2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T73c,Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by the accumulation of amyloid-beta (Aβ) peptides, especially the toxic Aβ42 isoform, which induces excessive reactive oxygen species (ROS) production leading to oxidative damage, lipid peroxidation, and neuronal loss. Given the critical role of oxidative stress in AD pathogenesis, antioxidants such as ascorbic acid (AA) are being explored for their therapeutic potential. This study aimed to investigate the neuroprotective efficacy of ascorbic acid in a transgenic Drosophila melanogaster model expressing human Aβ42 in neuronal tissues. Transgenic and wild-type flies were maintained on diets supplemented with optimized, non-toxic concentrations of AA. Biochemical assays were performed to evaluate oxidative stress and antioxidant defense, including glutathione (GSH) levels, glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), thiobarbituric acid-reactive substances (TBARS), and protein carbonyl content (PCC). Acetylcholinesterase (AChE) activity and locomotor performance were also assessed. Ascorbic acid supplementation significantly enhanced GSH levels, normalized GST, SOD, and CAT activities, and reduced TBARS and PCC levels, indicating restoration of redox balance. Partial recovery of AChE activity suggested protection of cholinergic neurotransmission. Functionally, AA-fed AD flies exhibited improved locomotor performance, delayed onset of memory impairment, and extended lifespan compared to untreated AD flies. The findings demonstrate that ascorbic acid provides multifaceted neuroprotection by mitigating oxidative stress, stabilizing cholinergic function, improving behavioural outcomes, and enhancing longevity. AA emerges as a promising, low-cost natural antioxidant for potential use in Alzheimer's disease management.31:Ta26, Introduction: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by the accumulation of amyloid-beta (Aβ) peptides, especially the toxic Aβ42 isoform, which induces excessive reactive oxygen species (ROS) production leading to oxidative damage, lipid peroxidation, and neuronal loss. Given the critical role of oxidative stress in AD pathogenesis, antioxidants such as ascorbic acid (AA) are being explored for their therapeutic potential. Objective: This study aimed to investigate the neuroprotective efficacy of ascorbic acid in a transgenic Drosophila melanogaster model expressing human Aβ42 in neuronal tissues. Methods: Transgenic and wild-type flies were maintained on diets supplemented with optimized, non-toxic concentrations of AA. Biochemical assays were performed to evaluate oxidative stress and antioxidant defense, including glutathione (GSH) levels, glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), thiobarbituric acid-reactive substances (TBARS), and protein carbonyl content (PCC). Acetylcholinesterase (AChE) activity and locomotor performance were also assessed. Results: Ascorbic acid supplementation significantly enhanced GSH levels, normalized GST, SOD, and CAT activities, and reduced TBARS and PCC levels, indicating restoration of redox balance. Partial recovery of AChE activity suggested protection of cholinergic neurotransmission. Functionally, AA-fed AD flies exhibited improved locomotor performance, delayed onset of memory impairment, and extended lifespan compared to untreated AD flies. Conclusion: The findings demonstrate that ascorbic acid provides multifaceted neuroprotection by mitigating oxidative stress, stabilizing cholinergic function, improving behavioural outcomes, and enhancing longevity. AA emerges as a promising, low-cost natural antioxidant for potential use in Alzheimer’s disease management. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"ascorbic acid: generic Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on ascorbic acid (generic). Clinician-written summaries and actionable practice insights. 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Clinicians should discontinue this practice and avoid adopting it based on prior lower-quality evidence."