2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T695,To describe disease activity and treatments received during the postpartum period, breastfeeding rates and their possible impact on rheumatoid arthritis (RA) and spondyloarthritis (SpA) activity. This ancillary study from the French multicentre prospective cohort (GR2-NCT02450396) included pregnant women with RA and SpA with at least one postpartum visit from October 2014 to October 2022. Disease activity, flares, treatments and breastfeeding rates were described. Factors associated with the occurrence of a flare were evaluated by survival analysis. Disease activity was compared according to breastfeeding duration (never, <6 months and ≥6 months). Ninety-four RA and 124 SpA patients were studied. In RA patients, the proportion of patients presenting with at least one flare was significantly higher during the first 6 months postpartum compared with pregnancy (62.0% vs 43.5%; p=0.02). For SpA patients, there was no difference in disease activity at 6 months postpartum compared with pregnancy (40.7% vs 40.7%; p=0.999). Disease activity in postpartum was similar between the different breastfeeding status in both diseases. 13/91 (14.3%) RA patients and 29/123 (23.6%) SpA patients continued a biologic Disease-Modifying Antirheumatic Drug (bDMARD) during the whole pregnancy and the postpartum. 78/91 RA and 94/123 SpA patients delivered without any DMARDs, and among them, 43/78 (55.1%) and 56/94 (59.6%) (re)started a bDMARD postpartum. RA patients were more likely to flare during early postpartum, while SpA patients remained stable. bDMARD continuation during pregnancy was more frequent in SpA patients, and half of the patients restarted bDMARD during postpartum.31:T9b8, Objective To describe disease activity and treatments received during the postpartum period, breastfeeding rates and their possible impact on rheumatoid arthritis (RA) and spondyloarthritis (SpA) activity. Method This ancillary study from the French multicentre prospective cohort (GR2- NCT02450396 ) included pregnant women with RA and SpA with at least one postpartum visit from October 2014 to October 2022. Disease activity, flares, treatments and breastfeeding rates were described. Factors associated with the occurrence of a flare were evaluated by survival analysis. Disease activity was compared according to breastfeeding duration (never, <6 months and ≥6 months). Results Ninety-four RA and 124 SpA patients were studied. In RA patients, the proportion of patients presenting with at least one flare was significantly higher during the first 6 months postpartum compared with pregnancy (62.0% vs 43.5%; p=0.02). For SpA patients, there was no difference in disease activity at 6 months postpartum compared with pregnancy (40.7% vs 40.7%; p=0.999). Disease activity in postpartum was similar between the different breastfeeding status in both diseases. 13/91 (14.3%) RA patients and 29/123 (23.6%) SpA patients continued a biologic Disease-Modifying Antirheumatic Drug (bDMARD) during the whole pregnancy and the postpartum. 78/91 RA and 94/123 SpA patients delivered without any DMARDs, and among them, 43/78 (55.1%) and 56/94 (59.6%) (re)started a bDMARD postpartum. Conclusion RA patients were more likely to flare during early postpartum, while SpA patients remained stable. bDMARD continuation during pregnancy was more frequent in SpA patients, and half of the patients restarted bDMARD during postpartum. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Spondyloarthritis: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Spondyloarthritis (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Spondyloarthritis\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Spondyloarthritis\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Spondyloarthritis\"}]}}"}}]],["$","$L2f",null,{"title":"Spondyloarthritis: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Spondyloarthritis with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1002/art.70297","pmid":"42605840","title":"Risk of Cancer according to Duration of Targeted Therapy Exposure in Spondyloarthritis: A Nationwide Cohort Study from the French Health Insurance Database","journal_title":"Arthritis & Rheumatology","journal_issn":"2326-5191","published_at":"2026-08-17T00:00:00.000Z","url":"https://doi.org/10.1002/art.70297","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-22T06:53:21.288Z","updated_at":"2026-08-22T06:53:21.288Z","tags":[{"paper_doi":"10.1002/art.70297","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"condition","value":"Axial Spondyloarthritis","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"condition","value":"Cancer","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"condition","value":"Psoriatic Arthritis","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"condition","value":"Spondyloarthritis","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"modality","value":"IL-12/23 