3b:I[281230,["/_next/static/immutable/chunks/0l5c-zsrs2aic.js","/_next/static/immutable/chunks/3_n0rk2989-8h.js","/_next/static/immutable/chunks/3ofw495lt1gr1.js","/_next/static/immutable/chunks/3tofdpg99uc12.js","/_next/static/immutable/chunks/2rzojj6zgb9d9.js","/_next/static/immutable/chunks/42jxjvozn2thc.js","/_next/static/immutable/chunks/1jp6nkbajpbfs.js","/_next/static/immutable/chunks/3jn_lf7v27x-6.js","/_next/static/immutable/chunks/33qq2-hg37d0b.js","/_next/static/immutable/chunks/15isb0svrppbz.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/0asz50g5_lfq9.js","/_next/static/immutable/chunks/30ia-cxa0yoyc.js","/_next/static/immutable/chunks/3ghibkczd0agr.js","/_next/static/immutable/chunks/20mjl75wrar8n.js","/_next/static/immutable/chunks/3nxreg9fiyt2y.js","/_next/static/immutable/chunks/0c04lgvo3p78i.js","/_next/static/immutable/chunks/1u78gf_avpn77.js"],"PaperListPageClient"] 3d:I[70339,["/_next/static/immutable/chunks/355lxm8rh3fxr.js"],"IconMark"] 3c:Tbbd, Background: Exercise and nutrition-based prehabilitation programs are promising emerging strategies for enhancing surgical recovery. However, prior studies have reported mixed findings regarding their impact on postoperative outcomes. The purpose of this study is to investigate the efficacy of exercise and nutrition-based prehabilitation on postoperative outcomes, including length-of-stay (LOS), complications, quality-of-life (QoL), pain, and mental health. Methods: A systematic review and meta-analysis was conducted, using MEDLINE, Cochrane Central, EMBASE, and Web of Science, following PRISMA guidelines. Studies published between 2004 and 2024 were identified with search terms including “prehabilitation,” “exercise,” “nutrition,” and “surgery.” Eligible studies (n=293) were randomized controlled trials (RCTs) evaluating exercise or nutrition-based prehabilitation programs and reporting LOS and complications as primary outcomes. Secondary outcomes included QoL, pain, and mental health scores. Random-effects meta-analyses estimated pooled effect sizes. Results: 23 RCTs were included (2,182 participants). Exercise or nutrition-based prehabilitation reduced complications (odds ratio (OR) 0.52. 95% confidence interval (CI):0.35,0.78, p<0.002, I 2 =47.1%) and LOS (mean difference (MD) -0.44 days, 95% CI:-0.78,-0.11, p=0.01, I 2 =44.8%) compared to standard treatment. When comparing interventions, nutrition only had a greater reduction in LOS than exercise only (MD -1.09 days, 95% CI:-1.72,-0.47 vs. MD -0.20 days, 95% CI: -0.51, 0.09; p=0.01). While QoL was not reported in nutrition only RCTs, exercise alone improved QoL measures (standardized mean difference 0.94, 95% CI: 0.24,1.64, p=0.01, I 2 =93.6%) compared to standard treatment. Conclusion: Exercise or nutrition-based prehabilitation programs reduce LOS and complications across multiple surgical contexts. Further work is needed to elucidate the impact of different intervention protocols and their impact on postoperative outcomes. 28:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Nutrition-Based Prehabilitation: Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Nutrition-Based Prehabilitation (modality). Clinician-written summaries and actionable practice insights. 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Tyson School of Medicine, Pasadena, CA, USA"}]},{"given":"Nghiem H","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California Los Angeles, David Geffen School of Medicine and the Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA"},{"name":"Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA"}]},{"given":"Chi-Hong","family":"Tseng","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine & Health Services Research, Internal Medicine-Pediatrics and Preventive Medicine Section, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA USA"}]},{"given":"Marco A","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine & Health Services Research, Internal Medicine-Pediatrics and Preventive Medicine Section, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA USA"},{"name":"UCLA Gender Health Program, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA"}]},{"given":"Justine C","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California Los Angeles, David Geffen School of Medicine and the Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA"},{"name":"UCLA Gender Health