2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T9f0,Sunscreen reduces vitamin D production in experimental studies. It is uncertain whether this translates to 'real-world' settings. We aimed to dtermine if routinely applying high-SPF sunscreen for one year reduces serum 25-hydroxyvitamin D [25(OH)D] concentration. We conducted a population-based, open-label, randomised, controlled trial in Australians aged 18-70 years, who were not routinely using sunscreen/vitamin D. Participants were randomised (1:1) using stratified, computer-generated permuted block randomisation to routine application of SPF 50+ sunscreen on days the UV Index was forecast to reach ≥3 (intervention), or discretionary sunscreen use (control), for ∼1 year. We measured 25(OH)D concentration at baseline (winter/spring 2022), and at end of summer and winter 2023; we excluded from analyses participants with no post-baseline concentrations (n=11). The primary outcome was change in 25(OH)D concentration from baseline. Vitamin D deficiency (25(OH)D concentration <50 nmol/L) in the final sample was an exploratory outcome. We analysed data using mixed-effects models and Poisson regression. We stratified our analysis by baseline 25(OH)D concentration, residential UV radiation zone, skin exposure (derived from time outdoors and clothing use), and personal UV radiation exposure (derived by combining UV radiation zone and skin exposure). Sample and data analysis were performed blind to randomisation group. Trial registration: Australian New Zealand Clinical Trials Registry (ACTRN12621001752853). Between June 30, 2022, and November 29, 2022, we randomised 639 participants (intervention, n=319; control, n=320). 628 participants were analysed (intervention, n=312; control, n=316; median age, 52 years (IQR 40-64)). 415 (66%) identified as female, 210 (33%) as male, 3 (0.5%) used another term. Baseline 25(OH)D concentration was balanced (mean (SD): intervention, 63.5 (21.9) nmol/L; control, 62.1 (22.8) nmol/L). Adjusted mean differences from baseline were 1.6 nmol/L (intervention) and 6.8 nmol/L (control) (between-group treatment effect, -5.2 nmol/L; 95% CI, -7.2, -3.2). The treatment effects were consistent across almost all subgroups. Vitamin D deficiency (final sample) was higher in the intervention (n=139 [46%]) compared with the control group (n=115 [37%]) (prevalence ratio, 1.33, 95% CI, 1.14, 1.55). Routinely applying high-SPF sunscreen results in lower 25(OH)D concentrations than would be observed with discretionary sunscreen use. Regular sunscreen users may need supplementary vitamin D.31:Td99,Abstract Background Sunscreen reduces vitamin D production in experimental studies. It is uncertain whether this translates to real-world settings. Objectives To determine if routinely applying high sun protection factor (SPF) sunscreen for a year reduces serum 25-hydroxyvitamin D [25(OH)D] concentration. Methods We conducted a population-based open-label randomized controlled trial in Australian participants aged 18–70 years who were not routinely using sunscreen or taking vitamin D supplements. Participants were randomized (1 : 1) using stratified, computer-generated permuted block randomization to routine application of SPF 50+ sunscreen on days the ultraviolet (UV) index was forecast to reach ≥ 3 (intervention) or discretionary sunscreen use (control), for approximately 1 year. We measured 25(OH)D concentration at baseline (winter/spring 2022) and at the end of summer and winter 2023; participants with no postbaseline concentrations (n = 11) were excluded from analyses. The primary outcome was change in 25(OH)D concentration from baseline. Vitamin D deficiency [25(OH)D concentration < 50 nmol L–1] in the final sample was an exploratory outcome. We analysed data using mixed-effects models and Poisson regression. We stratified our analysis by baseline 25(OH)D concentration, residential UV radiation (UVR) zone, skin exposure (derived from time outdoors and clothing use) and personal UVR exposure (derived by combining UVR zone and skin exposure). Sample and data analysis were performed blind to randomization group. The trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12621001752853). Results Between 30 June and 29 November 2022, we randomized 639 participants (intervention, n = 319; control, n = 320). In total, 628 participants were analysed [intervention, n = 312; control, n = 316; median age 52 years (interquartile range 40–64)]. Altogether, 415 (66.1%) identified as female, 210 (33.4%) as male and 3 (0.5%) used another term. Mean (SD) baseline 25(OH)D concentration was balanced [intervention 63.5 (21.9) nmol L–1; control 62.1 (22.8) nmol L–1]. Adjusted mean differences from baseline were 1.6 nmol L–1 (intervention) and 6.8 nmol L–1 (control) [between-group treatment effect –5.2 nmol L–1, 95% confidence interval (CI) –7.2 to –3.2]. Treatment effects were consistent across almost all subgroups. Vitamin D deficiency (final sample) was higher in the intervention (n = 139/304; 45.7%) than in the control group (n = 115/312; 36.9%) (prevalence ratio 1.33, 95% CI 1.14–1.55). Conclusions Routinely applying high SPF sunscreen results in lower 25(OH)D concentrations than would be seen with discretionary sunscreen use. Regular sunscreen users may need vitamin D supplementation. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Vitamin D Deficiency: condition Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Vitamin D Deficiency (condition). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/condition/Vitamin%20D%20Deficiency\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Conditions\",\"item\":\"https://www.reachrx.ai/hub/tag/condition\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Vitamin D Deficiency\",\"item\":\"https://www.reachrx.ai/hub/tag/condition/Vitamin%20D%20Deficiency\"}]}}"}}]],["$","$L2f",null,{"title":"Vitamin D Deficiency: Research & Clinical Takeaways","description":"Discover peer-reviewed research on Vitamin D Deficiency with concise clinician summaries and next-step guidance.","papers":[{"doi":"10.1016/j.jaip.2026.08.029","pmid":"42665186","title":"Vitamin D Deficiency Is Associated with Increased Depression Risk in Obese Asthma.","journal_title":"The Journal of Allergy and Clinical Immunology: In Practice","journal_issn":"2213-2198","published_at":"2026-08-28T00:00:00.000Z","url":"https://doi.org/10.1016/j.jaip.2026.08.029","source_score":4,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-02T06:22:22.426Z","updated_at":"2026-09-02T06:22:22.426Z","tags":[{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"condition","value":"Asthma","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"condition","value":"Depression","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"condition","value":"Obesity","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"condition","value":"Vitamin D Deficiency","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"generic","value":"cholecalciferol","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"modality","value":"Vitamin D Supplementation","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"sample_size","value":"n=4890","value_numeric":4890},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"warning","value":"Asthma and depression diagnoses in NHANES are partly self-reported, which may affect precision of associations.","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"warning","value":"Mendelian randomization used two-sample design; instrument validity and pleiotropy cannot be fully excluded.","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"warning","value":"The BMI-stratified subgroup finding is the headline result, but the interaction P-value (0.285) is not significant — the subgroup difference may be spurious and should be interpreted with caution.","value_numeric":null},{"paper_doi":"10.1016/j.jaip.2026.08.029","tag_type":"warning","value":"The study was conducted in a US population (NHANES); generalizability to other ethnicities or healthcare settings may be limited.","value_numeric":null}],"summaries":{"what_studied":"This cross-sectional study used NHANES 2007–2018 and 2021–2023 data to examine whether serum 25(OH)D levels are associated with depression risk in 4,890 adults with asthma, stratified by BMI, with Mendelian randomization (MR) and transcriptomic analyses to explore causal mechanisms.","key_result":"Lower 25(OH)D had a graded association with depression: insufficiency (50–74.9 nmol/L), mild deficiency (25–49.9 nmol/L), and severe deficiency (<25 nmol/L) were linked to ~40%, ~73%, and ~97% higher depression risk vs. sufficiency (≥75 nmol/L). The association was significant only in overweight/obese adults (OR 1.46, 95% CI 1.15–1.86), but the interaction term was not significant (P-interaction = 0.285). MR found no genetic causal effect of vitamin D on asthma or depression; BMI showed causal effects on both.","limitations":"- The interaction by BMI subgroup was not statistically significant (P = 0.285), limiting conclusions about effect modification.\n- Cross-sectional design prevents causal inference between vitamin D and depression.\n- NHANES relies on self-reported depression and asthma diagnoses, which may introduce misclassification.","practice_takeaway":"In adults with asthma who are overweight or obese, low vitamin D levels are associated with meaningfully higher odds of depression — consider screening for both vitamin D deficiency and depression in this group. However, current evidence does not confirm a direct causal relationship, so vitamin D repletion as a depression treatment strategy in asthma remains unproven."