2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:Te03,New primary preventive therapeutic strategies for atopic dermatitis (AD) are needed. Atopic diseases are associated with disrupted gut microbial balance in early life, suggesting that optimizing microflora through intervention could improve health. Prebiotics, which are immunomodulatory sugars, promote gut microbiota diversity. Most clinical trials focus on improving postnatal infant gut colonization, but prenatal life is crucial for establishing tolerance mechanisms. Preclinical studies indicate that maternal intake of galacto-oligosaccharide (GOS)/inulin prebiotics decreases the risk of food allergy in offspring. To determine whether antenatal prebiotic intake prevents AD in children at high risk of atopy. The multicentre double-blind randomized PREGRALL clinical trial ran from February 2018 to April 2023 (ClinicalTrials.gov NCT03183440). The follow-up period extended from 20 weeks of amenorrhoea in pregnant women to their infants reaching 1 year of age. Women with a physician-diagnosed history of atopy (asthma, allergic rhinitis, AD or food allergy) were selected for inclusion. The women were randomized to daily prebiotic GOS/inulin (n = 188) or placebo (maltodextrin; n = 188 participants) intake from 20 weeks' gestation until delivery. The first outcome was the occurrence of AD at 1 year in children at risk of the disease. Secondary endpoints included AD severity, quality of life, prebiotic tolerance and the prevalence of other atopic diseases. Of 376 pregnant women included in the trial, prebiotic supplementation did not prevent AD at 1 year (intention-to-treat population odds ratio 1.01, 95% confidence interval 0.59-1.74; P = 0.97) or reduce disease severity in their children. Subgroup analyses by breastfeeding status or delivery mode revealed no differences. No effects on allergen sensitization or food allergies were found. We found no evidence that maternal intervention with prebiotics protects against AD at 1 year of age in infants at risk of allergic diseases. Atopic dermatitis is a skin condition that causes skin to become red, itchy and inflamed. It is also known as eczema. The condition affects 1 in 5 children worldwide. In France, a team of specialists at a number of university hospitals ran a clinical trial called ‘PREGRALL’. The trial was designed to find out whether giving pregnant women daily prebiotics could lower the chances of eczema in their babies. Between February 2018 and April 2023, 376 pregnant women who had asthma, hay fever, eczema or food allergies were split into two groups. From 20 weeks of pregnancy until they gave birth, women in one group took the prebiotic mix each day. A prebiotic is a type of dietary fibre that feeds good bacteria in the gut. Women in the other group took a harmless dummy drug (‘placebo’) that looked the same as the prebiotic. Neither the doctors nor the mothers knew who was taking the prebiotic or the placebo. When the babies were 1 year old, doctors checked how many had eczema, how severe it was and whether they had any other allergies. We found there was no difference. Babies whose mothers had taken prebiotics when they were pregnant developed eczema just as often and just as severely as those whose mothers had taken the placebo. There were also no changes in food allergies or skin test reactions. Our findings suggest that taking prebiotics during pregnancy alone does not prevent eczema in babies at high risk of the condition. Future studies will need to explore a combination of strategies to find effective ways to prevent eczema before it starts.31:Taf5,Abstract Background New primary preventive therapeutic strategies for atopic dermatitis (AD) are needed. Atopic diseases are associated with disrupted gut microbial balance in early life, suggesting that optimizing microflora through intervention could improve health. Prebiotics, which are immunomodulatory sugars, promote gut microbiota diversity. Most clinical trials focus on improving postnatal infant gut colonization, but prenatal life is crucial for establishing tolerance mechanisms. Preclinical studies indicate that maternal intake of galacto-oligosaccharide (GOS)/inulin prebiotics decreases the risk of food allergy in offspring. Objectives To determine whether antenatal prebiotic intake prevents AD in children at high risk of atopy. Methods The multicentre double-blind randomized PREGRALL clinical trial ran from February 2018 to April 2023 (ClinicalTrials.gov NCT03183440). The follow-up period extended from 20 weeks of amenorrhoea in pregnant women to their infants reaching 1 year of age. Women with a physician-diagnosed history of atopy (asthma, allergic rhinitis, AD or food allergy) were selected for inclusion. The women were randomized to daily prebiotic GOS/inulin (n = 