2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T635,To provide guidance on the recommended management of cancer in pregnant patients. A multidisciplinary Expert Panel convened and conducted a systematic review of the literature. The systematic review identified 450 eligible studies. Much of the evidence consisted of observational data, case series, and case reports. Management of cancer during pregnancy should be grounded in a values-based informed-consent process outlining maternal and fetal risks and anticipated benefits. Diagnostic evaluation should follow the as low as reasonably achievable (ALARA) principle, with timing of diagnostic studies individualized based on urgency of cancer detection, potential dangers of delay, and the balance of risks to both the pregnant patient and her embryo or fetus. Due to significant risk of harm to the developing embryo and/or fetus, systemic therapy should be deferred until the second trimester. Methotrexate, hormonal therapies, human epidermal growth factor receptor 2-targeted agents, vascular endothelial growth factor and poly (ADP-ribose) polymerase inhibitors, antibody-drug conjugates, and all cellular therapies are contraindicated during pregnancy, regardless of gestational age. For patients who wish to continue their pregnancy, delivery should be planned at or after 37 weeks, with the final chemotherapy dose scheduled 2-4 weeks before birth. Referral to psychosocial support services is essential to address emotional and practical challenges, reduce distress, and support shared decision making.Additional information is available at www.asco.org/survivorship-guidelines.31:T11ae, ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following the guideline development process as outlined in the

ASCO Guidelines Methodology Manual

. ASCO Guidelines follow the ASCO Conflict of Interest Policy for Clinical Practice Guidelines . Clinical Practice Guidelines and other guidance (“Guidance”) provided by ASCO is not a comprehensive or definitive guide to treatment options. It is intended for voluntary use by clinicians and should be used in conjunction with independent professional judgment. Guidance may not be applicable to all patients, interventions, diseases or stages of diseases. Guidance is based on review and analysis of relevant literature, and is not intended as a statement of the standard of care. ASCO does not endorse third-party drugs, devices, services, or therapies and assumes no responsibility for any harm arising from or related to the use of this information. See complete disclaimer in Appendix 1 and Appendix 2 (online only) for more. PURPOSE To provide guidance on the recommended management of cancer in pregnant patients. METHODS A multidisciplinary Expert Panel convened and conducted a systematic review of the literature. RESULTS The systematic review identified 450 eligible studies. Much of the evidence consisted of observational data, case series, and case reports. RECOMMENDATIONS Management of cancer during pregnancy should be grounded in a values-based informed-consent process outlining maternal and fetal risks and anticipated benefits. Diagnostic evaluation should follow the as low as reasonably achievable (ALARA) principle, with timing of diagnostic studies individualized based on urgency of cancer detection, potential dangers of delay, and the balance of risks to both the pregnant patient and her embryo or fetus. Due to significant risk of harm to the developing embryo and/or fetus, systemic therapy should be deferred until the second trimester. Methotrexate, hormonal therapies, human epidermal growth factor receptor 2–targeted agents, vascular endothelial growth factor and poly (ADP-ribose) polymerase inhibitors, antibody-drug conjugates, and all cellular therapies are contraindicated during pregnancy, regardless of gestational age. For patients who wish to continue their pregnancy, delivery should be planned at or after 37 weeks, with the final chemotherapy dose scheduled 2-4 weeks before birth. Referral to psychosocial support services is essential to address emotional and practical challenges, reduce distress, and support shared decision making. Additional information is available at www.asco.org/survivorship-guidelines . 32:T593,Acne vulgaris commonly affects adults, adolescents, and preadolescents aged 9 years or older. The objective of this study was to provide evidence-based recommendations for the management of acne. A work group conducted a systematic review and applied the Grading of Recommendations, Assessment, Development, and Evaluation approach for assessing the certainty of evidence and formulating and grading recommendations. This guideline presents 18 evidence-based recommendations and 5 good practice statements. Strong recommendations are made for benzoyl peroxide, topical retinoids, topical antibiotics, and oral doxycycline. Oral isotretinoin is strongly recommended for acne that is severe, causing psychosocial burden or scarring, or failing standard oral or topical therapy. Conditional recommendations are made for topical clascoterone, salicylic acid, and azelaic acid, as well as for oral minocycline, sarecycline, combined oral contraceptive pills, and spironolactone. Combining topical therapies with multiple mechanisms of action, limiting systemic antibiotic use, combining systemic antibiotics with topical therapies, and adding intralesional corticosteroid injections for larger acne lesions are recommended as good practice statements. Analysis is based on the best available evidence at the time of the systematic review. These guidelines provide evidence-based recommendations for the management of acne vulgaris.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Hormonal Therapy: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Hormonal Therapy (modality). Clinician-written summaries and actionable practice insights. 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Emerging evidence suggests hormonal and microbiome-targeting strategies may one day complement or precede immunomodulatory therapy."}},{"doi":"10.1016/j.eururo.2026.04.013","pmid":"42457454","title":"EAU–EANM–ESTRO–ESUR–ISUP–SIOG Guidelines on Prostate Cancer—2026 Update. 