Inhibitor","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"modality","value":"IL-17 Inhibitor","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"modality","value":"IL-23 Inhibitor","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"modality","value":"JAK Inhibitor","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"modality","value":"TNF Inhibitor","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"sample_size","value":"n=56591","value_numeric":56591},{"paper_doi":"10.1002/art.70297","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"study_design","value":"Nationwide Cohort Study","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"warning","value":"Causal inference relies on inverse probability weighting from claims data; unmeasured confounders (e.g., disease severity, concomitant medications) may not be fully accounted for.","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"warning","value":"The protective signal for hematological malignancies (wHR 0.65) is based on only 116 events, so this estimate should be interpreted cautiously — wide confidence intervals reflect limited precision.","value_numeric":null},{"paper_doi":"10.1002/art.70297","tag_type":"warning","value":"The study pools multiple SpA subtypes and multiple drug classes (TNFi, IL-17i, IL-12/23i, IL-23i, JAKi) into a single exposure variable; drug-class-specific or subtype-specific cancer risks may differ and are not fully delineated in the abstract.","value_numeric":null}],"summaries":{"what_studied":"This nationwide French cohort study examined whether duration of targeted therapy exposure (TNFi, IL-17i, IL-12/23i, IL-23i, JAKi) affects cancer risk in 56,591 adults with spondyloarthritis (including psoriatic arthritis and axial SpA), followed for a median of 5.0 years (2014–2024).","key_result":"Exposure >6 months/year vs. ≤6 months/year was associated with a **lower** overall cancer risk (wHR 0.86, 95% CI 0.75–0.99), driven primarily by hematological malignancies (wHR 0.65, 95% CI 0.42–0.99); no significant reduction was seen for solid cancers (wHR 0.92, 95% CI 0.79–1.07). Of 1,224 total cancers, 1,029 were solid and 116 hematological. Cumulative multi-year exposure was not associated with cancer risk.","limitations":"- **Observational design**: residual confounding cannot be excluded despite inverse probability weighting.\n- **Database-based exposure**: therapy adherence is inferred from insurance claims, not directly measured.\n- **Heterogeneous SpA subtypes**: pooling psoriatic arthritis, axial SpA, and other subtypes may obscure subgroup-specific risks.","practice_takeaway":"Clinicians can reassure patients with SpA that prolonged targeted therapy use is not associated with increased cancer risk — and may even lower hematological malignancy risk. Cumulative years of exposure should not, on its own, prompt treatment discontinuation over cancer concerns."}},{"doi":"10.1093/rheumatology/keag395","pmid":"42565551","title":"Medication use during pregnancy and pregnancy outcomes in women with immune mediated inflammatory diseases: a UK-based matched cohort study","journal_title":"Rheumatology","journal_issn":"1462-0324","published_at":"2026-08-07T00:00:00.000Z","url":"https://doi.org/10.1093/rheumatology/keag395","source_score":11,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-19T06:28:55.988Z","updated_at":"2026-08-19T06:28:55.988Z","tags":[{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"condition","value":"Inflammatory Bowel Disease","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"condition","value":"Psoriasis","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"condition","value":"Psoriatic Arthritis","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"condition","value":"Rheumatoid Arthritis","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"condition","value":"Spondyloarthritis","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"generic","value":"azathioprine","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"generic","value":"mesalazine","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"generic","value":"sulfasalazine","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"modality","value":"Disease-Modifying Antirheumatic Drug","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"study_design","value":"Matched Cohort Study","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"warning","value":"Sample size not reported in the abstract or results excerpt; tags reflect available data only.","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"warning","value":"Study period ends June 2020; newer biologics (e.g., IL-17/IL-23 inhibitors) may not be well-represented in prescribing patterns.","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag395","tag_type":"warning","value":"The IBD MCM