2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T718,Uterine fibroids and atherosclerotic cardiovascular disease (ASCVD) share biological pathways, yet whether risk of ASCVD is different among those with fibroids compared with those without remains unexplored in large US cohorts with longitudinal data. This study assessed the association between uterine fibroids and risk of incident ASCVD. A US population-based cohort study was done using Optum's de-identified Clinformatics Data Mart Database (2000-2022). Follow-up continued until an ASCVD event, disenrollment, incident fibroid diagnosis in controls, or June 30, 2022. Individuals with fibroids were exact age-matched (1:5) to individuals without fibroids with an annual gynecologic claim. Incident ASCVD, a composite of coronary artery disease, cerebrovascular disease, and peripheral artery disease, was evaluated, including individual events (eg, myocardial infarction and ischemic stroke). Among 450 177 individuals with fibroids and 2 250 885 controls (mean age: 41 years, SD 6.3), the 1-year and 10-year cumulative incidence (95% CI) of ASCVD was 0.74% (0.71-0.77) and 5.42% (5.18-5.67) for the fibroid group versus 0.30% (0.29-0.31) and 3.00% (2.90-3.11) for controls. Adjusted analyses showed an increased ASCVD risk in the fibroid group (1-year risk ratio: 2.47 [95% CI, 2.32-2.61]; 1-year risk difference, 0.41% [95% CI, 0.40-0.47]; 10-year risk ratio, 1.81 [95% CI, 1.66-1.96]; 10-year risk difference, 2.40% [95% CI, 2.07, 2.77]. The increased risk was consistent for all individual components of ASCVD. Results were consistent across race and ethnicity and age subgroup analyses and sensitivity analyses addressing measurement error. Uterine fibroids are associated with sustained increased ASCVD risks up to 10 years postdiagnosis, supporting targeted ASCVD prevention in this population.31:T9f7, Background Uterine fibroids and atherosclerotic cardiovascular disease (ASCVD) share biological pathways, yet whether risk of ASCVD is different among those with fibroids compared with those without remains unexplored in large US cohorts with longitudinal data. This study assessed the association between uterine fibroids and risk of incident ASCVD. Methods A US population‐based cohort study was done using Optum’s de‐identified Clinformatics Data Mart Database (2000–2022). Follow‐up continued until an ASCVD event, disenrollment, incident fibroid diagnosis in controls, or June 30, 2022. Individuals with fibroids were exact age‐matched (1:5) to individuals without fibroids with an annual gynecologic claim. Incident ASCVD, a composite of coronary artery disease, cerebrovascular disease, and peripheral artery disease, was evaluated, including individual events (eg, myocardial infarction and ischemic stroke). Results Among 450 177 individuals with fibroids and 2 250 885 controls (mean age: 41 years, SD 6.3), the 1‐year and 10‐year cumulative incidence (95% CI) of ASCVD was 0.74% (0.71–0.77) and 5.42% (5.18–5.67) for the fibroid group versus 0.30% (0.29–0.31) and 3.00% (2.90–3.11) for controls. Adjusted analyses showed an increased ASCVD risk in the fibroid group (1‐year risk ratio: 2.47 [95% CI, 2.32–2.61]; 1‐year risk difference, 0.41% [95% CI, 0.40–0.47]; 10‐year risk ratio, 1.81 [95% CI, 1.66–1.96]; 10‐year risk difference, 2.40% [95% CI, 2.07, 2.77]. The increased risk was consistent for all individual components of ASCVD. Results were consistent across race and ethnicity and age subgroup analyses and sensitivity analyses addressing measurement error. Conclusions Uterine fibroids are associated with sustained increased ASCVD risks up to 10 years postdiagnosis, supporting targeted ASCVD prevention in this population. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Uterine Fibroids: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Uterine Fibroids (condition). 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Level of evidence is assigned as 7 (expert opinion/technique report).","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.07.035","tag_type":"warning","value":"Study design label 'Surgical Technique Description' is non-standard; closest canonical label applied.","value_numeric":null}],"summaries":{"what_studied":"A technique for ultrasound-guided robot-assisted myomectomy using a robotic drop-in intraoperative ultrasound probe, applied directly to the uterine surface after visual fibroid enucleation to detect occult intramural fibroids in real time.","key_result":"The technique enabled real-time correlation of ultrasound imaging with surgical anatomy on the robotic console, facilitating identification and enucleation of occult intramural fibroids not detectable by visual assessment alone; no quantitative outcomes were reported.","limitations":"This is a technique description with no comparative data, sample size, or outcomes reported. Generalizability and clinical benefit over standard robot-assisted myomectomy are unestablished.","practice_takeaway":"Consider adding a drop-in ultrasound probe to robot-assisted myomectomy when completeness of fibroid removal is critical, especially in fertility-preserving cases or patients with multiple myomas. This technique may reduce the risk of missing occult intramural fibroids without requiring open surgery."