2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T998,To compare the effectiveness of romosozumab (ROMO) with parathyroid hormone (PTH) receptor agonists [teriparatide (TPTD)/abaloparatide (APTD)] in reducing fracture risk following osteoporosis treatment. A TriNetX cohort study assessed fracture and mortality risks using Kaplan-Meier analysis with hazard ratios (HRs) and 95% confidence intervals (CIs). After propensity score matching (n = 2,258 pairs), ROMO users had lower risks of osteoporotic fractures (HR: 0.711, 95% CI: 0.542-0.931) and hypercalcemia (HR = 0.707, 95% CI: 0.511-0.977) compared with PTH receptor agonists. Five subgroup analyses demonstrated a reduced fracture risk in the ROMO cohort among women (HR: 0.738), patients aged ≥ 65 years (HR: 0.652), individuals with a history of prior fractures (HR: 0.659), and those without chronic kidney disease (CKD) (HR: 0.731). Sensitivity analyses confirmed the robustness of the findings across different covariate adjustments, data sources, and extended follow-up, consistently showing a lower risk of hypercalcemia and nonsignificant trends toward reduced fracture risk in the ROMO cohort. Compared with PTH analogs, ROMO offers stronger short-term protection against osteoporotic fractures and hypercalcemia, particularly in older women with prior fractures. Nonetheless, cardiovascular safety, calcium metabolism, and sequential therapy require careful consideration for individualized treatment. Osteoporosis is a disease that makes bones weak and more likely to break, especially in older adults and women after menopause. This study compared two types of bone-strengthening medicines: romosozumab (ROMO) and parathyroid hormone (PTH) drugs, including teriparatide and abaloparatide. Researchers used a large health database to see which treatment better prevented bone fractures. They found that people taking ROMO had fewer fractures and fewer cases of high calcium levels in the blood than those taking PTH drugs. The benefits of ROMO were strongest in women, people aged 65 and older, and those who had fractures before. These results suggest that ROMO may offer stronger short-term protection against fractures compared with PTH drugs. However, doctors still need to consider possible side effects and each person’s overall health before choosing the best treatment. This study provides helpful information for patients and doctors in deciding how to manage osteoporosis and reduce the risk of fragility fractures.31:T817,Abstract Background To compare the effectiveness of romosozumab (ROMO) with parathyroid hormone (PTH) receptor agonists [teriparatide (TPTD)/abaloparatide (APTD)] in reducing fracture risk following osteoporosis treatment. Methods A TriNetX cohort study assessed fracture and mortality risks using Kaplan–Meier analysis with hazard ratios (HRs) and 95% confidence intervals (CIs). Results After propensity score matching (n = 2,258 pairs), ROMO users had lower risks of osteoporotic fractures (HR: 0.711, 95% CI: 0.542–0.931) and hypercalcemia (HR = 0.707, 95% CI: 0.511–0.977) compared with PTH receptor agonists. Five subgroup analyses demonstrated a reduced fracture risk in the ROMO cohort among women (HR: 0.738), patients aged ≥ 65 years (HR: 0.652), individuals with a history of prior fractures (HR: 0.659), and those without chronic kidney disease (CKD) (HR: 0.731). Sensitivity analyses confirmed the robustness of the findings across different covariate adjustments, data sources, and extended follow-up, consistently showing a lower risk of hypercalcemia and nonsignificant trends toward reduced fracture risk in the ROMO cohort. Conclusion Compared with PTH analogs, ROMO offers stronger short-term protection against osteoporotic fractures and hypercalcemia, particularly in older women with prior fractures. Nonetheless, cardiovascular safety, calcium metabolism, and sequential therapy require careful consideration for individualized treatment. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"PTH Receptor Agonist: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on PTH Receptor Agonist (modality). Clinician-written summaries and actionable practice insights. 