finding (ORadj 1.31) reached borderline significance only on sensitivity analysis — authors caution against overinterpretation due to potential residual confounding.","value_numeric":null}],"summaries":{"what_studied":"This UK matched cohort study (CPRD, 2000–2020) examined prescribing patterns and pregnancy outcomes — spontaneous pregnancy loss and major congenital malformations (MCMs) — in women with RA, PsA, psoriasis, SpA, or IBD compared to matched women without these diagnoses. It also assessed outcomes in women exposed to azathioprine, mesalazine, and sulfasalazine.","key_result":"Spontaneous pregnancy loss risk was modestly elevated for psoriasis and IBD (IBD: HRadj 1.18, 95% CI 1.07–1.30), but not significantly increased for RA, PsA, or SpA (PsA: HRadj 1.01, 95% CI 0.79–1.28). MCM risk was not significantly raised for any IMID except IBD, where a borderline signal emerged on sensitivity analysis (ORadj 1.31, 95% CI 1.00–1.71). No increased spontaneous loss risk was seen with azathioprine, mesalazine, or sulfasalazine use.","limitations":"Residual confounding (e.g., disease activity, smoking, BMI) may explain the IBD MCM signal. The study relies on routinely coded primary care data, which may miss diagnoses or drug exposures. Individual IMID subgroup analyses (especially PsA, SpA) may be underpowered.","practice_takeaway":"Women with RA, PsA, or SpA can be counselled that their underlying condition does not appear to significantly raise spontaneous pregnancy loss risk; IBD carries a small but real increase. Azathioprine, mesalazine, and sulfasalazine use during pregnancy was not associated with increased spontaneous loss, supporting their continued use when clinically indicated."}},{"doi":"10.1002/acr.80114","pmid":"42439302","title":"Opioid Use Disorder and Treatment Uptake Among Patients With Rheumatic Conditions in the\n All of Us\n Research Program: A Descriptive Analysis","journal_title":"Arthritis Care & Research","journal_issn":"2151-464X","published_at":"2026-08-02T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13367410/","source_score":26,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-11T06:19:59.463Z","updated_at":"2026-09-11T06:19:59.463Z","tags":[{"paper_doi":"10.1002/acr.80114","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"condition","value":"Opioid Use Disorder","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"condition","value":"Osteoarthritis","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"condition","value":"Rheumatoid Arthritis","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"condition","value":"Spondyloarthritis","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"condition","value":"Systemic Lupus Erythematosus","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"generic","value":"buprenorphine","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"generic","value":"methadone","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"generic","value":"naltrexone","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"modality","value":"Disease-Modifying Antirheumatic Drug","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"modality","value":"Opioid Use Disorder Pharmacotherapy","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"sample_size","value":"n=37282","value_numeric":37282},{"paper_doi":"10.1002/acr.80114","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"study_design","value":"Cross-Sectional Descriptive Study","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"warning","value":"Geographic overrepresentation of the West U.S. Census Region in the OUD group may limit generalizability.","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"warning","value":"MOUD uptake figures may be slightly overestimated as methadone/buprenorphine/naltrexone can be prescribed for pain or other substance disorders, not exclusively OUD.","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"warning","value":"OUD billing code sensitivity is only 59%, so true OUD prevalence may be higher than reported 4.0%.","value_numeric":null},{"paper_doi":"10.1002/acr.80114","tag_type":"warning","value":"Study design is cross-sectional/descriptive using EHR billing codes; causality and directionality cannot be established.","value_numeric":null}],"summaries":{"what_studied":"This descriptive analysis used the national *All of Us* Research Program (2015–2023, n=37,282) to characterize patients with OA, SLE, RA, or SpA who also had opioid use disorder (OUD), and to measure uptake of medications for OUD (MOUD: buprenorphine, methadone, naltrexone) after first OUD diagnosis.","key_result":"4.0% of rheumatic disease patients had OUD (n=1,502). Those with OUD were younger (mean 57.5 vs 63.7 years), had higher Medicaid enrollment (50.7% vs 22.9%), more psychiatric comorbidities, higher prior opioid exposure (75.7% vs 45.8%), more corticosteroid use, and lower DMARD use (biologic/targeted synthetic: 3.2% vs 4.7%; conventional: 7.5% vs 10.0%). Only 14.5% of eligible patients with OUD received MOUD — well below the national estimate of ~25%.","limitations":"- OUD identified by billing codes only (PPV 64–80%, sensitivity 59%), so active vs. historical OUD cannot be distinguished.