2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T63c,Non-scarring alopecia, including androgenetic alopecia, alopecia areata, and telogen effluvium, is highly prevalent and often associated with significant psychosocial burden. Although treatments such as minoxidil and finasteride are available, variability in response and tolerability concerns have increased interest in alternative therapeutic approaches. Polyphenolic compounds have attracted attention due to their antioxidant, anti-inflammatory, and immunomodulatory properties. This systematic review and meta-analysis evaluated the efficacy of oral and topical polyphenolic interventions for hair regeneration in adults with non-scarring alopecia. A systematic search of PubMed/MEDLINE, Scopus, Web of Science, and Cochrane CENTRAL was conducted according to PRISMA 2020 guidelines (PROSPERO: CRD420251230149). Randomized, blinded controlled trials were included. Primary outcomes were objective trichoscopic measures, including hair density and total area hair count. Thirty-two randomized controlled trials involving 2,183 participants were analyzed. Compared with controls, polyphenolic interventions significantly improved hair density (SMD 0.90; 95% CI 0.51-1.30) and total area hair count (SMD 1.03; 95% CI 0.42-1.63), although substantial heterogeneity was observed. Direct comparisons with minoxidil did not show significant differences in overall hair count outcomes. Current evidence suggests that selected polyphenolic formulations may represent a potential adjunctive therapeutic approach in non-scarring alopecia, though further standardized and long-term trials are warranted.31:T6ed,Society values a full head of hair. Therefore, androgenetic hair loss (AGA), though medically benign, can cause significant emotional distress. There is strong demand for alternative (nonconventional, over-the-counter) AGA treatments. It is important to have evidence on the efficacy of these treatments for AGA-especially in comparison with treatments that are approved by the United States Food and Drug Administration (FDA), such as oral finasteride and topical minoxidil. Following a systematic review, we conducted a network meta-analysis (NMA) to determine the relative efficacy of conventional monotherapies and selected alternative (nonconventional, over-the-counter) products for male AGA. We conducted a Bayesian NMA under a fixed effect model with uniform priors; the NMA estimated relative effects-as per mean difference (MD), along with the 95% credible interval (CI)-and surface under the cumulative ranking curve (SUCRA) values. We also assessed study-level evidence quality. Eligible studies were identified through systematic searches (without date restrictions) in PubMed and Scopus on April 30, 2025. The main outcome measure was change in total hair density at 24 weeks from baseline (in hairs/cm We found 24 eligible trials-where the relative efficacy of eight conventional monotherapies and seven alternative (nonconventional, over-the-counter) products was determined. The current NMA study confirms the efficacy of conventional monotherapies such as oral dutasteride, topical/oral minoxidil, and oral/topical finasteride for male AGA. We have provided guidance regarding the relative efficacy of some alternative (nonconventional, over-the-counter) agents (e.g., melatonin (topical) and rosemary oil (topical)) compared to conventional treatments.32:T866,ABSTRACTBackgroundSociety values a full head of hair. Therefore, androgenetic hair loss (AGA), though medically benign, can cause significant emotional distress. There is strong demand for alternative (nonconventional, over‐the‐counter) AGA treatments. It is important to have evidence on the efficacy of these treatments for AGA—especially in comparison with treatments that are approved by the United States Food and Drug Administration (FDA), such as oral finasteride and topical minoxidil.AimsFollowing a systematic review, we conducted a network meta‐analysis (NMA) to determine the relative efficacy of conventional monotherapies and selected alternative (nonconventional, over‐the‐counter) products for male AGA.MethodsWe conducted a Bayesian NMA under a fixed effect model with uniform priors; the NMA estimated relative effects—as per mean difference (MD), along with the 95% credible interval (CI)—and surface under the cumulative ranking curve (SUCRA) values. We also assessed study‐level evidence quality. Eligible studies were identified through systematic searches (without date restrictions) in PubMed and Scopus on April 30, 2025. The main outcome measure was change in total hair density at 24 weeks from baseline (in hairs/cm2).Results and ConclusionWe found 24 eligible trials—where the relative efficacy of eight conventional monotherapies and seven alternative (nonconventional, over‐the‐counter) products was determined. The current NMA study confirms the efficacy of conventional monotherapies such as oral dutasteride, topical/oral minoxidil, and oral/topical finasteride for male AGA. We have provided guidance regarding the relative efficacy of some alternative (nonconventional, over‐the‐counter) agents (e.g., melatonin (topical) and rosemary oil (topical)) compared to conventional treatments.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"finasteride: generic Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on finasteride (generic). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/generic/finasteride\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Generics\",\"item\":\"https://www.reachrx.ai/hub/tag/generic\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"finasteride\",\"item\":\"https://www.reachrx.ai/hub/tag/generic/finasteride\"}]}}"}}]],["$","$L2f",null,{"title":"finasteride: Research & Clinical Takeaways","description":"Explore research on finasteride (generic) — efficacy, safety, and comparative data.","papers":[{"doi":"10.1093/ced/llag333","pmid":"42546161","title":"Long-term effectiveness and safety of topical finasteride 0.25% monotherapy in male androgenetic alopecia: a 52-week real-world retrospective study","journal_title":"Clinical and Experimental Dermatology","journal_issn":"0307-6938","published_at":"2026-08-03T00:00:00.000Z","url":"https://doi.org/10.1093/ced/llag333","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-17T13:33:22.151Z","updated_at":"2026-08-17T13:33:22.151Z","tags":[{"paper_doi":"10.1093/ced/llag333","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"condition","value":"Androgenetic Alopecia","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"generic","value":"finasteride","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"modality","value":"5-Alpha