2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T416,Squamous cell carcinomas (SCCs) originate in epithelial tissues of older individuals who have been exposed to environmental carcinogens. Despite overlapping clinical hallmarks, SCCs from different anatomic sites have different prognoses. Here we show that fibroblasts confer site-specific cues that determine SCC proliferation and invasion. Oral and lung fibroblasts have distinct lipid metabolism, transferring unique lipids to SCC cells that promote epithelial-to-mesenchymal transition, and oral and lung SCC invasion. Whereas oral fibroblasts transfer sphingomyelins, which activate the ceramide-sphingosine-1-phosphate-STAT3 pathway and promote oral SCC invasion, lung fibroblasts transfer triglycerides to lung SCCs, thereby triggering cholesterol synthesis and invasion, which is associated with poor survival. By contrast, dermal fibroblasts are lipid poor, and cutaneous SCC is less invasive. Our data indicate that targeting fibroblast lipid synthesis and SCC lipid uptake or breakdown inhibits oral and lung epithelial cancer invasion.31:T45f,Abstract Squamous cell carcinomas (SCCs) originate in epithelial tissues of older individuals who have been exposed to environmental carcinogens. Despite overlapping clinical hallmarks, SCCs from different anatomic sites have different prognoses. Here we show that fibroblasts confer site-specific cues that determine SCC proliferation and invasion. Oral and lung fibroblasts have distinct lipid metabolism, transferring unique lipids to SCC cells that promote epithelial-to-mesenchymal transition, and oral and lung SCC invasion. Whereas oral fibroblasts transfer sphingomyelins, which activate the ceramide–sphingosine-1-phosphate–STAT3 pathway and promote oral SCC invasion, lung fibroblasts transfer triglycerides to lung SCCs, thereby triggering cholesterol synthesis and invasion, which is associated with poor survival. By contrast, dermal fibroblasts are lipid poor, and cutaneous SCC is less invasive. Our data indicate that targeting fibroblast lipid synthesis and SCC lipid uptake or breakdown inhibits oral and lung epithelial cancer invasion.32:T4e5,A worldwide total of 153 993 melanoma, 1 463 424 squamous cell carcinoma (SCC), and 2 802 354 basal cell carcinoma (BCC) instances were estimated for 2021. SCC exhibited the highest age-standardized rate of prevalence (236.91 per 100 000 population; 95% uncertainty interval [UI], 188.23-303.82), deaths (6.16 per 100 000 population; 95% UI, 5.13-6.87), and DALYs (95.50 per 100 000 population; 95% UI, 81.65-106.39), whereas BCC displayed the highest incidence rate (371.97 per 100 000 population; 95% UI, 310.75-439.58). The disease burden was notably greater in male individuals than in female individuals. During the observation period, the global burden of skin cancer among older people demonstrated a general upward trend. Decomposition analysis indicated that population growth was the primary contributor to this increase. Health-inequality analysis revealed a disproportionately higher burden shouldered by countries with higher sociodemographic index (SDI) levels. Frontier analysis identified the countries with considerable potential to mitigate skin cancer. It was anticipated that only incidence and prevalence rates attributable to keratinocyte cancer (KC), along with DALYs rate related to BCC, would increase by 2050.33:T930,Skin cancer is a significant public health threat in the aging population, yet data on its burden and trends are limited. To evaluate the global burden of skin cancer among adults 65 years or older from 1990 to 2021, and to project its change to 2050. In this observational study, population-based registry data were extracted from the Global Burden of Diseases (GBD) Study 2021. The database covers 204 countries and territories, ensuring global applicability of the results. Data analysis was conducted from June 9, 2024, to February 18, 2025. Age-standardized rates of prevalence, incidence, deaths, and disability-adjusted life-years (DALYs) were calculated per 100 000 population. Estimated rates of disease burden were calculated for 2050. A worldwide total of 153 993 melanoma, 1 463 424 squamous cell carcinoma (SCC), and 2 802 354 basal cell carcinoma (BCC) instances were estimated for 2021. SCC exhibited the highest age-standardized rate of prevalence (236.91 per 100 000 population; 95% uncertainty interval [UI], 188.23-303.82), deaths (6.16 per 100 000 population; 95% UI, 5.13-6.87), and DALYs (95.50 per 100 000 population; 95% UI, 81.65-106.39), whereas BCC displayed the highest incidence rate (371.97 per 100 000 population; 