2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T739,The 2025 KDIGO Clinical Practice Guideline for Autosomal Dominant Polycystic Kidney Disease (ADPKD) addresses intracranial aneurysms (ICAs) and other vascular manifestations, an aspect of ADPKD care which is of considerable clinical importance and associated with significant patient anxiety. This commentary from the ERA Working Group Genes&Kidney provides a European perspective on guideline implementation, highlighting key areas requiring action and research. People with ADPKD face a 4-5-fold increased risk of ICA (prevalence ∼12.9%) compared to the general population, yet absolute rupture rates remain low (0.57 per 1,000 person-years). The guidelines appropriately emphasize risk-stratified, individualized approaches centered on family history, smoking history, and blood pressure control. Key points include importance of patient information; selective screening in those with family history of ICA, subarachnoid hemorrhage, or unexplained sudden death; and use of contrast-free MR angiography as the preferred imaging modality. Rescreening intervals of 5-10 years are suggested for high-risk individuals with negative initial screening. Treatment decisions require multidisciplinary expertise at high-volume centers, balancing rupture risk against intervention complications. Thoracic aortic aneurysms show clear association with ADPKD, warranting family screening when present, while abdominal aortic aneurysms demonstrate no increased prevalence. Patient and clinician education emerges as paramount, moving beyond anxiety-driven approaches toward informed shared decision-making. Future research priorities include leveraging European registries to identify genetic risk modifiers, developing validated risk prediction tools, and establishing whether screening translates to improved clinical outcomes in ADPKD-specific populations.31:T782,Abstract The 2025 KDIGO Clinical Practice Guideline for Autosomal Dominant Polycystic Kidney Disease (ADPKD) addresses intracranial aneurysms (ICAs) and other vascular manifestations, an aspect of ADPKD care which is of considerable clinical importance and associated with significant patient anxiety. This commentary from the ERA Working Group Genes&Kidney provides a European perspective on guideline implementation, highlighting key areas requiring action and research. People with ADPKD face a 4-5-fold increased risk of ICA (prevalence ∼12.9%) compared to the general population, yet absolute rupture rates remain low (0.57 per 1,000 person-years). The guidelines appropriately emphasize risk-stratified, individualized approaches centered on family history, smoking history, and blood pressure control. Key points include importance of patient information; selective screening in those with family history of ICA, subarachnoid hemorrhage, or unexplained sudden death; and use of contrast-free MR angiography as the preferred imaging modality. Rescreening intervals of 5-10 years are suggested for high-risk individuals with negative initial screening. Treatment decisions require multidisciplinary expertise at high-volume centers, balancing rupture risk against intervention complications. Thoracic aortic aneurysms show clear association with ADPKD, warranting family screening when present, while abdominal aortic aneurysms demonstrate no increased prevalence. Patient and clinician education emerges as paramount, moving beyond anxiety-driven approaches toward informed shared decision-making. Future research priorities include leveraging European registries to identify genetic risk modifiers, developing validated risk prediction tools, and establishing whether screening translates to improved clinical outcomes in ADPKD-specific populations.32:Tafe, Objective The objectives of this study were to evaluate the correlation and agreement between ultrasonography and computed tomography (CT) in measuring ascending aorta diameter in patients with giant cell arteritis (GCA) and to investigate the development of new ascending aortic aneurysms in patients with newly diagnosed GCA. Methods To achieve the primary objective, we performed a cross‐sectional study that included patients with GCA who were evaluated with both ultrasonography and CT of the ascending aorta within six months of each other. For the second objective, patients with baseline aortic imaging at GCA diagnosis were observed prospectively with new aortic imaging at the end of the follow‐up. A cutoff of ≥40 mm defined an aneurysm in both the ascending and the descending aorta. Results The cross‐sectional study included 140 patients with a total of 169 comparable CT and ultrasonography scans and a mean disease duration of 47.8 months (95% confidence interval [CI] 42.1–53.5). A strong positive correlation, as measured by Spearman's rho ( r = 0.801, P < 0.001), and a strong agreement, as indicated by an intraclass correlation coefficient of 0.849 ( P < 0.001), were found between ultrasonography and CT. In the prospective follow‐up study, 40 patients were included. Seven (17.5%) patients developed aneurysms in the ascending aorta in a mean follow‐up time of 54 months (95% CI 43.7–64.6); all of the patients experienced large vessel (LV) involvement (two patients with LV‐GCA and five patients with mixed‐GCA). Conclusion A strong correlation and agreement were observed between ultrasonography and CT measurements in assessing the diameter of the ascending aorta in patients with GCA. Ultrasonography may be a valuable tool for longitudinal monitoring and screening for aneurysm development. About 18% of patients developed aortic aneurysms over a mean follow‐up of 4.5 years, underscoring the critical need for regular aortic screening in this population. