2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T91c,Small molecules, like panthenol have been shown to penetrate hair. However, their interactions with the protein structures of hair have not been well studied. In this study, the penetration of panthenol into protein structures of hair was confirmed, and NMR methods were utilized to understand the protein-panthenol interaction. This interaction is likely the source of the tensile strength benefits measured with panthenol for hair. Cross-sections of hair treated with deuterium-labelled panthenol were studied using NanoSIMS to visualize the location of panthenol within hair. Solid-state NMR (both Penetration of panthenol into hair was demonstrated, with images indicating specific penetration into cortical protein regions. NMR results from various experiments provided evidence of direct interaction between the N-H of panthenol and protein aromatic side chains. A 'shared' proton was identified between panthenol and hair proteins, indicating spatial proximity and interaction. Break stress and elastic modulus of hair treated with panthenol were higher than those of control hair, suggesting that bonds-likely hydrogen bonds-were formed between panthenol and hair. Panthenol can deliver tensile strength benefits to hair. This benefit is proposed to result from hydrogen bonds formed between panthenol and hair proteins. si l'on sait que de petites molécules comme le panthénol pénètrent dans les cheveux, leurs interactions avec les structures protéiques des cheveux restent cependant peu étudiées. On a ici confirmé la pénétration du panthénol dans les structures protéiques des cheveux et tiré parti de méthodes de résonance magnétique nucléaire (RMN) pour comprendre l'interaction entre les protéines et le panthénol. Cette interaction explique probablement les bénéfices mesurés du panthénol pour les cheveux en termes de résistance à la traction. MÉTHODES: des coupes transversales de cheveux traités avec du panthénol marqué au deutérium ont été étudiées à l'aide d'un NanoSIMS afin de visualiser l'emplacement du panthénol dans les cheveux. La RMN à l'état solide ( le panthénol peut apporter des bénéfices en termes de résistance à la traction des cheveux. Ce bénéfice semble résulter des liaisons hydrogène formées entre le panthénol et les protéines capillaires.31:T7f5,AbstractObjectiveSmall molecules, like panthenol have been shown to penetrate hair. However, their interactions with the protein structures of hair have not been well studied. In this study, the penetration of panthenol into protein structures of hair was confirmed, and NMR methods were utilized to understand the protein–panthenol interaction. This interaction is likely the source of the tensile strength benefits measured with panthenol for hair.MethodsCross‐sections of hair treated with deuterium‐labelled panthenol were studied using NanoSIMS to visualize the location of panthenol within hair. Solid‐state NMR (both 1H–13C and 1H–2H) was employed to measure panthenol interactions inside hair using deuterium‐labelled panthenol. Stress/strain curves—where stress is defined as average force per unit area—were measured for hair treated with and without panthenol to generate tensile strength data.ResultsPenetration of panthenol into hair was demonstrated, with images indicating specific penetration into cortical protein regions. NMR results from various experiments provided evidence of direct interaction between the N–H of panthenol and protein aromatic side chains. A ‘shared’ proton was identified between panthenol and hair proteins, indicating spatial proximity and interaction. Break stress and elastic modulus of hair treated with panthenol were higher than those of control hair, suggesting that bonds—likely hydrogen bonds—were formed between panthenol and hair.ConclusionPanthenol can deliver tensile strength benefits to hair. This benefit is proposed to result from hydrogen bonds formed between panthenol and hair proteins.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Cosmetic Ingredient: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Cosmetic Ingredient (modality). Clinician-written summaries and actionable practice insights. 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NMR results from various experiments provided evidence of direct interaction between the N-H of panthenol and protein aromatic side chains. A 'shared' proton was identified between panthenol and hair proteins, indicating spatial proximity and interaction. Break stress and elastic modulus of hair treated with panthenol were higher than those of control hair, suggesting that bonds-likely hydrogen bonds-were formed between panthenol and hair.","abstract":"$30","keywords":["NMR","bonding","panthenol"],"pubmed_id":"40905518","conclusions":"Panthenol can deliver tensile strength benefits to hair. This benefit is proposed to result from hydrogen bonds formed between panthenol and hair proteins.\nle panthénol peut apporter des bénéfices en termes de résistance à la traction des cheveux. Ce bénéfice semble résulter des liaisons hydrogène formées entre le panthénol et les protéines capillaires.","publication_date":"2025-09-04T00:00:00"},"crossref":{"DOI":"10.1111/ics.70024","URL":"https://doi.org/10.1111/ics.70024","ISSN":["0142-5463","1468-2494"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/ics.70024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Strengthening benefits of panthenol for hair: Mechanistic evidence from advanced spectroscopic techniques"],"author":[{"given":"Jennifer M.","family":"Marsh","sequence":"first","affiliation":[{"name":"The Procter & Gamble Company, Mason Business Center Mason Ohio USA"}]},{"given":"Scott","family":"Cron","sequence":"additional","affiliation":[{"name":"The Procter & Gamble Company, Mason Business Center Mason Ohio 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sizes were provided.","value_numeric":null},{"paper_doi":"10.1111/ics.70024","tag_type":"warning","value":"Study type inferred as an in vitro mechanistic lab study.","value_numeric":null}],"summaries":{"what_studied":"Laboratory imaging and spectroscopy assessed how panthenol enters hair and interacts with hair proteins; deuterium‑labeled panthenol was visualized by NanoSIMS and interactions were probed by solid‑state NMR, with mechanical testing versus untreated control hair.","key_result":"Panthenol localized to cortical protein regions; NMR showed direct interaction between panthenol N‑H and protein aromatic side chains with a shared proton signal, and treated hair had higher break stress and elastic modulus than control hair (no numeric values reported).","limitations":"No numerical effect sizes, sample sizes, or exposure conditions are reported; outcomes are limited to lab imaging/NMR and mechanical tests without human or clinical endpoints.","practice_takeaway":"Panthenol penetrates the hair cortex and is associated with higher tensile properties versus untreated hair in lab testing, consistent with hydrogen bonding to hair proteins; consider this mechanistic support when discussing panthenol‑containing hair products, noting the absence of clinical outcomes."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Cosmetic Ingredient"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Cosmetic Ingredient"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Cosmetic Ingredient"}}}]]

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