\n- Small subgroup sizes prevented analysis of social risk factors and detailed substance-type breakdowns.\n- MOUD may be used for pain or other substance disorders, potentially overestimating true OUD treatment uptake.","practice_takeaway":"Rheumatologists should routinely screen for OUD in patients with SLE, RA, SpA, and OA — especially those on chronic opioids or corticosteroids — and facilitate MOUD access, as fewer than 1 in 7 affected patients currently receives treatment. Lower DMARD use in patients with OUD suggests unmet disease management needs that may compound OUD-related morbidity."}},{"doi":"10.1093/rheumatology/keag352","pmid":"42397204","title":"Vaccination coverage of influenza and pneumococcal vaccines in patients with rheumatic diseases: a systematic review and meta-analysis","journal_title":"Rheumatology","journal_issn":"1462-0324","published_at":"2026-07-03T00:00:00.000Z","url":"https://doi.org/10.1093/rheumatology/keag352","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-10T13:25:33.034Z","updated_at":"2026-07-10T13:25:33.034Z","tags":[{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"condition","value":"Psoriatic Arthritis","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"condition","value":"Rheumatoid Arthritis","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"condition","value":"Spondyloarthritis","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"condition","value":"Systemic Lupus Erythematosus","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"generic","value":"influenza vaccine","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"generic","value":"pneumococcal vaccine","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"level_of_evidence","value":"1","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"modality","value":"Vaccine","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"sample_size","value":"n=51","value_numeric":51},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"study_design","value":"Systematic Review and Meta-Analysis","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"warning","value":"High heterogeneity across pooled estimates is acknowledged; subgroup and sensitivity analyses were performed but specific I² values were not provided in the abstract.","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"warning","value":"Sample size tag reflects number of included studies (n=51), not total patient count — the latter was not reported in the abstract.","value_numeric":null},{"paper_doi":"10.1093/rheumatology/keag352","tag_type":"warning","value":"The 'limited_evidence' impact flag reflects the observational nature and heterogeneity of underlying studies, not the systematic review methodology itself.","value_numeric":null}],"summaries":{"what_studied":"This systematic review and meta-analysis (51 studies) examined influenza and pneumococcal vaccine coverage rates in patients with rheumatic diseases — RA, SLE, SpA, and PsA — and explored clinical and contextual factors driving heterogeneity.","key_result":"Pooled influenza vaccination rates were 50% (RA), 42% (SLE), 43% (SpA), and 53% (PsA); pneumococcal rates were lower at 37%, 30%, 39%, and 41%, respectively. Vaccinated RA patients were older and had more comorbidities. Geographic location and DMARD use were key sources of heterogeneity. \"Lack of awareness\" and \"not offered by doctors\" were the two most common reasons for non-vaccination.","limitations":"The review pooled observational studies with high heterogeneity; geographic variation and DMARD use complicate generalizability. Vaccination definitions and recall methods likely varied across included studies.","practice_takeaway":"Vaccine coverage for influenza and pneumococcus remains well below recommended targets in rheumatic disease patients — rheumatologists should proactively offer and educate about both vaccines at every visit. Targeting younger patients and those without comorbidities may help close the gap."