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Five subgroup analyses demonstrated a reduced fracture risk in the ROMO cohort among women (HR: 0.738), patients aged ≥ 65 years (HR: 0.652), individuals with a history of prior fractures (HR: 0.659), and those without chronic kidney disease (CKD) (HR: 0.731). Sensitivity analyses confirmed the robustness of the findings across different covariate adjustments, data sources, and extended follow-up, consistently showing a lower risk of hypercalcemia and nonsignificant trends toward reduced fracture risk in the ROMO cohort.","abstract":"$30","keywords":["Abaloparatide","Osteoporotic fracture","Romosozumab","Teriparatide","TriNetX"],"pubmed_id":"41484973","conclusions":"Compared with PTH analogs, ROMO offers stronger short-term protection against osteoporotic fractures and hypercalcemia, particularly in older women with prior fractures. Nonetheless, cardiovascular safety, calcium metabolism, and sequential therapy require careful consideration for individualized treatment.","publication_date":"2026-01-04T00:00:00"},"crossref":{"DOI":"10.1186/s13293-025-00817-1","URL":"https://doi.org/10.1186/s13293-025-00817-1","ISSN":["2042-6410"],"link":[{"URL":"https://link.springer.com/article/10.1186/s13293-025-00817-1","content-type":"text/html","content-version":"vor","intended-application":"text-mining"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Real-world evidence indicates romosozumab use is associated with a greater reduction in osteoporotic fractures than PTH (1–34) analogs in women"],"author":[{"given":"Ko-Hsiu","family":"Lu","sequence":"first","affiliation":[]},{"given":"Shiow-Ing","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Shun-Fa","family":"Yang","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/501100004699","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100004699","name":"Chung Shan Medical University Hospital","award":["CSH-2024-D-003"],"award-info":[{"award-number":["CSH-2024-D-003"]}],"doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2026,1,3]]},"member":"297","prefix":"10.1186","source":"Crossref","volume":null,"created":{"date-time":"2026-01-04T02:13:07Z","timestamp":1767492787000,"date-parts":[[2026,1,4]]},"indexed":{"date-time":"2026-01-04T02:14:36Z","timestamp":1767492876685,"date-parts":[[2026,1,4]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000,"date-parts":[[2026,1,3]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000,"date-parts":[[2026,1,3]]},"delay-in-days":0,"content-version":"am"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1186/s13293-025-00817-1"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"29 October 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"23 December 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"3 January 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"},"order":2,"value":"This study was approved by the Institutional Review Board of Chung Shan Medical University Hospital (approval no. CS2-23208) and was reported in accordance with the RECORD (Reporting of Studies Conducted Using Observational Routinely Collected Health Data) guidelines."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"},"order":3,"value":"Not Applicable."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":4,"value":"The authors declare no competing interests."}],"deposited":{"date-time":"2026-01-04T02:13:13Z","timestamp":1767492793000,"date-parts":[[2026,1,4]]},"issn-type":[{"type":"electronic","value":"2042-6410"}],"published":{"date-parts":[[2026,1,3]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":"10.1016/S0140-6736(18)32112-3","key":"817_CR1","year":"2019","issue":null,"author":"JE Compston","volume":"393","first-page":"364","unstructured":"Compston JE, McClung MR, Leslie WD. Osteoporosis. 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not randomized.","value_numeric":null}],"summaries":{"what_studied":"A real-world TriNetX cohort compared romosozumab with PTH receptor agonists (teriparatide/abaloparatide) for osteoporotic fracture and hypercalcemia risk over 1 year, using propensity score–matched pairs (n=2,258 per group), with subgroup and sensitivity analyses and an extended follow-up to 730 days.","key_result":"After matching (n=2,258 pairs), romosozumab was associated with lower osteoporotic fracture risk (HR 0.711, 95% CI 0.542–0.931) and lower hypercalcemia risk (HR 0.707, 95% CI 0.511–0.977) versus PTH agonists; reductions were observed in women (HR 0.738) and those ≥65 years (HR 0.652).","limitations":"The male subgroup was very small (n=22 matched pairs), with many outcomes unavailable; several analyses had masked counts (<10) and the extended follow-up showed nonsignificant fracture differences despite lower hypercalcemia risk.","practice_takeaway":"Romosozumab provided stronger short-term protection against osteoporotic fractures and hypercalcemia than teriparatide/abaloparatide, particularly in older women and those with prior fractures; 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