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Thoracic Aortic Aneurysm: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Thoracic Aortic Aneurysm (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Thoracic%20Aortic%20Aneurysm\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Thoracic Aortic Aneurysm\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Thoracic%20Aortic%20Aneurysm\"}]}}"}}]],["$","$L2f",null,{"title":"Thoracic Aortic Aneurysm: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Thoracic Aortic Aneurysm with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1161/atvbaha.126.324690","pmid":"42273728","title":"Microfibril Denudation Marks Early Aortic Vulnerability in SMAD3 Variant Carriers: A Multigenerational Study","journal_title":"Arteriosclerosis, Thrombosis, and Vascular Biology","journal_issn":"1079-5642","published_at":"2026-06-11T00:00:00.000Z","url":"https://doi.org/10.1161/atvbaha.126.324690","source_score":6,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-31T13:37:11.590Z","updated_at":"2026-07-31T13:37:11.590Z","tags":[{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"category","value":"Hematology","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"condition","value":"Aortic Dissection","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"condition","value":"Loeys-Dietz Syndrome Type 3","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"condition","value":"Thoracic Aortic Aneurysm","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"generic","value":"SMAD3","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"modality","value":"TGF-β Signaling Pathway","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"sample_size","value":"n=57","value_numeric":57},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"study_design","value":"Multigenerational Family Cohort Study with Molecular Substudy","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"warning","value":"The impact_flag 'practice_changing' reflects the clinical implication that aortic size alone is insufficient for risk stratification in LDS3, which is consistent with current guideline trends but not yet validated in prospective outcome studies.","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"warning","value":"The molecular mechanistic arm (RNA-seq, ChIP) used only 3 LDS3 and 3 control SMC cultures — small sample sizes for transcriptomic conclusions.","value_numeric":null},{"paper_doi":"10.1161/atvbaha.126.324690","tag_type":"warning","value":"The study design is a single-family cohort; findings may not generalize to all SMAD3 variant carriers or other LDS subtypes.","value_numeric":null}],"summaries":{"what_studied":"A 4-generation family (57 SMAD3 p.Arg287Gln variant carriers) was studied to characterize cardiovascular phenotypes and aortic wall pathology, including 2D/3D confocal profiling of the elastin-microfibril network, whole-genome RNA sequencing of ascending aortic smooth muscle cells (SMCs), and chromatin immunoprecipitation to map TGF-β–dependent regulatory networks.","key_result":"Median age at first aortic event was 36.5 years. Non- or minimally dilated ascending aortas (mean 3.5 ± 0.5 cm) showed SMC delamination from elastic lamellae, with well-apposed SMCs reduced to 66% vs. 93–96% in controls and bicuspid aortic valve patients (P<0.001). All 5 microfibril proteins (fibrillin-1, fibrillin-2, MAGP2, fibulin-1, fibulin-2) were depleted on elastic lamellae (55–92% reduction; P≤0.033). PRRX2 — a TGF-β–responsive transcription factor — was 93% downregulated in LDS3 SMCs, occupies promoters of all 5 microfibril genes, and its overexpression, along with SMAD3 overexpression, rescued microfibril gene expression.","limitations":"- Tissue samples came from only 7 variant-positive subjects at the time of surgical repair, limiting generalizability across disease stages.\n- TGF-β signaling observed in cultured SMCs may not fully reflect the in vivo aortic wall, where compensatory TGF-β activity has been documented.\n- Microfibril decoration of elastin depends on post-transcriptional steps (secretion, assembly) not fully addressed here.","practice_takeaway":"In LDS3 patients with SMAD3 variants, aortic dissection risk is high even without significant dilation — do not rely on aortic diameter alone to guide surgical timing. The SMAD3-PRRX2-microfibril axis identifies a potential therapeutic target; restoring microfibril sheath integrity may be a future strategy to reduce dissection risk."