188) or placebo (maltodextrin; n = 188 participants) intake from 20 weeks’ gestation until delivery. The first outcome was the occurrence of AD at 1 year in children at risk of the disease. Secondary endpoints included AD severity, quality of life, prebiotic tolerance and the prevalence of other atopic diseases. Results Of 376 pregnant women included in the trial, prebiotic supplementation did not prevent AD at 1 year (intention-to-treat population odds ratio 1.01, 95% confidence interval 0.59–1.74; P = 0.97) or reduce disease severity in their children. Subgroup analyses by breastfeeding status or delivery mode revealed no differences. No effects on allergen sensitization or food allergies were found. Conclusions We found no evidence that maternal intervention with prebiotics protects against AD at 1 year of age in infants at risk of allergic diseases. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"galacto-oligosaccharide: generic Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on galacto-oligosaccharide (generic). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/generic/galacto-oligosaccharide\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Generics\",\"item\":\"https://www.reachrx.ai/hub/tag/generic\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"galacto-oligosaccharide\",\"item\":\"https://www.reachrx.ai/hub/tag/generic/galacto-oligosaccharide\"}]}}"}}]],["$","$L2f",null,{"title":"galacto-oligosaccharide: Research & Clinical Takeaways","description":"Explore research on galacto-oligosaccharide (generic) — efficacy, safety, and comparative data.","papers":[{"doi":"10.1093/bjd/ljaf414","pmid":"41250898","title":"Evaluation of antenatal prebiotic intake in infants at risk of atopy: the double-blind PREGRALL randomized clinical trial","journal_title":"British Journal of Dermatology","journal_issn":"0007-0963","published_at":"2025-11-18T00:00:00.000Z","url":"https://doi.org/10.1093/bjd/ljaf414","source_score":10,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-11-22","doi":"10.1093/bjd/ljaf414","days":"7","issn":"0007-0963","rank":"1","field":"Clinical Medicine","score":"10","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1093/bjd/ljaf414","title":"Evaluation of antenatal prebiotic intake in infants at risk of atopy: the double-blind PREGRALL randomized clinical trial.","journal":"The British journal of dermatology","methods":"","results":"Of 376 pregnant women included in the trial, prebiotic supplementation did not prevent AD at 1 year (intention-to-treat population odds ratio 1.01, 95% confidence interval 0.59-1.74; P = 0.97) or reduce disease severity in their children. Subgroup analyses by breastfeeding status or delivery mode revealed no differences. No effects on allergen sensitization or food allergies were found.","abstract":"$30","keywords":[],"pubmed_id":"41250898","conclusions":"","publication_date":"2025-11-18T00:00:00"},"crossref":{"DOI":"10.1093/bjd/ljaf414","URL":"https://doi.org/10.1093/bjd/ljaf414","ISSN":["0007-0963","1365-2133"],"link":[{"URL":"https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljaf414/65366060/ljaf414.pdf","content-type":"application/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljaf414/65366060/ljaf414.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Evaluation of antenatal prebiotic intake in infants at risk of atopy: the double-blind PREGRALL randomized clinical trial"],"author":[{"given":"Sébastien","family":"Barbarot","sequence":"first","affiliation":[{"name":"INRAE Pays de la Loire, Phan , Nantes ,"},{"name":"CHU Nantes, Nantes Université, INSERM, Service de Dermatologie , CIC 1413, Nantes ,"}]},{"given":"Hélène","family":"Aubert","sequence":"additional","affiliation":[{"name":"CHU Nantes, Nantes Université, INSERM, Service de Dermatologie , CIC 1413, Nantes ,"}]},{"given":"Marion","family":"Boivin","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire De Nantes, CIC Femmes Enfants Adolescents , Nantes ,"}]},{"given":"Aurore","family":"Foureau","sequence":"additional","affiliation":[{"name":"CHU Nantes, Nantes Université, INSERM, Service de Dermatologie , CIC 1413, Nantes ,"}]},{"given":"Annabel","family":"Maruani","sequence":"additional","affiliation":[{"name":"Université de Tours, CHRU de Tours, Inserm1246-SPHERE, Service de Dermatologie et CIC Inserm 1415 , Tours ,"}]},{"given":"Catherine","family":"Droitcourt","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Rennes, Chu Pontchaillou, Service De Dermatologie , Rennes ,"}]},{"given":"Juliette","family":"Mazereeuw-Hautier","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Toulouse, Hôpital Larrey, Service De Dermatologie , Toulouse ,"}]},{"given":"Elodie","family":"Faurel-Paul","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire De Nantes, Direction Recherche et Innovation , Nantes ,"}]},{"given":"Aurélie","family":"Le Thuaut","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire De Nantes, Direction Recherche et Innovation, Plateforme De Méthodologie et Biostatistique , Nantes ,"}]},{"given":"Martine","family":"Tching-Sin","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire De Nantes, Service De Pharmacie , Nantes ,"}]},{"given":"Vincent","family":"Dochez","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire De Nantes, Service de Gynécologie Obstétrique, CIC Femmes Enfants Adolescents , Nantes ,"}]},{"given":"Carole","family":"Brosseau","sequence":"additional","affiliation":[{"name":"INRAE Pays De La Loire , UR 1268 BIA, Nantes ,"}]},{"given":"Marie","family":"Bodinier","sequence":"additional","affiliation":[{"name":"INRAE Pays De La Loire , UR 1268 BIA, Nantes ,"}]}],"issued":{"date-parts":[[2025,11,18]]},"member":"286","prefix":"10.1093","source":"Crossref","volume":null,"created":{"date-time":"2025-11-18T09:12:42Z","timestamp":1763457162000,"date-parts":[[2025,11,18]]},"indexed":{"date-time":"2025-11-21T07:40:24Z","timestamp":1763710824888,"date-parts":[[2025,11,21]]},"license":[{"URL":"https://academic.oup.com/pages/standard-publication-reuse-rights","start":{"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000,"date-parts":[[2025,11,18]]},"delay-in-days":0,"content-version":"am"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://academic.oup.com/bjd/advance-article/doi/10.1093/bjd/ljaf414/8326321"}},"subtitle":[],"deposited":{"date-time":"2025-11-21T07:36:38Z","timestamp":1763710598000,"date-parts":[[2025,11,21]]},"issn-type":[{"type":"print","value":"0007-0963"},{"type":"electronic","value":"1365-2133"}],"published":{"date-parts":[[2025,11,18]]},"publisher":"Oxford University Press (OUP)","reference":[{"DOI":"10.1016/j.anai.2020.12.020","key":"2025112102362748900_ljaf414-B1","year":"2021","issue":null,"author":"Silverberg","volume":"126","first-page":"417","unstructured":null,"article-title":"Atopic dermatitis in the pediatric population","journal-title":"Ann Allergy Asthma Immunol","doi-asserted-by":"crossref"},{"DOI":"10.1093/bjd/ljad339","key":"2025112102362748900_ljaf414-B2","year":"2023","issue":null,"author":"Tian","volume":"190","first-page":"55","unstructured":null,"article-title":"Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study","journal-title":"Br J Dermatol","doi-asserted-by":"crossref"},{"DOI":"10.1111/all.12268","key":"2025112102362748900_ljaf414-B3","year":"2014","issue":null,"author":"Dharmage","volume":"69","first-page":"17","unstructured":null,"article-title":"Atopic dermatitis and the atopic march revisited","journal-title":"Allergy","doi-asserted-by":"crossref"},{"DOI":"10.1016/S0140-6736(20)31286-1","key":"2025112102362748900_ljaf414-B4","year":"2020","issue":null,"author":"Langan","volume":"396","first-page":"345","unstructured":null,"article-title":"Atopic dermatitis","journal-title":"Lancet","doi-asserted-by":"crossref"},{"DOI":"10.1186/s12890-025-03518-y","key":"2025112102362748900_ljaf414-B5","year":"2025","issue":null,"author":"Zheng","volume":"25","first-page":"54","unstructured":null,"article-title":"Global, regional, and national epidemiology of allergic diseases in children from 1990 to 2021: findings from the Global Burden of Disease Study 2021","journal-title":"BMC Pulm Med","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaip.2024.04.048","key":"2025112102362748900_ljaf414-B6","year":"2024","issue":null,"author":"Chu","volume":"12","first-page":"1695","unstructured":null,"article-title":"How to prevent atopic dermatitis (eczema) in 2024: theory and evidence","journal-title":"J Allergy Clin Immunol Pract","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaci.2024.10.036","key":"2025112102362748900_ljaf414-B7","year":"2025","issue":null,"author":"Lee","volume":"155","first-page":"557","unstructured":null,"article-title":"Developmental trajectories of atopic dermatitis with multiomics approaches in the infant gut: COCOA birth cohort","journal-title":"J Allergy Clin Immunol","doi-asserted-by":"crossref"},{"DOI":"10.1111/all.12777","key":"2025112102362748900_ljaf414-B8","year":"2016","issue":null,"author":"Bouchaud","volume":"71","first-page":"68","unstructured":null,"article-title":"Maternal exposure to GOS/inulin mixture prevents food allergies and promotes tolerance in offspring in mice","journal-title":"Allergy","doi-asserted-by":"crossref"},{"DOI":"10.3389/fimmu.2021.745535","key":"2025112102362748900_ljaf414-B9","year":"2021","issue":null,"author":"Selle","volume":"12","first-page":"745535","unstructured":null,"article-title":"Prebiotic supplementation during gestation induces a tolerogenic environment and a protective microbiota in offspring mitigating food allergy","journal-title":"Front