2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T727,Management of complex hard-to-heal (chronic) wounds presents a substantial challenge in various healthcare settings where logistical constraints and patient-related factors can impede wound closure. This retrospective study evaluates outcomes associated with the use of a dehydrated, full-thickness placental allograft (CompleteFT; ExtremityCare, LLC, US) composed of the amnion, chorion and intermediate layers, when applied to complex hard-to-heal wounds in a mobile care environment. A retrospective analysis reviewed data collected between February 2024 and July 2025 from patients (aged ≥18 years) with complex hard-to-heal wounds. Data were retrieved from a single mobile wound care service provider team (Compassionate Care Concierge, US). Prior to allograft application, all wounds exhibited stalled healing for at least 30 days with standard of care (SoC). The allograft was applied to all wounds as an adjunct to SoC. Trend changes in wound surface area and percentage area reduction (PAR) across various wound aetiologies were assessed, with additional endpoints including the number of allograft applications and relevant patient parameters. The patient cohort (n=114, with a total of 184 hard-to-heal wounds), included 51 males and 63 females, with a mean age of 73.1 years. Analysis revealed statistically significant PAR values for various wound aetiologies, such that: p<0.0001 for diabetic foot ulcers (n=11); venous leg ulcers (n=48); pressure ulcers (n=73); and wounds classified as 'other' (n=39). Surgical wounds (n=13) demonstrated a p<0.0007. The study allograft was well-tolerated, with no adverse events directly attributable to the product. Application of the full-thickness allograft as an adjunct to SoC presents a promising option for supporting wound size regression in complex, hard-to-heal wounds.31:T97b, Objective: Management of complex hard-to-heal (chronic) wounds presents a substantial challenge in various healthcare settings where logistical constraints and patient-related factors can impede wound closure. This retrospective study evaluates outcomes associated with the use of a dehydrated, full-thickness placental allograft (CompleteFT; ExtremityCare, LLC, US) composed of the amnion, chorion and intermediate layers, when applied to complex hard-to-heal wounds in a mobile care environment. Method: A retrospective analysis reviewed data collected between February 2024 and July 2025 from patients (aged ≥18 years) with complex hard-to-heal wounds. Data were retrieved from a single mobile wound care service provider team (Compassionate Care Concierge, US). Prior to allograft application, all wounds exhibited stalled healing for at least 30 days with standard of care (SoC). The allograft was applied to all wounds as an adjunct to SoC. Trend changes in wound surface area and percentage area reduction (PAR) across various wound aetiologies were assessed, with additional endpoints including the number of allograft applications and relevant patient parameters. Results: The patient cohort (n=114, with a total of 184 hard-to-heal wounds), included 51 males and 63 females, with a mean age of 73.1 years. Analysis revealed statistically significant PAR values for various wound aetiologies, such that: p<0.0001 for diabetic foot ulcers (n=11); venous leg ulcers (n=48); pressure ulcers (n=73); and wounds classified as ‘other’ (n=39). Surgical wounds (n=13) demonstrated a p<0.0007. The study allograft was well-tolerated, with no adverse events directly attributable to the product. Conclusion: Application of the full-thickness allograft as an adjunct to SoC presents a promising option for supporting wound size regression in complex, hard-to-heal wounds. 32:T5df,Venous leg ulcers (VLUs) are traditionally managed with standard-of-care dressings, compression and appropriate adjunctive venous interventions for pathologic venous reflux. Due to pathophysiological complexity and underlying patient comorbidities, conducting randomised controlled trials to evaluate the comparative efficacy of advanced treatment modalities is difficult, as many patients would likely be excluded. This retrospective, pragmatic, real-world evidence (RWE) study compared the healing outcomes of VLUs treated with either ovine forestomach matrix (OFM) (n = 312) or collagen/oxidised regenerated cellulose (ORC) (n = 239) in outpatient wound care centres. Unlike restrictive randomised controlled trials, minimal inclusion and exclusion criteria were applied to create two treatment cohorts that reflected the general VLU population. The incidence (%) of closure was greater in OFM-treated VLUs