}},{"doi":"10.1111/jog.70394","pmid":"42397288","title":"Elevated Body Mass Index Associated With Uterine Fibroids: A Retrospective Cohort Study With Bioinformatic Validation","journal_title":"Journal of Obstetrics and Gynaecology Research","journal_issn":"1341-8076","published_at":"2026-07-03T00:00:00.000Z","url":"https://doi.org/10.1111/jog.70394","source_score":1,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-05T13:38:46.308Z","updated_at":"2026-07-05T13:38:46.308Z","tags":[{"paper_doi":"10.1111/jog.70394","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"category","value":"Obstetrics & Gynecology","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"condition","value":"Obesity","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"condition","value":"Uterine Fibroids","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"modality","value":"Weight Management","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"sample_size","value":"n=1170","value_numeric":1170},{"paper_doi":"10.1111/jog.70394","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"warning","value":"Exact fibroid incidence rates per BMI category and specific LDL cholesterol values are not reported in the abstract or results excerpt; only significance directions are available.","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"warning","value":"NHANES used for external validation of clinical associations only; molecular findings were not externally validated.","value_numeric":null},{"paper_doi":"10.1111/jog.70394","tag_type":"warning","value":"The bioinformatic component (GEO datasets, PPI network) is exploratory and lacks wet-lab validation, so hub gene findings (TGFBI, ITGA4, VCAN) should be interpreted cautiously.","value_numeric":null}],"summaries":{"practice_takeaway":"Women with overweight or obesity appear to have a higher risk of uterine fibroids, suggesting weight management counseling may be a relevant preventive conversation. These findings are preliminary and should not yet change screening or treatment protocols.","what_studied":"This retrospective cohort study (n=1,170 women) examined whether elevated BMI is associated with uterine fibroid incidence across weight categories, compared serum lipid profiles between fibroid and non-fibroid groups, and used GEO gene expression datasets plus bioinformatic tools to explore molecular mechanisms linking obesity and fibroids.","key_result":"Uterine fibroid incidence was significantly higher in overweight and obese women vs. normal-weight women; LDL cholesterol levels differed significantly between fibroid and non-fibroid groups. Bioinformatic analysis identified 85 shared differentially expressed genes enriched in extracellular matrix pathways, with three hub genes: **TGFBI**, **ITGA4**, and **VCAN**.","limitations":"- Retrospective design limits causal inference.\n- Single-center Chinese hospital cohort may limit generalizability, despite NHANES external validation.\n- Bioinformatic findings are hypothesis-generating only; no experimental validation of hub genes was performed."}},{"doi":"10.1016/j.ajog.2026.04.006","pmid":"41956310","title":"Uterine Fibroids in Latinas: Findings from the Environment, Leiomyomas, Latinas, and Adiposity Study","journal_title":"American Journal of Obstetrics and Gynecology","journal_issn":"0002-9378","published_at":"2026-04-07T00:00:00.000Z","url":"https://doi.org/10.1016/j.ajog.2026.04.006","source_score":49,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-07T22:49:40.524Z","updated_at":"2026-05-07T22:49:40.524Z","tags":[{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"category","value":"Obstetrics & Gynecology","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"condition","value":"Uterine Fibroids","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"modality","value":"Transvaginal Ultrasound","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"sample_size","value":"n=609","value_numeric":609},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"warning","value":"No comparator group (e.g., Black or White women) was included within this study; cross-racial prevalence comparisons are based on external literature, not internal data.","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"warning","value":"The paper is dated April 2026 and has a future-looking DOI; content is taken at face value as provided.","value_numeric":null},{"paper_doi":"10.1016/j.ajog.2026.04.006","tag_type":"warning","value":"The study recruited from two specific Michigan sites (a community health center and a fertility clinic), which may not represent the broader U.S. Latina population.","value_numeric":null}],"summaries":{"what_studied":"The ELLAS prospective cohort study evaluated uterine fibroid prevalence among reproductive-aged Latina females (ages 21–50) in Southeast Michigan, using transvaginal ultrasound confirmation in N=609 participants enrolled between October 2017 and October 2022.","key_result":"Fibroid prevalence was 11.2% (CI 8.6%–13.8%) overall, rising sharply with age: 3.5% (ages 21–30), 8.3% (ages 31–40), and 18.7% (ages 41–50). Younger age at menarche (aOR 0.84, 95% CI 0.72–0.99) and higher gravidity (aOR 0.80, 95% CI 0.66–0.97) were independently associated with fibroid presence. Most fibroids were solitary (75%), intramural (80.9%), and small (mean largest diameter 2.9 ± 1.2 cm).","limitations":"- Single geographic region (Southeast Michigan) limits generalizability to all U.S. Latinas.