2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:Tb93, Introduction Given the unique mental health challenges among transgender individuals, it is imperative to understand the effectiveness of gender-affirming treatments in alleviating psychological distress. The existing literature gap calls for studies with larger sample sizes, extended follow-up periods, and rigorous controls for confounding variables. This study aims to explore if gender-affirming surgery (GAS) and gender-affirming hormone therapy (GAHT) is associated with improvement in symptoms of depression, anxiety, and gender incongruence among transgender individuals attending a specialist clinic in Hong Kong. Methods In this retrospective cohort which consisted of 394 treatment-seeking transgender participants at baseline, 178 individuals were recruited from October 2023 to June 2024 and completed self-rated questionnaires to assess depressive and anxiety symptoms and gender incongruence. Socio-clinical profiles and questionnaire scores were compared among treatment status groups. Longitudinal changes in mental health outcome scores were analyzed using linear mixed-effects regression models, incorporating time-by-group interactions and random intercepts to account for individual baseline differences. Results Gender-affirming treatments did not reduce depressive or anxiety symptoms significantly, after controlling for coping and social support. However, both GAS and GAHT were associated with significant improvements in gender congruence over time. Mood symptoms were significantly associated with social support and coping. Various sociodemographic and psychosocial factors, including employment status, living situation, psychological care, and psychiatric medication use, were associated with psychological outcomes. Discussion Gender-affirming medical treatments alone may not entirely resolve the mental health difficulties faced by transgender individuals. Future research needs to better elucidate the impacts of persistent psychosocial challenges such as discrimination and rejection, as well as potential treatment complications. The treatment-seeking nature of this cohort, coupled with baseline psychiatric interventions, may have obscured significant correlations. While gender-affirming treatments can enhance gender congruence, our findings highlight the importance of holistic approaches to strengthen adaptive buffering mechanisms throughout the gender transition process. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Gender-Affirming Surgery: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Gender-Affirming Surgery (modality). Clinician-written summaries and actionable practice insights. 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Structured data was extracted solely from the abstract, so granular results, subgroup data, and methodological details from the full text could not be verified.","value_numeric":null}],"summaries":{"what_studied":"Retrospective chart review of 771 transgender individuals seen at the Cadiz (Andalusia, Spain) Gender Identity Unit from 2015–2023, describing demographics, gender-affirming hormone use, puberty blocker use, surgical procedures, and rates of gender identity change or detransition.","key_result":"Of 771 patients (mean age 21.36 ± 8.96 years; 56.2% assigned female at birth), 80.4% started gender-affirming hormones, 7% received puberty blockers, 194 breast surgeries and 130 genital surgeries were performed, and only 9 individuals (1.3%) later expressed a change in gender identity, with just 1 expressing regret about treatment.","limitations":"- High loss to follow-up means the detransition/regret rate of 1.3% is likely an underestimate.\n- Single-center retrospective design limits generalizability.\n- Study does not report long-term outcomes beyond identity change or regret.","practice_takeaway":"In this large Spanish cohort over 8 years, the rate of expressed regret after gender-affirming treatment was very low (1 of 771), but clinicians should note that substantial loss to follow-up may mask a higher true rate. 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Gender congruence improved with treatment (GAS time×group +11.99 points on GCLS, p<0.001; GAHT time effect +6.59 points, p<0.001; genital surgery +4.35 points, p=0.008; GAHT 2–5 years associated with higher chest/breast congruence, b=0.601, p=0.003).","limitations":"Single‑center, treatment‑seeking cohort with integrated psychological care and self‑reported measures limits generalizability and causal inference; no cisgender or non‑treatment control group; attrition from the original 394 cohort to 178 respondents may introduce selection bias.","practice_takeaway":"Expect meaningful gains in gender congruence after GAHT/GAS, but do not assume depression or anxiety will lessen without addressing psychosocial drivers. Strengthening social support and shifting from avoidant to facilitative coping should be part of routine care alongside medical transition."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Gender-Affirming Surgery"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Gender-Affirming Surgery"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Gender-Affirming Surgery"}}}]]

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