}},{"doi":"10.1093/ndt/gfag096","pmid":"42065712","title":"KDIGO 2025 Clinical Practice Guideline for ADPKD: a commentary on intracranial aneurysms and other vascular manifestations from the ERA Working Group Genes & Kidney","journal_title":"Nephrology Dialysis Transplantation","journal_issn":"0931-0509","published_at":"2026-05-01T00:00:00.000Z","url":"https://doi.org/10.1093/ndt/gfag096","source_score":29,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-05-08","doi":"10.1093/ndt/gfag096","days":"7","issn":"0931-0509","rank":"2","field":"Clinical Medicine","score":"29","category":"Urology & Nephrology","categories":["Urology & Nephrology"],"_categories":["Urology & Nephrology"]},"pubmed":{"doi":"10.1093/ndt/gfag096","title":"KDIGO 2025 Clinical Practice Guideline for ADPKD: a commentary on intracranial aneurysms and other vascular manifestations from the ERA Working Group Genes & Kidney.","journal":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","methods":"","results":"","abstract":"$30","keywords":["ADPKD","ICA","SAH","intracranial aneurysm","subarachnoid hemorrhage","thoracic aortic aneurysm"],"pubmed_id":"42065712","conclusions":"","publication_date":"2026-05-01T00:00:00"},"crossref":{"DOI":"10.1093/ndt/gfag096","URL":"https://doi.org/10.1093/ndt/gfag096","ISSN":["0931-0509","1460-2385"],"link":[{"URL":"https://academic.oup.com/ndt/advance-article-pdf/doi/10.1093/ndt/gfag096/68200490/gfag096.pdf","content-type":"application/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https://academic.oup.com/ndt/advance-article-pdf/doi/10.1093/ndt/gfag096/68200490/gfag096.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["KDIGO 2025 Clinical Practice Guideline for ADPKD: a commentary on intracranial aneurysms and other vascular manifestations from the ERA Working Group Genes & Kidney"],"author":[{"given":"Melanie M Y","family":"Chan","sequence":"first","affiliation":[{"name":"Imperial College Healthcare NHS Trust Department of Nephrology, , London ,"}]},{"given":"Tom","family":"Nijenhuis","sequence":"additional","affiliation":[{"name":"Research Institute for Medical Innovations and Radboud UMC of Expertise for Rare Kidney Diseases, Radboud University Medical Center Department of Nephrology, , Nijmegen ,"}]},{"given":"Flavia","family":"Galletti","sequence":"additional","affiliation":[{"name":"PKD International , Geneva ,"}]},{"given":"Lucile","family":"Figueres","sequence":"additional","affiliation":[{"name":"Service de Néphrologie et Immunologie Clinique, Centre de référence SORARE, Filière ORKID, Centre de référence Filière OSCAR , Nantes ,"},{"name":"Nantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology , UMR 1064, Nantes, F-44000 ,"}]},{"given":"Maria Vanessa Perez","family":"Gomez","sequence":"additional","affiliation":[{"name":"IIS-Fundación Jiménez Díaz UAM Department of Nephrology and Hypertension, , Madrid ,"},{"name":"RICORS2040 Department of Medicine, , Madrid ,"},{"name":"Facultad de Medicina, Universidad Autónoma de Madrid Departamento de Medicina, , Madrid ,"}]},{"given":"Jan","family":"Halbritter","sequence":"additional","affiliation":[{"name":"Charité Universitätsmedizin Berlin Department of Nephrology and Medical Intensive Care, , Berlin ,"},{"name":"Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg , 79106 Freiburg ,"}]},{"given":"Roman-Ulrich","family":"Müller","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital, University of Cologne Department II of Internal Medicine, , Cologne ,"},{"name":"Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne ,"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) , Cologne ,"},{"name":"Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf Department of Nephrology, , Düsseldorf ,"}]},{"given":"Emilie Cornec-Le","family":"Gall","sequence":"additional","affiliation":[{"name":"Service de Néphrologie, Hémodialyse et Transplantation Rénale, Centre de référence MARHEA, Filière ORKID, CHRU Brest, Brest ,"},{"name":"University Brest , Inserm, UMR 1078, GGB, Brest ,"}]}],"issued":{"date-parts":[[2026,5,1]]},"member":"286","prefix":"10.1093","source":"Crossref","volume":null,"created":{"date-time":"2026-05-01T12:15:22Z","timestamp":1777637722000,"date-parts":[[2026,5,1]]},"indexed":{"date-time":"2026-05-04T15:40:45Z","timestamp":1777909245163,"date-parts":[[2026,5,4]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000,"date-parts":[[2026,5,1]]},"delay-in-days":0,"content-version":"am"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt/gfag096/8666262"}},"subtitle":[],"deposited":{"date-time":"2026-05-01T14:26:16Z","timestamp":1777645576000,"date-parts":[[2026,5,1]]},"issn-type":[{"type":"print","value":"0931-0509"},{"type":"electronic","value":"1460-2385"}],"published":{"date-parts":[[2026,5,1]]},"publisher":"Oxford University Press (OUP)","reference":null,"short-title":[],"article-number":"gfag096","content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["Nephrology Dialysis Transplantation"],"reference-count":0,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,5,1]]},"references-count":0,"short-container-title":[],"is-referenced-by-count":1},"unpaywall":{"doi":"10.1093/ndt/gfag096","is_oa":true,"title":"KDIGO 2025 Clinical Practice Guideline for ADPKD: a commentary on intracranial aneurysms and other vascular manifestations from the ERA Working Group Genes & Kidney","updated":"2026-05-05T11:59:32+00:00","published_date":"2026-05-01","best_oa_location":{"url":"https://doi.org/10.1093/ndt/gfag096","pmh_id":null,"url_for_pdf":null,"url_for_landing_page":"https://doi.org/10.1093/ndt/gfag096"}}},"created_at":"2026-05-09T13:22:36.341Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1093/ndt/gfag096","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"category","value":"Urology & Nephrology","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"condition","value":"Autosomal Dominant Polycystic Kidney Disease","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"condition","value":"Intracranial Aneurysm","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"condition","value":"Thoracic Aortic Aneurysm","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"modality","value":"MR Angiography","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"study_design","value":"Clinical Practice Guideline Commentary","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"warning","value":"No sample size is reported; prevalence and rupture rate figures are drawn from cited literature within the guideline, not from a new study population.","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"warning","value":"Study design label 'Clinical Practice Guideline Commentary' is not a canonical design type; closest standard label would be 'Expert Opinion/Commentary'.","value_numeric":null},{"paper_doi":"10.1093/ndt/gfag096","tag_type":"warning","value":"This is an expert commentary on a guideline, not a primary study — level of evidence reflects opinion/expert consensus rather than direct data.","value_numeric":null}],"summaries":{"what_studied":"This ERA Working Group Genes & Kidney commentary evaluates the 2025 KDIGO Clinical Practice Guideline recommendations on intracranial aneurysms (ICAs) and other vascular manifestations in ADPKD, offering a European implementation perspective.","key_result":"People with ADPKD have a ~12.9% ICA prevalence (4–5× general population risk), but absolute rupture rates are low at 0.57 per 1,000 person-years; thoracic aortic aneurysms are clearly associated with ADPKD, while abdominal aortic aneurysms are not.","limitations":"Commentary format limits direct evidence generation; no new primary data or outcomes data on whether screening improves clinical outcomes in ADPKD-specific populations; European registry-based evidence on genetic risk modifiers is still lacking.","practice_takeaway":"Screen selectively — prioritize patients with a family history of ICA, subarachnoid hemorrhage, or unexplained sudden death, using contrast-free MR angiography, with rescreening every 5–10 years if initial screen is negative. Focus counseling on blood pressure control and smoking cessation rather than anxiety-driven blanket screening."}},{"doi":"10.1016/j.jacc.2026.03.035","pmid":"42053472","title":"Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions","journal_title":"JACC","journal_issn":"0735-1097","published_at":"2026-04-30T00:00:00.000Z","url":"https://doi.org/10.1016/j.jacc.2026.03.035","source_score":156,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-15T06:17:47.643Z","updated_at":"2026-09-15T06:17:47.643Z","tags":[{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"category","value":"Cardiac & Cardiovascular Systems","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"condition","value":"Atrial Fibrillation","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"condition","value":"Coronary Artery Disease","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"condition","value":"Elevated Lipoprotein(a)","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"condition","value":"Hypercholesterolemia","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"condition","value":"Hypertension","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"condition","value":"Thoracic Aortic Aneurysm","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"condition","value":"Type 2 Diabetes","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"condition","value":"Venous Thromboembolism","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"modality","value":"Polygenic Risk Score","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"sample_size","value":"n=298700","value_numeric":298700},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"study_design","value":"Validation Study","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"warning","value":"Full text page content was not available in the source (pages returned blank), so all extracted data are based solely on the abstract and results sections provided.","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"warning","value":"Study design is labeled 'Validation Study' (retrospective/cross-sectional with prospective outcome analyses); no randomization was performed. Level of evidence set to 3 accordingly.","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"warning","value":"The combined sample size of 298,700 reflects both the development cohort (All of Us, n=245,394) and validation cohort (MGB Biobank, n=53,306); these are distinct populations. The sample_size tag reflects the total across both cohorts.","value_numeric":null},{"paper_doi":"10.1016/j.jacc.2026.03.035","tag_type":"warning","value":"The 'practice_changing' impact flag reflects that this PRS panel is now clinically orderable; however, prospective interventional evidence of clinical utility is explicitly noted as lacking by the authors.","value_numeric":null}],"summaries":{"what_studied":"Integrated polygenic risk scores (PRS) for 8 cardiovascular conditions — coronary artery disease (CAD), atrial fibrillation (AF), type 2 diabetes (T2D), venous thromboembolism (VTE), thoracic aortic aneurysm (TAA), extreme