at 12, 24 and 36 weeks, and this difference was significant at 24 and 36 weeks compared to collagen/ORC. Median time to wound closure was significantly faster (p = 0.045) in the OFM cohort (11.1 ± 0.6 weeks) compared to the collagen/ORC group (12.3 ± 1.0 weeks). Cox proportional hazards analysis demonstrated that OFM-treated VLUs had a significantly greater probability of healing (up to ~40%). This RWE comparative efficacy study further substantiates the clinical benefit of OFM in the treatment of chronic wounds, such as VLU, in a real-world patient cohort.33:T66e,ABSTRACTVenous leg ulcers (VLUs) are traditionally managed with standard‐of‐care dressings, compression and appropriate adjunctive venous interventions for pathologic venous reflux. Due to pathophysiological complexity and underlying patient comorbidities, conducting randomised controlled trials to evaluate the comparative efficacy of advanced treatment modalities is difficult, as many patients would likely be excluded. This retrospective, pragmatic, real‐world evidence (RWE) study compared the healing outcomes of VLUs treated with either ovine forestomach matrix (OFM) (n = 312) or collagen/oxidised regenerated cellulose (ORC) (n = 239) in outpatient wound care centres. Unlike restrictive randomised controlled trials, minimal inclusion and exclusion criteria were applied to create two treatment cohorts that reflected the general VLU population. The incidence (%) of closure was greater in OFM‐treated VLUs at 12, 24 and 36 weeks, and this difference was significant at 24 and 36 weeks compared to collagen/ORC. Median time to wound closure was significantly faster (p = 0.045) in the OFM cohort (11.1 ± 0.6 weeks) compared to the collagen/ORC group (12.3 ± 1.0 weeks). Cox proportional hazards analysis demonstrated that OFM‐treated VLUs had a significantly greater probability of healing (up to ~40%). This RWE comparative efficacy study further substantiates the clinical benefit of OFM in the treatment of chronic wounds, such as VLU, in a real‐world patient cohort.34:T53d,We report the first clinical evaluation of a new enzymatic wound debridement product containing tarumase in venous leg ulcer patients. As a first-in-human study, this was a prospective, open-label, multi-centre, dose escalation study across five dose cohorts and involving a total of 43 patients treated three times weekly for up to 4 weeks (12 applications). The primary and secondary endpoints of the study were to assess the systemic safety, local tolerability, and early proof of concept both for wound debridement and healing. Results indicated that the tarumase enzyme was well tolerated when applied topically to wounds, with no indications of systemic absorption, no evidence of antibody generation, and no systemic effects on coagulation pathways. Locally, there was no evidence of pain on application, no local itching, no increases in erythema, oedema, exudate or bleeding and only a few treatment emergent adverse events were reported. As the concentration of tarumase was escalated, trends towards faster and improved effectiveness of wound debridement were observed, especially in patients with significant slough at baseline. Trends towards faster rates of healing were also noted based on observations of increased granulation tissue, increased linear healing and reduction in surface area over the 4-week treatment period.35:T579,AbstractWe report the first clinical evaluation of a new enzymatic wound debridement product containing tarumase in venous leg ulcer patients. As a first‐in‐human study, this was a prospective, open‐label, multi‐centre, dose escalation study across five dose cohorts and involving a total of 43 patients treated three times weekly for up to 4 weeks (12 applications). The primary and secondary endpoints of the study were to assess the systemic safety, local tolerability, and early proof of concept both for wound debridement and healing. Results indicated that the tarumase enzyme was well tolerated when applied topically to wounds, with no indications of systemic absorption, no evidence of antibody generation, and no systemic effects on coagulation pathways. Locally, there was no evidence of pain on application, no local itching, no increases in erythema, oedema, exudate or bleeding and only a few treatment emergent adverse events were reported. As the concentration of tarumase was escalated, trends towards faster and improved effectiveness of wound debridement were observed, especially in patients with significant slough at baseline. Trends towards faster rates of healing were also noted based on observations of increased granulation tissue, increased linear