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Sample size tag is not applicable as this is a guideline document, not a primary trial. The five-tier EAU classification mentioned is newly introduced and not yet widely validated in independent cohorts.","value_numeric":null}],"summaries":{"what_studied":"This 2026 update of the joint EAU–EANM–ESTRO–ESUR–ISUP–SIOG guidelines covers screening, diagnosis, and local curative-intent treatment of prostate cancer (PCa), based on a systematic literature review of evidence published between May 2023 and 2025.","key_result":"Key updates include: (1) risk-adapted PSA screening starting at age 50 based on individualised life expectancy; (2) mpMRI recommended before biopsy to avoid unnecessary procedures; (3) combined targeted plus regional biopsy when biopsy is indicated; (4) a new five-tier EAU risk classification; (5) PSMA PET as the most sensitive staging tool for metastatic spread; (6) active surveillance endorsed for low-risk and selected favourable intermediate-risk (ISUP GG2) PCa; (7) hypofractionated radiotherapy recommended for intermediate-risk patients; and (8) radiotherapy plus long-term intensified hormonal therapy for cN1 disease.","limitations":"Covers only localised/locally advanced PCa (Part I); evidence rapidly evolving, so some recommendations may have a short shelf life. Systematic review time frame (May 2023–2025) may exclude very recent data.","practice_takeaway":"Use mpMRI before biopsy to reduce unnecessary procedures, and offer active surveillance to low-risk and selected favourable ISUP GG2 patients. For cN1 disease, combine radiotherapy to the primary tumour with long-term intensified hormonal therapy."}},{"doi":"10.1016/j.eururo.2026.03.014","pmid":"42128753","title":"IDH1 Mutations Are Associated with Favorable Outcomes in Prostate Cancer","journal_title":"European Urology","journal_issn":"0302-2838","published_at":"2026-07-14T00:00:00.000Z","url":"https://doi.org/10.1016/j.eururo.2026.03.014","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-23T13:33:20.841Z","updated_at":"2026-07-23T13:33:20.841Z","tags":[{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"category","value":"Urology & Nephrology","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"condition","value":"Prostate Cancer","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"generic","value":"IDH1 inhibitor","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"modality","value":"Hormonal Therapy","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"modality","value":"Molecular Targeted Therapy","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"sample_size","value":"n=111","value_numeric":111},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"sex","value":"male","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"warning","value":"Full text was not accessible; structured data extracted solely from the abstract. Statistical methods, covariate adjustment details, and follow-up duration could not be verified.","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"warning","value":"IDH1 inhibitors are not mentioned as a treatment in this study — the modality tag reflects the broader therapeutic relevance, not a tested intervention.","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"warning","value":"impact_flag set to 'practice_changing' with caution: this is a retrospective study and prospective validation is needed before changing standard practice.","value_numeric":null},{"paper_doi":"10.1016/j.eururo.2026.03.014","tag_type":"warning","value":"The IDH2-mutated subgroup (n=12) is too small to draw reliable conclusions; survival data reported applies specifically to IDH1 mutations.","value_numeric":null}],"summaries":{"what_studied":"Retrospective multi-institutional analysis of clinical and molecular features in 99 IDH1-mutated and 12 IDH2-mutated prostate cancer cases versus a matched IDH1/2 wild-type control cohort, evaluating survival outcomes, co-occurring genomic alterations, and transcriptional changes.","key_result":"IDH1 mutations were associated with significantly better overall survival (HR 0.16, 95% CI 0.04–0.68), metastasis-free survival (HR 0.22, 95% CI 0.09–0.58), and progression-free survival on hormonal therapy (HR 0.35, 95% CI 0.16–0.76) vs. matched controls — despite high tumor stage (42% T3) and grade (54% grade group 5) at presentation.","limitations":"Retrospective design with cases drawn from genomics databases introduces selection bias. IDH2-mutated cohort is small (n=12), limiting conclusions for that subgroup. Full-text was not accessible for review of statistical methods or covariate adjustment details.","practice_takeaway":"When IDH1 mutations are identified on tumor genomic profiling in prostate cancer, clinicians should recognize this as a likely favorable-prognosis subtype — even when grade and stage appear high. Routine reporting of IDH1 mutation status may aid prognostic counseling."}},{"doi":"10.1200/jco-25-02115","pmid":"41380115","title":"Management of Cancer During Pregnancy: ASCO Guideline","journal_title":"Journal of Clinical Oncology","journal_issn":"0732-183X","published_at":"2025-12-11T00:00:00.000Z","url":"https://lirias.kuleuven.be/handle/20.500.12942/778669","source_score":190,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-18","doi":"10.1200/jco-25-02115","days":"7","issn":"0732-183X","rank":"3","field":"Clinical Medicine","score":"190","category":"Oncology","categories":["Oncology"],"_categories":["Oncology"]},"pubmed":{"doi":"10.1200/JCO-25-02115","title":"Management of Cancer During Pregnancy: ASCO Guideline.","journal":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","methods":"","results":"The systematic review identified 450 eligible studies. 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Strong recommendations are made for benzoyl peroxide, topical retinoids, topical antibiotics, and oral doxycycline. Oral isotretinoin is strongly recommended for acne that is severe, causing psychosocial burden or scarring, or failing standard oral or topical therapy. Conditional recommendations are made for topical clascoterone, salicylic acid, and azelaic acid, as well as for oral minocycline, sarecycline, combined oral contraceptive pills, and spironolactone. Combining topical therapies with multiple mechanisms of action, limiting systemic antibiotic use, combining systemic antibiotics with topical therapies, and adding intralesional corticosteroid injections for larger acne lesions are recommended as good practice statements.","abstract":"$32","keywords":["Acne","Cutibacterium acnes","acne vulgaris","adapalene","antiandrogens","antibiotics","azelaic acid","azithromycin","benzoyl peroxide","clascoterone","clindamycin","contraceptives","corticosteroids","diet and acne","doxycycline","erythromycin","grading and classification of acne","guidelines","hormonal therapy","isotretinoin","light therapies","microbiological and endocrine testing","minocycline","retinoids","salicylic 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