2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T614,This study aimed to compare the efficacy and safety of an initial 12 mg versus 6 mg adenosine dose for sinus rhythm conversion in patients presenting with supraventricular tachycardia (SVT) in the emergency department (ED). This prospective observational study was conducted between February 2025 and January 2026. Adult patients (≥ 18 years) presenting to the ED with hemodynamically stable SVT confirmed by 12-lead electrocardiography (ECG) were included. Patients were categorized into two groups according to the initial adenosine dose administered (6 mg vs. 12 mg). To address potential selection bias, 1:1 propensity score matching (PSM) was performed. The primary outcome was successful first-dose sinus rhythm conversion. Secondary outcomes included adenosine-related adverse effects and SVT recurrence during the ED stay. A total of 142 patients were analyzed (n = 71 per group). First-dose conversion was significantly higher with 12 mg compared with 6 mg (83.1% vs. 52.1%). In the PSM cohort (n = 104), the 12 mg dose maintained its superior efficacy (82.7% vs. 53.8%). The PSM-adjusted odds ratio for successful conversion was 4.12 (95% confidence interval [CI]: 1.85-9.14), with a number needed to treat (NNT) of 3.8 (95% CI: 2.5-8.3). SVT recurrence was numerically lower in the 12 mg group (1.4% vs. 9.9%). Adverse effects were similar between groups. An initial 12 mg adenosine dose was associated with higher first-dose sinus rhythm conversion than 6 mg, while adverse effects were similar between groups.31:T95f,ABSTRACT Objectives This study aimed to compare the efficacy and safety of an initial 12 mg versus 6 mg adenosine dose for sinus rhythm conversion in patients presenting with supraventricular tachycardia (SVT) in the emergency department (ED). Methods This prospective observational study was conducted between February 2025 and January 2026. Adult patients (≥ 18 years) presenting to the ED with hemodynamically stable SVT confirmed by 12‐lead electrocardiography (ECG) were included. Patients were categorized into two groups according to the initial adenosine dose administered (6 mg vs. 12 mg). To address potential selection bias, 1:1 propensity score matching (PSM) was performed. The primary outcome was successful first‐dose sinus rhythm conversion. Secondary outcomes included adenosine‐related adverse effects and SVT recurrence during the ED stay. Results A total of 142 patients were analyzed ( n = 71 per group). First‐dose conversion was significantly higher with 12 mg compared with 6 mg (83.1% vs. 52.1%). In the PSM cohort ( n = 104), the 12 mg dose maintained its superior efficacy (82.7% vs. 53.8%). The PSM‐adjusted odds ratio for successful conversion was 4.12 (95% confidence interval [CI]: 1.85–9.14), with a number needed to treat (NNT) of 3.8 (95% CI: 2.5–8.3). SVT recurrence was numerically lower in the 12 mg group (1.4% vs. 9.9%). Adverse effects were similar between groups. Conclusions An initial 12 mg adenosine dose was associated with higher first‐dose sinus rhythm conversion than 6 mg, while adverse effects were similar between groups. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Supraventricular Tachycardia: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Supraventricular Tachycardia (condition). Clinician-written summaries and actionable practice insights. 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First-dose conversion was significantly higher with 12 mg compared with 6 mg (83.1% vs. 52.1%). In the PSM cohort (n = 104), the 12 mg dose maintained its superior efficacy (82.7% vs. 53.8%). The PSM-adjusted odds ratio for successful conversion was 4.12 (95% confidence interval [CI]: 1.85-9.14), with a number needed to treat (NNT) of 3.8 (95% CI: 2.5-8.3). SVT recurrence was numerically lower in the 12 mg group (1.4% vs. 9.9%). Adverse effects were similar between groups.","abstract":"$30","keywords":["adenosine","adverse effects","emergency department","sinus rhythm conversion","supraventricular tachycardia"],"pubmed_id":"42057249","conclusions":"","publication_date":"2026-04-30T00:00:00"},"crossref":{"DOI":"10.1111/acem.70309","URL":"https://doi.org/10.1111/acem.70309","ISSN":["1069-6563","1553-2712"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/acem.70309","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/acem.70309","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/acem.70309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"5","score":1,"title":["Initial 12 mg Versus 6 mg Adenosine for Supraventricular Tachycardia in the Emergency Department"],"author":[{"given":"Ekrem Taha","family":"Sert","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Aksaray University Faculty of Medicine Aksaray Turkey"}]},{"given":"Kamil","family":"Kokulu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Aksaray University Faculty of Medicine Aksaray Turkey"}]},{"given":"Oğuz","family":"Yürük","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Aksaray University Faculty of Medicine Aksaray Turkey"}]},{"given":"Emin Hüseyin","family":"Akar","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Aksaray University Faculty of Medicine Aksaray Turkey"}]},{"given":"Muhammed Ali","family":"Topuz","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Aksaray University Faculty of Medicine Aksaray