healing and reduction in surface area over the 4‐week treatment period.36:T760,To review the literature to determine whether compression therapies and nutrition status influence venous ulcer healing. A systematized bibliographic review was carried out by searching PubMed, Scopus, and Cochrane databases for studies published between 2015 and 2020, using descriptors in Spanish and English. After establishing the research question and applying the filters based on inclusion and exclusion criteria, 114 articles were found. After screening, 11 articles were selected for the review: 8 were identified in the literature search, and 3 were added from the bibliographic references of other studies. The authors developed a data extraction sheet that recorded the following variables: author, country, year of publication, level of evidence, research design, therapy type, initial ulcer size, active ulcer history, pain, healed wounds, wound reduction, therapy tolerance, nutrition assessment method, body mass index, and nutrition disorders. Four studies analyzed the relationship between nutrition status and venous ulcer healing, finding that these patients tend to have a high body mass index; a deficit of nutrients such as vitamin A, D, or zinc; and an excess of lipids and carbohydrates. Seven studies compared different types of compression to determine which provided the best results, with two- and four-layer therapy being the most commonly used. Variables such as small wound size and recent onset were associated with better prognosis. In terms of nutrition, the parameters analyzed are very limited. Although several studies show that two-layer therapy produces the greatest ulcer healing, there is not enough information to recommend one type of therapy over the other. Therefore, more clinical trials are needed to study broader nutrition parameters and compare the types of therapy under matched conditions to determine their influence on ulcer healing.37:Ta61,ABSTRACT OBJECTIVE To review the literature to determine whether compression therapies and nutrition status influence venous ulcer healing. DATA SOURCE A systematized bibliographic review was carried out by searching PubMed, Scopus, and Cochrane databases for studies published between 2015 and 2020, using descriptors in Spanish and English. STUDY SELECTION After establishing the research question and applying the filters based on inclusion and exclusion criteria, 114 articles were found. After screening, 11 articles were selected for the review: 8 were identified in the literature search, and 3 were added from the bibliographic references of other studies. DATA EXTRACTION The authors developed a data extraction sheet that recorded the following variables: author, country, year of publication, level of evidence, research design, therapy type, initial ulcer size, active ulcer history, pain, healed wounds, wound reduction, therapy tolerance, nutrition assessment method, body mass index, and nutrition disorders. DATA SYNTHESIS Four studies analyzed the relationship between nutrition status and venous ulcer healing, finding that these patients tend to have a high body mass index; a deficit of nutrients such as vitamin A, D, or zinc; and an excess of lipids and carbohydrates. Seven studies compared different types of compression to determine which provided the best results, with two- and four-layer therapy being the most commonly used. Variables such as small wound size and recent onset were associated with better prognosis. CONCLUSIONS In terms of nutrition, the parameters analyzed are very limited. Although several studies show that two-layer therapy produces the greatest ulcer healing, there is not enough information to recommend one type of therapy over the other. Therefore, more clinical trials are needed to study broader nutrition parameters and compare the types of therapy under matched conditions to determine their influence on ulcer healing. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Venous Leg Ulcer: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Venous Leg Ulcer (condition). Clinician-written summaries and actionable practice insights. 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Searches covered MEDLINE, CINAHL, Embase, Scopus, and grey literature; 11 studies (published 2015 onward) met inclusion criteria.","key_result":"Validation studies showed good-to-excellent agreement between AI and manual wound measurements (ICC 0.799–0.995). AI measurement was 77% faster than manual methods and cut overall assessment time by 79%. Estimated health system savings ranged from AUD $1.7–3.3M/year (Australia) to ~US $958,201/year (Canada). Evidence on long-term sustainability and EHR interoperability was sparse.","limitations":"- Only 11 studies included, most from high-income countries, limiting generalisability.