}},{"doi":"10.2147/jaa.s594510","pmid":"42610060","title":"Vitamin D Deficiency in Children with Asthma and Overweight/Obesity in Qatar","journal_title":"Journal of Asthma and Allergy","journal_issn":"1178-6965","published_at":"2026-08-01T00:00:00.000Z","url":"https://doi.org/10.2147/jaa.s594510","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-21T06:28:19.164Z","updated_at":"2026-08-21T06:28:19.164Z","tags":[{"paper_doi":"10.2147/jaa.s594510","tag_type":"age_group","value":"adolescent","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"age_group","value":"child","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"condition","value":"Asthma","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"condition","value":"Obesity","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"condition","value":"Vitamin D Deficiency","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"generic","value":"cholecalciferol","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"modality","value":"Vitamin D Supplementation","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"sample_size","value":"n=364","value_numeric":364},{"paper_doi":"10.2147/jaa.s594510","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"warning","value":"Cholecalciferol (vitamin D3) was not specifically studied as a treatment — it was added as a plausible modality given the study's screening and supplementation recommendations; no intervention was actually tested.","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"warning","value":"Group sizes are unequal (NW group n=67 vs. others n=97–100), which may reduce statistical power for comparisons involving the NW group.","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"warning","value":"The paper is dated 2026-08-01 but was processed in August 2026; it is a recent publication and findings have not yet been independently replicated.","value_numeric":null},{"paper_doi":"10.2147/jaa.s594510","tag_type":"warning","value":"The study population is exclusively from MENA-region children residing in Qatar, limiting generalizability to other ethnicities or geographic settings.","value_numeric":null}],"summaries":{"what_studied":"Cross-sectional study of 364 children aged 6–17 years in Qatar, comparing serum 25-hydroxyvitamin D [25(OH)D] levels across four groups: normal weight with asthma (NW-A, n=97), overweight/obese with asthma (OO-A, n=100), overweight/obese without asthma (OO, n=100), and normal weight without asthma (NW, n=67), using multivariable logistic regression adjusted for age, sex, BMI, and atopy.","key_result":"Vitamin D deficiency (<50 nmol/L) was near-universal across all groups: 81.1% (OO), 73.9% (OO-A), 68.3% (NW), and 66.3% (NW-A) — with no statistically significant difference between groups (p=0.36). Higher BMI was inversely correlated with vitamin D in overweight/obese children (OO-A: ρ=−0.279, p=0.008; OO: ρ=−0.266, p=0.009), but asthma was not independently associated with vitamin D deficiency on multivariable regression (OR 1.27, 95% CI 0.50–3.24, p=0.611).","limitations":"- Key confounders not measured: vitamin D supplementation, sun exposure, seasonality, diet, and physical activity — leaving substantial residual confounding.\n- Clinic-based recruitment (pulmonology, endocrinology, general pediatrics) limits generalizability to the broader pediatric community.\n- Near-universal deficiency created a ceiling effect, reducing power to detect between-group differences in vitamin D status.","practice_takeaway":"Vitamin D deficiency is extremely common in Qatari children regardless of asthma or weight status, so routine screening is warranted across all pediatric patients in this region. Higher BMI — not asthma — is the key driver of lower vitamin D in this population, making overweight/obese children a priority group for nutritional and lifestyle intervention."}},{"doi":"10.1016/j.euroneuro.2026.112880","pmid":"42217371","title":"Prevalence and outcomes of co-occurring psychiatric and endocrine, metabolic, and nutritional disorders: An atlas based on umbrella review of 254,154,533 records","journal_title":"European Neuropsychopharmacology","journal_issn":"0924-977X","published_at":"2026-05-30T00:00:00.000Z","url":"https://doi.org/10.1016/j.euroneuro.2026.112880","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-07T13:26:34.220Z","updated_at":"2026-06-07T13:26:34.220Z","tags":[{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"category","value":"Clinical Neurology","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Anxiety Disorders","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Attention-Deficit/Hyperactivity Disorder","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Autism Spectrum Disorder","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Dementia","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Diabetic Foot Ulcer","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Major Depressive Disorder","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Metabolic Syndrome","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Mild Cognitive Impairment","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Obesity","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Polycystic Ovary Syndrome","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Schizophrenia","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Type 1 Diabetes Mellitus","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Type 2 Diabetes Mellitus","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"condition","value":"Vitamin D Deficiency","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"level_of_evidence","value":"1","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"sample_size","value":"n=254154533","value_numeric":254154533},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"study_design","value":"Umbrella