and histological analysis. Thirty-two patients (skin types III-V) underwent full-face monopolar RF treatment, with follow-ups over 24 weeks. Clinical photographs, 3D imaging, and specialized probes measured elasticity and sebum levels. Skin biopsies were taken before and 2 months post-treatment. Improvement was assessed through patient questionnaires and dermatologist evaluations. Significant improvements in jawline sagging and nasolabial folds were observed in 2D/3D images. Quantitative analysis confirmed RF-induced skin rejuvenation, with a statistically significant increase in skin radiance at 4 and 8 weeks. Sebum production decreased notably at 8 and 24 weeks, as confirmed by the sebum index. Elasticity improved, with increased viscoelasticity and reduced retraction time. Histological analysis revealed reduced dermal inflammation, decreased sebaceous gland volume, and enhanced collagen and elastic fiber density. At 2 months, 53.1% of patients reported over 50% improvement. No severe adverse events occurred. Monopolar RF effectively enhances skin laxity by remodeling collagen and reorganizing elastic fibers. Histological findings and skin analyzer data support RF as a reliable, noninvasive treatment for improving skin firmness and reducing oiliness.33:T79c,ABSTRACTBackgroundRadiofrequency (RF) therapy is a popular noninvasive skin‐tightening method, yet objective evaluations of its effectiveness remain limited.AimsThis study assesses RF therapy's impact on facial skin laxity and oiliness using a 3D skin analyzer, multi‐parameter skin analysis, and histological analysis.MethodsThirty‐two patients (skin types III–V) underwent full‐face monopolar RF treatment, with follow‐ups over 24 weeks. Clinical photographs, 3D imaging, and specialized probes measured elasticity and sebum levels. Skin biopsies were taken before and 2 months post‐treatment. Improvement was assessed through patient questionnaires and dermatologist evaluations.ResultsSignificant improvements in jawline sagging and nasolabial folds were observed in 2D/3D images. Quantitative analysis confirmed RF‐induced skin rejuvenation, with a statistically significant increase in skin radiance at 4 and 8 weeks. Sebum production decreased notably at 8 and 24 weeks, as confirmed by the sebum index. Elasticity improved, with increased viscoelasticity and reduced retraction time. Histological analysis revealed reduced dermal inflammation, decreased sebaceous gland volume, and enhanced collagen and elastic fiber density. At 2 months, 53.1% of patients reported over 50% improvement. No severe adverse events occurred.ConclusionMonopolar RF effectively enhances skin laxity by remodeling collagen and reorganizing elastic fibers. Histological findings and skin analyzer data support RF as a reliable, noninvasive treatment for improving skin firmness and reducing oiliness.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Skin Laxity: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Skin Laxity (condition). Clinician-written summaries and actionable practice insights. 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Botulinum toxin A outperformed RFMN for primary axillary hyperhidrosis. Side effects were mostly transient (erythema, edema, pain); post-inflammatory hyperpigmentation was infrequent and self-limited. PROs showed high satisfaction and minimal downtime.","limitations":"- Heterogeneity in devices, technical parameters (temperature, pulse width, cooling), and outcome measures limits cross-study comparisons.\n- Inconsistent reporting of device settings prevents protocol standardization.\n- No meta-analysis performed; findings are narratively synthesized only.","practice_takeaway":"RFMN is a safe, well-tolerated option for atrophic acne scars, skin laxity, and photoaging across diverse Fitzpatrick skin types — consider it as a first-line or adjunct procedure with a favorable recovery profile. For primary axillary hyperhidrosis, botulinum toxin A remains the stronger choice over RFMN."}},{"doi":"10.1097/dss.0000000000004881","pmid":"41025649","title":"A Single-Center, Blinded, Split-Body, Randomized Clinical Trial of High-Intensity, Parallel Ultrasound Beams Versus Microfocused Ultrasound With Visualization for the Treatment of Upper Inner Arm Skin Laxity","journal_title":"Dermatologic Surgery","journal_issn":"1076-0512","published_at":"2025-09-30T00:00:00.000Z","url":"https://doi.org/10.1097/dss.0000000000004881","source_score":1,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-10-06","doi":"10.1097/dss.0000000000004881","days":"7","issn":"1076-0512","rank":"7","field":"Clinical Medicine","score":"1","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1097/DSS.0000000000004881","title":"A Single-Center, Blinded, Split-Body, Randomized Clinical Trial of High-Intensity, Parallel Ultrasound Beams Versus Microfocused Ultrasound With Visualization for the Treatment of Upper Inner Arm Skin Laxity.","journal":"Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]","methods":"","results":"Fourteen female subjects completed the study. Assessments compared Day 30 and Day 90 follow-up visits with baseline. HIUS was as effective as MFU-V in improving arm laxity and crepiness. Investigators and subjects rated improved arm laxity/crepiness at Day 90. Most subjects were satisfied with the improvement of arm laxity/crepiness. There was no statistically significant difference in pain scores observed between the HIUS and MFU-V. The MFU-V treatment took more time to perform than the HIUS treatment.","abstract":"$30","keywords":[],"pubmed_id":"41025649","conclusions":"High-intensity, parallel beam ultrasound-based skin tightening was effective and delivered results with high patient satisfaction for improving upper arm skin laxity/crepiness.","publication_date":"2025-09-30T00:00:00"},"crossref":{"DOI":"10.1097/dss.0000000000004881","URL":"https://doi.org/10.1097/dss.0000000000004881","ISSN":["1076-0512","1524-4725"],"link":[{"URL":"https://journals.lww.com/10.1097/DSS.0000000000004881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["A Single-Center, Blinded, Split-Body, Randomized Clinical Trial of High-Intensity, Parallel Ultrasound Beams Versus Microfocused Ultrasound With Visualization for the Treatment of Upper Inner Arm Skin Laxity"],"author":[{"given":"Jameson","family":"Loyal","sequence":"first","affiliation":[{"name":"Cosmetic Laser Dermatology: A Platinum Dermatology Partners Company, San Diego, California;"}]},{"given":"Nina","family":"Hartman","sequence":"additional","affiliation":[{"name":"Washington Institute of Dermatologic Laser Surgery, Washington, District of Columbia;"}]},{"given":"Mitchel P.