2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:Ta32,Rosacea is a highly prevalent dermatosis affecting 5% of the world's population. Its impact is not only physical but also psychological, as over 60% of patients with rosacea also suffer from depression, anxiety, and other psychological comorbidities. Currently, topical treatments yield low or unsatisfactory success rates, and rosacea complications such as disfigurement, burning sensation, and pain can greatly affect patients' well-being. Intra-dermotherapy with high molecular weight non-cross-linked hyaluronic acid plus succinic acid has shown anti-inflammatory, regenerative, and vascular modulatory effects. To evaluate the efficacy and effectiveness of high molecular weight non-cross-linked hyaluronic acid (HMWNCHA) plus succinic acid (SA) mesotherapy in rosacea patients who are not responding to topical treatments. To determine the degree of improvement in general parameters such as erythema, telangiectasia, and skin laxity and hydration. To compare the cost of this treatment with that of laser therapy, a widely used modality. We performed a non-randomized, controlled interventional study, and we evaluated the results after three sessions (once monthly) as the primary endpoint of this mesotherapy, using a product containing 1.1% of high molecular weight non-cross-linked hyaluronic acid plus 1.6% succinic acid (full face, 2 mL per session, administered using the papule technique) in a group of 20 male and female patients, aged 40-45 years, Fitzpatrick skin types I-III, without comorbidities. All patients were already undergoing topical treatment with Ivermectin 1%, Metronidazole 0.75%, and photoprotection, but without good results or clear improvement, quantified as a reduction in the Investigator's Global Assessment (IGA) severity score of at least 1 point. Erythema, hydration, and facial telangiectasia were evaluated at every session for proper quantification. Our study group was compared with a control group that only continued their topical treatment, and the study lasted 4 months, with a prospective follow-up at 6 months. Our results showed a reduction of 80% in the baseline erythema, an improvement of 30% in skin hydration, and a reduction of 20% in facial telangiectasia after three sessions, compared with patients who used only topical treatment. In addition, the costs were significantly lower than those of three sessions of laser therapy in a private healthcare setting. We demonstrated that using this acid combination in mesotherapy is an efficient, safe, and cost-effective adjunct therapy for patients already using a particular topical treatment.31:Tbd2,ABSTRACTBackgroundRosacea is a highly prevalent dermatosis affecting 5% of the world's population. Its impact is not only physical but also psychological, as over 60% of patients with rosacea also suffer from depression, anxiety, and other psychological comorbidities. Currently, topical treatments yield low or unsatisfactory success rates, and rosacea complications such as disfigurement, burning sensation, and pain can greatly affect patients' well‐being. Intra‐dermotherapy with high molecular weight non‐cross‐linked hyaluronic acid plus succinic acid has shown anti‐inflammatory, regenerative, and vascular modulatory effects.ObjectivesTo evaluate the efficacy and effectiveness of high molecular weight non‐cross‐linked hyaluronic acid (HMWNCHA) plus succinic acid (SA) mesotherapy in rosacea patients who are not responding to topical treatments. To determine the degree of improvement in general parameters such as erythema, telangiectasia, and skin laxity and hydration. To compare the cost of this treatment with that of laser therapy, a widely used modality.MethodsWe performed a non‐randomized, controlled interventional study, and we evaluated the results after three sessions (once monthly) as the primary endpoint of this mesotherapy, using a product containing 1.1% of high molecular weight non‐cross‐linked hyaluronic acid plus 1.6% succinic acid (full face, 2 mL per session, administered using the papule technique) in a group of 20 male and female patients, aged 40–45 years, Fitzpatrick skin types I–III, without comorbidities. All patients were already undergoing topical treatment with Ivermectin 1%, Metronidazole 0.75%, and photoprotection, but without good results or clear improvement, quantified as a reduction in the Investigator's Global Assessment (IGA) severity score of at least 1 point. Erythema, hydration, and facial telangiectasia were evaluated at every session for proper quantification. Our study group was compared with a control group that only continued their topical treatment, and the study lasted 4 months, with a prospective follow‐up at 6 months.ResultsOur results showed a reduction of 80% in the baseline erythema, an improvement of 30% in skin hydration, and a reduction of 20% in facial telangiectasia after three sessions, compared with patients who used only topical treatment. In addition, the costs were significantly lower than those of three sessions of laser therapy in a private healthcare setting.ConclusionWe demonstrated that using this acid combination in mesotherapy is an efficient, safe, and cost‐effective adjunct therapy for patients already using a particular topical treatment.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"hyaluronic acid + succinic acid: generic Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on hyaluronic acid + succinic acid (generic). Clinician-written summaries and actionable practice insights. 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biopsy.","value_numeric":null},{"paper_doi":"10.1111/jocd.70484","tag_type":"warning","value":"Group allocation was based on willingness and the study was unblinded, introducing selection and measurement bias.","value_numeric":null},{"paper_doi":"10.1111/jocd.70484","tag_type":"warning","value":"The timepoint for the reported 80% erythema reduction is inconsistent (described ‘after three sessions’ in the abstract vs ~80% at month 4 in the results).","value_numeric":null}],"summaries":{"what_studied":"Adults with moderate rosacea (n=40; ages 40–45; Fitzpatrick I–III) already on ivermectin 1% + metronidazole 0.75% were assigned to receive three monthly sessions of intradermal high–molecular‑weight non‑cross‑linked hyaluronic acid 1.1% plus succinic acid 1.6% (n=20) versus continuing topicals alone (n=20) over 4 months, with planned 6‑month follow‑up.","key_result":"By month 4, the mesotherapy group had ~80% reduction in erythema (p<0.01) versus stable levels in controls, nearly 80% higher skin hydration (p<0.01) versus 10–15% (NS) in controls, ~50% higher skin elasticity, and decreased telangiectasias from month 2 (p<0.01) with no change in controls. Patient symptoms improved (soreness 7.1±1.3 to 1.2±0.3; burning 8.3±2.3 to 2.3±1.2; itching 7.9±1.2 to 1.5±0.2; tingling 6.2±1.8 to 2.1±0.3; all p<0.05), adverse effects were minor with an overall incidence ≤45% across 60 procedures, and reported per‑session costs were lower than laser/IPL in a local survey.","limitations":"Nonrandomized, unblinded, single‑center study with small sample (n=40) and group assignment based on willingness, risking selection and measurement bias. Short follow‑up, no independent assessment or laser/IPL comparator, biopsy data from one patient, and cost data derived from a limited local survey without formal cost‑effectiveness analysis.","practice_takeaway":"As an adjunct to standard topicals after inadequate response, monthly HMWNCHA+SA mesotherapy improved erythema, hydration, elasticity, and symptoms versus continuing topicals, with only transient injection‑site reactions and lower reported costs than laser/IPL. If used, counsel patients on the preliminary, nonrandomized evidence base and the need for confirmatory randomized trials."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"generic","value":"hyaluronic acid + succinic acid"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Generics","href":"/hub/tag/generic"},{"name":"hyaluronic acid + succinic acid"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"generic","hub_tag_value":"hyaluronic acid + succinic acid"}}}]]

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