Review","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"warning","value":"Full publisher text was inaccessible due to a CAPTCHA block; all structured data are derived exclusively from the abstract.","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"warning","value":"Sample size reflects the total number of records across all included meta-analyses, not unique individuals, so overlap between studies is likely.","value_numeric":null},{"paper_doi":"10.1016/j.euroneuro.2026.112880","tag_type":"warning","value":"The umbrella review pools observational meta-analyses only — causal direction between psychiatric and metabolic conditions cannot be established.","value_numeric":null}],"summaries":{"what_studied":"An umbrella review of 81 meta-analyses (254,154,533 records; 1,780 individual studies) examined the prevalence and clinical outcomes of co-occurring psychiatric disorders and endocrine, nutritional, or metabolic conditions, using DSM/ICD diagnostic criteria and AMSTAR-2 quality grading.","key_result":"10 of 64 prevalence estimates reached strong credibility, including MDD in diabetes mellitus (61.8%), vitamin D deficiency in schizophrenia (65.3%), anxiety in PCOS (48%), and mild cognitive impairment in type-2 diabetes (45%). Among outcomes with strong credibility: comorbid MDD roughly doubled dementia risk (RR=2.1) and raised all-cause mortality by 48% (RR=1.48) in diabetic patients; ADHD comorbidity raised HbA1c by ~0.6–0.7 SD in children with type-1 diabetes and women with type-2 diabetes.","limitations":"Only observational meta-analyses were included, limiting causal inference. Most estimates came from cross-sectional or heterogeneous studies, and many prevalence and outcome estimates did not meet strong credibility criteria (only 6.4% and 11.7%, respectively). Publisher full text was inaccessible; summary is based on the abstract alone.","practice_takeaway":"Clinicians managing diabetes, PCOS, or metabolic syndrome should routinely screen for depression and anxiety, given high co-prevalence and the finding that comorbid MDD nearly doubles dementia risk and raises mortality by 48% in diabetic patients. Children with type-1 diabetes and comorbid ADHD warrant closer glycemic monitoring, as HbA1c levels are meaningfully higher in this group."}},{"doi":"10.1093/ckj/sfag166","pmid":null,"title":"Cholecalciferol and muscle strength in hemodialysis patients: results from the randomized VITADIAL trial","journal_title":"Clinical Kidney Journal","journal_issn":"2048-8505","published_at":"2026-05-21T00:00:00.000Z","url":"https://doi.org/10.1093/ckj/sfag166","source_score":8,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":false,"crossref":true,"unpaywall":true},"created_at":"2026-05-24T13:23:09.063Z","updated_at":"2026-05-24T13:23:09.063Z","tags":[{"paper_doi":"10.1093/ckj/sfag166","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"category","value":"Urology & Nephrology","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"condition","value":"Chronic Kidney Disease","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"condition","value":"End-Stage Renal Disease","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"condition","value":"Vitamin D Deficiency","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"generic","value":"cholecalciferol","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"modality","value":"Vitamin D Supplement","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"sample_size","value":"n=143","value_numeric":143},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"warning","value":"143 patients were randomized from a screened cohort of 270; generalizability may be limited to vitamin D-deficient hemodialysis patients specifically.","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"warning","value":"Brand name of cholecalciferol was not reported in the abstract; no brand tag applied.","value_numeric":null},{"paper_doi":"10.1093/ckj/sfag166","tag_type":"warning","value":"The study is open-labeled, which may limit blinding rigor despite randomization.","value_numeric":null}],"summaries":{"what_studied":"This French multicenter RCT (VITADIAL) evaluated whether 6 months of monthly oral cholecalciferol (100,000 IU) vs. no treatment improved handgrip strength in chronic hemodialysis patients with 25-OH vitamin D ≤ 50 nmol/L (n=143 randomized).","key_result":"Cholecalciferol raised 25OHD levels to 89.78 ± 33.43 nmol/L at 6 months, but handgrip strength did not improve significantly in either group (+0.07 ± 3.40 kg vs. −0.19 ± 3.35 kg; p=0.682). No differences were found in autonomy or frailty measures.","limitations":"Open-label design may introduce assessment bias. The 6-month duration may be too short to detect meaningful muscle changes. The study focused solely on handgrip strength; other functional or structural muscle outcomes were not the primary endpoint.","practice_takeaway":"Cholecalciferol supplementation in vitamin D-deficient hemodialysis patients effectively corrects 25OHD levels but does not appear to improve muscle strength or frailty. Clinicians should not expect functional muscle benefits from routine cholecalciferol supplementation alone in this population."