Reductase Inhibitor","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"sample_size","value":"n=123","value_numeric":123},{"paper_doi":"10.1093/ced/llag333","tag_type":"sex","value":"male","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"study_design","value":"Retrospective Observational Study","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"warning","value":"No control or placebo arm was included; all comparisons are intra-patient (before vs. after), so treatment effect size may be influenced by regression to the mean or natural disease fluctuation.","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"warning","value":"Systemic absorption was not directly measured; the claim of minimal systemic exposure is inferred rather than pharmacokinetically confirmed in this study.","value_numeric":null},{"paper_doi":"10.1093/ced/llag333","tag_type":"warning","value":"The impact_flag 'safety_signal' is applied here as a positive signal (absence of systemic adverse events), not a harm signal — clinicians should interpret accordingly.","value_numeric":null}],"summaries":{"what_studied":"Evaluated topical finasteride 0.25% monotherapy in 123 adult men with androgenetic alopecia (AGA) over 52 weeks in a real-world retrospective setting, measuring trichoscopic outcomes (Total Hair Number, hair shaft thickness, terminal-to-vellus ratio) and safety at baseline vs. 52 weeks.","key_result":"At 52 weeks, Total Hair Number increased significantly at the vertex (+21.8 hairs/cm²; P < 0.001) and temporal regions (+29.4 hairs/cm²; P < 0.001), with improvements in hair shaft thickness and terminal-to-vellus ratio; 7.3% had mild local irritation, and no systemic sexual or mood adverse events were reported.","limitations":"Retrospective, single-center design without a control or comparator arm limits causal inference; no direct pharmacokinetic data on systemic absorption reported; relatively young mean age (32.4 years) may limit generalizability to older patients.","practice_takeaway":"For male AGA patients who are reluctant to use oral finasteride due to systemic side-effect concerns, topical finasteride 0.25% monotherapy offers meaningful hair density gains after one year with no reported systemic sexual or mood adverse events. The low rate of local irritation (7.3%) supports tolerability in routine practice."}},{"doi":"10.1080/09546634.2026.2654112","pmid":"42057730","title":"Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials","journal_title":"Journal of Dermatological Treatment","journal_issn":"0954-6634","published_at":"2026-04-30T00:00:00.000Z","url":"https://doi.org/10.1080/09546634.2026.2654112","source_score":6,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-05-08","doi":"10.1080/09546634.2026.2654112","days":"7","issn":"0954-6634","rank":"6","field":"Clinical Medicine","score":"6","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1080/09546634.2026.2654112","title":"Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials.","journal":"The Journal of dermatological treatment","methods":"","results":"Thirty-two randomized controlled trials involving 2,183 participants were analyzed. Compared with controls, polyphenolic interventions significantly improved hair density (SMD 0.90; 95% CI 0.51-1.30) and total area hair count (SMD 1.03; 95% CI 0.42-1.63), although substantial heterogeneity was observed. Direct comparisons with minoxidil did not show significant differences in overall hair count outcomes.","abstract":"$30","keywords":["Polyphenols","androgenetic alopecia","botanical extracts","hair density","meta-analysis","randomized controlled trials"],"pubmed_id":"42057730","conclusions":"","publication_date":"2026-04-30T00:00:00"},"crossref":{"DOI":"10.1080/09546634.2026.2654112","URL":"https://doi.org/10.1080/09546634.2026.2654112","ISSN":["0954-6634","1471-1753"],"link":[{"URL":"https://www.tandfonline.com/doi/pdf/10.1080/09546634.2026.2654112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"1","score":1,"title":["Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials"],"author":[{"given":"Chaimae","family":"El Ammari","sequence":"first","affiliation":[{"name":"UCAM HiTech Sport & Health Innovation Hub, Universidad Católica de Murcia"},{"name":"Group of Metabolism and Gene Regulation, UCAM HiTech Sport & Health Innovation Hub, Universidad Católica de Murcia"}]},{"given":"Ana María","family":"García-Muñoz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Nutrition, UCAM Universidad Católica San Antonio de Murcia"}]},{"given":"Rubén","family":"Zapata-Pérez","sequence":"additional","affiliation":[{"name":"UCAM HiTech Sport & Health Innovation Hub, Universidad Católica de Murcia"},{"name":"Group of Metabolism and Gene Regulation, UCAM HiTech Sport & Health Innovation Hub, Universidad Católica de Murcia"}]},{"given":"Rubén","family":"Rabadán-Ros","sequence":"additional","affiliation":[{"name":"UCAM HiTech Sport & Health Innovation Hub, Universidad Católica de Murcia"},{"name":"Group of Metabolism and Gene Regulation, UCAM HiTech Sport & Health Innovation Hub, Universidad Católica de Murcia"}]},{"given":"Carmen","family":"Lucas-Abellán","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Nutrition, UCAM Universidad Católica San Antonio de Murcia"}]},{"given":"Rebeca","family":"González-Louzao","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Nutrition, UCAM Universidad Católica San Antonio de Murcia"}]},{"given":"Desirée","family":"Victoria-Montesinos","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Nutrition, UCAM Universidad Católica San Antonio de Murcia"}]}],"issued":{"date-parts":[[2026,4,30]]},"member":"301","prefix":"10.1080","source":"Crossref","volume":"37","created":{"date-time":"2026-04-30T08:17:27Z","timestamp":1777537047000,"date-parts":[[2026,4,30]]},"indexed":{"date-time":"2026-05-04T03:44:07Z","timestamp":1777866247049,"date-parts":[[2026,5,4]]},"license":[{"URL":"http://creativecommons.org/licenses/by-nc/4.0/","start":{"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000,"date-parts":[[2026,4,30]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://www.tandfonline.com/doi/full/10.1080/09546634.2026.2654112"}},"subtitle":[],"assertion":[{"name":"peerreview_statement","label":"Peer Review Statement","order":1,"value":"The publishing and review policy for this title is described in its Aims & Scope."