95% UI, 310.75-439.58). The disease burden was notably greater in male individuals than in female individuals. During the observation period, the global burden of skin cancer among older people demonstrated a general upward trend. Decomposition analysis indicated that population growth was the primary contributor to this increase. Health-inequality analysis revealed a disproportionately higher burden shouldered by countries with higher sociodemographic index (SDI) levels. Frontier analysis identified the countries with considerable potential to mitigate skin cancer. It was anticipated that only incidence and prevalence rates attributable to keratinocyte cancer (KC), along with DALYs rate related to BCC, would increase by 2050. The older population (particularly male individuals and those living in high-SDI countries) is facing a substantial growing burden of skin cancer. Despite the relative incompleteness of KC data and lack of race and ethnicity data, these results highlight the urgency for more effective prevention and management strategies targeting high-risk groups.34:Tb8b,ImportanceSkin cancer is a significant public health threat in the aging population, yet data on its burden and trends are limited.ObjectiveTo evaluate the global burden of skin cancer among adults 65 years or older from 1990 to 2021, and to project its change to 2050.Design, Setting, and ParticipantsIn this observational study, population-based registry data were extracted from the Global Burden of Diseases (GBD) Study 2021. The database covers 204 countries and territories, ensuring global applicability of the results. Data analysis was conducted from June 9, 2024, to February 18, 2025.Main Outcomes and MeasuresAge-standardized rates of prevalence, incidence, deaths, and disability-adjusted life-years (DALYs) were calculated per 100 000 population. Estimated rates of disease burden were calculated for 2050.ResultsA worldwide total of 153 993 melanoma, 1 463 424 squamous cell carcinoma (SCC), and 2 802 354 basal cell carcinoma (BCC) instances were estimated for 2021. SCC exhibited the highest age-standardized rate of prevalence (236.91 per 100 000 population; 95% uncertainty interval [UI], 188.23-303.82), deaths (6.16 per 100 000 population; 95% UI, 5.13-6.87), and DALYs (95.50 per 100 000 population; 95% UI, 81.65-106.39), whereas BCC displayed the highest incidence rate (371.97 per 100 000 population; 95% UI, 310.75-439.58). The disease burden was notably greater in male individuals than in female individuals. During the observation period, the global burden of skin cancer among older people demonstrated a general upward trend. Decomposition analysis indicated that population growth was the primary contributor to this increase. Health-inequality analysis revealed a disproportionately higher burden shouldered by countries with higher sociodemographic index (SDI) levels. Frontier analysis identified the countries with considerable potential to mitigate skin cancer. It was anticipated that only incidence and prevalence rates attributable to keratinocyte cancer (KC), along with DALYs rate related to BCC, would increase by 2050.Conclusions and RelevanceThe older population (particularly male individuals and those living in high-SDI countries) is facing a substantial growing burden of skin cancer. Despite the relative incompleteness of KC data and lack of race and ethnicity data, these results highlight the urgency for more effective prevention and management strategies targeting high-risk groups.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Squamous Cell Carcinoma: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Squamous Cell Carcinoma (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Squamous%20Cell%20Carcinoma\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Squamous Cell Carcinoma\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Squamous%20Cell%20Carcinoma\"}]}}"}}]],["$","$L2f",null,{"title":"Squamous Cell Carcinoma: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Squamous Cell Carcinoma with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1001/jamadermatol.2026.2763","pmid":"42584914","title":"Risk Stratification Models for Cutaneous Malignant Neoplasms After Blood or Marrow Transplant","journal_title":"JAMA Dermatology","journal_issn":"2168-6068","published_at":"2026-08-12T00:00:00.000Z","url":"https://pubmed.ncbi.nlm.nih.gov/42584914/","source_score":2,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-17T13:33:02.013Z","updated_at":"2026-08-17T13:33:02.013Z","tags":[{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"condition","value":"Basal Cell