Program, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA"}]},{"given":null,"family":null,"sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,4,29]]},"member":"276","prefix":"10.1097","source":"Crossref","volume":null,"created":{"date-time":"2026-04-29T12:13:12Z","timestamp":1777464792000,"date-parts":[[2026,4,29]]},"indexed":{"date-time":"2026-05-02T21:03:01Z","timestamp":1777755781754,"date-parts":[[2026,5,2]]},"subject":[],"abstract":"$3c","language":"en","relation":{},"resource":{"primary":{"URL":"https://journals.lww.com/10.1097/XCS.0000000000001891"}},"subtitle":[],"deposited":{"date-time":"2026-04-29T12:13:13Z","timestamp":1777464793000,"date-parts":[[2026,4,29]]},"issn-type":[{"type":"print","value":"1072-7515"},{"type":"electronic","value":"1879-1190"}],"published":{"date-parts":[[2026,4,29]]},"publisher":"Ovid Technologies (Wolters Kluwer Health)","reference":null,"short-title":[],"update-policy":"https://doi.org/10.1097/lww.0000000000001000","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Journal of the American College of Surgeons"],"reference-count":0,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,4,29]]},"references-count":0,"short-container-title":[],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1097/xcs.0000000000001891","is_oa":false,"title":"Exercise-Based and Nutrition-Based Prehabilitation Programs in Surgery: A Systematic Review and Meta-Analysis","updated":"2026-05-03T08:48:54+00:00","published_date":"2026-04-29","best_oa_location":null}},"created_at":"2026-05-07T22:50:48.657Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"category","value":"Surgery","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"condition","value":"Surgical Recovery","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"level_of_evidence","value":"1","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"modality","value":"Exercise-Based Prehabilitation","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"modality","value":"Nutrition-Based Prehabilitation","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"sample_size","value":"n=2,182","value_numeric":2182},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"study_design","value":"Systematic Review and Meta-Analysis","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"warning","value":"Studies span 2004–2024; variation in prehabilitation protocols across this period may limit comparability of interventions.","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"warning","value":"The study covers 'multiple surgical contexts' but does not specify which specialties or procedures were included — generalizability to specific surgery types is unclear.","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001891","tag_type":"warning","value":"The very high heterogeneity for QoL (I²=93.6%) means the pooled QoL estimate should be interpreted with caution.","value_numeric":null}],"summaries":{"what_studied":"Systematic review and meta-analysis of 23 RCTs (n=2,182) evaluating exercise-based and/or nutrition-based prehabilitation programs versus standard treatment across multiple surgical contexts, with primary outcomes of LOS and postoperative complications, and secondary outcomes of QoL, pain, and mental health.","key_result":"Prehabilitation reduced postoperative complications (OR 0.52, 95% CI 0.35–0.78) and shortened LOS (MD −0.44 days, 95% CI −0.78 to −0.11). Nutrition-only programs cut LOS more than exercise-only (MD −1.09 vs −0.20 days; p=0.01). Exercise alone improved QoL (SMD 0.94, 95% CI 0.24–1.64); QoL was not reported for nutrition-only RCTs.","limitations":"- High heterogeneity for QoL outcome (I²=93.6%), limiting confidence in that estimate.\n- Only 23 RCTs met inclusion criteria from 293 identified studies, suggesting a large body of non-RCT or non-standardized evidence was excluded.\n- QoL data were unavailable for nutrition-only trials, preventing direct head-to-head comparison across all outcomes.","practice_takeaway":"Consider adding exercise or nutrition prehabilitation before elective surgery — both cut complications by roughly half and trim hospital stays. Nutrition-focused programs appear to shorten LOS more than exercise alone, so patient-specific barriers and surgical context should guide which modality to prioritize."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Nutrition-Based Prehabilitation"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Nutrition-Based Prehabilitation"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Nutrition-Based Prehabilitation"}}}]] 2b:null 2f:[["$","title","0",{"children":"Nutrition-Based Prehabilitation: Research & Clinical Takeaways | ReachRx"}],["$","meta","1",{"name":"description","content":"Explore peer-reviewed papers on Nutrition-Based Prehabilitation (modality). Clinician-written summaries and actionable practice insights. 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