3b:I[281230,["/_next/static/immutable/chunks/0l5c-zsrs2aic.js","/_next/static/immutable/chunks/3_n0rk2989-8h.js","/_next/static/immutable/chunks/3ofw495lt1gr1.js","/_next/static/immutable/chunks/3tofdpg99uc12.js","/_next/static/immutable/chunks/2rzojj6zgb9d9.js","/_next/static/immutable/chunks/42jxjvozn2thc.js","/_next/static/immutable/chunks/1jp6nkbajpbfs.js","/_next/static/immutable/chunks/3jn_lf7v27x-6.js","/_next/static/immutable/chunks/33qq2-hg37d0b.js","/_next/static/immutable/chunks/15isb0svrppbz.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/0asz50g5_lfq9.js","/_next/static/immutable/chunks/30ia-cxa0yoyc.js","/_next/static/immutable/chunks/3ghibkczd0agr.js","/_next/static/immutable/chunks/20mjl75wrar8n.js","/_next/static/immutable/chunks/3nxreg9fiyt2y.js","/_next/static/immutable/chunks/0c04lgvo3p78i.js","/_next/static/immutable/chunks/1u78gf_avpn77.js"],"PaperListPageClient"] 3e:I[70339,["/_next/static/immutable/chunks/355lxm8rh3fxr.js"],"IconMark"] 3c:T6a3,Although the role of cardiometabolic risk factors (CMRF) has been characterized in steatotic liver disease, their role in the severity of alcohol-associated hepatitis (AH) remains unclear. We aimed to evaluate the impact of CMRF on mortality. Multinational prospective cohort study (2015-2024) including hospitalized patients with severe AH across 32 centers in 14 countries. Diagnosis of AH was made using the NIAAA criteria. Analyses included adjusted competing-risk models by age, sex, ethnicity, history of cirrhosis, CMRF, corticosteroid use, MELD, and ACLF grade, with liver transplantation as a competing risk. 936 participants were included; mean age 48±11.2 years, and 88.9% were male. At least one CMRF was present in 46.6%; median body mass index (BMI) was 24.2 kg/m2 [IQR: 22.8-28.2], prevalence of diabetes 17.6%, hypertension 16.5%, and dyslipidemia 5.8%. Median MELD was 24.4 [19.3-31.4], 86.7% had severe AH, and 180-day survival was 72.9%. Survival did not differ by CMRF status (log-rank p=0.453). In adjusted competing-risk models, higher age (sHR 1.02; 95%CI:1.01-1.04), greater alcohol intake (per g/day; sHR 1.001; 95%CI:1.000-1.002), MELD (sHR 1.04; 95%CI:1.01-1.06), and ACLF grade 2-3 (sHR 2.34 and 4.34) predicted mortality. However, no individual CMRF independently increased mortality. A prespecified non-linear BMI analysis showed modestly lower mortality between 25-40 kg/m², with a higher risk above 40 kg/m². Among patients with severe AH, metabolic dysfunction was not associated with increased mortality. Although a higher BMI was associated with slightly lower mortality in AH, this may reflect better nutritional status rather than a true protective effect.3d:T9c4, Introduction: Although the role of cardiometabolic risk factors (CMRF) has been characterized in steatotic liver disease, their role in the severity of alcohol-associated hepatitis (AH) remains unclear. We aimed to evaluate the impact of CMRF on mortality. Methods: Multinational prospective cohort study (2015–2024) including hospitalized patients with severe AH across 32 centers in 14 countries. Diagnosis of AH was made using the NIAAA criteria. Analyses included adjusted competing-risk models by age, sex, ethnicity, history of cirrhosis, CMRF, corticosteroid use, MELD, and ACLF grade, with liver transplantation as a competing risk. Results: 936 participants were included; mean age 48±11.2 years, and 88.9% were male. At least one CMRF was present in 46.6%; median body mass index (BMI) was 24.2 kg/m 2 [IQR: 22.8–28.2], prevalence of diabetes 17.6%, hypertension 16.5%, and dyslipidemia 5.8%. Median MELD was 24.4 [19.3–31.4], 86.7% had severe AH, and 180-day survival was 72.9%. Survival did not differ by CMRF status (log-rank p =0.453). In adjusted competing-risk models, higher age (sHR 1.02; 95%CI:1.01–1.04), greater alcohol intake (per g/day; sHR 1.001; 95%CI:1.000–1.002), MELD (sHR 1.04; 95%CI:1.01–1.06), and ACLF grade 2–3 (sHR 2.34 and 4.34) predicted mortality. However, no individual CMRF independently increased mortality. A prespecified non-linear BMI analysis showed modestly lower mortality between 25–40 kg/m², with a higher risk above 40 kg/m². Conclusion: Among patients with severe AH, metabolic dysfunction was not associated with increased mortality. Although a higher BMI was associated with slightly lower mortality in AH, this may reflect better nutritional status rather than a true protective effect. 28:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Corticosteroid Therapy: Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Corticosteroid Therapy (modality). 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At least one CMRF was present in 46.6%; median body mass index (BMI) was 24.2 kg/m2 [IQR: 22.8-28.2], prevalence of diabetes 17.6%, hypertension 16.5%, and dyslipidemia 5.8%. Median MELD was 24.4 [19.3-31.4], 86.7% had severe AH, and 180-day survival was 72.9%. Survival did not differ by CMRF status (log-rank p=0.453). In adjusted competing-risk models, higher age (sHR 1.02; 95%CI:1.01-1.04), greater alcohol intake (per g/day; sHR 1.001; 95%CI:1.000-1.002), MELD (sHR 1.04; 95%CI:1.01-1.06), and ACLF grade 2-3 (sHR 2.34 and 4.34) predicted mortality. However, no individual CMRF independently increased mortality. A prespecified non-linear BMI analysis showed modestly lower mortality between 25-40 kg/m², with a higher risk above 40 kg/m².","abstract":"$3c","keywords":["alcohol use disorder","alcoholic hepatitis","cardiometabolic risk factors","cirrhosis","metabolic syndrome","obesity"],"pubmed_id":"42090455","conclusions":"Among patients with severe AH, metabolic dysfunction was not associated with increased mortality. Although a higher BMI was associated with slightly lower mortality in AH, this may reflect better nutritional status rather than a true protective effect.","publication_date":"2026-05-06T00:00:00"},"crossref":{"DOI":"10.1097/hep.0000000000001780","URL":"https://doi.org/10.1097/hep.0000000000001780","ISSN":["0270-9139","1527-3350"],"link":[{"URL":"https://journals.lww.com/10.1097/HEP.0000000000001780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Exploring the interaction between metabolic dysfunction and alcohol-associated hepatitis: A global study"],"author":[{"given":"Vania","family":"Cari","sequence":"first","affiliation":[{"name":"Departamento de Medicina Interna, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile"}]},{"given":"María Ignacia","family":"Perez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile"}]},{"given":"Ignacio","family":"Tellez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile"}]},{"given":"Francisco","family":"Idalsoaga","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile"},{"name":"Observatorio Multicéntrico de Enfermedades Gastrointestinales (OMEGA), Santiago, Chile"},{"name":"Department Of Medicine, Division Of Gastroenterology, Western University, London Health Sciences Center, London, Ontario, Canada"}]},{"given":"Arun","family":"Valsan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology Division, Amrita Institute of Medical Sciences and Research Centre, Kerala, India"}]},{"given":"Gowripriya","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology Division, Amrita Institute of Medical Sciences and Research Centre, Kerala, India"}]},{"given":"Kriti","family":"Soni","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, 23298, USA"}]},{"given":"S. Fisher","family":"Rhoads","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, 23298, USA"}]},{"given":"Jorge","family":"Arnold","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile"}]},{"given":"Maria","family":"Ayala-Valverde","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile"}]},{"given":"Carolina","family":"Ramirez-Cadiz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA"}]},{"given":"Prasun K.","family":"Jalal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology And Hepatology, Baylor College of Medicine, Houston, Texas, USA"}]},{"given":"Mohamad Ali","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology And Hepatology, Baylor College of Medicine, Houston, Texas, USA"}]},{"given":"Mohamed A.","family":"Elfeki","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota, USA"}]},{"given":"Juan Pablo","family":"Roblero","sequence":"additional","affiliation":[{"name":"Seccion Gastroenterologia, Hospital Clinico Universidad de Chile, Escuela de Medicina Universidad de Chile, Santiago, Chile"}]},{"given":"Daniela","family":"Simian","sequence":"additional","affiliation":[{"name":"Seccion Gastroenterologia, Hospital Clinico Universidad de Chile, Escuela de Medicina Universidad de Chile, Santiago, Chile"}]},{"given":"Jose Antonio","family":"Velarde-Ruiz Velasco","sequence":"additional","affiliation":[{"name":"Hospital Civil Guadalajara, Guadalajara, Mexico"}]},{"given":"Jacqueline","family":"Cordova","sequence":"additional","affiliation":[{"name":"Hospital General Manuel Gea Gonzalez, Mexico