}},{"doi":"10.1007/s10067-026-08238-0","pmid":"42348128","title":"Uveitis in spondyloarthritis: clinical patterns and differences between axial and peripheral forms","journal_title":"Clinical Rheumatology","journal_issn":"0770-3198","published_at":"2026-06-25T00:00:00.000Z","url":"https://doi.org/10.1007/s10067-026-08238-0","source_score":2,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-03T13:38:42.087Z","updated_at":"2026-07-03T13:38:42.087Z","tags":[{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"condition","value":"Axial Spondyloarthritis","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"condition","value":"Inflammatory Bowel Disease-Associated Spondyloarthritis","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"condition","value":"Psoriatic Arthritis","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"condition","value":"Spondyloarthritis","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"condition","value":"Uveitis","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"generic","value":"methotrexate","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"generic","value":"sulfasalazine","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"modality","value":"Biologic DMARD","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"modality","value":"Conventional Synthetic DMARD","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"sample_size","value":"n=163","value_numeric":163},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"study_design","value":"Retrospective Observational Study","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"warning","value":"Age group tagged as 'adult' — the paper does not explicitly state an age range or restrict enrollment to adults, but the SpA context and multidisciplinary uveitis clinic setting make a predominantly adult population highly likely.","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"warning","value":"Biologic drug names (e.g., adalimumab) are referenced in the literature review but not reported as distinct treatment arms in the results; they were not tagged as individual brands/generics to avoid misrepresentation.","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08238-0","tag_type":"warning","value":"The impact flag 'confirms_prior' was applied because the study largely validates known clinical patterns; no single practice-changing finding was identified.","value_numeric":null}],"summaries":{"what_studied":"Retrospective observational study of 163 patients with non-infectious uveitis and spondyloarthritis (SpA) from a multidisciplinary uveitis clinic, comparing uveitis clinical patterns across SpA subtypes (radiographic axSpA, non-radiographic axSpA, IBD-SpA, psoriatic arthritis, peripheral SpA) and between axial vs. peripheral forms.","key_result":"Anterior uveitis (97%), acute relapsing course (79%), and alternating laterality (47.4%) dominated overall. Peripheral SpA forms showed exclusively non-anterior locations (intermediate, posterior, panuveitis), more chronic courses (p<0.001), more bilateralism (p<0.05), and greater systemic therapy use (p=0.05). Among all patients, 28.2% needed immunomodulatory therapy and 17.8% needed biologics.","limitations":"- Retrospective single-center design limits generalizability.\n- Peripheral SpA subgroups (pSpA 4%, PsA 12%, IBD-SpA 13%) were small, reducing statistical power for subgroup comparisons.\n- Biologic discontinuation difference in peripheral forms did not reach significance (p=0.059).","practice_takeaway":"Patients with peripheral SpA (including PsA and IBD-SpA) are at higher risk for non-anterior, chronic, and bilateral uveitis and need closer ophthalmologic monitoring and earlier consideration of systemic immunomodulatory therapy. Predictors of greater systemic therapy need include chronic course, bilateralism, frequent episodes, younger onset age, peripheral joint involvement, and vitritis."}},{"doi":"10.1136/rmdopen-2025-006593","pmid":"42049394","title":"Impact of postpartum on patients with rheumatoid arthritis and spondyloarthritis: an ancillary analysis of the GR2 prospective cohort","journal_title":"RMD Open","journal_issn":"2056-5933","published_at":"2026-04-29T00:00:00.000Z","url":"https://doi.org/10.1136/rmdopen-2025-006593","source_score":17,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-04-30","doi":"10.1136/rmdopen-2025-006593","days":"14","issn":"2056-5933","rank":"6","field":"Clinical Medicine","score":"17","category":"Rheumatology","categories":["Rheumatology"],"_categories":["Rheumatology"]},"pubmed":{"doi":"10.1136/rmdopen-2025-006593","title":"Impact of postpartum on patients with rheumatoid arthritis and spondyloarthritis: an ancillary analysis of the GR2 prospective cohort.","journal":"RMD open","methods":"This ancillary study from the French multicentre prospective cohort (GR2-NCT02450396) included pregnant women with RA and SpA with at least one postpartum visit from October 2014 to October 2022. Disease activity, flares, treatments and breastfeeding rates were described. Factors associated with the occurrence of a flare were evaluated by survival analysis. Disease activity was compared according to breastfeeding duration (never, <6 months and ≥6 months).","results":"Ninety-four RA and 124 SpA patients were studied. In RA patients, the proportion of patients presenting with at least one flare was significantly higher during the first 6 months postpartum compared with pregnancy (62.0% vs 43.5%; p=0.02). For SpA patients, there was no difference in disease activity at 6 months postpartum compared with pregnancy (40.7% vs 40.7%; p=0.999). Disease activity in postpartum was similar between the different breastfeeding status in both diseases. 