hypertension, severe hypercholesterolemia, and elevated lipoprotein(a) — were developed using 245,394 All of Us participants and externally validated in 53,306 Mass General Brigham Biobank participants (55.6% women, mean age 53 ± 17 years).","key_result":"High genetic risk (top 10% PRS) vs. average risk yielded meaningful odds ratios across all 8 traits: lipoprotein(a) had the strongest association (OR 41.0 [95% CI: 27.0–62.2]), followed by hypercholesterolemia (OR 4.1 [3.7–4.5]), CAD (OR 3.7 [3.4–4.1]), T2D (OR 3.1 [2.8–3.3]), AF (OR 3.0 [2.7–3.3]), hypertension (OR 2.1 [1.8–2.3]), VTE (OR 1.9 [1.6–2.0]), and TAA (OR 1.7 [1.5–1.9]); adding PRS to clinical models improved risk classification and prospective analyses confirmed associations with incident outcomes.","limitations":"- Prospective, real-world clinical utility (impact on management and outcomes) has not yet been demonstrated in interventional trials.\n- External validation was conducted in a single health system (Mass General Brigham), which may not reflect all U.S. patient populations.\n- Ancestry-related generalizability is uncertain despite use of a diverse development cohort.","practice_takeaway":"PRS for these 8 cardiovascular conditions are now available as a clinically orderable test and can meaningfully stratify inherited risk — particularly for lipoprotein(a) and hypercholesterolemia — on top of standard clinical models. Clinicians should interpret results cautiously pending broader prospective validation of downstream clinical benefit."}},{"doi":"10.1002/acr.25657","pmid":null,"title":"Ultrasonography Compared With Computed Tomography in Identifying Thoracic Aortic Aneurysms in Patients With Giant Cell Arteritis","journal_title":"Arthritis Care & Research","journal_issn":"2151-464X","published_at":"2025-12-19T00:00:00.000Z","url":"https://doi.org/10.1002/acr.25657","source_score":17,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-12-19","doi":"10.1002/acr.25657","days":"30","issn":"2151-464X","rank":"8","field":"Clinical Medicine","score":"17","category":"Rheumatology","categories":["Rheumatology"],"_categories":["Rheumatology"]},"pubmed":null,"crossref":{"DOI":"10.1002/acr.25657","URL":"https://doi.org/10.1002/acr.25657","ISSN":["2151-464X","2151-4658"],"link":[{"URL":"https://acrjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/acr.25657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Ultrasonography Compared With Computed Tomography in Identifying Thoracic Aortic Aneurysms in Patients With Giant Cell Arteritis"],"author":[{"given":"Anne C.","family":"Bull Haaversen","sequence":"first","affiliation":[{"name":"Martina Hansens Hospital Bærum Norway"},{"name":"University of Oslo Oslo Norway"}]},{"given":"Lene K.","family":"Brekke","sequence":"additional","affiliation":[{"name":"Hospital for Rheumatic Diseases Haugesund Norway"}]},{"given":"Tanaz A.","family":"Kermani","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}]},{"given":"Øyvind","family":"Molberg","sequence":"additional","affiliation":[{"name":"University of Oslo Oslo Norway"},{"name":"Oslo University Hospital Rikshospitalet Oslo Norway"}]},{"given":"Andreas P.","family":"Diamantopoulos","sequence":"additional","affiliation":[{"name":"Akershus University Hospital Lørenskog Norway"}]}],"issued":{"date-parts":[[2025,12,19]]},"member":"311","prefix":"10.1002","source":"Crossref","volume":null,"archive":["Portico"],"created":{"date-time":"2025-10-01T05:52:16Z","timestamp":1759297936000,"date-parts":[[2025,10,1]]},"indexed":{"date-time":"2025-12-19T09:54:56Z","timestamp":1766138096773,"date-parts":[[2025,12,19]]},"license":[{"URL":"http://creativecommons.org/licenses/by-nc/4.0/","start":{"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000,"date-parts":[[2025,12,19]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$32","language":"en","relation":{},"resource":{"primary":{"URL":"https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/acr.25657"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-04-09"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-09-04"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2025-12-19"}],"deposited":{"date-time":"2025-12-19T09:51:07Z","timestamp":1766137867000,"date-parts":[[2025,12,19]]},"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"published":{"date-parts":[[2025,12,19]]},"publisher":"Wiley","reference":[{"DOI":"10.1002/art.37715","key":"e_1_2_6_2_1","year":"2013","issue":"1","author":"Jennette JC","volume":"65","first-page":"1","unstructured":null,"article-title":"2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","journal-title":"Arthritis Rheum","doi-asserted-by":"crossref"},{"DOI":"10.1093/rheumatology/keab871","key":"e_1_2_6_3_1","year":"2022","issue":"7","author":"Therkildsen P","volume":"61","first-page":"2931","unstructured":null,"article-title":"Increased risk of thoracic aortic complications among patients with giant cell arteritis: a nationwide, population‐based cohort study","journal-title":"Rheumatology (Oxford)","doi-asserted-by":"crossref"},{"DOI":"10.7326/0003-4819-122-7-199504010-00004","key":"e_1_2_6_4_1","year":"1995","issue":"7","author":"Evans JM","volume":"122","first-page":"502","unstructured":null,"article-title":"Increased incidence of aortic aneurysm and dissection in giant cell (temporal) arteritis. A population‐based study","journal-title":"Ann