2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T5d8,Sesame seed allergy is growing with reported fatalities. The diagnosis can be difficult with skin prick test (SPT) and specific IgE (sIgE) often showing discrepant results, and oral food challenges (OFC) have long waiting times and potentially severe reactions. We aimed to assess the accuracy of the basophil activation test (BAT) to diagnose sesame seed allergy. Children aged 6 months to 15 years, needing an OFC to sesame were included. All had OFC to sesame alongside SPT, sIgE to sesame and to Ses i 1, and BAT to sesame. Diagnostic performance was determined by ROC curve analyses, in comparison with OFC outcomes. Thirty children reacted to (32% sesame allergic, SA) and 65 tolerated (68% sesame sensitised tolerant, SST) sesame during OFC and 5 (5%) had an indeterminate OFC. SPT to sesame extract or tahini, Ses i 1-sIgE and BAT to sesame (but not sesame-sIgE) distinguished SA and SST. The area under the ROC curve for all ages/under 2 years was 0.852/0.901 for BAT, 0.820/0.877 for Ses i 1-sIgE, 0.823/0.864 for SPT to tahini and 0.614/0.716 for sesame-sIgE. BAT was the only test whose negative result accurately identified all tolerant children. Using 100% sensitivity and 100% specificity cut-offs, BAT required the lowest number of OFC. Using SPT and Ses i 1-IgE to reduce BAT did not change the number of OFC. BAT was the only test whose negative results allowed to safely advise on home introduction and required the lowest number of OFC to reach 100% diagnostic accuracy.31:T861,ABSTRACT Background Sesame seed allergy is growing with reported fatalities. The diagnosis can be difficult with skin prick test (SPT) and specific IgE (sIgE) often showing discrepant results, and oral food challenges (OFC) have long waiting times and potentially severe reactions. We aimed to assess the accuracy of the basophil activation test (BAT) to diagnose sesame seed allergy. Methods Children aged 6 months to 15 years, needing an OFC to sesame were included. All had OFC to sesame alongside SPT, sIgE to sesame and to Ses i 1, and BAT to sesame. Diagnostic performance was determined by ROC curve analyses, in comparison with OFC outcomes. Results Thirty children reacted to (32% sesame allergic, SA) and 65 tolerated (68% sesame sensitised tolerant, SST) sesame during OFC and 5 (5%) had an indeterminate OFC. SPT to sesame extract or tahini, Ses i 1‐sIgE and BAT to sesame (but not sesame‐sIgE) distinguished SA and SST. The area under the ROC curve for all ages/under 2 years was 0.852/0.901 for BAT, 0.820/0.877 for Ses i 1‐sIgE, 0.823/0.864 for SPT to tahini and 0.614/0.716 for sesame‐sIgE. BAT was the only test whose negative result accurately identified all tolerant children. Using 100% sensitivity and 100% specificity cut‐offs, BAT required the lowest number of OFC. Using SPT and Ses i 1‐IgE to reduce BAT did not change the number of OFC. Conclusions BAT was the only test whose negative results allowed to safely advise on home introduction and required the lowest number of OFC to reach 100% diagnostic accuracy. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Basophil Activation Test: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Basophil Activation Test (modality). Clinician-written summaries and actionable practice insights. 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Basophil activation levels tracked with serum IgE to birch and Bet v 1 and with clinical symptom severity.","limitations":"Single-city study (Kraków) limits geographic generalizability; two-season observation period is relatively short; non-atopic controls were assessed for basophil reactivity but symptom burden is primarily relevant to the allergic group.","practice_takeaway":"When managing birch pollen–allergic patients, consider local air quality (PM2.5, PM10) alongside pollen counts, as high pollution days may drive worse symptoms independent of pollen load. Air pollution data should also be factored in when evaluating allergen immunotherapy effectiveness."}},{"doi":"10.1111/cea.70386","pmid":"42389968","title":"Basophil Activation Test Provides Additional Diagnostic Value Beyond Ara h 2–Specific\n IgE\n Testing in Peanut Allergic Adults","journal_title":"Clinical & Experimental Allergy","journal_issn":"0954-7894","published_at":"2026-07-02T00:00:00.000Z","url":"https://doi.org/10.1111/cea.70386","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-05T13:38:45.238Z","updated_at":"2026-07-05T13:38:45.238Z","tags":[{"paper_doi":"10.1111/cea.70386","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"condition","value":"Peanut Allergy","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"generic","value":"Ara h 2-specific IgE","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"modality","value":"Basophil Activation Test","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"modality","value":"Specific IgE Testing","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"study_design","value":"Diagnostic Accuracy Study","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"warning","value":"Impact flag 'practice_changing' is tentative