limited_evidence: Research & Clinical Takeaways

In one patient, the skin metastasis from breast cancer showed expression of SARS-CoV-2 spike protein.

Stent‑based photobiomodulation was feasible, well tolerated, and associated with a low rate of severe mucositis in this small cohort. Continue using...

A Viewpoint outlines approaches to evaluating and managing melanoma in situ to reduce harms from overdiagnosis.

For alopecia areata nonresponders to one JAK inhibitor, a trial of a different JAK inhibitor may still be effective, based on this observational...

Short-course taVNS improved clinician-rated erythema and mood symptoms versus sham in ETR with few adverse events; clinicians may discuss this...

Three sessions of a 1726‑nm sebum‑selective laser produced sustained acne improvement through 1 year in Fitzpatrick II–VI with only transient...

Delivery-room teams report low confidence in identifying and explaining congenital skin lesions and strongly want training. Establish targeted...

In darker phototypes with refractory melasma, a single 755‑nm picosecond alexandrite laser session followed by topical JAK inhibition and...

Case series describing four patients with cutaneous leishmaniasis, detailing clinical features, histopathology, immunohistochemistry, and outcomes.

When selecting retinol products for sensitive skin, co‑formulations with 2% PLG, 5% ceramides, 3% acetyl glucosamine, 2% panthenol, 0.2% TECA, or...

For teams adopting AI, start by building AI literacy, use the provided rigor checklists to plan and vet projects, and embed ethics and bias...

When using tomotherapy with paclitaxel for cutaneous angiosarcoma, clinicians can counsel that this series observed a 2-year overall survival of 70%...

As an adjunct to standard topicals after inadequate response, monthly HMWNCHA+SA mesotherapy improved erythema, hydration, elasticity, and symptoms...

In women with epidermal melasma, a niacinamide/2‑mercaptonicotinyl glycine dermocosmetic achieved similar 6‑month MASI reductions to Kligman triple...

The patient experienced substantial improvement in symptoms with upadacitinib.

Expect stronger PASI responses to ixekizumab in milder plaque psoriasis than in severe disease; set patient expectations accordingly and consider...

Speed diagnosis and treatment for Latino patients with melanoma by ensuring linguistically appropriate care and supporting patient advocacy, while...

Dressings engineered to dissipate shear through internal layer-on-layer sliding may lower modeled heel tissue stress, but clinical effectiveness for...

In pediatric HSCT recipients, spiny folliculocentric eruptions mimicking lichen spinulosus can signal cutaneous cGVHD; exclude trichodysplasia...

In SSc—especially early diffuse cutaneous disease with anti–RNA polymerase III antibodies—consider early evaluation for GAVE to prevent bleeding and...

For adults who cannot take oral antifungals, an 8‑session diode laser plus red‑laser PDT protocol achieved higher clinical cure and faster healing...

In this small split-body RCT, HIUS achieved similar improvement and pain scores as MFU-V for upper arm laxity/crepiness at 90 days, while taking less...

When multiple soft, flesh‑colored papules or nodules cluster within one dermatome, consider segmental neurofibromatosis; biopsy showing S100‑positive...

Combining BV with RTx (sequentially or concurrently) was feasible and generally well tolerated, with expected toxicities and no new safety signals....

Monopolar RF can improve mid–lower face laxity metrics and reduce oiliness over 2–24 weeks in adults with skin types III–V, with mostly mild,...

XP-A due to c.389G>A (p.R130K) can present with mild cutaneous disease yet later neurologic decline; functional testing can reveal marked NER defects...

Use real‑time ultrasound to individualize depth and density: abdomen typically treated with a 12‑column (2×4 cm) grid delivering a median 720 lines...

Pretreatment NLR ≥2.54, PLR ≥117, and LMR ≤3.69 are simple blood-based markers that may help flag higher risk of disease-specific death in EMPD and...

In stage IIB/C melanoma, many dermato-oncologists prioritize avoiding severe AEs—especially in older, comorbid patients—and prefer infusions at...

dCPD formation was restored by both tyrosine repletion and DHICA supplementation, indicating pigment presence is sufficient. DHICA alone induced...

A set of 356 DNB genes showed temporal fluctuations that identified a pre-disease state before AD-like dermatitis onset; these genes were enriched in...

RB-PCL allowed suture removal by Day 5 (controls required longer), with less inflammation and corneal opacity at Weeks 1–2. By Weeks 2–4, α-SMA...

For adults with mild to moderate psoriasis on stable topical therapy, a 16-week, dietitian-guided Mediterranean diet produced clinically meaningful...

In vasculitic-appearing eruptions, consider monoclonal cryoglobulinemia and assess for an underlying B‑cell lymphoproliferative disorder when...

In routine practice, oral JAK inhibitors produced meaningful repigmentation for many patients with vitiligo; extending treatment beyond 6 months was...

In CSU clinics, expect higher burden and poorer control in women—especially those aged 51–65—and proactively assess angioedema, systemic symptoms,...

Docetaxel can trigger localized, unilateral scleroderma without Raynaud’s or nailfold changes; consider biopsy to confirm when new, limb-limited...

In a child with vesicular hand lesions that spread into concentric rings, include bullous tinea manuum in the differential diagnosis.

Expect accelerated epigenetic aging in psoriatic arthritis, while psoriasis alone may not; signals are also seen in pediatric atopic dermatitis and...

Higher skin porphyrin levels were associated with greater pigmentation and wrinkle measures, suggesting porphyrins may be relevant markers in skin...