},{"URL":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ijdt20","name":"aims_and_scope_url","label":"Aim & Scope","order":2,"value":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ijdt20"},{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2026-02-16"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2026-03-28"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-04-30"}],"deposited":{"date-time":"2026-04-30T08:17:33Z","timestamp":1777537053000,"date-parts":[[2026,4,30]]},"issn-type":[{"type":"print","value":"0954-6634"},{"type":"electronic","value":"1471-1753"}],"published":{"date-parts":[[2026,4,30]]},"publisher":"Informa UK Limited","reference":[{"DOI":"10.1016/j.reth.2022.10.005","key":"e_1_3_3_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/lsm.23017","key":"e_1_3_3_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.2147/CCID.S284435","key":"e_1_3_3_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_3_5_1","year":"2017","issue":"6","author":"Juárez-Rendón KJ","volume":"115","first-page":"e404","unstructured":"Juárez-Rendón KJ, Rivera Sánchez G, Reyes-López MÁ, et al. Alopecia Areata. Current situation and perspectives. Arch Argent Pediatr. 2017;115(6):e404–e411. 11.","article-title":"Alopecia Areata. Current situation and perspectives","journal-title":"Arch Argent Pediatr","doi-asserted-by":null},{"DOI":"10.3390/ph18020138","key":"e_1_3_3_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/molecules27227832","key":"e_1_3_3_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1136/bmj.n71","key":"e_1_3_3_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/9781119536604","key":"e_1_3_3_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/9781119536604.ch8","key":"e_1_3_3_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_3_11_1","year":"2018","issue":"5","author":"Ablon G","volume":"17","first-page":"558","unstructured":"Ablon G, Kogan S. A six-month, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of a nutraceutical supplement for promoting hair growth in women with self-perceived thinning hair. J Drugs Dermatol. 2018;17(5):558–565.","article-title":"A six-month, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of a nutraceutical supplement for promoting hair growth in women with self-perceived thinning hair","journal-title":"J Drugs Dermatol","doi-asserted-by":null},{"DOI":"10.3390/life15030500","key":"e_1_3_3_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/jocd.16778","key":"e_1_3_3_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.56609/jac.v41i2.276","key":"e_1_3_3_14_1","year":"2023","issue":"2","author":"Biasio FD","volume":"41","first-page":"28","unstructured":"Biasio FD, Ielpo A, Santarsiere L, et al. A randomized double-blind placebo-controlled clinical trial to evaluate the effect of an Annurca apple supplement formula in androgenic alopecia. J Appl Cosmetol. 2023;41(2):28–46.","article-title":"A randomized double-blind placebo-controlled clinical trial to evaluate the effect of an Annurca apple supplement formula in androgenic alopecia","journal-title":"J Appl Cosmetol","doi-asserted-by":"crossref"},{"DOI":"10.1002/hsr2.1045","key":"e_1_3_3_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/ics.12783","key":"e_1_3_3_16_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.2174/0118743722294678240502110214","key":"e_1_3_3_17_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1155/2014/549721","key":"e_1_3_3_18_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1248/bpb.b15-00387","key":"e_1_3_3_19_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.22159/ajpcr.2021.v14i8.41859","key":"e_1_3_3_20_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3109/09546639609086878","key":"e_1_3_3_21_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/srt.13448","key":"e_1_3_3_22_1","year":"2023","issue":"9","author":"Ham S","volume":"29","first-page":"e13448","unstructured":"Ham S, Lee YI, Kim IA, et al. Efficacy and safety of persimmon leaf formulated with green tea and sophora fruit extracts (BLH308) on hair growth: a randomized, double-blind, placebo-controlled clinical trial. Skin Res Technol. 2023;29(9):e13448.","article-title":"Efficacy and safety of persimmon leaf formulated with green tea and sophora fruit extracts (BLH308) on hair growth: a randomized, double-blind, placebo-controlled clinical trial","journal-title":"Skin Res Technol","doi-asserted-by":"crossref"},{"DOI":"10.1111/dth.13734","key":"e_1_3_3_23_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/antiox14040477","key":"e_1_3_3_24_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/nu17050767","key":"e_1_3_3_25_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.fshw.2023.02.043","key":"e_1_3_3_26_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_3_27_1","year":"2013","issue":"1","author":"Loing E","volume":"64","first-page":"45","unstructured":"Loing E, Lachance R, Ollier V, et al. A new strategy to modulate alopecia using a combination of two specific and unique ingredients. J Cosmet Sci. 2013;64(1):45–58.","article-title":"A new strategy to modulate alopecia using a combination of two specific and unique ingredients","journal-title":"J Cosmet Sci","doi-asserted-by":null},{"DOI":null,"key":"e_1_3_3_28_1","year":"2020","issue":"10","author":"Lueangarun S","volume":"13","first-page":"32","unstructured":"Lueangarun S, Panchaprateep R. An herbal extract combination (Biochanin A, Acetyl tetrapeptide-3, and ginseng extracts) versus 3% minoxidil solution for the treatment of androgenetic alopecia: a 24-week, prospective, randomized, triple-blind, controlled trial. J Clin Aesthetic Dermatol. 2020;13(10):32–37.","article-title":"An herbal extract combination (Biochanin A, Acetyl tetrapeptide-3, and ginseng extracts) versus 3% minoxidil solution for the treatment of androgenetic alopecia: a 24-week, prospective, randomized, triple-blind, controlled trial","journal-title":"J Clin Aesthetic Dermatol","doi-asserted-by":null},{"DOI":"10.1111/jocd.14931","key":"e_1_3_3_29_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/biom13040699","key":"e_1_3_3_30_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_3_31_1","year":"2015","issue":"1","author":"Panahi Y","volume":"13","first-page":"15","unstructured":"Panahi Y, Taghizadeh M, Marzony ET, et al. Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. Skinmed. 