13/91 (14.3%) RA patients and 29/123 (23.6%) SpA patients continued a biologic Disease-Modifying Antirheumatic Drug (bDMARD) during the whole pregnancy and the postpartum. 78/91 RA and 94/123 SpA patients delivered without any DMARDs, and among them, 43/78 (55.1%) and 56/94 (59.6%) (re)started a bDMARD postpartum.","abstract":"$30","keywords":["Arthritis, Rheumatoid","Axial Spondyloarthritis","Biological Therapy"],"pubmed_id":"42049394","conclusions":"RA patients were more likely to flare during early postpartum, while SpA patients remained stable. bDMARD continuation during pregnancy was more frequent in SpA patients, and half of the patients restarted bDMARD during postpartum.","publication_date":"2026-04-29T00:00:00"},"crossref":{"DOI":"10.1136/rmdopen-2025-006593","URL":"https://doi.org/10.1136/rmdopen-2025-006593","ISSN":["2056-5933"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1136/rmdopen-2025-006593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"e006593","type":"journal-article","issue":"2","score":1,"title":["Impact of postpartum on patients with rheumatoid arthritis and spondyloarthritis: an ancillary analysis of the GR2 prospective cohort"],"author":[{"given":"Marie","family":"Hornez","sequence":"first","affiliation":[{"name":"Service de Rhumatologie, Université de Lille, CHU Lille, Lille, France"}]},{"given":"Anna","family":"Molto","sequence":"additional","affiliation":[{"name":"Centre for Research in Epidemiology and Statistics, Université Paris Cité; Université Sorbonne Paris Nord; INSERM; INRAE, Paris, France"},{"name":"Service de Rhumatologie, Hôpital Bichat, APHP, Paris, France"}]},{"given":"Maxime","family":"Leroy","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, CHU Lille, Lille, France"}]},{"given":"Béatrice","family":"Banneville","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France"}]},{"given":"Rakiba","family":"Belkhir","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Université Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin-Bicetre, France"}]},{"given":"Elodie","family":"Chauvet","sequence":"additional","affiliation":[{"name":"Service de Médecine Interne, CHU Montpellier, Montpellier, France"}]},{"given":"Marion","family":"Couderc","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, CHU Gabriel Montpied, Clermont-Ferrand, France"}]},{"given":"Emmanuelle","family":"Dernis","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, CHU Caen, Caen, France"}]},{"given":"Valérie","family":"Devauchelle-Pensec","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, UMR1227, Lymphocytes B et Autoimmunité, Université de Bretagne occidentale, Inserm, CHU Brest, LabEx IGO, Brest, France"},{"name":"Rheumatology Unit, Centre National de Référence des Maladies Auto-Immunes Rares (CERAINOM), CHU, Brest, France"}]},{"given":"Aline","family":"Frazier","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Université Paris Cité, AP-HP, Hôpital Lariboisière, Paris, France"}]},{"given":"Laure","family":"Gossec","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France"}]},{"given":"Elisabeth","family":"Gervais","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, CHU Poitiers, Poitiers, France"}]},{"given":"Hubert","family":"Marotte","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Université Jean Monnet Saint-Étienne, CHU Saint-Etienne, Mines Saint-Etienne, INSERM, SAINBIOSE U1059, Saint-Étienne, France"}]},{"given":"Christophe","family":"Richez","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, National Reference Center for Systemic Autoimmune Rare Diseases, Bordeaux University Hospital, Hôpital Pellegrin, Bordeaux, France"},{"name":"CNRS, Immunoconcept, UMR 5164, Bordeaux University, Bordeaux, France"}]},{"given":"Jérémie","family":"Sellam","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Hôpital Saint-Antoine; Assistance Publique–Hôpitaux de Paris (AP-HP); Sorbonne Université, Paris, France"}]},{"given":"Raphaele","family":"Seror","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Université Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin-Bicetre, France"}]},{"given":"Véronique","family":"Le Guern","sequence":"additional","affiliation":[{"name":"Service de Médecine Interne, Centre de Référence Maladies Autoimmunes et Systémiques Rares Île de France, APHP Hôpital Cochin, Paris, France"}]},{"given":"Gaëlle","family":"Guettrot-Imbert","sequence":"additional","affiliation":[{"name":"Service de Médecine Interne, Centre de Référence Maladies Autoimmunes et Systémiques Rares Île de France, APHP Hôpital Cochin, Paris, France"}]},{"given":"Nathalie","family":"Costedoat-Chalumeau","sequence":"additional","affiliation":[{"name":"Service