2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T7f4,Several widely used drugs have photosensitizing properties, and much research has been conducted to find associations between their use and the risk of developing cutaneous malignant melanoma (cM), basal cell carcinoma (BCC) or cutaneous squamous cell carcinoma (cSCC), often with conflicting results. To assess whether the use of commonly prescribed photosensitizing drugs increases skin cancer risk. Analyses were performed using a large cohort of women, with prospectively collected information on phenotypic traits and sun exposure. Comprehensive information on pharmaceutical treatments and skin cancer occurrence was obtained through national registries. Drugs with photosensitizing properties were grouped according to the Anatomical Therapeutic Chemical system in nine groups, and associations between the use of such drugs were investigated using multivariable Cox regression analysis. The number of retrieved daily doses was analyzed to test the dose-response relationship. Hormone replacement therapy significantly increased the risk of BCC (hazard ratio [HR] 1.24; 95% confidence interval [CI]: 1.11-1.39), cSCC (HR 1.23; 95% CI: 1.03-1.47) and cM (HR 1.31; 95% CI: 1.01-1.69), with estrogen driving this risk. There was a trend of increased risk of BCC and cM with higher doses of estrogen treatment. Subgroup analysis among those using diuretics showed that loop diuretics were associated with increased cSCC risk (HR 1.6; 95% CI: 1.3-2.0), including a positive association between risk and dose. Furthermore, increased risks of BCC (HR 1.25; 95% CI: 1.09-1.44) and cM (HR 1.41; 95% CI: 1.03-1.93) were associated with thiazide use. NSAIDs showed a possible curvilinear association to BCC and cSCC. Estrogen treatment increased the risk of all investigated skin cancers. Among those using diuretics, loop diuretics increased the risk of cSCC, and thiazide use increased the risk of BCC. We suggest that physicians should advise female patients prescribed estrogen, thiazides, or loop diuretics to limit their sun exposure.31:T986,ABSTRACTBackgroundSeveral widely used drugs have photosensitizing properties, and much research has been conducted to find associations between their use and the risk of developing cutaneous malignant melanoma (cM), basal cell carcinoma (BCC) or cutaneous squamous cell carcinoma (cSCC), often with conflicting results.ObjectiveTo assess whether the use of commonly prescribed photosensitizing drugs increases skin cancer risk.MethodsAnalyses were performed using a large cohort of women, with prospectively collected information on phenotypic traits and sun exposure. Comprehensive information on pharmaceutical treatments and skin cancer occurrence was obtained through national registries. Drugs with photosensitizing properties were grouped according to the Anatomical Therapeutic Chemical system in nine groups, and associations between the use of such drugs were investigated using multivariable Cox regression analysis. The number of retrieved daily doses was analyzed to test the dose–response relationship.ResultsHormone replacement therapy significantly increased the risk of BCC (hazard ratio [HR] 1.24; 95% confidence interval [CI]: 1.11–1.39), cSCC (HR 1.23; 95% CI: 1.03–1.47) and cM (HR 1.31; 95% CI: 1.01–1.69), with estrogen driving this risk. There was a trend of increased risk of BCC and cM with higher doses of estrogen treatment. Subgroup analysis among those using diuretics showed that loop diuretics were associated with increased cSCC risk (HR 1.6; 95% CI: 1.3–2.0), including a positive association between risk and dose. Furthermore, increased risks of BCC (HR 1.25; 95% CI: 1.09–1.44) and cM (HR 1.41; 95% CI: 1.03–1.93) were associated with thiazide use. NSAIDs showed a possible curvilinear association to BCC and cSCC.ConclusionsEstrogen treatment increased the risk of all investigated skin cancers. Among those using diuretics, loop diuretics increased the risk of cSCC, and thiazide use increased the risk of BCC. We suggest that physicians should advise female patients prescribed estrogen, thiazides, or loop diuretics to limit their sun exposure.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Loop Diuretic: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Loop Diuretic (modality). Clinician-written summaries and actionable practice insights. 