2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T920,Patients with intermediate-high risk pulmonary embolism (PE) have an elevated right ventricular (RV) to left ventricular (LV) diameter ratio and are at risk of early clinical decompensation and mortality. Reperfusion therapy aims to rapidly relieve acute RV pressure overload and to normalize hemodynamics. STORM-PE (A Prospective, Multicenter, Randomized Controlled Trial Evaluating Anticoagulation Alone Versus Anticoagulation Plus Mechanical Aspiration With the Indigo Aspiration System for the Treatment of Intermediate-High Risk Acute Pulmonary Embolism) is the first reported randomized controlled trial to test the efficacy and to evaluate the safety of mechanical thrombectomy, specifically computer-assisted vacuum thrombectomy (CAVT) with anticoagulation compared to anticoagulation alone. STORM-PE is an international randomized controlled trial with 1:1 randomization to CAVT with anticoagulation or anticoagulation alone. Eligible adults had acute-onset (symptoms ≤14 days), intermediate-high risk PE and were normotensive, with an RV/LV ratio ≥1.0 on computed tomographic pulmonary angiography and elevated cardiac biomarkers. The primary end-point analysis tested for a difference between groups for the change in RV/LV ratio at 48 hours, assessed by a blinded independent imaging core laboratory. Secondary end points included major adverse events within 7 days (a composite of clinical deterioration necessitating rescue therapy, PE-related mortality, symptomatic recurrent PE, and major bleeding), adjudicated by an external clinical events committee. Additional outcomes included change in vital signs and core laboratory-assessed pulmonary artery obstruction at 48 hours. A total of 100 patients enrolled across 22 sites were randomized to CAVT (n=47) or anticoagulation alone (n=53). Baseline characteristics were comparable between arms. At 48 hours, mean reduction in RV/LV ratio was greater for CAVT (0.52±0.37) than anticoagulation (0.24±0.40), a difference of 0.27 (95% CI, 0.12-0.43; CAVT was superior to anticoagulation alone in reducing RV/LV ratio within 48 hours in patients with intermediate-high risk PE, accompanied by earlier normalization of vital signs and major adverse event rates comparable to those for anticoagulation. URL: https://www.clinicaltrials.gov; Unique identifier: NCT05684796.31:Tfac, BACKGROUND: Patients with intermediate-high risk pulmonary embolism (PE) have an elevated right ventricular (RV) to left ventricular (LV) diameter ratio and are at risk of early clinical decompensation and mortality. Reperfusion therapy aims to rapidly relieve acute RV pressure overload and to normalize hemodynamics. STORM-PE (A Prospective, Multicenter, Randomized Controlled Trial Evaluating Anticoagulation Alone Versus Anticoagulation Plus Mechanical Aspiration With the Indigo Aspiration System for the Treatment of Intermediate-High Risk Acute Pulmonary Embolism) is the first reported randomized controlled trial to test the efficacy and to evaluate the safety of mechanical thrombectomy, specifically computer-assisted vacuum thrombectomy (CAVT) with anticoagulation compared to anticoagulation alone. METHODS: STORM-PE is an international randomized controlled trial with 1:1 randomization to CAVT with anticoagulation or anticoagulation alone. Eligible adults had acute-onset (symptoms ≤14 days), intermediate-high risk PE and were normotensive, with an RV/LV ratio ≥1.0 on computed tomographic pulmonary angiography and elevated cardiac biomarkers. The primary end-point analysis tested for a difference between groups for the change in RV/LV ratio at 48 hours, assessed by a blinded independent imaging core laboratory. Secondary end points included major adverse events within 7 days (a composite of clinical deterioration necessitating rescue therapy, PE-related mortality, symptomatic recurrent PE, and major bleeding), adjudicated by an external clinical events committee. Additional outcomes included change in vital signs and core laboratory–assessed pulmonary artery obstruction at 48 hours. RESULTS: A total of 100 patients enrolled across 22 sites were randomized to CAVT (n=47) or anticoagulation alone (n=53). Baseline characteristics were comparable between arms. At 48 hours, mean reduction in RV/LV ratio was greater for CAVT (0.52±0.37) than anticoagulation (0.24±0.40), a difference of 0.27 (95% CI, 0.12–0.43; P <0.001). Refined modified and modified Miller scores exhibited greater changes for CAVT than anticoagulation alone at 48 hours ( P <0.001). Early normalization of vital signs within 48 hours was more frequent after CAVT. The major adverse event rate within 7 days was not different between groups (CAVT, 4.3% versus anticoagulation, 7.5%; P =0.681). Two PE-related deaths occurred in the CAVT arm. CONCLUSIONS: CAVT was superior to anticoagulation alone in reducing RV/LV ratio within 48 hours in patients with intermediate-high risk PE, accompanied by earlier normalization of vital signs and major adverse event rates comparable to those for anticoagulation. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT05684796. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Mechanical Thrombectomy: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Mechanical Thrombectomy (modality). Clinician-written summaries and actionable practice insights. 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LB catheters met the prespecified 10% noninferiority margin vs SLB for both FPE and recanalization.","limitations":"- SLB group was markedly smaller (n=107 vs n=1925 pre-match), limiting statistical power to detect modest differences.\n- Retrospective design introduces potential unmeasured confounding despite propensity matching.\n- SLB catheter technology is still emerging; specific device-level variation within each category was not analyzed.","practice_takeaway":"Standard large-bore aspiration catheters appear noninferior to superlarge-bore catheters for stroke thrombectomy — clinicians do not need to default to SLB devices to achieve comparable reperfusion and functional outcomes. Device selection can reasonably continue to be guided by operator familiarity, vessel anatomy, and availability."}},{"doi":"10.1136/jnis-2026-025573","pmid":"42660659","title":"Millipede Aspiration for Revascularization in Stroke (MARRS): prospective trial of a novel 0.088 inch corrugated catheter","journal_title":"Journal of NeuroInterventional Surgery","journal_issn":"1759-8478","published_at":"2026-08-27T00:00:00.000Z","url":"https://doi.org/10.1136/jnis-2026-025573","source_score":45,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-09-02T06:22:39.759Z","updated_at":"2026-09-02T06:22:39.759Z","tags":[{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"brand","value":"Millipede","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"category","value":"Surgery","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"condition","value":"Acute Ischemic Stroke","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"condition","value":"Large Vessel Occlusion","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"modality","value":"Aspiration Catheter","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"modality","value":"Mechanical Thrombectomy","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"sample_size","value":"n=180","value_numeric":180},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"study_design","value":"Prospective Single-Arm Trial","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"warning","value":"Catheter assignment was based on vessel diameter rather than randomization, which may introduce selection bias between Millipede88 and Millipede70 subgroups.","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"warning","value":"No randomized control arm; comparisons to historical benchmarks should be made with caution.","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025573","tag_type":"warning","value":"Study includes both US and EU sites; regional differences in patient selection or practice patterns are not reported.","value_numeric":null}],"summaries":{"what_studied":"Prospective, multicenter, single-arm pivotal trial evaluating safety and efficacy of the corrugated Millipede aspiration catheter system (0.088 inch) in 180 adults aged 18–85 with acute ischemic stroke from large vessel occlusion (ICA, M1, M2, or basilar artery), treated within 8 hours.","key_result":"Primary efficacy endpoint (mTICI ≥2b in ≤3 passes without rescue) was met in 160/180 patients (88.9%; 95% CI lower bound 84.3%). First-pass mTICI ≥2c was 60% overall with Millipede88, rising to 75% in M1 occlusions. Symptomatic intracranial hemorrhage: 2.3%; intracranial dissection: 1.1%; no perforations; 90-day all-cause mortality: 13.9%.","limitations":"Single-arm design with no randomized comparator limits causal inference. Catheter selection was vessel-diameter based, introducing allocation variability. Generalizability may be limited as trial enrolled only ICA, M1, M2, and basilar occlusions.","practice_takeaway":"The Millipede 0.088-inch aspiration catheter achieved high rates of first-pass and final reperfusion (mTICI ≥2c) with low complication rates, particularly in M1 occlusions. Clinicians treating large vessel occlusion may find this system a viable front-line aspiration option, especially for larger-caliber target vessels."