Immunol","doi-asserted-by":"crossref"},{"DOI":"10.3945/jn.114.197707","key":"2025112102362748900_ljaf414-B10","year":"2015","issue":null,"author":"Hogenkamp","volume":"145","first-page":"640","unstructured":null,"article-title":"Supplementing pregnant mice with a specific mixture of nondigestible oligosaccharides reduces symptoms of allergic asthma in male offspring","journal-title":"J Nutr","doi-asserted-by":"crossref"},{"DOI":"10.1017/S000711450999198X","key":"2025112102362748900_ljaf414-B11","year":"2010","issue":null,"author":"Fujiwara","volume":"103","first-page":"530","unstructured":null,"article-title":"Maternal consumption of fructo-oligosaccharide diminishes the severity of skin inflammation in offspring of NC/Nga mice","journal-title":"Br J Nutr","doi-asserted-by":"crossref"},{"DOI":"10.1371/journal.pmed.1002507","key":"2025112102362748900_ljaf414-B12","year":"2018","issue":null,"author":"Garcia-Larsen","volume":"15","first-page":"e1002507","unstructured":null,"article-title":"Diet during pregnancy and infancy and risk of allergic or autoimmune disease: a systematic review and meta-analysis","journal-title":"PLoS Med","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaci.2024.08.009","key":"2025112102362748900_ljaf414-B13","year":"2025","issue":null,"author":"Palmer","volume":"155","first-page":"144","unstructured":null,"article-title":"Effects of pregnancy and lactation prebiotics supplementation on infant allergic disease: a randomized controlled trial","journal-title":"J Allergy Clin Immunol","doi-asserted-by":"crossref"},{"DOI":"10.1136/bmjopen-2018-024974","key":"2025112102362748900_ljaf414-B14","year":"2019","issue":null,"author":"Cabridain","volume":"9","first-page":"e024974","unstructured":null,"article-title":"Effectiveness of an antenatal maternal supplementation with prebiotics for preventing atopic dermatitis in high-risk children (the PREGRALL study): protocol for a randomised controlled trial","journal-title":"BMJ Open","doi-asserted-by":"crossref"},{"DOI":null,"key":"2025112102362748900_ljaf414-B15","year":"2010","issue":null,"author":"Schulz","volume":"8","first-page":"604","unstructured":null,"article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","journal-title":"BMJ","doi-asserted-by":null},{"DOI":"10.1079/BJN19970141","key":"2025112102362748900_ljaf414-B16","year":"1997","issue":null,"author":"Pedersen","volume":"78","first-page":"215","unstructured":null,"article-title":"The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females","journal-title":"Br J Nutr","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1365-2133.1994.tb08530.x","key":"2025112102362748900_ljaf414-B17","year":"1994","issue":null,"author":"Williams","volume":"131","first-page":"383","unstructured":null,"article-title":"The U.K. Working Party’s Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis","journal-title":"Br J Dermatol","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaci.2012.01.075","key":"2025112102362748900_ljaf414-B18","year":"2012","issue":null,"author":"Simpson","volume":"130","first-page":"137","unstructured":null,"article-title":"How should an incident case of atopic dermatitis be defined? A systematic review of primary prevention studies","journal-title":"J Allergy Clin Immunol","doi-asserted-by":"crossref"},{"DOI":"10.1183/09031936.95.08030483","key":"2025112102362748900_ljaf414-B19","year":"1995","issue":null,"author":"Asher","volume":"8","first-page":"483","unstructured":null,"article-title":"International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods","journal-title":"Eur Respir J","doi-asserted-by":"crossref"},{"DOI":null,"key":"2025112102362748900_ljaf414-B20","year":"1993","issue":null,"author":"Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis","volume":"186","first-page":"23","unstructured":null,"article-title":null,"journal-title":"Dermatol Basel Switz","doi-asserted-by":null},{"DOI":"10.1001/archderm.140.12.1513","key":"2025112102362748900_ljaf414-B21","year":"2004","issue":null,"author":"Charman","volume":"140","first-page":"1513","unstructured":null,"article-title":"The Patient-Oriented Eczema Measure: development and initial validation of a new tool for measuring atopic eczema severity from the patients’ perspective","journal-title":"Arch Dermatol","doi-asserted-by":"crossref"},{"DOI":"10.1093/bjd/ljad497","key":"2025112102362748900_ljaf414-B22","year":"2024","issue":null,"author":"Thomas","volume":"190","first-page":"527","unstructured":null,"article-title":"How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide","journal-title":"Br J Dermatol","doi-asserted-by":"crossref"},{"DOI":null,"key":"2025112102362748900_ljaf414-B23","year":"2012","issue":null,"author":"Kramer","volume":"9","first-page":"CD000133","unstructured":null,"article-title":"Maternal dietary antigen avoidance during pregnancy or lactation, or both, for preventing