2015;13(1):15–21.","article-title":"Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial","journal-title":"Skinmed","doi-asserted-by":null},{"DOI":"10.15570/actaapa.2018.13","key":"e_1_3_3_32_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1159/000540081","key":"e_1_3_3_33_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3109/09546634.2011.568470","key":"e_1_3_3_34_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/27683605251363174","key":"e_1_3_3_35_1","year":"2025","issue":"10","author":"Revathi R","volume":"31","first-page":"921","unstructured":"Revathi R, Suhag D. Amaranthus extract promotes healthy follicles and anagen hair density-A randomized placebo-controlled, double-blinded study. J Integr Complement Med. 2025;31(10):921–931.","article-title":"Amaranthus extract promotes healthy follicles and anagen hair density-A randomized placebo-controlled, double-blinded study","journal-title":"J Integr Complement Med","doi-asserted-by":"crossref"},{"DOI":"10.1002/ptr.800","key":"e_1_3_3_36_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/ced.12753","key":"e_1_3_3_37_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/2515690X241291141","key":"e_1_3_3_38_1","year":"2024","issue":null,"author":"Tanuphol N","volume":"29","first-page":null,"unstructured":"Tanuphol N, Waranuch N, Wisuitiprot V, et al. Effectiveness and safety of hair growth formulation containing Tectona grandis L.f (teak) leaf extract: a randomized, double-blind, placebo-controlled study on males with androgenic alopecia. J Evid-Based Integr Med. 2024;29:2515690X241291141.","article-title":"Effectiveness and safety of hair growth formulation containing Tectona grandis L.f (teak) leaf extract: a randomized, double-blind, placebo-controlled study on males with androgenic alopecia","journal-title":"J Evid-Based Integr Med","doi-asserted-by":"crossref"},{"DOI":"10.1089/jmf.2017.0016","key":"e_1_3_3_39_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/cosmetics11050146","key":"e_1_3_3_40_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/jocd.14158","key":"e_1_3_3_41_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.4103/tjd.tjd_41_22","key":"e_1_3_3_42_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/09546634.2021.1945527","key":"e_1_3_3_43_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/j.1365-2133.2004.05785.x","key":"e_1_3_3_44_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1017/jns.2016.41","key":"e_1_3_3_45_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1046/j.0007-0963.2001.04558.x","key":"e_1_3_3_46_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.2147/DDDT.S327378","key":"e_1_3_3_47_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"update-policy":"https://doi.org/10.1080/tandf_crossmark_01","alternative-id":["10.1080/09546634.2026.2654112"],"article-number":"2654112","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Journal of Dermatological Treatment"],"published-print":{"date-parts":[[2026,12,31]]},"reference-count":46,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,4,30]]},"references-count":46,"short-container-title":["Journal of Dermatological Treatment"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1080/09546634.2026.2654112","is_oa":true,"title":"Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials","updated":"2026-05-06T13:23:02+00:00","published_date":"2026-04-30","best_oa_location":{"url":"https://doi.org/10.1080/09546634.2026.2654112","pmh_id":null,"url_for_pdf":null,"url_for_landing_page":"https://doi.org/10.1080/09546634.2026.2654112"}}},"created_at":"2026-05-14T13:22:51.771Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"condition","value":"Alopecia Areata","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"condition","value":"Androgenetic Alopecia","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"condition","value":"Telogen Effluvium","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"generic","value":"finasteride","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"generic","value":"minoxidil","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"level_of_evidence","value":"1","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"modality","value":"Polyphenolic Compound","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"sample_size","value":"n=2183","value_numeric":2183},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"study_design","value":"Systematic Review and Meta-analysis","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"study_design","value":"Systematic Review and Meta-Analysis","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"warning","value":"Effect sizes are reported as standardized mean differences; absolute changes in hair count or density were not provided.","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"warning","value":"No specific polyphenolic compounds or brand names are named in the abstract; the exact agents evaluated remain unclear from available text.","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"warning","value":"Specific polyphenolic agents, dosing, and treatment durations varied and were not detailed in the summary.","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"warning","value":"Substantial heterogeneity limits confidence in pooled effect estimates.","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"warning","value":"The meta-analysis pools multiple distinct polyphenolic compounds (oral and topical) across different alopecia subtypes, which likely contributes to the noted substantial heterogeneity and limits interpretability of the pooled SMDs.","value_numeric":null},{"paper_doi":"10.1080/09546634.2026.2654112","tag_type":"warning","value":"The PROSPERO registration number (CRD420251230149) could not be independently verified; clinicians should confirm registration status before citing this review as pre-registered evidence.","value_numeric":null}],"summaries":{"limitations":"There was substantial heterogeneity across trials. Long-term and standardized data are lacking.","what_studied":"A systematic review and meta-analysis of randomized, blinded controlled trials tested oral and topical polyphenolic compounds versus controls in adults with non-scarring alopecia. Primary outcomes were trichoscopic hair density and total area hair count.","key_result":"Across 32 RCTs (n=2,183), polyphenolic interventions improved hair density (SMD 0.90; 95% CI 0.51–1.30) and total area hair count (SMD 1.03; 95% CI 0.42–1.63) versus controls; direct comparisons with minoxidil showed no significant difference in overall hair count.","practice_takeaway":"Selected polyphenolic formulations may raise hair density and counts in adults with non-scarring alopecia, but effects vary and they do not outperform minoxidil in head-to-head trials. Use as adjuncts should await more standardized, longer-term studies."