}},{"doi":"10.1136/jnis-2026-025894","pmid":"42562636","title":"Thunderbolt System for acute ischemic stroke secondary to large vessel occlusion: primary results of the THUNDER study","journal_title":"Journal of NeuroInterventional Surgery","journal_issn":"1759-8478","published_at":"2026-08-06T00:00:00.000Z","url":"https://doi.org/10.1136/jnis-2026-025894","source_score":4,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-14T13:25:02.360Z","updated_at":"2026-08-14T13:25:02.360Z","tags":[{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"brand","value":"Thunderbolt","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"category","value":"Surgery","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"condition","value":"Acute Ischemic Stroke","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"condition","value":"Large Vessel Occlusion","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"modality","value":"Computer-Assisted Vacuum Thrombectomy","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"modality","value":"Mechanical Thrombectomy","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"sample_size","value":"n=216","value_numeric":216},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"study_design","value":"Prospective Single-Arm Multicenter Study","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"warning","value":"Level of evidence assigned as 3 (prospective cohort); no randomized control arm was included.","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"warning","value":"Single-arm study design: no randomized comparator, so effectiveness claims vs. other devices rely on indirect historical comparisons only.","value_numeric":null},{"paper_doi":"10.1136/jnis-2026-025894","tag_type":"warning","value":"The 'Thunderbolt' brand name refers to aspiration tubing within the broader Penumbra System; clinicians should note this is a component-level innovation, not a fully standalone device.","value_numeric":null}],"summaries":{"what_studied":"The THUNDER study evaluated the safety and effectiveness of the Penumbra Thunderbolt computer-assisted vacuum thrombectomy (CAVT) system with modulated aspiration in 216 patients with emergent large vessel occlusion (ELVO) across 29 US centers, using a single-arm prospective multicenter design.","key_result":"The primary endpoint was met: post-Thunderbolt mTICI 2b-3 revascularization was achieved in 87.5% of patients (95% CI 82.3%–91.6%; p<0.001). First-pass mTICI 2b-3 was 64.8%, median time to revascularization was 20 min, sICH occurred in 0.9%, device/procedure-related SAEs in 2.8%, 90-day mRS 0–2 was 55.4%, and all-cause mortality at 90 days was 11.7%.","limitations":"Single-arm design without a concurrent control group limits causal inference. Comparison to prior large-bore catheter data is indirect and subject to patient selection differences. The study was conducted exclusively at US centers, which may limit generalizability.","practice_takeaway":"The Thunderbolt CAVT system achieved high revascularization rates (87.5% mTICI 2b-3) with a short median procedure time of 20 minutes and a low complication profile, making it a viable first-line aspiration option for ELVO. The first-pass effect rate (64.8%) numerically exceeded historical benchmarks for large-bore catheters and approached those of ultra-bore devices."}},{"doi":"10.1161/circinterventions.126.016573","pmid":"42312382","title":"Is There a Golden Hour for Thrombectomy in Intermediate-Risk Pulmonary Embolism? Insights From SYMPHONY-PE","journal_title":"Circulation: Cardiovascular Interventions","journal_issn":"1941-7640","published_at":"2026-06-18T00:00:00.000Z","url":"https://doi.org/10.1161/circinterventions.126.016573","source_score":26,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-22T13:24:15.137Z","updated_at":"2026-06-22T13:24:15.137Z","tags":[{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"category","value":"Cardiac & Cardiovascular Systems","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"condition","value":"Pulmonary Embolism","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"modality","value":"Catheter-Based Therapy","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"modality","value":"Mechanical Thrombectomy","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"sample_size","value":"n=109","value_numeric":109},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"study_design","value":"Prospective Cohort Study (Registry Sub-analysis)","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"warning","value":"No specific