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Cosmetic Laser Dermatology: A Platinum Dermatology Partners Company, San Diego, California;"},{"name":"Volunteer Clinical Professor of Dermatology—Retired, University of California, San Diego, 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split-body RCT, HIUS achieved similar improvement and pain scores as MFU-V for upper arm laxity/crepiness at 90 days, while taking less time to perform."}},{"doi":"10.1111/jocd.70463","pmid":"41014039","title":"Evaluation of Improvement in Skin Laxity and Oiliness After Monopolar Radiofrequency Treatment: A Pilot Study Utilizing Multiple Assessment Tools","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2025-09-27T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70463","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-10-01","doi":"10.1111/jocd.70463","days":"7","issn":"1473-2130","rank":"10","field":"Clinical Medicine","score":"1","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70463","title":"Evaluation of Improvement in Skin Laxity and Oiliness After Monopolar Radiofrequency Treatment: A Pilot Study Utilizing Multiple Assessment Tools.","journal":"Journal of cosmetic dermatology","methods":"","results":"Significant improvements in jawline sagging and nasolabial folds were observed in 2D/3D images. Quantitative analysis confirmed RF-induced skin rejuvenation, with a statistically significant increase in skin radiance at 4 and 8 weeks. Sebum production decreased notably at 8 and 24 weeks, as confirmed by the sebum index. Elasticity improved, with increased viscoelasticity and reduced retraction time. Histological analysis revealed reduced dermal inflammation, decreased sebaceous gland volume, and enhanced collagen and elastic fiber density. At 2 months, 53.1% of patients reported over 50% improvement. No severe adverse events occurred.","abstract":"$32","keywords":["collagen","elasticity","elastin","histological review","laxity","monopolar radiofrequency","multiparameter skin analysis unit","sebum","skin rejuvenation","three‐dimensional skin analysis device"],"pubmed_id":"41014039","conclusions":"Monopolar RF effectively enhances skin laxity by remodeling collagen and reorganizing elastic fibers. Histological findings and skin analyzer data support RF as a reliable, noninvasive treatment for improving skin firmness and reducing oiliness.","publication_date":"2025-09-27T00:00:00"},"crossref":{"DOI":"10.1111/jocd.70463","URL":"https://doi.org/10.1111/jocd.70463","ISSN":["1473-2130","1473-2165"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"10","score":1,"title":["Evaluation of Improvement in Skin Laxity and Oiliness After Monopolar Radiofrequency Treatment: A Pilot Study Utilizing Multiple Assessment Tools"],"author":[{"given":"Dong Hye","family":"Suh","sequence":"first","affiliation":[{"name":"Arumdaun Nara Dermatologic Clinic Seoul Korea"}]},{"given":"Sang Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Arumdaun Nara Dermatologic Clinic Seoul Korea"}]},{"given":"Kye Yong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine Chung‐Ang University Seoul Korea"}]},{"given":"Haerin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital Ansan Korea"}]},{"given":"Su Ji","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital Ansan Korea"}]},{"given":"Hwa Jung","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital Ansan 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patients.","value_numeric":null},{"paper_doi":"10.1111/jocd.70463","tag_type":"warning","value":"Outcomes rely on device-specific analyzers; results may not translate across platforms.","value_numeric":null}],"summaries":{"what_studied":"Single-session, full-face monopolar radiofrequency was tested in 32 adults with Fitzpatrick skin types III–V, with follow-up at 4, 8, and 24 weeks using 3D imaging, multi-parameter skin analysis (sebum, viscoelasticity, retraction time), histology in 12, and patient/dermatologist improvement ratings.","key_result":"At 2 months, sebum production fell from 32.88%±31.80% to 12.25%±20.39% (p=0.005), viscoelasticity rose from 4.61±3.00 to 6.06±2.84 MPa (p=0.023), and retraction time dropped from 242.00±172.99 to 167.86±68.16 ms (p=0.017); 53.1% of patients and 62.5% of investigators rated >50% overall improvement. Radiance scores increased at 4 and 8 weeks (p=0.037; p<0.001) and 3D sebum scores decreased at 8 and 24 weeks (p=0.016; p<0.001); no severe adverse events occurred (5 transient erythema, 3 small burns).","limitations":"Single-arm pre–post design without a control group; small sample with sex imbalance (93.8% female); histology limited to 12 participants with potential inter-operator variability.","practice_takeaway":"Monopolar RF can improve mid–lower face laxity metrics and reduce oiliness over 2–24 weeks in adults with skin types III–V, with mostly mild, transient AEs; fine wrinkles and pore scores did not change significantly."}}],"initialOffset":3,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Skin Laxity"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Skin Laxity"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Skin Laxity"}}}]]

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