3b:I[281230,["/_next/static/immutable/chunks/0l5c-zsrs2aic.js","/_next/static/immutable/chunks/3_n0rk2989-8h.js","/_next/static/immutable/chunks/3ofw495lt1gr1.js","/_next/static/immutable/chunks/3tofdpg99uc12.js","/_next/static/immutable/chunks/2rzojj6zgb9d9.js","/_next/static/immutable/chunks/42jxjvozn2thc.js","/_next/static/immutable/chunks/1jp6nkbajpbfs.js","/_next/static/immutable/chunks/3jn_lf7v27x-6.js","/_next/static/immutable/chunks/33qq2-hg37d0b.js","/_next/static/immutable/chunks/15isb0svrppbz.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/0asz50g5_lfq9.js","/_next/static/immutable/chunks/30ia-cxa0yoyc.js","/_next/static/immutable/chunks/3ghibkczd0agr.js","/_next/static/immutable/chunks/20mjl75wrar8n.js","/_next/static/immutable/chunks/3nxreg9fiyt2y.js","/_next/static/immutable/chunks/0c04lgvo3p78i.js","/_next/static/immutable/chunks/1u78gf_avpn77.js"],"PaperListPageClient"] 3e:I[70339,["/_next/static/immutable/chunks/355lxm8rh3fxr.js"],"IconMark"] 3c:T4f0,Hot flashes are a common side effect reported by men receiving androgen-deprivation therapy (ADT) for the treatment of prostate cancer. We sought to determine whether oxybutynin could improve hot flash symptoms in men with prostate cancer. Patients with prostate cancer receiving a stable regimen of ADT with at least 28 hot flashes per week were randomly assigned to receive either oxybutynin 2.5 mg twice daily, oxybutynin 5 mg twice daily, or matching placebo for 6 weeks. The primary end point was the change in patient-reported hot flash scores since baseline at 6 weeks. Additional outcomes included incidence of adverse events (AEs), changes since baseline in Hot Flash-Related Daily Interference Scale (HFRDIS) scores, and patient-reported symptoms. Eighty-eight patients were enrolled, with the 81 participants eligible for final analysis reporting an average of 10.1 (standard deviation [SD], 5.55) hot flashes per day and an average daily hot flash score of 18.2 (SD, 13.5) included in final analysis. On average, patients on the placebo arm, 2.5 mg oxybutynin arm, and 5 mg oxybutynin arm had reductions in hot flashes/day of 2.15, 4.77 ( Oxybutynin is superior to a placebo for the management of ADT-associated hot flashes in men with prostate cancer.3d:Tb25, PURPOSE Hot flashes are a common side effect reported by men receiving androgen-deprivation therapy (ADT) for the treatment of prostate cancer. We sought to determine whether oxybutynin could improve hot flash symptoms in men with prostate cancer. PATIENTS AND METHODS Patients with prostate cancer receiving a stable regimen of ADT with at least 28 hot flashes per week were randomly assigned to receive either oxybutynin 2.5 mg twice daily, oxybutynin 5 mg twice daily, or matching placebo for 6 weeks. The primary end point was the change in patient-reported hot flash scores since baseline at 6 weeks. Additional outcomes included incidence of adverse events (AEs), changes since baseline in Hot Flash–Related Daily Interference Scale (HFRDIS) scores, and patient-reported symptoms. RESULTS Eighty-eight patients were enrolled, with the 81 participants eligible for final analysis reporting an average of 10.1 (standard deviation [SD], 5.55) hot flashes per day and an average daily hot flash score of 18.2 (SD, 13.5) included in final analysis. On average, patients on the placebo arm, 2.5 mg oxybutynin arm, and 5 mg oxybutynin arm had reductions in hot flashes/day of 2.15, 4.77 ( P = .02), and 6.89 ( P < .001), respectively. Daily hot flash scores for placebo, 2.5 mg oxybutynin, and 5 mg oxybutynin reduced by an average of 4.85, 9.94 ( P = .07), and 13.95 ( P = .002) points, respectively. No treatment-related grade 3+ AEs occurred. HFRDIS total scores improved by 14.2 and 20.7 points in the 2.5 mg ( P = .042) and 5 mg ( P < .01) oxybutynin arms, respectively, compared with a 3.1-point improvement with placebo. CONCLUSION Oxybutynin is superior to a placebo for the management of ADT-associated hot flashes in men with prostate cancer. 28:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Anticholinergic Agent: Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Anticholinergic Agent (modality). Clinician-written summaries and actionable practice insights. 