City, Mexico"}]},{"given":"Fátima","family":"Higuera-de-la-Tijera","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia, Hospital General de Mexico “Dr. Eduardo Liceaga”, Mexico City, Mexico"},{"name":"Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico"}]},{"given":"Rita","family":"Silva","sequence":"additional","affiliation":[{"name":"Unidade de Transplante de Figado e do Hospital de Base da Faculdade de Medicina de São Jose do Rio Preto, Sao Paulo, Brazil"}]},{"given":"Cristina Melo","family":"Rocha","sequence":"additional","affiliation":[{"name":"Fhaj Fundação Hospital Adriano Jorge, Amazonas, Brazil"}]},{"given":"Roberta C.","family":"Araujo","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, Brazil"}]},{"given":"Guilherme Massote","family":"Fontani","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, Brazil"}]},{"given":"Gustavo Henrique","family":"Pereira","sequence":"additional","affiliation":[{"name":"Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil"}]},{"given":"Fernando","family":"Bessone","sequence":"additional","affiliation":[{"name":"Hospital Provincial del Centenario, Santa Fe, Argentina"}]},{"given":"Mario","family":"Tanno","sequence":"additional","affiliation":[{"name":"Hospital Provincial del Centenario, Santa Fe, Argentina"}]},{"given":"Ayelen","family":"Kisch","sequence":"additional","affiliation":[{"name":"Hospital de Gastroenterologia “ Dr. Carlos Bonorino Udaondo”, Buenos Aires, Argentina"}]},{"given":"Manuel","family":"Mendizabal","sequence":"additional","affiliation":[{"name":"Hospital Universitario Austral, Buenos Aires, Argentina"}]},{"given":"Sebastian","family":"Marciano","sequence":"additional","affiliation":[{"name":"Hospital Italiano Buenos Aires, Buenos Aires, Argentina"}]},{"given":"Gonzalo","family":"Gomez-Perdiguero","sequence":"additional","affiliation":[{"name":"Hospital Italiano Buenos Aires, Buenos Aires, Argentina"}]},{"given":"Pedro","family":"Montes","sequence":"additional","affiliation":[{"name":"Hospital Nacional Daniel Alcides Carrion - Callao, Bellavista, Peru"}]},{"given":"Patricia","family":"Guerra Salazar","sequence":"additional","affiliation":[{"name":"Instituto Gastroenterologico Boliviano- Japones, Cochabamba, Bolivia"}]},{"given":"Geraldine","family":"Ramos","sequence":"additional","affiliation":[{"name":"Instituto Gastroenterologico Boliviano- Japones, Cochabamba, Bolivia"}]},{"given":"Kristina R.","family":"Chacko","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology And Hepatology, Montefiore Medical Center, Bronx, New York, USA"}]},{"given":"Lubomir","family":"Skladaný","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Gastroenterology And Liver Transplantation, Department of Internal Medicine II, Slovak Medical University, F. D. Roosevelt University Hospital, Banska Bystrica, Slovak Republic"},{"name":"Department of Internal Medicine 2, Safarik University Faculty of Medicine, Kosice, Slovak Republic"}]},{"given":"Rakhi","family":"Maiwall","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India"}]},{"given":"Douglas","family":"Simonetto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA"}]},{"given":"Arun J.","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, 23298, USA"}]},{"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA"}]},{"given":"Ashwani K.","family":"Singal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA"}]},{"given":"Winston","family":"Dunn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA"}]},{"given":"Patrick S.","family":"Kamath","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA"}]},{"given":"Rohit","family":"Loomba","sequence":"additional","affiliation":[{"name":"MASLD Research Center, Division of Gastroenterology and Hepatology, University of California San Diego, San Diego, California, USA"}]},{"given":"Marco","family":"Arrese","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile"},{"name":"Observatorio Multicéntrico de Enfermedades Gastrointestinales (OMEGA), Santiago, Chile"}]},{"given":"Ramon","family":"Bataller","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Clinic, Barcelona, Spain"}]},{"given":"Luis Antonio","family":"Díaz","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile"},{"name":"Observatorio Multicéntrico de Enfermedades Gastrointestinales (OMEGA), Santiago, Chile"},{"name":"MASLD Research Center, Division of Gastroenterology and Hepatology, University of California San Diego, San Diego, California, USA"}]},{"given":"Juan Pablo","family":"Arab","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile"},{"name":"Observatorio