Intern Med","doi-asserted-by":"crossref"},{"DOI":"10.3390/jcm11041005","key":"e_1_2_6_5_1","year":"2022","issue":"4","author":"Boysson H","volume":"11","first-page":"1005","unstructured":null,"article-title":"An updated review of cardiovascular events in giant cell arteritis","journal-title":"J Clin Med","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.autrev.2017.11.029","key":"e_1_2_6_6_1","year":"2018","issue":"4","author":"Boysson H","volume":"17","first-page":"391","unstructured":null,"article-title":"Large‐vessel involvement and aortic dilation in giant‐cell arteritis. A multicenter study of 549 patients","journal-title":"Autoimmun Rev","doi-asserted-by":"crossref"},{"DOI":"10.1136/annrheumdis-2013-204113","key":"e_1_2_6_7_1","year":"2015","issue":"1","author":"Robson JC","volume":"74","first-page":"129","unstructured":null,"article-title":"The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK","journal-title":"Ann Rheum Dis","doi-asserted-by":"crossref"},{"DOI":"10.1136/annrheumdis-2012-202145","key":"e_1_2_6_8_1","year":"2014","issue":"1","author":"Mackie SL","volume":"73","first-page":"143","unstructured":null,"article-title":"Should I send my patient with previous giant cell arteritis for imaging of the thoracic aorta? A systematic literature review and meta‐analysis","journal-title":"Ann Rheum Dis","doi-asserted-by":"crossref"},{"DOI":"10.1136/annrheumdis-2013-203322","key":"e_1_2_6_9_1","year":"2014","issue":"10","author":"García‐Martínez A","volume":"73","first-page":"1826","unstructured":null,"article-title":"Prospective long term follow‐up of a cohort of patients with giant cell arteritis screened for aortic structural damage (aneurysm or dilatation)","journal-title":"Ann Rheum Dis","doi-asserted-by":"crossref"},{"DOI":"10.1136/annrheumdis-2012-202408","key":"e_1_2_6_10_1","year":"2013","issue":"12","author":"Kermani TA","volume":"72","first-page":"1989","unstructured":null,"article-title":"Large‐vessel involvement in giant cell arteritis: a population‐based cohort study of the incidence‐trends and prognosis","journal-title":"Ann Rheum Dis","doi-asserted-by":"crossref"},{"DOI":"10.7326/M23-0679","key":"e_1_2_6_11_1","year":"2023","issue":"10","author":"Moreel L","volume":"176","first-page":"1321","unstructured":null,"article-title":"Association between vascular 18F‐fluorodeoxyglucose uptake at diagnosis and change in aortic dimensions in giant cell arteritis: a cohort study","journal-title":"Ann Intern Med","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaut.2019.05.011","key":"e_1_2_6_12_1","year":"2019","issue":null,"author":"Boysson H","volume":"103","first-page":null,"unstructured":null,"article-title":"Different patterns and specific outcomes of large‐vessel involvements in giant cell arteritis","journal-title":"J Autoimmun","doi-asserted-by":"crossref"},{"DOI":"10.1177/1759720X211006967","key":"e_1_2_6_13_1","year":"2021","issue":null,"author":"Mornac D","volume":"13","first-page":null,"unstructured":null,"article-title":"Risk factors for symptomatic vascular events in giant cell arteritis: a study of 254 patients with large‐vessel imaging at diagnosis","journal-title":"Ther Adv Musculoskelet Dis","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_6_14_1","year":"2014","issue":"3","author":"Muratore F","volume":"32","first-page":"S106","unstructured":null,"article-title":"Large‐vessel involvement in giant cell arteritis and polymyalgia rheumatica","journal-title":"Clin Exp Rheumatol","doi-asserted-by":null},{"DOI":"10.1093/rheumatology/ken119","key":"e_1_2_6_15_1","year":"2008","issue":"8","author":"Blockmans D","volume":"47","first-page":"1179","unstructured":null,"article-title":"Relationship between fluorodeoxyglucose uptake in the large vessels and late aortic diameter in giant cell arteritis","journal-title":"Rheumatology (Oxford)","doi-asserted-by":"crossref"},{"DOI":"10.3389/fmed.2022.1082604","key":"e_1_2_6_16_1","year":"2023","issue":null,"author":"Haaversen AB","volume":"9","first-page":null,"unstructured":null,"article-title":"Norwegian society of rheumatology recommendations on diagnosis and treatment of patients with giant cell arteritis","journal-title":"Front Med (Lausanne)","doi-asserted-by":"crossref"},{"DOI":"10.1136/annrheumdis-2017-212649","key":"e_1_2_6_17_1","year":"2018","issue":"5","author":"Dejaco C","volume":"77","first-page":"636","unstructured":null,"article-title":"EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice","journal-title":"Ann Rheum Dis","doi-asserted-by":"crossref"},{"DOI":"10.1136/annrheumdis-2023-eular.7009","key":"e_1_2_6_18_1","year":"2023","issue":null,"author":"Dejaco C","volume":"82","first-page":"205","unstructured":null,"article-title":"EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice: 2023 update","journal-title":"Ann Rheum Dis","doi-asserted-by":"crossref"},{"DOI":"10.1136/annrheumdis-2019-215672","key":"e_1_2_6_19_1","year":"2020","issue":"1","author":"Hellmich B","volume":"79","first-page":"19","unstructured":null,"article-title":"2018 Update of the EULAR recommendations for the management of large vessel vasculitis","journal-title":"Ann Rheum Dis","doi-asserted-by":"crossref"},{"DOI":"10.1002/acr.24632","key":"e_1_2_6_20_1","year":"2021","issue":"8","author":"Maz