de Médecine Interne, Centre de Référence Maladies Autoimmunes et Systémiques Rares Île de France, APHP Hôpital Cochin, Paris, France"}]},{"given":"René-Marc","family":"Flipo","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Université de Lille, CHU Lille, FHU PRECISE, Lille, France"}]},{"given":"Jean-Guillaume","family":"Letarouilly","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Université de Lille, CHU Lille, FHU PRECISE, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France"}]}],"funder":[{"name":"the Association Prix Veronique Roualet"},{"id":[{"id":"10.13039/100011110","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100011110","name":"UCB","doi-asserted-by":"publisher"},{"name":"AFM-Telethon"},{"name":"Cochin Hospital"},{"name":"Association Francophone contre la Polychondrite chronique atrophiante"},{"id":[{"id":"10.13039/100020799","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100020799","name":"Association des Sclérodermiques de France","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/501100014034","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100014034","name":"Foundation for Research in Rheumatology","doi-asserted-by":"publisher"},{"name":"the French Society of Internal Medicine and Rheumatology"},{"name":"Association Gougerot Sjogren"},{"name":"The French Health Ministry"},{"name":"Lupus France"}],"issued":{"date-parts":[[2026,4]]},"member":"239","prefix":"10.1136","source":"Crossref","volume":"12","created":{"date-time":"2026-04-28T13:25:21Z","timestamp":1777382721000,"date-parts":[[2026,4,28]]},"indexed":{"date-time":"2026-04-29T12:21:56Z","timestamp":1777465316482,"date-parts":[[2026,4,29]]},"license":[{"URL":"https://creativecommons.org/licenses/by-nc/4.0/","start":{"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000,"date-parts":[[2026,4,28]]},"delay-in-days":27,"content-version":"unspecified"}],"subject":[],"abstract":"$31","accepted":{"date-parts":[[2026,3,31]]},"language":"en","relation":{},"resource":{"primary":{"URL":"https://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2025-006593"}},"subtitle":[],"deposited":{"date-time":"2026-04-28T13:25:26Z","timestamp":1777382726000,"date-parts":[[2026,4,28]]},"issn-type":[{"type":"electronic","value":"2056-5933"}],"published":{"date-parts":[[2026,4]]},"publisher":"BMJ","reference":[{"DOI":"10.1016/j.jbspin.2021.105289","key":"2026042806251264000_12.2.e006593.1","year":"2022","issue":null,"author":"Fakih","volume":"89","first-page":"105289","unstructured":null,"article-title":"Differences in distribution by department of prevalence and incidence of spondyloarthritis and inflammatory bowel diseases declared to the French National Health Insurance and their evolution between 2008 and 2018","journal-title":"Joint Bone Spine","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jbspin.2022.105460","key":"2026042806251264000_12.2.e006593.2","year":"2023","issue":null,"author":"Pina Vegas","volume":"90","first-page":"105460","unstructured":null,"article-title":"Prevalence, mortality, and treatment of patients with rheumatoid arthritis: A cohort study of the French National Health Data System, 2010-2019","journal-title":"Joint Bone Spine","doi-asserted-by":"crossref"},{"DOI":null,"key":"2026042806251264000_12.2.e006593.3","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Hench PS . The ameliorating effect of pregnancy on chronic atrophic (infectious rheumatoid) arthritis, fibrositis, and intermittent hydrarthrosis. In: Classic Papers in Rheumatology. 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no brand-level data were reported in the paper.","value_numeric":null},{"paper_doi":"10.1136/rmdopen-2025-006593","tag_type":"warning","value":"Definitions of flare and the specific disease activity measures are not provided in the abstract.","value_numeric":null},{"paper_doi":"10.1136/rmdopen-2025-006593","tag_type":"warning","value":"Disease activity scores were frequently missing, especially CRP, which may have reduced sensitivity to detect objective changes in activity.","value_numeric":null},{"paper_doi":"10.1136/rmdopen-2025-006593","tag_type":"warning","value":"Observational ancillary cohort analysis without randomized comparisons; causal inferences are limited.","value_numeric":null},{"paper_doi":"10.1136/rmdopen-2025-006593","tag_type":"warning","value":"Self-reported flare definitions may overestimate true flare rates compared to validated score-based definitions.","value_numeric":null},{"paper_doi":"10.1136/rmdopen-2025-006593","tag_type":"warning","value":"The association between bDMARD resumption and postpartum flare is likely reverse causation (flare prompts treatment restart) rather than treatment causing flare—authors acknowledge this.","value_numeric":null},{"paper_doi":"10.1136/rmdopen-2025-006593","tag_type":"warning","value":"Treatment denominators (e.g., 