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It did lower odds of severe bradycardia (aOR 0.33, 95% CI 0.26–0.41), while increasing odds of oxygen desaturation (aOR 1.35, 95% CI 1.22–1.49) and reducing first-attempt success (aOR 0.76, 95% CI 0.69–0.85).","limitations":"Retrospective registry design limits causal inference; residual confounding is likely (e.g., indication for atropine use, operator experience, urgency of intubation); cardiac arrest events were rare, limiting power to detect a true effect.","practice_takeaway":"Routine atropine use before neonatal intubation does not appear to prevent cardiac arrest and is linked to more desaturation events and lower first-attempt success rates; clinicians should weigh these trade-offs rather than applying atropine universally."}},{"doi":"10.1200/jco-25-01486","pmid":"41587370","title":"Alliance A222001: Oxybutynin Versus Placebo for the Treatment of Hot Flashes in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer","journal_title":"Journal of Clinical Oncology","journal_issn":"0732-183X","published_at":"2026-01-26T00:00:00.000Z","url":"https://doi.org/10.1200/jco-25-01486","source_score":223,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-02","doi":"10.1200/jco-25-01486","days":"14","issn":"0732-183X","rank":"1","field":"Clinical Medicine","score":"223","category":"Oncology","categories":["Oncology"],"_categories":["Oncology"]},"pubmed":{"doi":"10.1200/JCO-25-01486","title":"Alliance A222001: Oxybutynin Versus Placebo for the Treatment of Hot Flashes in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer.","journal":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","methods":"","results":"Eighty-eight patients were enrolled, with the 81 participants eligible for final analysis reporting an average of 10.1 (standard deviation [SD], 5.55) hot flashes per day and an average daily hot flash score of 18.2 (SD, 13.5) included in final analysis. On average, patients on the placebo arm, 2.5 mg oxybutynin arm, and 5 mg oxybutynin arm had reductions in hot flashes/day of 2.15, 4.77 (","abstract":"$3c","keywords":[],"pubmed_id":"41587370","conclusions":"Oxybutynin is superior to a placebo for the management of ADT-associated hot flashes in men with prostate cancer.","publication_date":"2026-01-26T00:00:00"},"crossref":{"DOI":"10.1200/jco-25-01486","URL":"https://doi.org/10.1200/jco-25-01486","ISSN":["0732-183X","1527-7755"],"link":[{"URL":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO-25-01486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"1198-1205","type":"journal-article","issue":"13","score":1,"title":["Alliance A222001: Oxybutynin Versus Placebo for the Treatment of Hot Flashes in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer"],"author":[{"given":"Bradley J.","family":"Stish","sequence":"first","affiliation":[{"name":"Mayo Clinic Department 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The impact_flag 'practice_changing' is applied cautiously given the small sample size and short follow-up; larger confirmatory trials would strengthen this designation.","value_numeric":null}],"summaries":{"what_studied":"A randomized, placebo-controlled trial (Alliance A222001) evaluated oxybutynin 2.5 mg BID vs. 5 mg BID vs. placebo over 6 weeks in men with prostate cancer on stable ADT who had ≥28 hot flashes/week (n=81 eligible).","key_result":"Both oxybutynin doses outperformed placebo: reductions in hot flashes/day were 4.77 (2.5 mg, P=.02) and 6.89 (5 mg, P<.001) vs. 2.15 with placebo; HFRDIS scores improved by 14.2 and 20.7 points vs. 3.1 with placebo; no treatment-related grade 3+ adverse events occurred.","limitations":"Small sample size (n=81 in final analysis); short 6-week follow-up limits conclusions about durability of benefit or long-term safety; study limited to men, so findings may not generalize broadly.","practice_takeaway":"Consider oxybutynin (especially 5 mg BID) as an effective, well-tolerated option for managing ADT-induced hot flashes in men with prostate cancer. 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