Carcinoma","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"condition","value":"Graft-Versus-Host Disease","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"condition","value":"Melanoma","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"condition","value":"Squamous Cell Carcinoma","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"modality","value":"Hematopoietic Stem Cell Transplantation","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"modality","value":"Total Body Irradiation","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"sample_size","value":"n=3448","value_numeric":3448},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"study_design","value":"Prognostic Cohort Study","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"warning","value":"Outcome ascertainment was based partly on patient self-report; medical record validation was not available for all participants, which may introduce misclassification bias.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"warning","value":"The cohort spans 40 years (1974–2014), and transplant practices have evolved considerably; risk factor estimates may not fully apply to patients receiving modern conditioning regimens or targeted immunosuppression.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2026.2763","tag_type":"warning","value":"The study is classified as a prognostic cohort study; the 'level of evidence 2' rating reflects validated prediction modeling in a longitudinal cohort but no external validation in an independent dataset is explicitly reported.","value_numeric":null}],"summaries":{"what_studied":"This prognostic study developed and validated risk stratification models for subsequent cutaneous malignant neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma) in 3,448 BMT survivors from the multi-institutional BMTSS cohort (1974–2014), followed ≥2 years post-transplant. Candidate predictors included age, sex, race, ethnicity, prior skin cancer, pretransplant monoclonal antibody exposure, total body irradiation, chronic graft-vs-host disease, and posttransplant immunosuppression.","key_result":"At 15 years post-BMT, model AUCs were 0.81 for BCC, 0.90 for SCC, and 0.83 for melanoma. High-risk patients had 15-year cumulative incidences of 13.3% (BCC), 13.6% (SCC), and 4.4% (melanoma), versus 2.4%, 3.2%, and 0.8% in the low-risk group—roughly a 5-fold difference across all three cancer types.","limitations":"- Outcomes relied partly on self-report; medical record validation was not universal.\n- The cohort spans transplants from 1974–2014, so older-era practices may not reflect current BMT protocols.\n- Study sites were limited to 3 U.S. centers, which may limit generalizability to other populations or settings.","practice_takeaway":"Clinicians can use age, sex, prior skin cancer, total body irradiation, chronic GVHD, and immunosuppression status to stratify BMT survivors into low- vs. high-risk groups for skin cancer, enabling targeted dermatologic surveillance. High-risk survivors face a >13% 15-year risk of BCC or SCC and warrant more intensive monitoring."}},{"doi":"10.1016/j.abd.2026.501374","pmid":"42364360","title":"Skin cancer and actinic keratosis in people with albinism: a systematic review and meta-analysis","journal_title":"Anais Brasileiros de Dermatologia","journal_issn":"0365-0596","published_at":"2026-06-27T00:00:00.000Z","url":"https://doi.org/10.1016/j.abd.2026.501374","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-03T13:38:42.688Z","updated_at":"2026-07-03T13:38:42.688Z","tags":[{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"condition","value":"Actinic Keratosis","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"condition","value":"Albinism","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"condition","value":"Basal Cell Carcinoma","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"condition","value":"Malignant Melanoma","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"condition","value":"Skin Cancer","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"condition","value":"Squamous Cell Carcinoma","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"level_of_evidence","value":"1","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"sample_size","value":"n=1747","value_numeric":1747},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"study_design","value":"Systematic Review and Meta-Analysis","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"warning","value":"Heterogeneity was extremely high (I² up to 99%) across most outcomes, which substantially limits the reliability and generalizability of the pooled prevalence