2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/2iy5wruuedsh6.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/00yc7rcvua6a7.js","/_next/static/immutable/chunks/37ktb71aq3480.js","/_next/static/immutable/chunks/2d50b-7eu4558.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/2d6noqpp6ehas.js","/_next/static/immutable/chunks/1sx186c93bpzg.js","/_next/static/immutable/chunks/3dc-1n866s65i.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2w1bvggzb0ga8.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T12f8,The emergence of new human and environmental-related toxicity data associated with some common UV filters has catalysed growing interest in the inclusion of boosters and stabilizing ingredients in sunscreens. One approach is to incorporate alternative materials inspired by or mimetic of systems in biology, which offer a notable evolutionary advantage of multifunctionality and stability with increased biocompatibility. We describe the use of a natural product, Xanthochrome® (INCI: Ammonium Xanthommatin), in a series of studies designed to not only assess its safety with marine systems but also its formulation compatibility and function in water-in-oil mineral sunscreens. Xanthochrome is the synthetic form of the naturally occurring chromophore xanthommatin (XA) present in cephalopod skin, which doubles as a photostable antioxidant; however, it has never been explored in combination with mineral UV filters in finished formulations. Given the recent controversies associated with the environmental toxicological effects of some chemicals used in sunscreens, the safety of XA with coral cuttings was first validated at concentrations 5× above those used in our formulations. Next, a particle-based delivery of XA was designed and incorporated into a zinc oxide (ZnO)-based water-in-oil sunscreen, where the SPF, critical wavelength, and visible light (VL) blocking potential were measured. We observed no adverse effects of XA at 100 mg/L when tested with coral cuttings, demonstrating its safety at concentrations exceeding those used in our sunscreens. When formulated with ZnO-based sunscreens, the inclusion of XA increased the total UV absorbance profile by 28% and the total blocking potential of VL by 45%. The formulations also elicited no dermal irritation or sensitization in a human insult repeat patch test (N = 100 subjects). XA is differentiated as a photostable, water-soluble compound that is a VL booster proven safe for skin and coral cuttings. To the best of our knowledge, there are no other boosters that can be classified as such, despite a growing body of literature highlighting the need in the industry. L'émergence de nouvelles données de toxicité liées à l'environnement et à l'homme associées à certains filtres UV courants a suscité un intérêt croissant pour l'inclusion d'agents rehausseurs et d'ingrédients stabilisants dans les écrans solaires. Une approche consiste à intégrer des matériaux alternatifs inspirés ou mimétiques des systèmes en biologie, ce qui offre une biocompatibilité accrue et un avantage évolutif notable en matière de multifonctionnalité et de stabilité. Nous décrivons l'utilization d'un produit naturel, le Xanthochrome® (INCI: ammonium de xanthommatine), dans une série d'études conçues non seulement pour évaluer sa sécurité d'emploi avec les systèmes marins, mais également sa compatibilité et sa fonction de formulation dans les écrans solaires minéraux à base d'eau en huile. Le xanthochrome est la forme synthétique de la xanthommatine chromophore (XA) naturellement présente dans la peau des céphalopodes, qui fait office d'antioxydant photostable; cependant, il n'a jamais été étudié en association avec des filtres minéraux UV dans des formulations finies. MÉTHODES: Compte tenu des controverses récentes associées aux effets toxicologiques environnementaux de certains produits chimiques utilisés dans les écrans solaires, la sécurité d'emploi de l'XA sur les coupes de corail a été d'abord validée à des concentrations 5 fois supérieures à celles utilisées dans nos formulations. Ensuite, une application d'XA à base de particules a été conçue et incorporée dans un écran solaire à base d'oxyde de zinc (ZnO), dans lequel le facteur SPF, la longueur d'onde critique et le potentiel bloquant de la lumière visible (LV) ont été mesurés. RÉSULTATS: Nous n'avons pas observé d'effets indésirables de l'XA à raison de 100 mg/L lors de tests sur des coupes de corail, ce qui démontre sa sécurité d'emploi à des concentrations supérieures à celles utilisées dans nos écrans solaires. Lorsqu'il est formulé avec des écrans solaires à base de ZnO, l'inclusion de XA a augmenté le profil d'absorbance totale des UV de 28% et le potentiel bloquant total de la LV de 45%. Les formulations n'ont également entraîné aucune irritation ou sensibilisation cutanée lors d'un test épicutané d'exposition répétée chez l'homme (N = 100 sujets). Le XA se différencie par un composé soluble dans l'eau et photostable qui est un amplificateur de la LV éprouvé sans danger pour les coupes de peau et de corail. À notre connaissance, il n'existe aucun autre agent rehausseur pouvant être classé comme tel, malgré un corpus croissant de littérature soulignant le besoin dans l'industrie.31:T9cb,AbstractObjectiveThe emergence of new human and environmental‐related toxicity data associated with some common UV filters has catalysed growing interest in the inclusion of boosters and stabilizing ingredients in sunscreens. One approach is to incorporate alternative materials inspired by or mimetic of systems in biology, which offer a notable evolutionary advantage of multifunctionality and stability with increased biocompatibility. We describe the use of a natural product, Xanthochrome® (INCI: Ammonium Xanthommatin), in a series of studies designed to not only assess its safety with marine systems but also its formulation compatibility and function in water‐in‐oil mineral sunscreens. Xanthochrome is the synthetic form of the naturally occurring chromophore xanthommatin (XA) present in cephalopod skin, which doubles as a photostable antioxidant; however, it has never been explored in combination with mineral UV filters in finished formulations.MethodsGiven the recent controversies associated with the environmental toxicological effects of some chemicals used in sunscreens, the safety of XA with coral cuttings was first validated at concentrations 5× above those used in our formulations. Next, a particle‐based delivery of XA was designed and incorporated into a zinc oxide (ZnO)‐based water‐in‐oil sunscreen, where the SPF, critical wavelength, and visible light (VL) blocking potential were measured.ResultsWe observed no adverse effects of XA at 100 mg/L when tested with coral cuttings, demonstrating its safety at concentrations exceeding those used in our sunscreens. When formulated with ZnO‐based sunscreens, the inclusion of XA increased the total UV absorbance profile by 28% and the total blocking potential of VL by 45%. The formulations also elicited no dermal irritation or sensitization in a human insult repeat patch test (N = 100 subjects).ConclusionsXA is differentiated as a photostable, water‐soluble compound that is a VL booster proven safe for skin and coral cuttings. To the best of our knowledge, there are no other boosters that can be classified as such, despite a growing body of literature highlighting the need in the industry.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"zinc oxide: generic Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on zinc oxide (generic). Clinician-written summaries and actionable practice insights. 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When formulated with ZnO-based sunscreens, the inclusion of XA increased the total UV absorbance profile by 28% and the total blocking potential of VL by 45%. 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