2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T7b8,To evaluate the odds of congenital syphilis in neonates of mothers with a history of adequately treated prepregnancy syphilis compared with those with no prepregnancy history of syphilis. We conducted a retrospective cohort study of deliveries within a large multihospital health care system in the southern United States from January 2015 to December 2023. Pregnant individuals were stratified based on whether there was a prepregnancy history of adequately treated syphilis infection. Propensity score full matching was performed, retaining all 382 patients with prior treated syphilis, with covariates including maternal age, neighborhood Area Deprivation Index, tobacco use, insurance payer, prenatal visits, and gestational age at delivery. The primary outcome was congenital syphilis as defined by Centers for Disease Control and Prevention case criteria; secondary outcomes included maternal syphilis infection during pregnancy and neonatal administration of a single intramuscular dose of penicillin-G. Among 57,925 pregnancies, 382 patients (0.66%) had a history of adequately treated syphilis before pregnancy. Congenital syphilis occurred in 26 of 382 (6.8%) pregnancies in women with prior treated syphilis compared with 40 of 57,543 (0.1%) without (adjusted odds ratio [aOR] 19.61; 95% CI, 4.57-84.25). This is equivalent to 6,806 per 100,000 live births in those with a prior history compared with 70 per 100,000 live births in those with no prior history. Maternal syphilis reinfection occurred in 68 of 382 (17.8%) with prior treated syphilis compared with 258 of 57,543 (0.4%) without (aOR 11.92; 95% CI, 5.89-24.10). A history of treated syphilis infection before pregnancy was associated with dramatically increased risks of congenital syphilis and maternal syphilis reinfection during pregnancy. These findings challenge assumptions about the protective effects of prior treatment and support enhanced surveillance strategies for this high-risk population.31:Ta07, OBJECTIVE: To evaluate the odds of congenital syphilis in neonates of mothers with a history of adequately treated prepregnancy syphilis compared with those with no prepregnancy history of syphilis. METHODS: We conducted a retrospective cohort study of deliveries within a large multihospital health care system in the southern United States from January 2015 to December 2023. Pregnant individuals were stratified based on whether there was a prepregnancy history of adequately treated syphilis infection. Propensity score full matching was performed, retaining all 382 patients with prior treated syphilis, with covariates including maternal age, neighborhood Area Deprivation Index, tobacco use, insurance payer, prenatal visits, and gestational age at delivery. The primary outcome was congenital syphilis as defined by Centers for Disease Control and Prevention case criteria; secondary outcomes included maternal syphilis infection during pregnancy and neonatal administration of a single intramuscular dose of penicillin-G. RESULTS: Among 57,925 pregnancies, 382 patients (0.66%) had a history of adequately treated syphilis before pregnancy. Congenital syphilis occurred in 26 of 382 (6.8%) pregnancies in women with prior treated syphilis compared with 40 of 57,543 (0.1%) without (adjusted odds ratio [aOR] 19.61; 95% CI, 4.57–84.25). This is equivalent to 6,806 per 100,000 live births in those with a prior history compared with 70 per 100,000 live births in those with no prior history. Maternal syphilis reinfection occurred in 68 of 382 (17.8%) with prior treated syphilis compared with 258 of 57,543 (0.4%) without (aOR 11.92; 95% CI, 5.89–24.10). CONCLUSION: A history of treated syphilis infection before pregnancy was associated with dramatically increased risks of congenital syphilis and maternal syphilis reinfection during pregnancy. These findings challenge assumptions about the protective effects of prior treatment and support enhanced surveillance strategies for this high-risk population. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"penicillin G: generic Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on penicillin G (generic). Clinician-written summaries and actionable practice insights. 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Results were consistent across all prespecified sensitivity analyses, including a stricter CSF-based neurosyphilis definition and 12-month follow-up.","limitations":"- Unmeasured confounding likely persists; CSF parameters (which differed between groups) could not be included in the propensity score model because lumbar punctures were not routinely performed at outpatient centers.\n- The study was underpowered for formal noninferiority testing — no margin was prespecified, so noninferiority cannot be concluded.\n- Treatment failure could not be distinguished from reinfection in a high-exposure population.","practice_takeaway":"For people with HIV who have neurosyphilis, ocular syphilis, or otosyphilis, ceftriaxone appears to produce similar 6-month serological responses to IV penicillin G — and avoids hospitalization in most cases (23% vs. 95% inpatient rate). Ceftriaxone is a reasonable substitute when penicillin is unavailable, inpatient capacity is limited, or costs are prohibitive."