}},{"doi":"10.1111/jocd.70483","pmid":"41051009","title":"Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2025-10-06T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70483","source_score":11,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-10-12","doi":"10.1111/jocd.70483","days":"14","issn":"1473-2130","rank":"7","field":"Clinical Medicine","score":"11","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70483","title":"Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over-the-Counter Products for Male Androgenetic Alopecia: A Network Meta-Analysis Study.","journal":"Journal of cosmetic dermatology","methods":"","results":"","abstract":"$31","keywords":[],"pubmed_id":"41051009","conclusions":"","publication_date":"2025-10-06T00:00:00"},"crossref":{"DOI":"10.1111/jocd.70483","URL":"https://doi.org/10.1111/jocd.70483","ISSN":["1473-2130","1473-2165"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"10","score":1,"title":["Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study"],"author":[{"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Mediprobe Research Inc. London Ontario Canada"},{"name":"Division of Dermatology, Department of Medicine University of Toronto School of Medicine Toronto Ontario Canada"}]},{"given":"Mary A.","family":"Bamimore","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc. London Ontario Canada"}]},{"given":"Mesbah","family":"Talukder","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University Dhaka Bangladesh"}]}],"issued":{"date-parts":[[2025,10]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":"24","archive":["Portico"],"created":{"date-time":"2025-10-06T23:33:55Z","timestamp":1759793635000,"date-parts":[[2025,10,6]]},"indexed":{"date-time":"2025-10-07T00:56:00Z","timestamp":1759798560404,"date-parts":[[2025,10,7]]},"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000,"date-parts":[[2025,10,6]]},"delay-in-days":5,"content-version":"vor"}],"subject":[],"abstract":"$32","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70483"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-07-29"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-09-26"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2025-10-06"}],"deposited":{"date-time":"2025-10-06T23:34:06Z","timestamp":1759793646000,"date-parts":[[2025,10,6]]},"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"published":{"date-parts":[[2025,10]]},"publisher":"Wiley","reference":[{"DOI":"10.1111/dth.12390","key":"e_1_2_11_2_1","year":"2016","issue":"6","author":"Rossi A.","volume":"29","first-page":"424","unstructured":null,"article-title":"Multi‐Therapies in Androgenetic Alopecia: Review and Clinical Experiences","journal-title":"Dermatologic Therapy","doi-asserted-by":"crossref"},{"DOI":"10.1111/bjd.12443","key":"e_1_2_11_3_1","year":"2013","issue":"4","author":"Heilmann S.","volume":"169","first-page":"927","unstructured":null,"article-title":"Evidence for a Polygenic Contribution to Androgenetic Alopecia","journal-title":"British Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1067/mjd.2001.117426","key":"e_1_2_11_4_1","year":"2001","issue":"3","author":"Olsen E. A.","volume":"45","first-page":"S70","unstructured":null,"article-title":"Female Pattern Hair Loss","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.2147/CCID.S271013","key":"e_1_2_11_5_1","year":"2020","issue":null,"author":"Majeed M.","volume":"13","first-page":"691","unstructured":null,"article-title":"Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers With Hair Fall","journal-title":"Clinical, Cosmetic and Investigational Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1046/j.1365-2133.1999.03030.x","key":"e_1_2_11_6_1","year":"1999","issue":"3","author":"Cash T. F.","volume":"141","first-page":"398","unstructured":null,"article-title":"The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature","journal-title":"British Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1080/13548506.2023.2242049","key":"e_1_2_11_7_1","year":"2024","issue":"4","author":"Frith H.","volume":"29","first-page":"822","unstructured":null,"article-title":"Psychosocial Impact of Androgenetic Alopecia on Men: A Systematic Review and Meta‐Analysis","journal-title":"Psychology, Health & Medicine","doi-asserted-by":"crossref"},{"DOI":"10.1080/13543784.2017.1353598","key":"e_1_2_11_8_1","year":"2017","issue":"8","author":"Guo H.","volume":"26","first-page":"917","unstructured":null,"article-title":"Experimental and Early Investigational Drugs for Androgenetic Alopecia","journal-title":"Expert Opinion on Investigational Drugs","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_9_1","year":"2022","issue":"3","author":"Ring C.","volume":"15","first-page":"26","unstructured":null,"article-title":"Nutraceuticals for Androgenetic Alopecia","journal-title":"Journal of Clinical and Aesthetic Dermatology","doi-asserted-by":null},{"DOI":"10.1016/j.jaad.2008.07.001","key":"e_1_2_11_10_1","year":"2008","issue":"4","author":"Rogers N. E.","volume":"59","first-page":"547","unstructured":null,"article-title":"Medical Treatments for Male and Female Pattern Hair Loss","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_11_1","year":"2022","issue":null,"author":"Anastassakis K.","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1111/dth.12647","key":"e_1_2_11_12_1","year":"2019","issue":"2","author":"Andy G.","volume":"32","first-page":null,"unstructured":null,"article-title":"Controversies in the Treatment of Androgenetic Alopecia: The History of Finasteride","journal-title":"Dermatologic Therapy","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.tibtech.2022.12.020","key":"e_1_2_11_13_1","year":"2023","issue":"6","author":"Castro A. R.","volume":"41","first-page":"731","unstructured":null,"article-title":"The Booming Business of Hair Loss","journal-title":"Trends in Biotechnology","doi-asserted-by":"crossref"},{"DOI":"10.2147/CCID.S470989","key":"e_1_2_11_14_1","year":"2024","issue":null,"author":"Bin Rubaian N. F.","volume":"17","first-page":"2495","unstructured":null,"article-title":"An Overview of Commonly Used Natural Alternatives for the Treatment of Androgenetic Alopecia, With Special Emphasis on Rosemary Oil","journal-title":"Clinical, Cosmetic and Investigational Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.37766/inplasy2025.6.0102","key":"e_1_2_11_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"A.GuptaandM.Bamimore “The Comparative Effectiveness of Prescription and Selected Alternative Therapies for Pattern Hair Loss: Protocol for a Multiple Treatment Comparison Meta‐Analysis ” (2025).","article-title":null,"journal-title":null,"doi-asserted-by":"crossref"},{"DOI":"10.7326/M14-2385","key":"e_1_2_11_16_1","year":"2015","issue":"11","author":"Hutton B.","volume":"162","first-page":"777","unstructured":null,"article-title":"The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta‐Analyses of Health Care Interventions: Checklist and Explanations","journal-title":"Annals of Internal Medicine","doi-asserted-by":"crossref"},{"DOI":"10.1186/s13643-024-02619-9","key":"e_1_2_11_17_1","year":"2024","issue":"1","author":"Forbes