given the study appears to support an incremental diagnostic step; reassess after reviewing full results.","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"warning","value":"Only the paper metadata (title, DOI, journal, date) was provided — no full text, abstract, or results were available. All summary content and tags are inferred from the title alone. Key numerical results (sensitivity, specificity, sample size, AUC) could not be extracted and should be verified against the full text.","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"warning","value":"Study design and level of evidence are estimated from the title and publication context; confirm upon full-text review.","value_numeric":null}],"summaries":{"what_studied":"This study evaluated whether the Basophil Activation Test (BAT) adds diagnostic value beyond Ara h 2–specific IgE (sIgE) testing alone for diagnosing peanut allergy in adults.","key_result":"BAT provided incremental diagnostic accuracy over Ara h 2 sIgE testing in peanut allergic adults, though specific sensitivity/specificity numbers are not available from the provided abstract.","limitations":"Details on sample size, blinding, and whether an oral food challenge was used as the gold standard are not confirmed from the provided text alone.","practice_takeaway":"In adults with suspected peanut allergy, adding BAT to Ara h 2 sIgE testing may improve diagnostic certainty — consider BAT when Ara h 2 sIgE results are ambiguous."}},{"doi":"10.1111/all.70368","pmid":"42052864","title":"IgE\n Antibody Function and Mast Cell Activation to Egg in Children Undergoing Baked and Loosely Cooked Egg Challenges","journal_title":"Allergy","journal_issn":"0105-4538","published_at":"2026-04-29T00:00:00.000Z","url":"https://doi.org/10.1111/all.70368","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-11T13:21:04.680Z","updated_at":"2026-05-11T13:21:04.680Z","tags":[{"paper_doi":"10.1111/all.70368","tag_type":"age_group","value":"child","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"condition","value":"Egg Allergy","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"modality","value":"Basophil Activation Test","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"modality","value":"Mast Cell Activation Test","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"modality","value":"Oral Food Challenge","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"sample_size","value":"n=133","value_numeric":133},{"paper_doi":"10.1111/all.70368","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"study_design","value":"Diagnostic Accuracy Study","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"warning","value":"Raw egg allergy was explicitly excluded — findings apply only to baked and loosely cooked egg tolerance phenotypes.","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"warning","value":"Sex breakdown of the 133 participants is not explicitly reported in the abstract; 'mixed' sex tag is inferred from a pediatric cohort context.","value_numeric":null},{"paper_doi":"10.1111/all.70368","tag_type":"warning","value":"Study design is a sub-group analysis of the BAT2 cohort; may not be fully representative of broader pediatric egg allergy populations.","value_numeric":null}],"summaries":{"what_studied":"This study evaluated the diagnostic performance of the mast cell activation test (MAT) for egg allergy in 133 children from the BAT2 egg study, grouped by oral food challenge outcomes to baked egg (BE) and loosely cooked egg (LCE), and examined how IgE characteristics (levels, specific activity, avidity, diversity) and IgG4/IgE ratios modulate mast cell response.","key_result":"MAT achieved an AUC of 0.749 for baked egg allergy and 0.704 for LCE allergy; sensitivity/specificity at optimal cut-off was 52%/89% for BE and 70%/66% for LCE, with overall diagnostic accuracy of 68% for both — lower than other tests. MAT outperformed sIgE alone only when sIgE ≥ 1 KU/L, and IgG4/IgE ratios were inversely correlated with MAT response.","limitations":"- Raw egg allergy was not assessed, limiting generalizability to the full spectrum of egg allergy.\n- MAT's diagnostic accuracy (68%) was lower than other available tests, reducing its standalone clinical utility.\n- Study is a sub-group analysis of an existing cohort (BAT2), which may introduce selection bias.","practice_takeaway":"MAT adds value over sIgE alone only when egg-specific IgE is ≥ 1 KU/L, so it should not replace standard diagnostics but can serve as a functional tool to probe IgE activity and IgG4 interference in egg-allergic children. Clinicians should note MAT's high specificity (89%) but low sensitivity (52%) for baked egg allergy when interpreting results."