Clinical and Experimental Dermatology

<jats:title>Abstract</jats:title>
               <jats:p>This nationwide population-based cohort study investigates the incidence of cutaneous malignancies associated with the concomitant treatment of cyclosporine (CsA) and narrowband UV-B phototherapy (NBUVB) in patients with vitiligo, using the Korean National Health Insurance Service database. The concomitant CsA and NBUVB therapy may not significantly increase the incidence of cutaneous malignancies. Given the chronic autoimmune nature of vitiligo and the economic burden it imposes, these findings provide novel insights into the potential safety of these combination regimens.</jats:p>

This nationwide population-based cohort study investigates the incidence of cutaneous malignancies associated with the concomitant treatment of cyclosporine (CsA) and narrowband UV-B phototherapy (NBUVB) in patients with vitiligo, using the Korean National Health Insurance Service database. The concomitant CsA and NBUVB therapy may not significantly increase the incidence of cutaneous malignancies. Given the chronic autoimmune nature of vitiligo and the economic burden it imposes, these findings provide novel insights into the potential safety of these combination regimens.

Incidence of cutaneous malignancy following the concomitant use of cyclosporine and narrowband UV-B phototherapy in patients with vitiligo.

Incidence of cutaneous malignancy following the concomitant use of cyclosporine and narrowband UV-B phototherapy in patients with vitiligo

Journal of Investigative Dermatology

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Korea Ministry of Health and Welfare

Seoul National University

National Research Foundation of Korea

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UV irradiation of the human skin downregulates lipid synthesis and adipokine production in subcutaneous fat. Recent evidence has suggested that UV exposure limits body weight gain in mouse models of obesity. However, the relationship between norepinephrine and UV irradiation has not been previously reported. Chronic UV exposure stimulated food intake but prevented body weight gain. Leptin, an appetite-suppressing hormone, was significantly reduced in the serum of the UV-irradiated mice. In contrast, UV irradiation induced browning of subcutaneous white adipose tissues without increasing physical activity. Notably, UV irradiation significantly increased norepinephrine levels, and the inhibition of norepinephrine production reversed the effects of chronic UV irradiation on food intake and body weight gain. In conclusion, chronic UV irradiation induces norepinephrine release, resulting in the stimulation of food intake due to the downregulation of leptin levels, but it prevents weight gain by inducing the browning process and elevating energy expenditure.

UV Irradiation Increases Appetite and Prevents Body Weight Gain through the Upregulation of Norepinephrine in Mice.

UV Irradiation Increases Appetite and Prevents Body Weight Gain through the Upregulation of Norepinephrine in Mice

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