}},{"doi":"10.1093/bjd/ljaf310","pmid":"40927943","title":"Effect of daily sunscreen application on vitamin D: findings from the open-label randomized controlled Sun-D Trial","journal_title":"British Journal of Dermatology","journal_issn":"0007-0963","published_at":"2025-09-10T00:00:00.000Z","url":"https://doi.org/10.1093/bjd/ljaf310","source_score":175,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-10-16","doi":"10.1093/bjd/ljaf310","days":"30","issn":"0007-0963","rank":"5","field":"Clinical Medicine","score":"175","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1093/bjd/ljaf310","title":"The effect of daily sunscreen application on vitamin D: findings from the open-label, randomised, controlled Sun-D Trial.","journal":"The British journal of dermatology","methods":"","results":"Between June 30, 2022, and November 29, 2022, we randomised 639 participants (intervention, n=319; control, n=320). 628 participants were analysed (intervention, n=312; control, n=316; median age, 52 years (IQR 40-64)). 415 (66%) identified as female, 210 (33%) as male, 3 (0.5%) used another term. Baseline 25(OH)D concentration was balanced (mean (SD): intervention, 63.5 (21.9) nmol/L; control, 62.1 (22.8) nmol/L). Adjusted mean differences from baseline were 1.6 nmol/L (intervention) and 6.8 nmol/L (control) (between-group treatment effect, -5.2 nmol/L; 95% CI, -7.2, -3.2). The treatment effects were consistent across almost all subgroups. Vitamin D deficiency (final sample) was higher in the intervention (n=139 [46%]) compared with the control group (n=115 [37%]) (prevalence ratio, 1.33, 95% CI, 1.14, 1.55).","abstract":"$30","keywords":[],"pubmed_id":"40927943","conclusions":"","publication_date":"2025-09-10T00:00:00"},"crossref":{"DOI":"10.1093/bjd/ljaf310","URL":"https://doi.org/10.1093/bjd/ljaf310","ISSN":["0007-0963","1365-2133"],"link":[{"URL":"https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljaf310/64235112/ljaf310.pdf","content-type":"application/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljaf310/64235112/ljaf310.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Effect of daily sunscreen application on vitamin D: findings from the open-label randomized controlled Sun-D 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,"}]},{"given":"Tamara","family":"Dawson","sequence":"additional","affiliation":[{"name":"Melanoma and Skin Cancer Advocacy Network , Melbourne ,"}]},{"given":"Gunter","family":"Hartel","sequence":"additional","affiliation":[{"name":"Population Health Program, QIMR Berghofer , Brisbane ,"}]},{"given":"James G","family":"Lefevre","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics, The University of Queensland , Brisbane ,"},{"name":"ARC Centre of Excellence for Plant Success in Nature and Agriculture ,"}]},{"given":"Robyn M","family":"Lucas","sequence":"additional","affiliation":[{"name":"National Centre for Epidemiology and Population Health, The Australian National University , Canberra ,"}]},{"given":"Donald S A","family":"McLeod","sequence":"additional","affiliation":[{"name":"Population Health Program, QIMR Berghofer , Brisbane ,"},{"name":"The University of Queensland Medical School , Brisbane ,"},{"name":"Department of Endocrinology and Diabetes, Royal Brisbane and Women’s Hospital , Brisbane ,"}]},{"given":"Roger L","family":"Milne","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria , Melbourne ,"}]},{"given":"Craig","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Prevention Division, Cancer Council Victoria , Melbourne ,"}]},{"given":"David C","family":"Whiteman","sequence":"additional","affiliation":[{"name":"Population Health Program, QIMR Berghofer , Brisbane ,"},{"name":"School of Public Health, The University of Queensland , Brisbane ,"}]},{"given":"Mary","family":"Waterhouse","sequence":"additional","affiliation":[{"name":"Population Health Program, QIMR Berghofer , Brisbane ,"}]},{"given":"Rachel E","family":"Neale","sequence":"additional","affiliation":[{"name":"Population Health Program, QIMR Berghofer , Brisbane ,"},{"name":"School of Public Health, The University of Queensland , Brisbane 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Vitamin D deficiency in the final sample occurred in 139 (46%) vs 115 (37%); prevalence ratio 1.33 (95% CI, 1.14–1.55).","limitations":"Open-label design with participants unblinded; vitamin D deficiency was an exploratory outcome. Eleven randomized participants had no post-baseline 25(OH)D and were excluded.","practice_takeaway":"Routine high-SPF sunscreen use over a year led to lower 25(OH)D and more deficiency than discretionary use; regular sunscreen users may need vitamin D supplementation."}}],"initialOffset":5,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"condition","value":"Vitamin D Deficiency"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Conditions","href":"/hub/tag/condition"},{"name":"Vitamin D Deficiency"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"condition","hub_tag_value":"Vitamin D Deficiency"}}}]]

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