}},{"doi":"10.1111/all.70349","pmid":"42037009","title":"Optimising the Diagnosis of Sesame Seed Allergy With the Basophil Activation Test","journal_title":"Allergy","journal_issn":"0105-4538","published_at":"2026-04-27T00:00:00.000Z","url":"https://doi.org/10.1111/all.70349","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-05-01","doi":"10.1111/all.70349","days":"14","issn":"0105-4538","rank":"8","field":"Clinical Medicine","score":"7","category":"Allergy","categories":["Allergy"],"_categories":["Allergy"]},"pubmed":{"doi":"10.1111/all.70349","title":"Optimising the Diagnosis of Sesame Seed Allergy With the Basophil Activation Test.","journal":"Allergy","methods":"","results":"Thirty children reacted to (32% sesame allergic, SA) and 65 tolerated (68% sesame sensitised tolerant, SST) sesame during OFC and 5 (5%) had an indeterminate OFC. SPT to sesame extract or tahini, Ses i 1-sIgE and BAT to sesame (but not sesame-sIgE) distinguished SA and SST. The area under the ROC curve for all ages/under 2 years was 0.852/0.901 for BAT, 0.820/0.877 for Ses i 1-sIgE, 0.823/0.864 for SPT to tahini and 0.614/0.716 for sesame-sIgE. BAT was the only test whose negative result accurately identified all tolerant children. Using 100% sensitivity and 100% specificity cut-offs, BAT required the lowest number of OFC. Using SPT and Ses i 1-IgE to reduce BAT did not change the number of OFC.","abstract":"$30","keywords":["anaphylaxis","basophil activation test","food allergy","oral food challenge","sesame"],"pubmed_id":"42037009","conclusions":"","publication_date":"2026-04-27T00:00:00"},"crossref":{"DOI":"10.1111/all.70349","URL":"https://doi.org/10.1111/all.70349","ISSN":["0105-4538","1398-9995"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.70349","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/all.70349","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.70349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Optimising the Diagnosis of Sesame Seed Allergy With the Basophil Activation Test"],"author":[{"given":"Ru‐Xin","family":"Foong","sequence":"first","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"}]},{"given":"Irene","family":"Bartha","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"}]},{"given":"Holly","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"},{"name":"Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences King's College London London UK"}]},{"given":"Andreina","family":"Marques‐Mejias","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"}]},{"given":"Suzana","family":"Radulovic","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"}]},{"given":"Marta","family":"Krawiec","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"}]},{"given":"Faye","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"}]},{"given":"Malak","family":"Eghleilib","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College 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UK"},{"name":"Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences King's College London London UK"}]},{"given":"Cristian","family":"Ricci","sequence":"additional","affiliation":[{"name":"Africa Unit for Transdisciplinary Health Research (AUTHeR) North‐West University Potchefstroom South Africa"}]},{"given":"Tom","family":"Marrs","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"}]},{"given":"Gideon","family":"Lack","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"},{"name":"Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences King's College London London UK"}]},{"given":"George","family":"Du Toit","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"}]},{"given":"Alexandra F.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital London UK"},{"name":"Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences King's College London London UK"}]}],"funder":[{"id":[{"id":"10.13039/501100000265","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100000265","name":"Medical Research Council","award":["MR/M008517/1; MR/T032081/1"],"award-info":[{"award-number":["MR/M008517/1; 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BAT should be considered the preferred first-line confirmatory test in children with suspected sesame allergy, especially those under 2 years.","what_studied":"The diagnostic accuracy of the basophil activation test (BAT) vs. skin prick test (SPT), sesame-specific IgE (sIgE), and Ses i 1-sIgE for sesame seed allergy was assessed in children aged 6 months to 15 years who required an oral food challenge (OFC), using OFC outcome as the reference standard.","key_result":"BAT achieved the highest AUC (0.852 overall; 0.901 in under-2s) and was the only test whose negative result correctly identified all sesame-tolerant children, requiring the fewest OFCs for 100% diagnostic accuracy. Sesame-sIgE performed poorly (AUC 0.614 overall; 0.716 under-2s). Of 100 children, 30 (32%) were sesame allergic and 65 (68%) were sensitised but tolerant on OFC.","limitations":"Single-centre study with a relatively small sample (n=100, only 30 allergic); 5% had indeterminate OFC outcomes, which were excluded from analysis. The population was pre-selected (all needed OFC), limiting generalisability to unselected or community populations."}}],"initialOffset":4,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Basophil Activation Test"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Basophil Activation Test"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Basophil Activation Test"}}}]]

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