91/123) differ from total enrolled (94/124), suggesting missing data or exclusions.","value_numeric":null}],"summaries":{"what_studied":"An ancillary analysis of a French multicentre prospective cohort (GR2) followed pregnant women with rheumatoid arthritis (RA) or spondyloarthritis (SpA) who had at least one postpartum visit (2014–2022) to describe disease activity, flares, breastfeeding, and treatments. Postpartum disease activity was compared with pregnancy, flares were examined with survival analysis, and outcomes were explored by breastfeeding duration (never, <6 months, ≥6 months).","key_result":"In RA, the proportion with at least one flare in the first 6 months postpartum was higher than during pregnancy (62.0% vs 43.5%; p=0.02). In SpA, disease activity at 6 months postpartum was unchanged versus pregnancy (40.7% vs 40.7%; p=0.999); postpartum activity did not differ by breastfeeding status in either disease; 13/91 (14.3%) RA and 29/123 (23.6%) SpA continued a bDMARD through pregnancy and postpartum, and among those delivering without any DMARDs (RA 78/91; SpA 94/123), 43/78 (55.1%) and 56/94 (59.6%) (re)started a bDMARD postpartum.","limitations":"Only patients with at least one postpartum visit were included, and denominators varied across analyses (e.g., 91/123 vs totals 94/124), indicating missing data or exclusions. The abstract does not specify flare definitions or disease activity measures, and adjusted analyses are not reported.","practice_takeaway":"Plan closer monitoring of women with RA in the first 6 months after delivery, when flares were more frequent than during pregnancy; SpA activity appeared stable. Breastfeeding did not change postpartum activity, and many who stopped DMARDs in pregnancy restarted bDMARDs after delivery."}},{"doi":"10.1007/s10067-026-08144-5","pmid":"42033584","title":"Exploring the phenotypic expression of HLA-B27 in psoriatic arthritis","journal_title":"Clinical Rheumatology","journal_issn":"0770-3198","published_at":"2026-04-25T00:00:00.000Z","url":"https://doi.org/10.1007/s10067-026-08144-5","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-10T13:20:35.230Z","updated_at":"2026-05-10T13:20:35.230Z","tags":[{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"condition","value":"Psoriatic Arthritis","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"condition","value":"Spondyloarthritis","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"modality","value":"Genetic Biomarker","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"sample_size","value":"n=333","value_numeric":333},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"warning","value":"Full text was not available; all extracted data come from the abstract and publisher page only. Details on biologic types used, imaging confirmation of axial disease, and multivariate analyses are not reported here.","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"warning","value":"Study design is labeled 'Brief Report,' which may indicate limited sample size discussion or supplementary methods not visible in the abstract.","value_numeric":null},{"paper_doi":"10.1007/s10067-026-08144-5","tag_type":"warning","value":"The FIB-4 finding in HLA-B27-negative patients is exploratory and should be interpreted cautiously given the single p-value reported without further context.","value_numeric":null}],"summaries":{"what_studied":"Retrospective analysis of 333 PsA patients (CASPAR criteria) with documented HLA-B27 status at a single Spanish center, comparing clinical, laboratory, and treatment features between HLA-B27-positive (11.7%) and HLA-B27-negative patients.","key_result":"HLA-B27-positive patients had earlier disease onset (42.8 vs. 49.1 years, p=0.003), more axial involvement (46.2% vs. 24.5%, p=0.004), more enthesitis (33.3% vs. 18.4%, p=0.028), and higher CRP (median 5.5 vs. 3.2 mg/L, p=0.015). HLA-B27 status did not affect treatment response, comorbidities, or rates of difficult-to-treat/refractory disease. HLA-B27-negative patients had higher FIB-4 scores (p=0.034).","limitations":"- Single-center retrospective design limits generalizability.\n- Full-text not available; details on biologic use, imaging criteria for axial disease, and confounders are not described.\n- HLA-B27 prevalence (11.7%) reflects the study population's background rate, which may differ across ethnicities.","practice_takeaway":"Testing HLA-B27 in PsA patients may help identify those at higher risk for axial disease and enthesitis, supporting earlier imaging and appropriate treatment. HLA-B27 status alone should not guide treatment choices, as it did not predict treatment response in this cohort."}}],"initialOffset":7,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Spondyloarthritis"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Spondyloarthritis"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Spondyloarthritis"}}}]]