estimates.","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"warning","value":"No age- or sex-stratified data were reported, so age_group and sex tags reflect the assumed mixed nature of included study populations.","value_numeric":null},{"paper_doi":"10.1016/j.abd.2026.501374","tag_type":"warning","value":"The full text body was not extractable from the PDF (pages appear image-based); all data are sourced from the abstract and results sections only.","value_numeric":null}],"summaries":{"what_studied":"This systematic review and meta-analysis estimated the pooled prevalence of skin cancer (SC) and actinic keratosis (AK) among individuals with albinism, drawing from 12 cross-sectional and cohort studies identified via PubMed, Embase, Web of Science, and Cochrane databases.","key_result":"Among 1,747 individuals with albinism, pooled AK prevalence was 38% (95% CI 17.7–60.3; I² = 99%) and SC prevalence was 19% (95% CI 13.5–24.4; I² = 89%). Within SC cases, SCC was most common at 55.4% (95% CI 36.2–73.8), BCC at 33.7% (95% CI 19.6–49.2), and malignant melanoma at 0% (95% CI 0.00–0.56).","limitations":"- Heterogeneity was very high across all outcomes (I² up to 99%), driven by differences in study design, diagnostic criteria, and geographic variation — making pooled estimates difficult to interpret precisely.\n- Study pool was predominantly cross-sectional, limiting causal or temporal inferences.\n- Lack of detailed patient-level data (e.g., age, UV exposure, albinism subtype) prevented meaningful subgroup analyses.","practice_takeaway":"Nearly 1 in 5 people with albinism may have skin cancer, and nearly 2 in 5 may have actinic keratosis — clinicians should prioritize regular full-body skin surveillance and aggressive photoprotection counseling in this population.\nSCC is the dominant skin cancer subtype in albinism; early detection programs should focus on this lesion type, particularly in high-prevalence regions such as sub-Saharan Africa."}},{"doi":"10.1111/jdv.70562","pmid":"42324974","title":"The worldwide burden of skin diseases: Lessons from the Global Burden of Disease data","journal_title":"Journal of the European Academy of Dermatology and Venereology","journal_issn":"0926-9959","published_at":"2026-06-22T00:00:00.000Z","url":"https://doi.org/10.1111/jdv.70562","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-28T13:27:20.921Z","updated_at":"2026-06-28T13:27:20.921Z","tags":[{"paper_doi":"10.1111/jdv.70562","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"condition","value":"Acne","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"condition","value":"Atopic Dermatitis","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"condition","value":"Basal Cell Carcinoma","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"condition","value":"Contact Dermatitis","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"condition","value":"Decubitus Ulcer","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"condition","value":"Fungal Skin Infections","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"condition","value":"Scabies","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"condition","value":"Sexually Transmitted Infections","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"condition","value":"Skin and Subcutaneous Diseases","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"condition","value":"Squamous Cell Carcinoma","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"study_design","value":"Cross-Sectional / Epidemiological Analysis","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"warning","value":"Level of evidence assigned as 3 (epidemiological/cross-sectional analysis of registry data); some may classify GBD analyses differently depending on institutional hierarchy frameworks.","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"warning","value":"Study design is a secondary analysis of GBD aggregate data — no primary patient-level data collected; causality cannot be inferred.","value_numeric":null},{"paper_doi":"10.1111/jdv.70562","tag_type":"warning","value":"The 25.7% prevalence figure explicitly excludes STIs and skin cancers, so direct comparisons with other overall skin disease burden estimates require caution.","value_numeric":null}],"summaries":{"what_studied":"Global epidemiology and disease burden of skin diseases using GBD 2021 data (2000–2021), including prevalence, incidence, DALYs, and YLDs across demographics and regions — excluding sexually transmitted infections (STIs) and skin cancers from the primary burden category.","key_result":"Skin and subcutaneous diseases (excluding STIs and skin cancers) affected 25.7% of the global population, ranking 6th in prevalence and 8th in YLDs (495.1 per 100,000 person-years). The most prevalent conditions overall were STIs excluding HIV (16.8%), fungal infections (7.8%), and acne (3.0%). Squamous cell carcinoma, basal cell carcinoma, and decubitus ulcers are rising; atopic dermatitis, scabies, and viral infections are declining slightly.","limitations":"- GBD captures only a subset of dermatological conditions, likely underestimating true burden due to widespread underreporting and misdiagnosis.