M","volume":"73","first-page":"1071","unstructured":null,"article-title":"2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis","journal-title":"Arthritis Care Res (Hoboken)","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.ijcard.2015.01.086","key":"e_1_2_6_21_1","year":"2015","issue":null,"author":"Amsallem M","volume":"184","first-page":"22","unstructured":null,"article-title":"Comparative assessment of ascending aortic aneurysms in Marfan patients using ECG‐gated computerized tomographic angiography versus trans‐thoracic echocardiography","journal-title":"Int J Cardiol","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.echo.2016.04.006","key":"e_1_2_6_22_1","year":"2016","issue":"9","author":"Rodríguez‐Palomares JF","volume":"29","first-page":"819","unstructured":null,"article-title":"Multimodality assessment of ascending aortic diameters: comparison of different measurement methods","journal-title":"J Am Soc Echocardiogr","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_6_23_1","year":"2017","issue":"4","author":"Dejaco C","volume":"56","first-page":"506","unstructured":null,"article-title":"The spectrum of giant cell arteritis and polymyalgia rheumatica: revisiting the concept of the disease","journal-title":"Rheumatology (Oxford)","doi-asserted-by":null},{"DOI":"10.1002/art.1780330810","key":"e_1_2_6_24_1","year":"1990","issue":"8","author":"Hunder GG","volume":"33","first-page":"1122","unstructured":null,"article-title":"The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis","journal-title":"Arthritis Rheum","doi-asserted-by":"crossref"},{"DOI":"10.1186/s13075-017-1374-1","key":"e_1_2_6_25_1","year":"2017","issue":"1","author":"Terslev L","volume":"19","first-page":"167","unstructured":null,"article-title":"Settings and artefacts relevant for Doppler ultrasound in large vessel vasculitis","journal-title":"Arthritis Res Ther","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.echo.2021.05.012","key":"e_1_2_6_26_1","year":"2021","issue":"10","author":"Patel HN","volume":"34","first-page":"1113","unstructured":null,"article-title":"Normal values of aortic root size according to age, sex, and race: results of the World Alliance of Societies of Echocardiography Study","journal-title":"J Am Soc Echocardiogr","doi-asserted-by":"crossref"},{"DOI":"10.1093/ehjci/jev014","key":"e_1_2_6_27_1","year":"2015","issue":"3","author":"Lang RM","volume":"16","first-page":"233","unstructured":null,"article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","journal-title":"Eur Heart J Cardiovasc Imaging","doi-asserted-by":"crossref"},{"DOI":"10.1161/CIR.0b013e3181d47d48","key":"e_1_2_6_28_1","year":"2010","issue":"13","author":"Hiratzka LF","volume":"121","first-page":"e266","unstructured":null,"article-title":"Society for Vascular Medicine 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine","journal-title":"Circulation","doi-asserted-by":"crossref"},{"DOI":"10.1093/eurheartj/ehae179","key":"e_1_2_6_29_1","year":"2024","issue":"36","author":"Mazzolai L","volume":"45","first-page":"3538","unstructured":null,"article-title":"ESC Scientific Document Group 2024 ESC Guidelines for the management of peripheral arterial and aortic diseases","journal-title":"Eur Heart J","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_6_30_1","year":"2022","issue":"10","author":"Borgbjerg J","volume":"11","first-page":null,"unstructured":null,"article-title":"Ultra‐low‐dose non‐contrast CT and CT angiography can be used interchangeably for assessing maximal abdominal aortic diameter","journal-title":"Acta Radiol Open","doi-asserted-by":null},{"DOI":"10.1016/j.ejvs.2023.11.002","key":"e_1_2_6_31_1","year":"2024","issue":"2","author":"Wanhainen A","volume":"67","first-page":"192","unstructured":null,"article-title":"ESVS Guidelines Committee; Document Reviewers. Editor's Choice ‐‐ European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto‐Iliac Artery Aneurysms","journal-title":"Eur J Vasc Endovasc Surg","doi-asserted-by":"crossref"},{"DOI":"10.1002/art.11353","key":"e_1_2_6_32_1","year":"2003","issue":"12","author":"Nuenninghoff DM","volume":"48","first-page":"3522","unstructured":null,"article-title":"Incidence and predictors of large‐artery complication (aortic aneurysm, aortic dissection, and/or large‐artery stenosis) in patients with giant cell arteritis: a population‐based study over 50 years","journal-title":"Arthritis Rheum","doi-asserted-by":"crossref"},{"DOI":"10.1097/01.md.0000145366.40805.f8","key":"e_1_2_6_33_1","year":"2004","issue":"6","author":"Gonzalez‐Gay MA","volume":"83","first-page":"335","unstructured":null,"article-title":"Aortic aneurysm and dissection in patients with biopsy‐proven giant cell arteritis from northwestern Spain: a population‐based study","journal-title":"Medicine (Baltimore)","doi-asserted-by":"crossref"},{"DOI":"10.1002/art.23315","key":"e_1_2_6_34_1","year":"2008","issue":"3","author":"García‐Martínez A","volume":"59","first-page":"422","unstructured":null,"article-title":"Development of aortic aneurysm/dilatation during the followup of patients with giant cell arteritis: a cross‐sectional screening of fifty‐four prospectively followed patients","journal-title":"Arthritis Rheum","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.ejim.2024.03.038","key":"e_1_2_6_35_1","year":"2024","issue":null,"author":"Gallou S","volume":"129","first-page":"71","unstructured":null,"article-title":"Evolution