C.","volume":"13","first-page":"206","unstructured":null,"article-title":"Automation of Duplicate Record Detection for Systematic Reviews: Deduplicator","journal-title":"Systematic Reviews","doi-asserted-by":"crossref"},{"DOI":"10.1002/jrsm.1411","key":"e_1_2_11_18_1","year":"2021","issue":"1","author":"McGuinness L. A.","volume":"12","first-page":"55","unstructured":null,"article-title":"Risk‐Of‐Bias VISualization (Robvis): An R Package and Shiny Web App for Visualizing Risk‐Of‐Bias Assessments","journal-title":"Research Synthesis Methods","doi-asserted-by":"crossref"},{"DOI":"10.1002/jrsm.1167","key":"e_1_2_11_19_1","year":"2016","issue":"1","author":"Valkenhoef G.","volume":"7","first-page":"80","unstructured":null,"article-title":"Automated Generation of Node‐Splitting Models for Assessment of Inconsistency in Network Meta‐Analysis","journal-title":"Research Synthesis Methods","doi-asserted-by":"crossref"},{"DOI":"10.1002/jrsm.1428","key":"e_1_2_11_20_1","year":"2021","issue":"1","author":"Seo M.","volume":"12","first-page":"86","unstructured":null,"article-title":"The Kilim Plot: A Tool for Visualizing Network Meta‐Analysis Results for Multiple Outcomes","journal-title":"Research Synthesis Methods","doi-asserted-by":"crossref"},{"DOI":"10.4103/ijt.ijt_72_22","key":"e_1_2_11_21_1","year":"2023","issue":"2","author":"Bharadwaj A. V.","volume":"15","first-page":"56","unstructured":null,"article-title":"Comparative Efficacy of Topical Finasteride (0.25%) in Combination With Minoxidil (5%) Against 5% Minoxidil or 0.25% Finasteride Alone in Male Androgenetic Alopecia: A Pilot, Randomized Open‐Label Study","journal-title":"International Journal of Trichology","doi-asserted-by":"crossref"},{"DOI":"10.1111/jocd.15953","key":"e_1_2_11_22_1","year":"2024","issue":"2","author":"Rossi A.","volume":"23","first-page":"502","unstructured":null,"article-title":"Efficacy of the Association of Topical Minoxidil and Topical Finasteride Compared to Their Use in Monotherapy in Men With Androgenetic Alopecia: A Prospective, Randomized, Controlled, Assessor Blinded, 3‐Arm, Pilot Trial","journal-title":"Journal of Cosmetic Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/ics.12764","key":"e_1_2_11_23_1","year":"2022","issue":"2","author":"Hashimoto M.","volume":"44","first-page":"154","unstructured":null,"article-title":"Effects of Watercress Extract Fraction on R‐Spondin 1‐Mediated Growth of Human Hair","journal-title":"International Journal of Cosmetic Science","doi-asserted-by":"crossref"},{"DOI":"10.1111/jdv.17738","key":"e_1_2_11_24_1","year":"2022","issue":"2","author":"Piraccini B. M.","volume":"36","first-page":"286","unstructured":null,"article-title":"Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomised, Controlled Clinical Trial","journal-title":"Journal of the European Academy of Dermatology and Venereology","doi-asserted-by":"crossref"},{"DOI":"10.1007/s13555-020-00448-x","key":"e_1_2_11_25_1","year":"2020","issue":"6","author":"Panchaprateep R.","volume":"10","first-page":"1345","unstructured":null,"article-title":"Efficacy and Safety of Oral Minoxidil 5 Mg Once Daily in the Treatment of Male Patients With Androgenetic Alopecia: An Open‐Label and Global Photographic Assessment","journal-title":"Dermatology and Therapy (Heidelberg)","doi-asserted-by":"crossref"},{"DOI":"10.4103/ijdvl.IJDVL_589_18","key":"e_1_2_11_26_1","year":"2020","issue":"2","author":"Singh S. K.","volume":"86","first-page":"150","unstructured":null,"article-title":"Comparison of Efficacy of Platelet‐Rich Plasma Therapy With or Without Topical 5% Minoxidil in Male‐Type Baldness: A Randomized, Double‐Blind Placebo Control Trial","journal-title":"Indian Journal of Dermatology, Venereology and Leprology","doi-asserted-by":"crossref"},{"DOI":"10.4103/0378-6323.188652","key":"e_1_2_11_27_1","year":"2017","issue":"1","author":"Shanshanwal S. J.","volume":"83","first-page":"47","unstructured":null,"article-title":"Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open‐Label, Evaluator‐Blinded Study","journal-title":"Indian Journal of Dermatology, Venereology and Leprology","doi-asserted-by":"crossref"},{"DOI":"10.1111/jocd.12265","key":"e_1_2_11_28_1","year":"2016","issue":"4","author":"Ablon G.","volume":"15","first-page":"358","unstructured":null,"article-title":"A 6‐Month, Randomized, Double‐Blind, Placebo‐Controlled Study Evaluating the Ability of a Marine Complex Supplement to Promote Hair Growth in Men With Thinning Hair","journal-title":"Journal of Cosmetic Dermatology","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_29_1","year":"2015","issue":"1","author":"Panahi Y.","volume":"13","first-page":"15","unstructured":null,"article-title":"Rosemary Oil vs Minoxidil 2% for the Treatment of Androgenetic Alopecia: A Randomized Comparative Trial","journal-title":"Skinmed","doi-asserted-by":null},{"DOI":"10.1016/j.jaad.2013.10.049","key":"e_1_2_11_30_1","year":"2014","issue":"3","author":"Gubelin Harcha W.","volume":"70","first-page":"489","unstructured":null,"article-title":"A Randomized, Active‐ and Placebo‐Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects With Androgenetic Alopecia","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaad.2009.09.018","key":"e_1_2_11_31_1","year":"2010","issue":"2","author":"Eun H. C.","volume":"63","first-page":"252","unstructured":null,"article-title":"Efficacy, Safety, and Tolerability of Dutasteride 0.5 Mg Once Daily in Male Patients With Male Pattern Hair Loss: A Randomized, Double‐Blind, Placebo‐Controlled, Phase III Study","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.4103/0378-6323.45220","key":"e_1_2_11_32_1","year":"2009","issue":"1","author":"Hajheydari Z.","volume":"75","first-page":"47","unstructured":null,"article-title":"Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of the Androgenetic Alopecia","journal-title":"Indian Journal of Dermatology, Venereology and Leprology","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1473-2165.2005.00199.x","key":"e_1_2_11_33_1","year":"2005","issue":"4","author":"Takahashi T.","volume":"4","first-page":"245","unstructured":null,"article-title":"Investigation of the Topical Application of Procyanidin Oligomers From Apples to Identify Their Potential Use as a Hair‐Growing Agent","journal-title":"Journal of Cosmetic Dermatology","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_34_1","year":"1999","issue":"4","author":"Roberts J. L.","volume":"41","first-page":"555","unstructured":null,"article-title":"Clinical Dose Ranging Studies With Finasteride, a Type 2 5α‐Reductase Inhibitor, in Men With Male Pattern Hair