Multicéntrico de Enfermedades Gastrointestinales (OMEGA), Santiago, Chile"},{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, 23298, USA"}]}],"issued":{"date-parts":[[2026,5,6]]},"member":"276","prefix":"10.1097","source":"Crossref","volume":null,"created":{"date-time":"2026-05-06T18:01:22Z","timestamp":1778090482000,"date-parts":[[2026,5,6]]},"indexed":{"date-time":"2026-05-06T18:18:22Z","timestamp":1778091502732,"date-parts":[[2026,5,6]]},"subject":[],"abstract":"$3d","language":"en","relation":{},"resource":{"primary":{"URL":"https://journals.lww.com/10.1097/HEP.0000000000001780"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","value":"2025-11-19"},{"name":"accepted","group":{"name":"publication_history","label":"Publication 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study","updated":"2026-05-07T14:04:23+00:00","published_date":"2026-05-06","best_oa_location":null}},"created_at":"2026-05-10T13:20:41.495Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"category","value":"Gastroenterology & Hepatology","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"condition","value":"Acute-on-Chronic Liver Failure","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"condition","value":"Alcohol-Associated Hepatitis","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"condition","value":"Metabolic Dysfunction","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"modality","value":"Corticosteroid Therapy","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"sample_size","value":"n=936","value_numeric":936},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"study_design","value":"Prospective Cohort Study","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"warning","value":"The BMI obesity subgroup (>40 kg/m²) likely represents a very small fraction of the cohort given a median BMI of 24.2 kg/m², which may limit the reliability of that specific finding.","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"warning","value":"The cohort is heavily male (88.9%), so findings may not apply equally to female patients with AH.","value_numeric":null},{"paper_doi":"10.1097/hep.0000000000001780","tag_type":"warning","value":"The full text PDF content was not accessible — it contained an unrelated GI society statement rather than the study body. All structured data were derived exclusively from the abstract and results section.","value_numeric":null}],"summaries":{"what_studied":"This multinational prospective cohort study (2015–2024) across 32 centers in 14 countries evaluated whether cardiometabolic risk factors (CMRF) — including diabetes, hypertension, dyslipidemia, and BMI — affect 180-day mortality in 936 hospitalized patients with severe alcohol-associated hepatitis (AH), using adjusted competing-risk models with liver transplantation as a competing risk.","key_result":"No individual CMRF independently predicted mortality (log-rank p=0.453 for CMRF status). Independent predictors of death were older age (sHR 1.02), higher alcohol intake (sHR 1.001/g/day), higher MELD (sHR 1.04), and ACLF grade 2 (sHR 2.34) or grade 3 (sHR 4.34). BMI 25–40 kg/m² was associated with modestly lower mortality; BMI >40 kg/m² with higher risk. 180-day survival was 72.9%.","limitations":"- Cohort was 88.9% male, limiting generalizability to women.\n- Median BMI was 24.2 kg/m², with few patients in the obese range, which may underpowered the BMI analysis.\n- The PDF full text was not available; findings rely solely on the abstract and results section.","practice_takeaway":"Clinicians need not consider the presence of diabetes, hypertension, or dyslipidemia as independent drivers of short-term mortality in severe AH — disease severity (MELD, ACLF grade) and ongoing alcohol intake remain the key prognostic factors. The apparent survival benefit at BMI 25–40 kg/m² likely reflects nutritional reserve rather than a protective metabolic effect."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Corticosteroid Therapy"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Corticosteroid Therapy"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Corticosteroid Therapy"}}}]] 2b:null 2f:[["$","title","0",{"children":"Corticosteroid Therapy: Research & Clinical Takeaways | ReachRx"}],["$","meta","1",{"name":"description","content":"Explore peer-reviewed papers on Corticosteroid Therapy (modality). Clinician-written summaries and actionable practice insights. 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