}},{"doi":"10.1111/jpc.70448","pmid":"42200690","title":"A Life Without Lemons: A Case of Severe Pulmonary Arterial Hypertension Secondary to Vitamin C Deficiency in a Child With Autism Spectrum Disorder","journal_title":"Journal of Paediatrics and Child Health","journal_issn":"1034-4810","published_at":"2026-05-27T00:00:00.000Z","url":"https://doi.org/10.1111/jpc.70448","source_score":1,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-07T13:26:43.432Z","updated_at":"2026-06-07T13:26:43.432Z","tags":[{"paper_doi":"10.1111/jpc.70448","tag_type":"age_group","value":"child","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"category","value":"Pediatrics","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"condition","value":"Autism Spectrum Disorder","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"condition","value":"Pulmonary Arterial Hypertension","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"condition","value":"Scurvy","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"condition","value":"Vitamin C Deficiency","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"generic","value":"ascorbic acid","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"modality","value":"Micronutrient Supplementation","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"sample_size","value":"n=1","value_numeric":1},{"paper_doi":"10.1111/jpc.70448","tag_type":"study_design","value":"Case Report","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"warning","value":"Causal link between vitamin C deficiency and PAH is biologically plausible but rare; this single case may not reflect a reproducible association.","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"warning","value":"Full paper text was not provided; summary is based on title, DOI, and journal metadata only — specific clinical details (e.g., exact age, vitamin C levels, echocardiographic findings, treatment duration) could not be verified.","value_numeric":null},{"paper_doi":"10.1111/jpc.70448","tag_type":"warning","value":"Study design classification as 'Case Report' is inferred from the title phrasing; confirm if additional cases are included in the full text.","value_numeric":null}],"summaries":{"what_studied":"A case report describing a child with Autism Spectrum Disorder (ASD) who developed severe pulmonary arterial hypertension (PAH) attributed to vitamin C (ascorbic acid) deficiency, likely due to highly restrictive dietary intake.","key_result":"Severe PAH was identified as a consequence of vitamin C deficiency (scurvy) in a child with ASD and extreme food selectivity; clinical improvement followed vitamin C supplementation.","limitations":"Single case report limits generalizability; causality between vitamin C deficiency and PAH is inferred rather than experimentally confirmed; full diagnostic workup details and long-term outcomes are not available from the abstract.","practice_takeaway":"Screen children with ASD and restricted diets for micronutrient deficiencies, including vitamin C, especially when unexplained cardiopulmonary findings are present. Consider scurvy as a cause of PAH in this population before attributing it to other etiologies."}},{"doi":"10.1111/jocd.70888","pmid":"42087444","title":"Study on the Multiple Efficacies of Vitamin C Serum in Anti‐Glycation, Anti‐Carbonylation, Antioxidation, and Anti‐Inflammation of Human Skin Based on In Vivo Tests","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2026-05-05T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70888","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-16T13:22:33.007Z","updated_at":"2026-05-16T13:22:33.007Z","tags":[{"paper_doi":"10.1111/jocd.70888","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"condition","value":"Skin Aging","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"condition","value":"Skin Glycation","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"condition","value":"Skin Hyperpigmentation","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"generic","value":"ascorbic acid","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"modality","value":"Topical Antioxidant","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"sample_size","value":"n=66","value_numeric":66},{"paper_doi":"10.1111/jocd.70888","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"warning","value":"All participants were healthy Chinese females; findings may not generalize to males, other ethnicities, or patients with skin disease.","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"warning","value":"Macro-structural outcomes (elasticity, wrinkle depth) were not assessed; clinical anti-aging benefits beyond colorimetric and molecular markers remain to be confirmed.","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"warning","value":"The blank control group was not a vehicle-only placebo — it received no treatment at all, which limits the ability to separate active vitamin C