\n- Evidence concentrated around a small number of commercial platforms (e.g., Tissue Analytics, Swift Skin and Wound), with frequent industry ties among study authors.\n- Most evaluations were short-term, single-arm, or pre-post designs without confounding adjustment, weakening sustainability conclusions.","practice_takeaway":"AI wound tools can reliably measure wounds and reduce documentation burden across outpatient, community, and home settings — treat them as decision-support aids that augment, not replace, clinical judgement. Successful adoption will likely hinge on EHR interoperability and organisational investment in training, not just technical accuracy."}},{"doi":"10.12968/jowc.2025.0459","pmid":"41205152","title":"Application of a full-thickness placental allograft in complex wound management: a case series across diverse aetiologies","journal_title":"Journal of Wound Care","journal_issn":"0969-0700","published_at":"2025-11-08T00:00:00.000Z","url":"https://doi.org/10.12968/jowc.2025.0459","source_score":38,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-11-30","doi":"10.12968/jowc.2025.0459","days":"7","issn":"0969-0700","rank":"2","field":"Clinical Medicine","score":"38","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.12968/jowc.2025.0459","title":"Application of a full-thickness placental allograft in complex wound management: a case series across diverse aetiologies.","journal":"Journal of wound care","methods":"A retrospective analysis reviewed data collected between February 2024 and July 2025 from patients (aged ≥18 years) with complex hard-to-heal wounds. Data were retrieved from a single mobile wound care service provider team (Compassionate Care Concierge, US). Prior to allograft application, all wounds exhibited stalled healing for at least 30 days with standard of care (SoC). The allograft was applied to all wounds as an adjunct to SoC. Trend changes in wound surface area and percentage area reduction (PAR) across various wound aetiologies were assessed, with additional endpoints including the number of allograft applications and relevant patient parameters.","results":"The patient cohort (n=114, with a total of 184 hard-to-heal wounds), included 51 males and 63 females, with a mean age of 73.1 years. Analysis revealed statistically significant PAR values for various wound aetiologies, such that: p<0.0001 for diabetic foot ulcers (n=11); venous leg ulcers (n=48); pressure ulcers (n=73); and wounds classified as 'other' (n=39). Surgical wounds (n=13) demonstrated a p<0.0007. The study allograft was well-tolerated, with no adverse events directly attributable to the product.","abstract":"$30","keywords":["CompleteFT","amniotic membrane","chronic wounds","complex wounds","full-thickness membrane","hard-to-heal","placental allograft","wound","wound care","wound closure","wound covering","wound dressing"],"pubmed_id":"41205152","conclusions":"Application of the full-thickness allograft as an adjunct to SoC presents a promising option for supporting wound size regression in complex, hard-to-heal wounds.","publication_date":"2025-11-08T00:00:00"},"crossref":{"DOI":"10.12968/jowc.2025.0459","URL":"https://doi.org/10.12968/jowc.2025.0459","ISSN":["0969-0700","2052-2916"],"link":[{"URL":"http://www.magonlinelibrary.com/doi/pdf/10.12968/jowc.2025.0459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"S15-S24","type":"journal-article","issue":"S11a","score":1,"title":["Application of a full-thickness 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Consider OFM when selecting advanced matrices for VLUs, while interpreting results in light of observational design and potential confounding.","what_studied":"Retrospective real‑world analysis of venous leg ulcers in US outpatient wound centers (2014–2020), comparing ovine forestomach matrix (OFM) with collagen/oxidized regenerated cellulose (collagen/ORC) under compression. Outcomes were time to closure and incidence of closure at 12, 24, and 36 weeks across 830 VLUs (OFM n=470; collagen/ORC n=360) in 551 patients.","key_result":"Median time to closure was shorter with OFM vs collagen/ORC (11.1±0.6 vs 12.3±1.0 weeks; p=0.045); closure incidence was higher with OFM at 24 weeks (77.6% vs 69.2%; p=0.012) and 36 weeks (86.3% vs 79.7%; p=0.027). Adjusted Cox models showed greater probability of healing with OFM (HR 1.268 [95% CI 1.022–1.573] for ≥4 applications; HR 1.375 [1.011–1.869] for ≥8 applications), and the treatment effect persisted after further adjustment for compression type and skin substitute use (p=0.002).","limitations":"Nonrandomized, retrospective database study with imbalances in compression type and adjunctive skin substitute use between groups; key variables such as venous ablation were absent and debridement details were missing for many wounds; industry funding with multiple author conflicts of interest."