and outcomes of aortic dilations in giant cell arteritis","journal-title":"Eur J Intern Med","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.semarthrit.2020.11.003","key":"e_1_2_6_36_1","year":"2021","issue":"4","author":"Jud P","volume":"51","first-page":"911","unstructured":null,"article-title":"Prevalence and prognostic factors for aortic dilatation in giant cell arteritis ‐ a longitudinal study","journal-title":"Semin Arthritis Rheum","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.amjcard.2013.01.306","key":"e_1_2_6_37_1","year":"2013","issue":"10","author":"Rogers IS","volume":"111","first-page":"1510","unstructured":null,"article-title":"Distribution, determinants, and normal reference values of thoracic and abdominal aortic diameters by computed tomography (from the Framingham Heart Study)","journal-title":"Am J Cardiol","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_6_38_1","year":"2003","issue":"6","author":"Agmon Y","volume":"42","first-page":"1076","unstructured":null,"article-title":"Is aortic dilatation an atherosclerosis‐related process? Clinical, laboratory, and transesophageal echocardiographic correlates of thoracic aortic dimensions in the population with implications for thoracic aortic aneurysm formation","journal-title":"J Am Coll Cardiol","doi-asserted-by":null},{"DOI":"10.1016/j.jacc.2020.03.084","key":"e_1_2_6_39_1","year":"2020","issue":"2","author":"Elefteriades JA","volume":"76","first-page":"201","unstructured":null,"article-title":"Discrepancies in measurement of the thoracic aorta: JACC review topic of the week","journal-title":"J Am Coll Cardiol","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_6_40_1","year":"2008","issue":null,"author":"ES M.","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null}],"short-title":[],"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1002/acr.25657"],"article-number":"acr.25657","content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Arthritis Care & Research"],"reference-count":39,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2025,12,19]]},"references-count":39,"short-container-title":["Arthritis Care & Research"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1002/acr.25657","is_oa":true,"title":"Ultrasonography Compared With Computed Tomography in Identifying Thoracic Aortic Aneurysms in Patients With Giant Cell Arteritis","updated":"2025-12-21T03:41:08+00:00","published_date":"2025-10-01","best_oa_location":{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acr.25657","pmh_id":null,"url_for_pdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acr.25657","url_for_landing_page":"https://doi.org/10.1002/acr.25657"}}},"created_at":"2026-01-14T18:30:49.575Z","updated_at":"2026-01-18T22:40:12.285Z","tags":[{"paper_doi":"10.1002/acr.25657","tag_type":"category","value":"Rheumatology","value_numeric":null},{"paper_doi":"10.1002/acr.25657","tag_type":"condition","value":"Giant Cell Arteritis","value_numeric":null},{"paper_doi":"10.1002/acr.25657","tag_type":"condition","value":"Thoracic Aortic Aneurysm","value_numeric":null},{"paper_doi":"10.1002/acr.25657","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1002/acr.25657","tag_type":"sample_size","value":"n=140","value_numeric":140},{"paper_doi":"10.1002/acr.25657","tag_type":"study_design","value":"Cohort Study","value_numeric":null},{"paper_doi":"10.1002/acr.25657","tag_type":"warning","value":"Design combines cross-sectional and prospective cohorts; design label is approximate.","value_numeric":null},{"paper_doi":"10.1002/acr.25657","tag_type":"warning","value":"Key imaging methods (e.g., acquisition protocols, blinding) are not described in the abstract.","value_numeric":null},{"paper_doi":"10.1002/acr.25657","tag_type":"warning","value":"Unclear whether the 40 patients in the prospective follow-up are a subset of the 140; overlap not specified.","value_numeric":null}],"summaries":{"what_studied":"A cross-sectional study compared ultrasonography with computed tomography for measuring ascending aorta diameter in patients with giant cell arteritis (GCA) when scans were obtained within six months, and a prospective follow-up evaluated new ascending aortic aneurysms after baseline imaging at GCA diagnosis (aneurysm cutoff ≥40 mm).","key_result":"In 140 patients with 169 paired scans, ultrasonography and CT showed strong correlation (Spearman r=0.801, P<0.001) and agreement (ICC=0.849, P<0.001). In the prospective cohort (n=40), 7/40 (17.5%) developed ascending aortic aneurysms over a mean 54 months (95% CI 43.7–64.6); all had large-vessel involvement (2 LV-GCA, 5 mixed-GCA).","limitations":"Ultrasonography and CT were performed up to six months apart, not simultaneously. The prospective follow-up included only 40 patients, limiting precision.","practice_takeaway":"In GCA, ultrasonography aligns closely with CT for ascending aorta sizing and may be used for longitudinal monitoring and screening. About 18% developed ascending aortic aneurysms over ~4.5 years, supporting regular aortic screening in this population."}}],"initialOffset":4,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Thoracic Aortic Aneurysm"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Thoracic Aortic Aneurysm"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Thoracic Aortic Aneurysm"}}}]]

Papers