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Children not on diuretics had a greater improvement in weight z-score (0.97 vs. 0.64, p<0.001), but this difference disappeared on adjusted, site-clustered analysis.","limitations":"- Retrospective design with no granular data on diuretic dose, duration, or adherence; discharge weight z-scores were unavailable, limiting trajectory analysis during active diuretic exposure.\n- Detailed nutritional data (caloric density, fortification) not captured — residual confounding by nutrition possible.\n- Cohort drawn from two tertiary BPD centers enriched for severe disease, limiting generalizability to milder BPD; 15-year enrollment window introduces risk of temporal confounding from evolving care practices.","practice_takeaway":"Outpatient diuretic therapy does not appear to impair weight gain in infants with BPD — clinicians need not discontinue diuretics based on growth concerns alone. An individualized approach guided by respiratory status, with close weight monitoring and gradual weaning as the child outgrows the dose, remains reasonable practice."}},{"doi":"10.1111/phpp.70013","pmid":"40102189","title":"Photosensitizing Drugs and Risk of Skin Cancer in Women—A Prospective Population‐Based Study","journal_title":"Photodermatology, Photoimmunology & Photomedicine","journal_issn":"0905-4383","published_at":"2025-03-19T00:00:00.000Z","url":"https://doi.org/10.1111/phpp.70013","source_score":64,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-04-07","doi":"10.1111/phpp.70013","days":"30","issn":"0905-4383","rank":"5","field":"Clinical Medicine","score":"64","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/phpp.70013","title":"Photosensitizing Drugs and Risk of Skin Cancer in Women-A Prospective Population-Based Study.","journal":"Photodermatology, photoimmunology & photomedicine","methods":"","results":"Hormone replacement therapy significantly increased the risk of BCC (hazard ratio [HR] 1.24; 95% confidence interval [CI]: 1.11-1.39), cSCC (HR 1.23; 95% CI: 1.03-1.47) and cM (HR 1.31; 95% CI: 1.01-1.69), with estrogen driving this risk. There was a trend of increased risk of BCC and cM with higher doses of estrogen treatment. Subgroup analysis among those using diuretics showed that loop diuretics were associated with increased cSCC risk (HR 1.6; 95% CI: 1.3-2.0), including a positive association between risk and dose. Furthermore, increased risks of BCC (HR 1.25; 95% CI: 1.09-1.44) and cM (HR 1.41; 95% CI: 1.03-1.93) were associated with thiazide use. NSAIDs showed a possible curvilinear association to BCC and cSCC.","abstract":"$30","keywords":["basal cell carcinoma","melanoma","photosensitizing drugs","prospective","squamous cell carcinoma"],"pubmed_id":"40102189","conclusions":"","publication_date":"2025-03-19T00:00:00"},"crossref":{"DOI":"10.1111/phpp.70013","URL":"https://doi.org/10.1111/phpp.70013","ISSN":["0905-4383","1600-0781"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/phpp.70013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"2","score":1,"title":["Photosensitizing Drugs and Risk of Skin Cancer in Women—A Prospective Population‐Based Study"],"author":[{"given":"Gustav Boelsgaard","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Dermatology Skåne University Hospital Lund Sweden"},{"name":"Lund University Skin Cancer Research Group, Dermatology, Department of Clinical 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Among diuretic users, loop diuretics increased cSCC risk (HR 1.6; 95% CI 1.3-2.0) with a dose relation, thiazides increased BCC (HR 1.25; 95% CI 1.09-1.44) and melanoma (HR 1.41; 95% CI 1.03-1.93), and NSAIDs showed a possible curvilinear association with BCC and cSCC.","practice_takeaway":"Counsel women prescribed estrogen therapy, thiazides, or loop diuretics to limit sun exposure and practice photoprotection, given observed increases in skin cancer risk."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Loop Diuretic"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Loop Diuretic"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Loop Diuretic"}}}]]

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