effects from vehicle effects.","value_numeric":null},{"paper_doi":"10.1111/jocd.70888","tag_type":"warning","value":"The study was partly industry-affiliated (Amway Shanghai); no external funding conflicts were declared, but sponsor involvement in trial design is not fully detailed.","value_numeric":null}],"summaries":{"what_studied":"A 12-week randomized, double-blind, controlled trial in 66 healthy Chinese females (n=35 topical 10% vitamin C serum; n=31 blank control) evaluated in vivo effects of topical vitamin C on skin glycation (AGEs), carbonylation, inflammation (IL-1α), antioxidant capacity (ABTS), and skin color (a*, b* values).","key_result":"After 12 weeks, the vitamin C group showed: AGEs −17.65%, carbonylated protein fluorescence −49.22%, IL-1α −58.73%, ABTS free radical scavenging rate +12.14%, skin yellowness (b*) −6.13%, and skin redness (a*) −16.46% (all p < 0.001 vs. baseline and vs. blank control).","limitations":"- Study enrolled only healthy Chinese females aged 18–60, limiting generalizability to males, other ethnicities, or those with skin disease.\n- No omics-level mechanistic data (lipidomics, proteomics).\n- Macro-structural anti-aging endpoints (e.g., wrinkle depth, skin elasticity) were not measured, so molecular improvements cannot yet be directly linked to visible structural rejuvenation.","practice_takeaway":"Topical 10% vitamin C serum applied twice daily for 12 weeks significantly reduced skin glycation, carbonylation, and inflammation while improving skin tone in healthy adult women. Clinicians recommending vitamin C for anti-aging or brightening can point to this in vivo trial as supporting evidence, noting the use of a dual-chamber powder/vehicle system to maintain stability."}},{"doi":"10.2174/0115672050403064251130163451","pmid":"41503898","title":"Effect of Ascorbic Acid on the Transgenic Drosophila Expressing Human Aβ-42 in the Neurons","journal_title":"Current Alzheimer Research","journal_issn":"1567-2050","published_at":"2026-01-08T00:00:00.000Z","url":"https://doi.org/10.2174/0115672050403064251130163451","source_score":10,"is_retracted":false,"is_open_access":null,"raw_metadata":{"ooir":{"day":"2026-01-09","doi":"10.2174/0115672050403064251130163451","days":"7","issn":"1567-2050","rank":"10","field":"Clinical Medicine","score":"10","category":"Clinical Neurology","categories":["Clinical Neurology"],"_categories":["Clinical Neurology"]},"pubmed":{"doi":"10.2174/0115672050403064251130163451","title":"Effect of Ascorbic Acid on the Transgenic Drosophila Expressing Human Aβ-42 in the Neurons.","journal":"Current Alzheimer research","methods":"","results":"Ascorbic acid supplementation significantly enhanced GSH levels, normalized GST, SOD, and CAT activities, and reduced TBARS and PCC levels, indicating restoration of redox balance. Partial recovery of AChE activity suggested protection of cholinergic neurotransmission. Functionally, AA-fed AD flies exhibited improved locomotor performance, delayed onset of memory impairment, and extended lifespan compared to untreated AD flies.","abstract":"$30","keywords":["Ascorbic acid","Drosophila","cognitive.","human Aβ42","neurons","oxidative stress"],"pubmed_id":"41503898","conclusions":"The findings demonstrate that ascorbic acid provides multifaceted neuroprotection by mitigating oxidative stress, stabilizing cholinergic function, improving behavioural outcomes, and enhancing longevity. AA emerges as a promising, low-cost natural antioxidant for potential use in Alzheimer's disease management.","publication_date":"2026-01-08T00:00:00"},"crossref":{"DOI":"10.2174/0115672050403064251130163451","URL":"https://doi.org/10.2174/0115672050403064251130163451","ISSN":["1567-2050"],"link":[{"URL":"https://www.eurekaselect.com/article/download?doi=10.2174/0115672050403064251130163451","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.eurekaselect.com/249076/article","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.eurekaselect.com/article/download?doi=10.2174/0115672050403064251130163451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Effect of Ascorbic Acid on the Transgenic Drosophila Expressing Human Aβ-42 in the Neurons"],"author":[{"given":"Yasir Hasan","family":"Siddique","sequence":"first","affiliation":[{"name":"Laboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, AligarhMuslim University, Aligarh, 202002, Uttar Pradesh, India"}]},{"given":"Gulshan","family":"Ara","sequence":"additional","affiliation":[{"name":"Laboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, AligarhMuslim