\n- Major data gaps exist for low- and middle-income countries.\n- Quality-adjusted life year estimates do not adequately account for cultural and social variation.","practice_takeaway":"Skin diseases affect roughly 1 in 3 people globally, with infectious conditions dominating in Sub-Saharan Africa and tropical regions, while chronic inflammatory diseases and skin cancers predominate in high-income countries — clinicians should tailor screening and management to regional burden profiles. The true burden is likely higher than GBD figures suggest, underscoring the need for improved reporting, especially in resource-limited settings."}},{"doi":"10.1038/s42255-026-01514-y","pmid":"42045479","title":"Tissue-specific fibroblast lipid cues impose the rate of epithelial cancer invasion","journal_title":"Nature Metabolism","journal_issn":"2522-5812","published_at":"2026-04-28T00:00:00.000Z","url":"https://doi.org/10.1038/s42255-026-01514-y","source_score":30,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-04-30","doi":"10.1038/s42255-026-01514-y","days":"14","issn":"2522-5812","rank":"7","field":"Clinical Medicine","score":"30","category":"Endocrinology & Metabolism","categories":["Endocrinology & Metabolism"],"_categories":["Endocrinology & Metabolism"]},"pubmed":{"doi":"10.1038/s42255-026-01514-y","title":"Tissue-specific fibroblast lipid cues impose the rate of epithelial cancer invasion.","journal":"Nature metabolism","methods":"","results":"","abstract":"$30","keywords":[],"pubmed_id":"42045479","conclusions":"","publication_date":"2026-04-28T00:00:00"},"crossref":{"DOI":"10.1038/s42255-026-01514-y","URL":"https://doi.org/10.1038/s42255-026-01514-y","ISSN":["2522-5812"],"link":[{"URL":"https://www.nature.com/articles/s42255-026-01514-y.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s42255-026-01514-y","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s42255-026-01514-y.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Tissue-specific fibroblast lipid cues impose the rate of epithelial cancer invasion"],"author":[{"given":"Timothy","family":"Budden","sequence":"first","affiliation":[]},{"given":"Noah","family":"Palombo","sequence":"additional","affiliation":[]},{"given":"Shilpa","family":"Gurung","sequence":"additional","affiliation":[]},{"given":"Martha","family":"Gutteridge","sequence":"additional","affiliation":[]},{"given":"Charlotte","family":"Russell","sequence":"additional","affiliation":[]},{"given":"Jair","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Alex","family":"von Kriegsheim","sequence":"additional","affiliation":[]},{"given":"Lyutong","family":"An","sequence":"additional","affiliation":[]},{"given":"Catherine","family":"Harwood","sequence":"additional","affiliation":[]},{"given":"Luisa","family":"Motta","sequence":"additional","affiliation":[]},{"given":"Claus","family":"Jorgensen","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"López-Garcîa","sequence":"additional","affiliation":[]},{"given":"Caroline","family":"Gaudy-Marqueste","sequence":"additional","affiliation":[]},{"given":"Kevin","family":"Harrington","sequence":"additional","affiliation":[]},{"given":"Malin","family":"Pedersen","sequence":"additional","affiliation":[]},{"given":"Ben","family":"O’Leary","sequence":"additional","affiliation":[]},{"given":"Antonio","family":"Rullan","sequence":"additional","affiliation":[]},{"given":"Amaya","family":"Virós","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/501100000289","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100000289","name":"Cancer 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Burden was higher in men, rose over time mainly from population growth, was greater in high-SDI countries, and by 2050 only keratinocyte cancer incidence/prevalence and BCC DALY rates are projected to increase.","limitations":"Keratinocyte cancer data were relatively incomplete, and race and ethnicity were not available.","practice_takeaway":"Older men in high-SDI settings carry a growing skin cancer burden; intensify prevention and management for these high-risk groups. 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