Turkey"}]}],"issued":{"date-parts":[[2026,4,29]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":"33","archive":["Portico"],"created":{"date-time":"2026-04-30T04:15:21Z","timestamp":1777522521000,"date-parts":[[2026,4,30]]},"indexed":{"date-time":"2026-05-04T02:24:42Z","timestamp":1777861482030,"date-parts":[[2026,5,4]]},"license":[{"URL":"http://creativecommons.org/licenses/by-nc/4.0/","start":{"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000,"date-parts":[[2026,4,29]]},"delay-in-days":0,"content-version":"vor"},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","start":{"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000,"date-parts":[[2026,4,29]]},"delay-in-days":0,"content-version":"tdm"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/acem.70309"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2026-03-15"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2026-04-20"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-04-29"}],"deposited":{"date-time":"2026-04-30T04:15:31Z","timestamp":1777522531000,"date-parts":[[2026,4,30]]},"issn-type":[{"type":"print","value":"1069-6563"},{"type":"electronic","value":"1553-2712"}],"published":{"date-parts":[[2026,4,29]]},"publisher":"Wiley","reference":[{"DOI":"10.1186/s12873-025-01288-8","key":"e_1_2_14_2_1","year":"2025","issue":null,"author":"Zou H.","volume":"25","first-page":"125","unstructured":null,"article-title":"Current Practices and Knowledge of Adenosine Administration for Paroxysmal Supraventricular Tachycardia: A Multi‐Province Survey in Chinese Emergency Departments","journal-title":"BMC Emergency Medicine","doi-asserted-by":"crossref"},{"DOI":"10.1093/eurheartj/ehz467","key":"e_1_2_14_3_1","year":"2020","issue":null,"author":"Brugada J.","volume":"41","first-page":"655","unstructured":null,"article-title":"2019 ESC Guidelines for the Management of Patients With Supraventricular Tachycardia","journal-title":"European Heart Journal","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_14_4_1","year":"2016","issue":null,"author":"Page R. 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SVT recurrence during the ED stay was numerically lower with 12 mg (1.4% vs. 9.9%), though not statistically significant. Adverse effects (chest tightness ~85–89%, flushing, dyspnea, etc.) were similar between groups.","limitations":"- Non-randomized observational design with physician-discretion dosing; residual confounding cannot be excluded despite PSM.\n- Single-center study at one tertiary ED in Turkey, limiting generalizability.\n- SVT recurrence and adverse effects were only assessed during the ED stay; no long-term follow-up.","practice_takeaway":"Starting with 12 mg adenosine instead of 6 mg roughly doubled first-dose conversion rates (83% vs. 52%) with no increase in adverse effects — about 1 in 4 patients was spared a repeat dose. Clinicians managing stable SVT in the ED may consider 12 mg as the initial dose, pending confirmation in randomized trials."}},{"doi":"10.1097/pec.0000000000003556","pmid":"42050967","title":"Letter to the Editor Regarding Comparison of Adenosine Administration Utilizing a Single-Syringe Versus a Double-Syringe Method in a Simulated Pediatric Patient; Authors Response","journal_title":"Pediatric Emergency Care","journal_issn":"0749-5161","published_at":"2026-04-29T00:00:00.000Z","url":"https://doi.org/10.1097/pec.0000000000003556","source_score":1,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-07T22:50:47.853Z","updated_at":"2026-05-07T22:50:47.853Z","tags":[{"paper_doi":"10.1097/pec.0000000000003556","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003556","tag_type":"category","value":"Emergency Medicine","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003556","tag_type":"condition","value":"Supraventricular Tachycardia","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003556","tag_type":"generic","value":"adenosine","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003556","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003556","tag_type":"modality","value":"Antiarrhythmic","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003556","tag_type":"study_design","value":"Letter to the Editor / Author Response","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003556","tag_type":"warning","value":"Study design label is approximate; letters/author responses do not fit standard evidence hierarchy levels.","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003556","tag_type":"warning","value":"The underlying study being discussed (single- vs double-syringe adenosine in a simulated pediatric patient) is a separate publication; summaries here reflect only the correspondence, not that study's findings.","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003556","tag_type":"warning","value":"This paper is a letter to the editor and author response, not a primary research article — no original data, sample size, or outcomes are available to extract.","value_numeric":null}],"summaries":{"what_studied":"This is an authors' response to a letter to the editor regarding a study comparing single-syringe versus double-syringe methods of adenosine administration in a simulated pediatric patient model.","limitations":"As a letter/author response, this document contains no primary data, outcomes, or statistical results of its own."