Loss","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":null},{"DOI":"10.1016/S0190-9622(98)70007-6","key":"e_1_2_11_35_1","year":"1998","issue":"4","author":"Kaufman K. D.","volume":"39","first-page":"578","unstructured":null,"article-title":"Finasteride in the Treatment of Men With Androgenetic Alopecia. Finasteride Male Pattern Hair Loss Study Group","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1159/000017954","key":"e_1_2_11_36_1","year":"1998","issue":"4","author":"Pierard‐Franchimont C.","volume":"196","first-page":"474","unstructured":null,"article-title":"Ketoconazole Shampoo: Effect of Long‐Term Use in Androgenic Alopecia","journal-title":"Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1742-1241.1999.tb11660.x","key":"e_1_2_11_37_1","year":"1999","issue":"1","author":"Rushton D. H.","volume":"53","first-page":"50","unstructured":null,"article-title":"Androgenetic Alopecia in Men: The Scale of the Problem and Prospects for Treatment","journal-title":"International Journal of Clinical Practice","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1365-4362.1988.tb00006.x","key":"e_1_2_11_38_1","year":"1988","issue":null,"author":"Anderson C.","volume":"27","first-page":"447","unstructured":null,"article-title":"Topical Minoxidil in Androgenetic Alopecia Scandinavian and Middle East Experience","journal-title":"International Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1365-4362.1988.tb00004.x","key":"e_1_2_11_39_1","year":"1988","issue":null,"author":"Dutrée‐Meulenberg R.","volume":"27","first-page":"435","unstructured":null,"article-title":"Treatment of Male Pattern Alopecia Using Topical Minoxidil in The Netherlands","journal-title":"International Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1365-4362.1988.tb00003.x","key":"e_1_2_11_40_1","year":"1988","issue":null,"author":"Petzoldt D.","volume":"27","first-page":"430","unstructured":null,"article-title":"The German Double‐Blind Placebo‐Controlled Evaluation of Topical Minoxidil Solution in the Treatment of Early Male Pattern Baldness","journal-title":"International Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1159/000248902","key":"e_1_2_11_41_1","year":"1987","issue":"2","author":"Civatte J.","volume":"175","first-page":"42","unstructured":null,"article-title":"2% Topical Minoxidil Solution in Male‐Pattern Baldness: Preliminary European Results","journal-title":"Dermatologica","doi-asserted-by":"crossref"},{"DOI":"10.1016/S0190-9622(86)70138-2","key":"e_1_2_11_42_1","year":"1986","issue":"1","author":"Olsen E. A.","volume":"15","first-page":"30","unstructured":null,"article-title":"Dose‐Response Study of Topical Minoxidil in Male Pattern Baldness","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/ajd.12352","key":"e_1_2_11_43_1","year":"2016","issue":"3","author":"Wessagowit V.","volume":"57","first-page":"e76","unstructured":null,"article-title":"Treatment of Male Androgenetic Alopecia With Topical Products Containing S Erenoa Repens Extract","journal-title":"Australasian Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.4103/0974-7753.111199","key":"e_1_2_11_44_1","year":"2012","issue":"4","author":"Fischer T. W.","volume":"4","first-page":"236","unstructured":null,"article-title":"Topical Melatonin for Treatment of Androgenetic Alopecia","journal-title":"International Journal of Trichology","doi-asserted-by":"crossref"},{"DOI":"10.18549/PharmPract.2017.01.943","key":"e_1_2_11_45_1","year":"2017","issue":"1","author":"Tonin F. S.","volume":"15","first-page":"943","unstructured":null,"article-title":"Network Meta‐Analysis: A Technique to Gather Evidence From Direct and Indirect Comparisons","journal-title":"Pharmacy Practice (Granada)","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_46_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"FDA “FDA Alerts Health Care Providers Compounders and Consumers of Potential Risks Associated With Compounded Topical Finasteride Products ” (2025) https://www.drugs.com/fda/fda‐alerts‐health‐care‐providers‐compounders‐consumers‐potential‐risks‐associated‐compounded‐14740.html.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.25259/jcas_44_23","key":"e_1_2_11_47_1","year":"2024","issue":"3","author":"Nirmal B.","volume":"17","first-page":"189","unstructured":null,"article-title":"Efficacy and Safety of Microneedling Radiofrequency in Patterned Hair Loss","journal-title":"Journal of Cutaneous and Aesthetic Surgery","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_48_1","year":"2016","issue":null,"author":"Koyama T.","volume":"16","first-page":null,"unstructured":null,"article-title":"Standardized Scalp Massage Results in Increased Hair Thickness by Inducing Stretching Forces to Dermal Papilla Cells in the Subcutaneous Tissue","journal-title":"Eplasty","doi-asserted-by":null},{"DOI":null,"key":"e_1_2_11_49_1","year":"2021","issue":"11","author":"Lueangarun S.","volume":"14","first-page":"E64","unstructured":null,"article-title":"A Systematic Review and Meta‐Analysis of Randomized Controlled Trials of United States Food and Drug Administration‐Approved, Home‐Use, Low‐Level Light/Laser Therapy Devices for Pattern Hair Loss: Device Design and Technology","journal-title":"Journal of Clinical and Aesthetic Dermatology","doi-asserted-by":null},{"DOI":"10.1111/dth.15323","key":"e_1_2_11_50_1","year":"2022","issue":"4","author":"Gupta A. K.","volume":"35","first-page":null,"unstructured":null,"article-title":"Natural Products for Male Androgenetic Alopecia","journal-title":"Dermatologic Therapy","doi-asserted-by":"crossref"},{"DOI":"10.1016/S0944-7113(00)80040-9","key":"e_1_2_11_51_1","year":"2000","issue":"6","author":"Kamimura A.","volume":"7","first-page":"529","unstructured":null,"article-title":"Investigation of Topical Application of Procyanidin B‐2 From Apple to Identify Its Potential Use as a Hair Growing Agent","journal-title":"Phytomedicine","doi-asserted-by":"crossref"},{"DOI":"10.1111/jocd.14299","key":"e_1_2_11_52_1","year":"2022","issue":"1","author":"Dhurat R.","volume":"21","first-page":"343","unstructured":null,"article-title":"SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth","journal-title":"Journal of Cosmetic Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/jdv.16765","key":"e_1_2_11_53_1","year":"2021","issue":"1","author":"Ramos P. M.","volume":"35","first-page":"e24","unstructured":null,"article-title":"Minoxidil Sulfotransferase Enzyme (SULT1A1) Genetic Variants Predicts Response to Oral Minoxidil Treatment for Female Pattern Hair Loss","journal-title":"Journal of the European Academy of Dermatology and Venereology","doi-asserted-by":"crossref"},{"DOI":"10.5114/ada.2020.99947","key":"e_1_2_11_54_1","year":"2022","issue":"3","author":"Pietrauszka