}},{"doi":"10.1097/aog.0000000000006314","pmid":"42096714","title":"History of Treated Syphilis Before Pregnancy and Risk of Congenital Syphilis","journal_title":"Obstetrics & Gynecology","journal_issn":"0029-7844","published_at":"2026-05-07T00:00:00.000Z","url":"https://doi.org/10.1097/aog.0000000000006314","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-12","doi":"10.1097/aog.0000000000006314","days":"7","issn":"0029-7844","rank":"3","field":"Clinical Medicine","score":"7","category":"Obstetrics & Gynecology","categories":["Obstetrics & Gynecology"],"_categories":["Obstetrics & Gynecology"]},"pubmed":{"doi":"10.1097/AOG.0000000000006314","title":"History of Treated Syphilis Before Pregnancy and Risk of Congenital Syphilis.","journal":"Obstetrics and gynecology","methods":"","results":"Among 57,925 pregnancies, 382 patients (0.66%) had a history of adequately treated syphilis before pregnancy. Congenital syphilis occurred in 26 of 382 (6.8%) pregnancies in women with prior treated syphilis compared with 40 of 57,543 (0.1%) without (adjusted odds ratio [aOR] 19.61; 95% CI, 4.57-84.25). This is equivalent to 6,806 per 100,000 live births in those with a prior history compared with 70 per 100,000 live births in those with no prior history. Maternal syphilis reinfection occurred in 68 of 382 (17.8%) with prior treated syphilis compared with 258 of 57,543 (0.4%) without (aOR 11.92; 95% CI, 5.89-24.10).","abstract":"$30","keywords":[],"pubmed_id":"42096714","conclusions":"A history of treated syphilis infection before pregnancy was associated with dramatically increased risks of congenital syphilis and maternal syphilis reinfection during pregnancy. These findings challenge assumptions about the protective effects of prior treatment and support enhanced surveillance strategies for this high-risk population.","publication_date":"2026-05-07T00:00:00"},"crossref":{"DOI":"10.1097/aog.0000000000006314","URL":"https://doi.org/10.1097/aog.0000000000006314","ISSN":["0029-7844","1873-233X"],"link":[{"URL":"https://journals.lww.com/10.1097/AOG.0000000000006314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["History of Treated Syphilis Before Pregnancy and Risk of Congenital Syphilis"],"author":[{"given":"J. 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Study","value_numeric":null},{"paper_doi":"10.1097/aog.0000000000006314","tag_type":"warning","value":"Propensity score matching retained all 382 exposed patients but the control group is much larger; balance on unmeasured confounders (e.g., sexual risk behaviors, partner treatment status) cannot be confirmed.","value_numeric":null},{"paper_doi":"10.1097/aog.0000000000006314","tag_type":"warning","value":"The brand tag 'Bicillin' is inferred from the context of intramuscular penicillin-G use; the paper does not explicitly name a brand.","value_numeric":null},{"paper_doi":"10.1097/aog.0000000000006314","tag_type":"warning","value":"The wide confidence interval for the primary outcome (aOR 4.57–84.25) reflects small absolute numbers of congenital syphilis cases in the prior-treatment group (n=26), so the point estimate should be interpreted cautiously.","value_numeric":null}],"summaries":{"what_studied":"This retrospective cohort study evaluated whether a history of adequately treated prepregnancy syphilis increases the odds of congenital syphilis and maternal reinfection, comparing 382 pregnant individuals with prior treated syphilis to 57,543 without, across a large multihospital system in the southern US (January 2015–December 2023).","key_result":"Congenital syphilis occurred in 6.8% (26/382) of those with prior treated syphilis vs. 0.1% (40/57,543) without (aOR 19.61; 95% CI 4.57–84.25; 6,806 vs. 70 per 100,000 live births). Maternal reinfection during pregnancy occurred in 17.8% vs. 0.4% (aOR 11.92; 95% CI 5.89–24.10).","limitations":"- Single health care system in the southern US limits generalizability to other regions or demographics.\n- Retrospective design cannot establish causation; residual confounding is possible despite propensity score matching.\n- \"Adequate treatment\" before pregnancy was defined by chart documentation, which may misclassify some cases.","practice_takeaway":"Pregnant patients with any prior history of treated syphilis should be considered high-risk and flagged for enhanced surveillance and more frequent serologic screening throughout pregnancy. Prior successful treatment should **not** be taken as reassurance against reinfection or congenital syphilis risk."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"generic","value":"penicillin G"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Generics","href":"/hub/tag/generic"},{"name":"penicillin G"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"generic","hub_tag_value":"penicillin G"}}}]]

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