drug brand or generic agent is associated with mechanical thrombectomy in this study; modality tags reflect the procedural intervention only.","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"warning","value":"The primary efficacy endpoint (RV/LV ratio reduction) only approached statistical significance (P=0.071); the mean pulmonary artery pressure result was significant but should be interpreted cautiously given the observational design.","value_numeric":null},{"paper_doi":"10.1161/circinterventions.126.016573","tag_type":"warning","value":"This is a non-randomized sub-analysis of the SYMPHONY-PE registry; the early vs. late thrombectomy groups were not randomly assigned, so confounding by clinical urgency or operator judgment is possible.","value_numeric":null}],"summaries":{"what_studied":"Among 109 intermediate-risk PE patients enrolled in SYMPHONY-PE (NCT06062329), early mechanical thrombectomy (<12 hours from CT pulmonary angiography) was compared with late thrombectomy (≥12 hours) on acute pulmonary hemodynamics and RV mechanics, with safety assessed at 48 hours.","key_result":"Early thrombectomy (44% of patients, n=48) produced a greater reduction in mean pulmonary artery pressure vs. late (8.6±5.2 vs. 5.8±5.0 mmHg; P=0.006) and a larger but non-significant reduction in RV/LV ratio (0.52±0.50 vs. 0.37±0.34; P=0.071); major adverse event rates were similar between groups (P=0.431) with zero mortalities.","limitations":"Non-randomized comparison within an observational registry, limiting causal inference; timing cutoff of 12 hours was pre-specified but may not capture the full continuum of benefit; results may not generalize beyond intermediate-risk PE.","practice_takeaway":"Early mechanical thrombectomy (<12 hours) appears to yield greater hemodynamic benefit than delayed treatment in intermediate-risk PE, especially in higher-risk patients by Composite PE Shock score — but randomized trials are still needed before changing practice."}},{"doi":"10.1161/strokeaha.125.053829","pmid":"41582810","title":"Guidelines in Action: Pediatric Acute Ischemic Stroke Treatments (Thrombolysis and Thrombectomy)","journal_title":"Stroke","journal_issn":"0039-2499","published_at":"2026-01-26T00:00:00.000Z","url":"https://doi.org/10.1161/strokeaha.125.053829","source_score":13,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-08-05T13:23:01.492Z","updated_at":"2026-08-05T13:23:01.492Z","tags":[{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"category","value":"Clinical Neurology","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"condition","value":"Acute Ischemic Stroke","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"generic","value":"alteplase","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"modality","value":"Mechanical Thrombectomy","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"modality","value":"Thrombolysis","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"study_design","value":"Guideline / Review","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"warning","value":"Full paper text was not provided; summary is based solely on the title, journal, DOI, and publication date. Specific patient numbers, outcome data, and detailed recommendations could not be extracted.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"warning","value":"Level of evidence set to 7 (expert opinion/guideline) given the nature of the article, but this may not reflect individual cited studies within the paper.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.053829","tag_type":"warning","value":"Study design tagged as 'Guideline / Review' based on the article title ('Guidelines in Action'); the exact format (narrative review, structured guideline commentary, etc.) is uncertain without full text.","value_numeric":null}],"summaries":{"what_studied":"This guideline-in-action article evaluates the use of thrombolysis (tPA) and mechanical thrombectomy for acute ischemic stroke (AIS) in pediatric patients, synthesizing current evidence and guideline recommendations for these reperfusion therapies in children.","key_result":"Current evidence supporting thrombolysis and thrombectomy in pediatric AIS remains limited; guideline recommendations are largely extrapolated from adult trials, with pediatric-specific data derived mainly from registries and small case series rather than randomized controlled trials.","limitations":"No large pediatric RCTs exist for either intervention; evidence is largely registry-based or extrapolated from adult data; pediatric stroke is rare, making prospective trial enrollment challenging.","practice_takeaway":"Clinicians should consider thrombolysis and thrombectomy for eligible pediatric AIS patients using adult-derived criteria adapted to age, while recognizing that decisions must be individualized given the limited pediatric evidence base. Collaboration with pediatric stroke centers and neurology expertise is strongly advised."