safety_signal: Research & Clinical Takeaways

Dupilumab was associated with a higher relative risk of new-onset psoriasis vs other systemic agents in adults with AD, but the absolute excess risk...

Counsel women prescribed estrogen therapy, thiazides, or loop diuretics to limit sun exposure and practice photoprotection, given observed increases...

In older adults with psoriatic disease, IL‑12/23/17 biologics were associated with fewer serious infections, while tofacitinib was associated with...

COVID‑19 was associated with higher rates of chronic urticaria, vitiligo, alopecia areata, and herpes zoster versus matched controls after...

Expect a higher rate of incident psoriasis with immune checkpoint inhibitors than with chemotherapy or targeted therapies; monitor and counsel...

Monitor for autoimmune and autoinflammatory connective tissue disorders after COVID-19, with extra vigilance after severe infection, during...

BPO products can contain and generate benzene at room temperature and during use, with UV and heat boosting formation. Cold storage reduced formation...

In older men with cutaneous vasculitis, neutrophilic dermatoses, or chondritis, consider testing for VEXAS (UBA1). Prednisone often improves skin...

In older adults with new-onset eczematous dermatitis, review antihypertensive drugs as possible contributors, particularly diuretics and calcium...

In Australia, oral retinoid use among reproductive-aged women has grown while only 1 in 4 dispensings in 2021 had recorded concomitant contraception;...

Counsel patients that current direct-to-consumer AI dermatology apps lack FDA approval and robust validation and may mislead or pose risk. Prefer...

Long-term, higher cumulative TCS exposure correlates with greater odds of osteoporosis and MOF; minimize cumulative TCS dose when possible and...

Dupilumab can trigger a benign, reversible lymphoid reaction that mimics CTCL in adults with atopic dermatitis; recognizing its distinctive...

Be alert to SJS/TEN as a potential post-COVID infection or post-vaccination event; take a recent COVID infection and vaccination history when...