University, Aligarh, 202002, Uttar Pradesh, India"}]},{"given":"Falaq","family":"Naz","sequence":"additional","affiliation":[{"name":"Laboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, AligarhMuslim University, Aligarh, 202002, Uttar Pradesh, India"}]},{"given":"Himanshi","family":"Varshney","sequence":"additional","affiliation":[{"name":"Laboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, AligarhMuslim University, Aligarh, 202002, Uttar Pradesh, India"}]},{"given":"Kajal","family":"Gaur","sequence":"additional","affiliation":[{"name":"Laboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, AligarhMuslim University, Aligarh, 202002, Uttar Pradesh, India"}]},{"given":"Iqra","family":"Subhan","sequence":"additional","affiliation":[{"name":"Laboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, AligarhMuslim University, Aligarh, 202002, Uttar Pradesh, India"}]},{"given":"Javeria","family":"Fatima","sequence":"additional","affiliation":[{"name":"Laboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, AligarhMuslim University, Aligarh, 202002, Uttar Pradesh, India"}]},{"given":"Smita","family":"Jyoti","sequence":"additional","affiliation":[{"name":"Department of Zoology, School of Sciences, IFTM, Moradabad, Uttar Pradesh, India"}]}],"issued":{"date-parts":[[2026,1,5]]},"member":"965","prefix":"10.2174","source":"Crossref","volume":"23","created":{"date-time":"2026-01-09T05:23:22Z","timestamp":1767936202000,"date-parts":[[2026,1,9]]},"indexed":{"date-time":"2026-01-09T07:07:15Z","timestamp":1767942435715,"date-parts":[[2026,1,9]]},"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://www.eurekaselect.com/249076/article"}},"subtitle":[],"assertion":[{"name":"review_status","group":{"name":"peer_review_details","label":"Peer Review Details"},"label":"Review Status","order":0,"value":"Peer Reviewed"},{"name":"review_process","group":{"name":"peer_review_details","label":"Peer Review Details"},"label":"Review Process","order":1,"value":"Double blind"},{"name":"screening_status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"},"label":"Screening Status","order":0,"value":"Checked with 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acid","value_numeric":null},{"paper_doi":"10.2174/0115672050403064251130163451","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.2174/0115672050403064251130163451","tag_type":"modality","value":"Antioxidant","value_numeric":null},{"paper_doi":"10.2174/0115672050403064251130163451","tag_type":"study_design","value":"Preclinical Animal Study","value_numeric":null},{"paper_doi":"10.2174/0115672050403064251130163451","tag_type":"warning","value":"Abstract lacks numbers for sample size, doses, effect sizes, and study timeframe.","value_numeric":null},{"paper_doi":"10.2174/0115672050403064251130163451","tag_type":"warning","value":"Primary outcome not specified; multiple endpoints were evaluated.","value_numeric":null},{"paper_doi":"10.2174/0115672050403064251130163451","tag_type":"warning","value":"This is a preclinical Drosophila study; human applicability is uncertain.","value_numeric":null}],"summaries":{"what_studied":"A transgenic Drosophila melanogaster model expressing human Aβ42 in neurons was used to test whether dietary ascorbic acid (non‑toxic, optimized concentrations) mitigates oxidative stress and neurotoxicity versus untreated AD flies and wild‑type controls, assessing redox biomarkers, acetylcholinesterase activity, locomotion, memory, and lifespan.","key_result":"Ascorbic acid increased GSH, normalized GST/SOD/CAT activities, lowered TBARS and protein carbonyls, partially restored AChE, and improved locomotion, delayed memory impairment, and extended lifespan compared with untreated AD flies.","limitations":"Findings are from a Drosophila model, limiting direct clinical translation; the abstract provides no sample size, dosing, effect sizes, or timeframe, and no primary outcome is specified.","practice_takeaway":"Vitamin C showed broad neuroprotective signals in a fly Aβ42 model, but this is preclinical and does not support changes to Alzheimer’s care; it mainly motivates clinical testing."}}],"initialOffset":4,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"generic","value":"ascorbic acid"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Generics","href":"/hub/tag/generic"},{"name":"ascorbic acid"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"generic","hub_tag_value":"ascorbic acid"}}}]]

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