\n- No direct head-to-head comparison group (Black or White women) within this same study, so cross-racial comparisons rely on external literature.\n- Self-selection and clinic-based recruitment (primary care + fertility center) may introduce participation bias.","practice_takeaway":"Uterine fibroid prevalence in Latina women appears substantially lower (~11%) than rates reported in Black and White women, though it still rises markedly after age 40. Clinicians should screen Latina patients for fibroids with increasing vigilance as they approach their 40s, while recognizing that younger age at menarche may be an additional risk marker in this group."}},{"doi":"10.1161/jaha.125.044014","pmid":"41371752","title":"Association Between Uterine Fibroids and Risk of Atherosclerotic Cardiovascular Disease","journal_title":"Journal of the American Heart Association","journal_issn":"2047-9980","published_at":"2025-12-11T00:00:00.000Z","url":"https://doi.org/10.1161/jaha.125.044014","source_score":440,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-16","doi":"10.1161/jaha.125.044014","days":"7","issn":"2047-9980","rank":"1","field":"Clinical Medicine","score":"440","category":"Cardiac & Cardiovascular Systems","categories":["Cardiac & Cardiovascular Systems"],"_categories":["Cardiac & Cardiovascular Systems"]},"pubmed":{"doi":"10.1161/JAHA.125.044014","title":"Association Between Uterine Fibroids and Risk of Atherosclerotic Cardiovascular Disease.","journal":"Journal of the American Heart Association","methods":"","results":"Among 450 177 individuals with fibroids and 2 250 885 controls (mean age: 41 years, SD 6.3), the 1-year and 10-year cumulative incidence (95% CI) of ASCVD was 0.74% (0.71-0.77) and 5.42% (5.18-5.67) for the fibroid group versus 0.30% (0.29-0.31) and 3.00% (2.90-3.11) for controls. Adjusted analyses showed an increased ASCVD risk in the fibroid group (1-year risk ratio: 2.47 [95% CI, 2.32-2.61]; 1-year risk difference, 0.41% [95% CI, 0.40-0.47]; 10-year risk ratio, 1.81 [95% CI, 1.66-1.96]; 10-year risk difference, 2.40% [95% CI, 2.07, 2.77]. The increased risk was consistent for all individual components of ASCVD. Results were consistent across race and ethnicity and age subgroup analyses and sensitivity analyses addressing measurement error.","abstract":"$30","keywords":["cardiovascular disease","causal inference","uterine fibroids"],"pubmed_id":"41371752","conclusions":"","publication_date":"2025-12-11T00:00:00"},"crossref":{"DOI":"10.1161/jaha.125.044014","URL":"https://doi.org/10.1161/jaha.125.044014","ISSN":["2047-9980"],"link":[{"URL":"https://www.ahajournals.org/doi/full/10.1161/JAHA.125.044014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"1","score":1,"title":["Association Between Uterine Fibroids and Risk of Atherosclerotic Cardiovascular Disease"],"author":[{"given":"Julia D.","family":"DiTosto","sequence":"first","affiliation":[{"name":"University of Pennsylvania"}]},{"given":"Jennifer","family":"Lewey","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine"}]},{"given":"Jarcy","family":"Zee","sequence":"additional","affiliation":[{"name":"University of Pennsylvania"},{"name":"Children’s Hospital of Philadelphia Research Institute"}]},{"given":"Anuja","family":"Dokras","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine"}]},{"given":"Kyle R.","family":"Busse","sequence":"additional","affiliation":[{"name":"University of Pennsylvania"}]},{"given":"Snigdha","family":"Alur‐Gupta","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center"}]},{"given":"Stefanie","family":"Hinkle","sequence":"additional","affiliation":[{"name":"University of Pennsylvania"},{"name":"University of Pennsylvania Perelman School of Medicine"}]},{"given":"Enrique F.","family":"Schisterman","sequence":"additional","affiliation":[{"name":"University of Pennsylvania"},{"name":"University of Pennsylvania Perelman School of Medicine"}]},{"given":"Sunni L.","family":"Mumford","sequence":"additional","affiliation":[{"name":"University of Pennsylvania"},{"name":"University of Pennsylvania Perelman School of Medicine"}]},{"given":"Ellen C.","family":"Caniglia","sequence":"additional","affiliation":[{"name":"University of Pennsylvania"},{"name":"University of Pennsylvania Perelman School of Medicine"}]}],"issued":{"date-parts":[[2026,1,6]]},"member":"276","prefix":"10.1161","source":"Crossref","volume":"15","created":{"date-time":"2025-12-11T01:35:11Z","timestamp":1765416911000,"date-parts":[[2025,12,11]]},"indexed":{"date-time":"2026-01-08T18:53:44Z","timestamp":1767898424155,"date-parts":[[2026,1,8]]},"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://www.ahajournals.org/doi/10.1161/JAHA.125.044014"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication 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Adjusted risk was higher with fibroids (1-year RR 2.47; RD 0.41%; 10-year RR 1.81; RD 2.40%), consistent across ASCVD components, race/ethnicity, age subgroups, and sensitivity analyses.","practice_takeaway":"Individuals with uterine fibroids had sustained higher 1- and 10-year ASCVD risk; prioritize targeted ASCVD risk assessment and prevention in this population."}}],"initialOffset":4,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Uterine Fibroids"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Uterine Fibroids"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Uterine Fibroids"}}}]]

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