}},{"doi":"10.1161/circulationaha.125.077232","pmid":"41183181","title":"Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial","journal_title":"Circulation","journal_issn":"0009-7322","published_at":"2025-11-03T00:00:00.000Z","url":"https://doi.org/10.1161/circulationaha.125.077232","source_score":56,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-12-31","doi":"10.1161/circulationaha.125.077232","days":"14","issn":"0009-7322","rank":"8","field":"Clinical Medicine","score":"56","category":"Cardiac & Cardiovascular Systems","categories":["Cardiac & Cardiovascular Systems"],"_categories":["Cardiac & Cardiovascular Systems"]},"pubmed":{"doi":"10.1161/CIRCULATIONAHA.125.077232","title":"Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial.","journal":"Circulation","methods":"","results":"A total of 100 patients enrolled across 22 sites were randomized to CAVT (n=47) or anticoagulation alone (n=53). Baseline characteristics were comparable between arms. At 48 hours, mean reduction in RV/LV ratio was greater for CAVT (0.52±0.37) than anticoagulation (0.24±0.40), a difference of 0.27 (95% CI, 0.12-0.43; ","abstract":"$30","keywords":["anticoagulants","pulmonary embolism","randomized controlled trial","thrombectomy"],"pubmed_id":"41183181","conclusions":"","publication_date":"2025-11-03T00:00:00"},"crossref":{"DOI":"10.1161/circulationaha.125.077232","URL":"https://doi.org/10.1161/circulationaha.125.077232","ISSN":["0009-7322","1524-4539"],"link":[{"URL":"https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.125.077232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"21-34","type":"journal-article","issue":"1","score":1,"title":["Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial"],"author":[{"given":"Robert 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Embolism","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.077232","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.077232","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.077232","tag_type":"modality","value":"Mechanical Thrombectomy","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.077232","tag_type":"sample_size","value":"n=100","value_numeric":100},{"paper_doi":"10.1161/circulationaha.125.077232","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.077232","tag_type":"warning","value":"No numeric data for major adverse events or vital sign changes were included in the provided text.","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.077232","tag_type":"warning","value":"Primary outcomes focus on 48‑hour imaging changes; longer‑term clinical outcomes are not reported here.","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.077232","tag_type":"warning","value":"The abstract excerpt appears truncated; p‑value(s) and complete endpoint data are not provided.","value_numeric":null}],"summaries":{"what_studied":"An international randomized controlled trial compared computer-assisted vacuum thrombectomy (CAVT) plus anticoagulation versus anticoagulation alone in adults with acute intermediate-high risk pulmonary embolism (symptoms ≤14 days, RV/LV ≥1.0, elevated biomarkers). The primary endpoint was change in RV/LV ratio at 48 hours; key secondary endpoints included 7‑day major adverse events.","key_result":"At 48 hours, mean RV/LV ratio reduction was 0.52±0.37 with CAVT versus 0.24±0.40 with anticoagulation, a difference of 0.27 (95% CI, 0.12–0.43). Earlier normalization of vital signs and major adverse event rates comparable to anticoagulation were reported.","limitations":"Small sample size (n=100) across 22 sites. Short follow-up for efficacy (48 hours) and safety (7 days), and the primary outcome was an imaging surrogate rather than longer-term clinical events.","practice_takeaway":"For adults with intermediate-high risk PE, adding CAVT to anticoagulation produced greater 48-hour RV unloading (larger RV/LV ratio reduction) with similar short‑term major adverse events compared with anticoagulation alone. Longer‑term clinical benefits were not detailed in the provided text."}}],"initialOffset":6,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Mechanical Thrombectomy"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Mechanical Thrombectomy"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Mechanical Thrombectomy"}}}]]

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