}},{"doi":"10.1111/iwj.14805","pmid":"38385795","title":"First clinical evaluation of the safety and efficacy of tarumase for the debridement of venous leg ulcers","journal_title":"International Wound 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open-label, multi-centre, dose-escalation study of topical tarumase for enzymatic debridement in venous leg ulcer patients (n=43), applied three times weekly for up to 4 weeks (12 applications), assessing systemic safety, local tolerability, and early signals of debridement and healing.","key_result":"Tarumase was well tolerated with no indications of systemic absorption, no antibody generation, and no systemic coagulation effects; locally, no pain on application, no itching, and no increases in erythema, oedema, exudate, or bleeding were observed, with only a few treatment-emergent adverse events. Higher concentrations showed trends toward faster and improved debridement—especially in ulcers with significant baseline slough—and trends toward faster healing (more granulation tissue, increased linear healing, reduced surface area) over 4 weeks.","limitations":"Open-label, first-in-human dose-escalation with a small sample (n=43) and no control group. Efficacy findings are described as trends without quantitative outcomes.","practice_takeaway":"In venous leg ulcers, short-term topical tarumase appears locally and systemically well tolerated over 4 weeks, with early signals of dose-related debridement and healing benefits. 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Review","updated":"2025-08-17T18:46:03+00:00","published_date":"2022-12-20","best_oa_location":null}},"created_at":"2025-09-22T14:20:55.574Z","updated_at":"2025-09-22T14:20:55.574Z","tags":[{"paper_doi":"10.1097/01.asw.0000902492.97059.f2","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1097/01.asw.0000902492.97059.f2","tag_type":"condition","value":"Venous Leg Ulcer","value_numeric":null},{"paper_doi":"10.1097/01.asw.0000902492.97059.f2","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1097/01.asw.0000902492.97059.f2","tag_type":"modality","value":"Compression Therapy","value_numeric":null},{"paper_doi":"10.1097/01.asw.0000902492.97059.f2","tag_type":"study_design","value":"Systematic Review","value_numeric":null},{"paper_doi":"10.1097/01.asw.0000902492.97059.f2","tag_type":"warning","value":"Comparisons between compression systems may be confounded by unmatched baseline wound characteristics.","value_numeric":null},{"paper_doi":"10.1097/01.asw.0000902492.97059.f2","tag_type":"warning","value":"Design described as a ‘systematized bibliographic review,’ which may not meet full systematic review standards.","value_numeric":null},{"paper_doi":"10.1097/01.asw.0000902492.97059.f2","tag_type":"warning","value":"No pooled effect sizes or total participant numbers were reported.","value_numeric":null}],"summaries":{"what_studied":"A systematized bibliographic review (2015–2020; PubMed, Scopus, Cochrane) evaluated whether compression therapies and nutrition status affect venous leg ulcer healing, selecting 11 studies from 114 records.","key_result":"Of 11 studies, 4 assessed nutrition (patients tended to have high BMI, deficits in vitamins A/D or zinc, and excess lipids/carbohydrates) and 7 compared compression types (two- and four-layer were most used); several studies favored two-layer systems for healing, but evidence was insufficient to recommend one approach over another, and smaller, newer ulcers had better prognosis.","limitations":"Nutrition parameters assessed were narrow; comparisons of compression systems were not conducted under matched conditions; the review included only 11 studies without pooled effect sizes.","practice_takeaway":"Continue using compression therapy while recognizing no clear superiority among systems; consider assessing nutrition (BMI and micronutrient deficits such as vitamins A/D and zinc) and note that smaller, recent-onset ulcers have better healing prospects, though stronger trials are needed."}}],"initialOffset":5,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Venous Leg Ulcer"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Venous Leg Ulcer"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Venous Leg Ulcer"}}}]]

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