}},{"doi":"10.1097/pec.0000000000003527","pmid":"42050966","title":"Letter to the Editor Regarding Comparison of Adenosine Administration Utilizing a Single-Syringe Versus a Double-Syringe Method in a Simulated Pediatric Patient","journal_title":"Pediatric Emergency Care","journal_issn":"0749-5161","published_at":"2026-04-29T00:00:00.000Z","url":"https://doi.org/10.1097/pec.0000000000003527","source_score":1,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-07T22:50:47.340Z","updated_at":"2026-05-07T22:50:47.340Z","tags":[{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"category","value":"Emergency Medicine","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"condition","value":"Supraventricular Tachycardia","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"generic","value":"adenosine","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"modality","value":"Antiarrhythmic Agent","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"study_design","value":"Letter to the Editor","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"warning","value":"No abstract or full text was provided; summary is based solely on the title and publication metadata.","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"warning","value":"The study referenced is simulation-based, which limits generalizability to real clinical scenarios.","value_numeric":null},{"paper_doi":"10.1097/pec.0000000000003527","tag_type":"warning","value":"This is a letter to the editor, not a primary research article — no original data, sample size, or outcomes are directly reported in the provided metadata.","value_numeric":null}],"summaries":{"what_studied":"This letter to the editor addresses a study comparing single-syringe versus double-syringe methods of adenosine administration in a simulated pediatric patient model.","limitations":"As a letter to the editor, this article likely does not present primary data or original outcomes; it comments on or critiques an existing study. The simulated (non-clinical) model limits direct applicability to real patients.","practice_takeaway":"Clinicians managing pediatric SVT should be aware of ongoing debate about optimal adenosine delivery technique; the single- vs. double-syringe method comparison may have practical implications for rapid drug delivery in emergencies."}},{"doi":"10.1016/j.hrthm.2026.03.1946","pmid":"41933631","title":"Precise localization of the ventricular insertion of a bystander concealed nodoventricular pathway in east–slow atrioventricular nodal reentrant tachycardia","journal_title":"Heart Rhythm","journal_issn":"1547-5271","published_at":"2026-03-31T00:00:00.000Z","url":"https://doi.org/10.1016/j.hrthm.2026.03.1946","source_score":13,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-05T13:38:33.474Z","updated_at":"2026-07-05T13:38:33.474Z","tags":[{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"category","value":"Cardiac & Cardiovascular Systems","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"condition","value":"Atrioventricular Nodal Reentrant Tachycardia","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"condition","value":"Nodoventricular Pathway","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"condition","value":"Supraventricular Tachycardia","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"modality","value":"Electrophysiology Study","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"modality","value":"Radiofrequency Catheter Ablation","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"sample_size","value":"n=1","value_numeric":1},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"study_design","value":"Case Report","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"warning","value":"The study design is labeled 'Case Report' — clinical applicability of PPI mapping for cNVP localization remains to be validated prospectively.","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"warning","value":"The tachycardia cycle length variability noted during the case may limit reproducibility of the PPI technique in similar patients.","value_numeric":null},{"paper_doi":"10.1016/j.hrthm.2026.03.1946","tag_type":"warning","value":"This is a single case report (n=1); findings on PPI-guided localization technique cannot be generalized without larger studies.","value_numeric":null}],"summaries":{"what_studied":"A case report of a 48-year-old woman with fast–slow AVNRT and a bystander concealed nodoventricular pathway (cNVP), evaluating whether post-pacing interval (PPI) analysis after ventricular overdrive pacing (VOP) from multiple right ventricular sites could localize the ventricular insertion of the cNVP.","key_result":"PPI–TCL analysis across multiple RV sites identified the mid-RV septum as the ventricular insertion site (shortest PPI–TCL of 177 ms). Radiofrequency ablation there eliminated cNVP participation; subsequent slow pathway ablation rendered AVNRT non-inducible.","limitations":"Single case report limits generalizability. The technique's utility in tachycardias with beat-to-beat cycle length variability was not tested. No systematic validation across multiple patients or centers.","practice_takeaway":"In AVNRT with a bystander cNVP, systematic PPI–TCL mapping from multiple RV sites can pinpoint the ventricular insertion — particularly useful when the cNVP also drives orthodromic reciprocating tachycardia and targeted ventricular ablation is needed. Slow pathway ablation remains the primary target for pure AVNRT."}}],"initialOffset":4,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Supraventricular Tachycardia"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Supraventricular Tachycardia"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Supraventricular Tachycardia"}}}]]

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