2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T583,Limited data exist on the use of novel iron therapies in children with chronic kidney disease (CKD). We conducted a cross-over study to compare iron polymaltose complex (IPC) and liposomal iron in pediatric patients with CKD and iron deficiency anemia (IDA). Cross-over study of 33 children with CKD and IDA was conducted. They were randomized into 2 groups (group A: 17 patients, group B: 16 patients) to receive either liposomal iron or IPC for 3 months. After an 8-week washout period, they were switched to the other therapy. Red cell and iron indices, as well as bone minerals and 25(OH)D Hb levels increased by at least 1 g/dL in 48% following liposomal iron therapy and 51.5% following IPC therapy. There was no statistically significant difference in ΔHb, ΔFe, ΔsTR (transferrin receptor), or ΔTSAT (transferrin saturation) levels between the groups (p > 0.05). By mixed model analysis, IPC showed a higher Hb and TSAT and lower TRresponse compared with liposomal iron. IPC, but not liposomal iron, led to a significant reduction in serum phosphorus in both groups. Thirty-six percent of IPC recipients experienced adverse effects, compared to 3% of liposomal iron recipients. Both IPC and liposomal iron effectively improved iron status in children with CKD and IDA. However, IPC indicated a superior response, whereas liposomal iron was associated with a more favorable tolerability profile.31:Ta0c,Abstract Background Limited data exist on the use of novel iron therapies in children with chronic kidney disease (CKD). We conducted a cross-over study to compare iron polymaltose complex (IPC) and liposomal iron in pediatric patients with CKD and iron deficiency anemia (IDA). Methods Cross-over study of 33 children with CKD and IDA was conducted. They were randomized into 2 groups (group A: 17 patients, group B: 16 patients) to receive either liposomal iron or IPC for 3 months. After an 8-week washout period, they were switched to the other therapy. Red cell and iron indices, as well as bone minerals and 25(OH)D 3 , were measured at baseline and after each 3-month period. A follow-up visit was conducted at 4 weeks during the treatment period to report any possible adverse events. Results Hb levels increased by at least 1 g/dL in 48% following liposomal iron therapy and 51.5% following IPC therapy. There was no statistically significant difference in ΔHb, ΔFe, ΔsTR (transferrin receptor), or ΔTSAT (transferrin saturation) levels between the groups ( p > 0.05). By mixed model analysis, IPC showed a higher Hb and TSAT and lower TRresponse compared with liposomal iron. IPC, but not liposomal iron, led to a significant reduction in serum phosphorus in both groups. Thirty-six percent of IPC recipients experienced adverse effects, compared to 3% of liposomal iron recipients. Conclusions Both IPC and liposomal iron effectively improved iron status in children with CKD and IDA. However, IPC indicated a superior response, whereas liposomal iron was associated with a more favorable tolerability profile. Graphical abstract 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"iron polymaltose complex: generic Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on iron polymaltose complex (generic). Clinician-written summaries and actionable practice insights. 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There was no statistically significant difference in ΔHb, ΔFe, ΔsTR (transferrin receptor), or ΔTSAT (transferrin saturation) levels between the groups (p > 0.05). By mixed model analysis, IPC showed a higher Hb and TSAT and lower TRresponse compared with liposomal iron. IPC, but not liposomal iron, led to a significant reduction in serum phosphorus in both groups. Thirty-six percent of IPC recipients experienced adverse effects, compared to 3% of liposomal iron recipients.","abstract":"$30","keywords":["CKD","Iron deficiency anemia","Iron polymaltose complex","Iron therapy","Liposomal iron","Pediatric"],"pubmed_id":"41540129","conclusions":"","publication_date":"2026-01-16T00:00:00"},"crossref":{"DOI":"10.1007/s00467-025-07138-w","URL":"https://doi.org/10.1007/s00467-025-07138-w","ISSN":["0931-041X","1432-198X"],"link":[{"URL":"https://link.springer.com/content/pdf/10.1007/s00467-025-07138-w.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/article/10.1007/s00467-025-07138-w","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/content/pdf/10.1007/s00467-025-07138-w.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Oral liposomal iron vs. oral iron polymaltose in children with chronic kidney disease iron deficiency anemia: a cross-over study"],"author":[{"given":"Happy","family":"Sawires","sequence":"first","affiliation":[]},{"given":"Eman Abobakr","family":"Abd Alazem","sequence":"additional","affiliation":[]},{"given":"Fatma","family":"Atia","sequence":"additional","affiliation":[]},{"given":"Amr","family":"Salem","sequence":"additional","affiliation":[]},{"given":"Amira","family":"Samy","sequence":"additional","affiliation":[]},{"given":"Mohamed","family":"Gamal","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/501100002386","id-type":"DOI","asserted-by":"crossref"}],"DOI":"10.13039/501100002386","name":"Cairo University","doi-asserted-by":"crossref"}],"issued":{"date-parts":[[2026,1,15]]},"member":"297","prefix":"10.1007","source":"Crossref","volume":null,"created":{"date-time":"2026-01-15T18:10:29Z","timestamp":1768500629000,"date-parts":[[2026,1,15]]},"indexed":{"date-time":"2026-01-16T10:48:26Z","timestamp":1768560506700,"date-parts":[[2026,1,16]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000,"date-parts":[[2026,1,15]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000,"date-parts":[[2026,1,15]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1007/s00467-025-07138-w"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"8 August 2025"},{"name":"revised","group":{"name":"ArticleHistory","label":"Article History"},"label":"Revised","order":2,"value":"3 December 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":3,"value":"16 December 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":4,"value":"15 January 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"},"order":2,"value":"The authors declare no competing interests."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"},"order":3,"value":"The Research Ethical Committee of the Faculty of Medicine of Cairo University approved and monitored this study (N-87–2023)."}],"deposited":{"date-time":"2026-01-15T18:10:36Z","timestamp":1768500636000,"date-parts":[[2026,1,15]]},"issn-type":[{"type":"print","value":"0931-041X"},{"type":"electronic","value":"1432-198X"}],"published":{"date-parts":[[2026,1,15]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":"10.3390/jcm8020152","key":"7138_CR1","year":"2019","issue":null,"author":"KH Lee","volume":"8","first-page":"152","unstructured":"Lee KH, Park E, Choi HJ, Kang HG, Ha IS, Cheong HI, Park YS, Cho H, Han KH, Kim SH, Cho MH, Lee JH, Shin JI (2019) Anemia and iron deficiency in children with chronic kidney disease (CKD): data from the Know-Ped CKD study. 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Mixed-model analysis favored IPC with higher Hb and TSAT and lower sTR (p≈0.039, 0.023, 0.044), IPC reduced serum phosphorus in both periods (p=0.043 and 0.044), and adverse effects were more frequent with IPC (12/33, 36%) than liposomal iron (3/33, 9%; p<0.001).","practice_takeaway":"Both formulations improved iron indices in pediatric CKD; IPC showed a modestly greater hematologic response but caused more adverse effects, while liposomal iron was better tolerated. IPC also lowered serum phosphorus; choice may hinge on balancing efficacy with tolerability and mineral effects."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"generic","value":"iron polymaltose complex"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Generics","href":"/hub/tag/generic"},{"name":"iron polymaltose complex"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"generic","hub_tag_value":"iron polymaltose complex"}}}]]

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