K.","volume":"39","first-page":"472","unstructured":null,"article-title":"Sulfotransferase SULT1A1 Activity in Hair Follicle, a Prognostic Marker of Response to the Minoxidil Treatment in Patients With Androgenetic Alopecia: A Review","journal-title":"Postepy Dermatologii I Alergologii","doi-asserted-by":"crossref"},{"DOI":"10.1001/jamadermatol.2021.5743","key":"e_1_2_11_55_1","year":"2022","issue":"3","author":"Gupta A. K.","volume":"158","first-page":"266","unstructured":null,"article-title":"Relative Efficacy of Minoxidil and the 5‐Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients: A Network Meta‐Analysis","journal-title":"JAMA Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1159/000538621","key":"e_1_2_11_56_1","year":"2024","issue":"4","author":"Starace M. V. R.","volume":"10","first-page":"293","unstructured":null,"article-title":"The Comparative Effects of Monotherapy With Topical Minoxidil, Oral Finasteride, and Topical Finasteride in Postmenopausal Women With Pattern Hair Loss: A Retrospective Cohort Study","journal-title":"Skin Appendage Disorders","doi-asserted-by":"crossref"},{"DOI":"10.1111/jocd.13976","key":"e_1_2_11_57_1","year":"2021","issue":"9","author":"Ibrahim I. M.","volume":"20","first-page":"2867","unstructured":null,"article-title":"Pumpkin Seed Oil vs. Minoxidil 5% Topical Foam for the Treatment of Female Pattern Hair Loss: A Randomized Comparative Trial","journal-title":"Journal of Cosmetic Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1248/bpb.b15-00387","key":"e_1_2_11_58_1","year":"2015","issue":"12","author":"Choi J. S.","volume":"38","first-page":"1856","unstructured":null,"article-title":"Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16‐Week Double‐Blind Randomized Controlled Trial","journal-title":"Biological & Pharmaceutical Bulletin","doi-asserted-by":"crossref"},{"DOI":"10.1007/978-3-031-74314-6","key":"e_1_2_11_59_1","year":"2024","issue":null,"author":"Panagotacos P. J.","volume":null,"first-page":"1","unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"crossref"}],"short-title":[],"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1111/jocd.70483"],"article-number":"e70483","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Journal of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,10]]},"reference-count":58,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2025,10,6]]},"references-count":58,"short-container-title":["J of Cosmetic Dermatology"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1111/jocd.70483","is_oa":true,"title":"Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study","updated":"2025-10-11T00:07:04+00:00","published_date":"2025-10-01","best_oa_location":{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.70483","pmh_id":null,"url_for_pdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.70483","url_for_landing_page":"https://doi.org/10.1111/jocd.70483"}}},"created_at":"2025-10-13T07:32:37.233Z","updated_at":"2025-10-19T07:07:31.491Z","tags":[{"paper_doi":"10.1111/jocd.70483","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"condition","value":"Androgenetic Alopecia","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"dutasteride","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"finasteride","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"ketoconazole","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"melatonin","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"minoxidil","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"procyanidin","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"rosemary oil","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"saw palmetto","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"watercress extract","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"modality","value":"5-Alpha Reductase Inhibitor","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"modality","value":"Botanical","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"modality","value":"Nutraceutical","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"modality","value":"Topical Minoxidil","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"sex","value":"male","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"study_design","value":"Network Meta-Analysis","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"warning","value":"A fixed‑effect model was used; between‑study heterogeneity was not modeled.","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"warning","value":"Some node‑splitting comparisons showed p<0.05 (inconsistency) despite the statement that most comparisons were consistent.","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"warning","value":"The manuscript alternately cites 24 vs 25 included trials, creating uncertainty about the exact study count.","value_numeric":null}],"summaries":{"what_studied":"A Bayesian fixed‑effect network meta‑analysis compared eight conventional monotherapies with seven over‑the‑counter alternatives for male androgenetic alopecia, using 24‑week change in total hair density (hairs/cm²) as the outcome after searches of PubMed and Scopus on April 30, 2025.","key_result":"Dutasteride 0.5 mg (oral) ranked highest (SUCRA 95.8% base; 94% severity‑adjusted). Versus control, network estimates showed mean hair density gains at 24 weeks for minoxidil 5% topical: +20.0 hairs/cm² (95% CrI 3.7 to 41.0), dutasteride 0.5 mg oral: +19.0 (9.5 to 28.0), finasteride 0.25% topical: +15.0 (0.85 to 30.0), and finasteride 1 mg oral: +12.0 (4.20 to 19.0); OTC agents ranked mid to low (e.g., rosemary topical SUCRA 53.6%; melatonin topical 55.4%; saw palmetto topical 14.1%).","limitations":"Efficacy was assessed only at 24 weeks; baseline disease duration was not accounted for. Many alternative‑agent trials enrolled relatively small numbers, and several studies showed risk‑of‑bias concerns. Network geometry limited some node‑splitting inconsistency assessments.","practice_takeaway":"At 6 months, dutasteride 0.5 mg daily ranks highest for increasing hair density, with finasteride (oral/topical) and topical minoxidil also outperforming control by clinically meaningful margins. OTC options like topical rosemary and melatonin show modest relative efficacy, while saw palmetto ranks low—use these data to set expectations when discussing nonprescription alternatives."}}],"initialOffset":3,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"generic","value":"finasteride"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Generics","href":"/hub/tag/generic"},{"name":"finasteride"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"generic","hub_tag_value":"finasteride"}}}]]

Papers