or treating atopic disease in the child","journal-title":"Cochrane Database Syst Rev","doi-asserted-by":null},{"DOI":"10.1016/j.clnu.2024.02.030","key":"2025112102362748900_ljaf414-B24","year":"2024","issue":null,"author":"Jones","volume":"43","first-page":"969","unstructured":null,"article-title":"Maternal prebiotic supplementation during pregnancy and lactation modifies the microbiome and short chain fatty acid profile of both mother and infant","journal-title":"Clin Nutr","doi-asserted-by":"crossref"},{"DOI":"10.1016/S0140-6736(24)02519-4","key":"2025112102362748900_ljaf414-B25","year":"2025","issue":null,"author":"Guttman-Yassky","volume":"405","first-page":"583","unstructured":null,"article-title":"Atopic dermatitis","journal-title":"Lancet","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1365-2133.2006.07617.x","key":"2025112102362748900_ljaf414-B26","year":"2007","issue":null,"author":"Basra","volume":"156","first-page":"528","unstructured":null,"article-title":"The Family Dermatology Life Quality Index: measuring the secondary impact of skin disease","journal-title":"Br J Dermatol","doi-asserted-by":"crossref"},{"DOI":"10.1016/S2666-5247(24)00040-5","key":"2025112102362748900_ljaf414-B27","year":"2024","issue":null,"author":"Piewngam","volume":"5","first-page":"e606","unstructured":null,"article-title":"Staphylococcus aureus colonisation and strategies for decolonisation","journal-title":"Lancet Microbe","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.tim.2019.01.008","key":"2025112102362748900_ljaf414-B28","year":"2019","issue":null,"author":"Parlet","volume":"27","first-page":"497","unstructured":null,"article-title":"Commensal staphylococci influence Staphylococcus aureus skin colonization and disease","journal-title":"Trends Microbiol","doi-asserted-by":"crossref"}],"short-title":[],"article-number":"ljaf414","content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["British Journal of Dermatology"],"reference-count":28,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2025,11,18]]},"references-count":28,"short-container-title":[],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1093/bjd/ljaf414","is_oa":false,"title":"Evaluation of antenatal prebiotic intake in infants at risk of atopy: the double-blind PREGRALL randomized clinical trial","updated":"2025-11-19T00:48:40+00:00","published_date":"2025-11-18","best_oa_location":null}},"created_at":"2025-11-29T07:06:31.192Z","updated_at":"2025-11-29T07:06:31.192Z","tags":[{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"age_group","value":"infant","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"condition","value":"Atopic Dermatitis","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"condition","value":"Food Allergy","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"generic","value":"galacto-oligosaccharide","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"generic","value":"inulin","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"modality","value":"Prebiotic","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"sample_size","value":"n=376","value_numeric":376},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"warning","value":"Absolute event rates are not reported; only an odds ratio is provided in the abstract.","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"warning","value":"Adherence, dosing details, and AD diagnostic criteria are not provided in the abstract.","value_numeric":null},{"paper_doi":"10.1093/bjd/ljaf414","tag_type":"warning","value":"Outcomes are limited to age 1 year; longer-term effects are not described in the abstract.","value_numeric":null}],"summaries":{"what_studied":"A multicentre double-blind randomized trial (PREGRALL) assigned 376 pregnant women with physician-diagnosed atopy to daily galacto-oligosaccharide/inulin prebiotics vs placebo from 20 weeks’ gestation until delivery, assessing atopic dermatitis (AD) occurrence at age 1 year in their infants.","key_result":"Prebiotics did not reduce AD at 1 year (intention-to-treat OR 1.01, 95% CI 0.59–1.74; P=0.97) and did not lessen AD severity; no subgroup differences by breastfeeding or delivery mode, and no effects on allergen sensitization or food allergies.","practice_takeaway":"Maternal GOS/inulin prebiotics from mid-pregnancy to delivery did not prevent infant AD at 1 year or other atopic outcomes in high-risk families; routine antenatal prebiotic supplementation for AD prevention is not supported by these data."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"generic","value":"galacto-oligosaccharide"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Generics","href":"/hub/tag/generic"},{"name":"galacto-oligosaccharide"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"generic","hub_tag_value":"galacto-oligosaccharide"}}}]]

Papers