2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T6e1,Novel stroke risk factors have received widespread attention. This study examined the association between sarcopenia status, grip strength, and walking pace with incident stroke (any stroke, ischemic stroke, and hemorrhagic stroke) and poststroke mortality. This prospective study included 482 699 participants from the UK Biobank, a large-scale, population-based cohort. Sarcopenia status was assessed according to the EWGSOP2 criteria (European Working Group on Sarcopenia in Older People 2). Incident strokes were ascertained based on health records. Stroke risk was assessed using multivariable-adjusted Cox proportional hazards models, whereas poststroke mortality was compared using the Kaplan-Meier analysis with log-rank tests. A 2-sample Mendelian randomization analysis, utilizing genetic instruments from public genome-wide association studies, was conducted to infer causal associations. The cohort (mean age±SD: 56.4±8.1 years; 45.37% were men; n=219 015) had a probable sarcopenia prevalence of 4.7% and a confirmed sarcopenia prevalence of 0.4%. Participants with probable sarcopenia had a higher risk of any stroke (adjusted hazard ratio [aHR], 1.30 [95% CI, 1.21-1.39]), ischemic stroke (aHR, 1.31 [95% CI, 1.22-1.42]), and hemorrhagic stroke (aHR, 1.41 [95% CI, 1.20-1.67]) than those without. Among those who had a stroke, probable or confirmed sarcopenia was associated with increased all-cause mortality. Higher risk of any stroke was associated with lower grip strength (absolute: aHR, 1.07 [95% CI, 1.06-1.09] per 5 kg; relative: aHR, 1.36 [95% CI, 1.28-1.44] per 1 kg/[kg/m Sarcopenia status, lower grip strength, and slower walking pace were associated with an increased risk of incident stroke and all-cause poststroke mortality.31:Tafe, BACKGROUND: Novel stroke risk factors have received widespread attention. This study examined the association between sarcopenia status, grip strength, and walking pace with incident stroke (any stroke, ischemic stroke, and hemorrhagic stroke) and poststroke mortality. METHODS: This prospective study included 482 699 participants from the UK Biobank, a large-scale, population-based cohort. Sarcopenia status was assessed according to the EWGSOP2 criteria (European Working Group on Sarcopenia in Older People 2). Incident strokes were ascertained based on health records. Stroke risk was assessed using multivariable-adjusted Cox proportional hazards models, whereas poststroke mortality was compared using the Kaplan-Meier analysis with log-rank tests. A 2-sample Mendelian randomization analysis, utilizing genetic instruments from public genome-wide association studies, was conducted to infer causal associations. RESULTS: The cohort (mean age±SD: 56.4±8.1 years; 45.37% were men; n=219 015) had a probable sarcopenia prevalence of 4.7% and a confirmed sarcopenia prevalence of 0.4%. Participants with probable sarcopenia had a higher risk of any stroke (adjusted hazard ratio [aHR], 1.30 [95% CI, 1.21−1.39]), ischemic stroke (aHR, 1.31 [95% CI, 1.22−1.42]), and hemorrhagic stroke (aHR, 1.41 [95% CI, 1.20−1.67]) than those without. Among those who had a stroke, probable or confirmed sarcopenia was associated with increased all-cause mortality. Higher risk of any stroke was associated with lower grip strength (absolute: aHR, 1.07 [95% CI, 1.06−1.09] per 5 kg; relative: aHR, 1.36 [95% CI, 1.28−1.44] per 1 kg/[kg/m 2 ]) and a slow walking pace (aHR, 1.64 [95% CI, 1.54−1.75]; compared with brisk pace). Mendelian randomization analysis demonstrated that a faster walking pace was associated with a lower risk of any stroke (odds ratio, 0.94 [95% CI, 0.90−0.97] per-SD increase) and ischemic stroke (odds ratio, 0.95 [95% CI, 0.91−0.98] per-SD increase). CONCLUSIONS: Sarcopenia status, lower grip strength, and slower walking pace were associated with an increased risk of incident stroke and all-cause poststroke mortality. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Physical Function Assessment: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Physical Function Assessment (modality). Clinician-written summaries and actionable practice insights. 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Participants with probable sarcopenia had a higher risk of any stroke (adjusted hazard ratio [aHR], 1.30 [95% CI, 1.21-1.39]), ischemic stroke (aHR, 1.31 [95% CI, 1.22-1.42]), and hemorrhagic stroke (aHR, 1.41 [95% CI, 1.20-1.67]) than those without. Among those who had a stroke, probable or confirmed sarcopenia was associated with increased all-cause mortality. Higher risk of any stroke was associated with lower grip strength (absolute: aHR, 1.07 [95% CI, 1.06-1.09] per 5 kg; relative: aHR, 1.36 [95% CI, 1.28-1.44] per 1 kg/[kg/m","abstract":"$30","keywords":["hand strength","hemorrhagic stroke","ischemic stroke","sarcopenia","stroke","walking speed"],"pubmed_id":"42101654","conclusions":"","publication_date":"2026-05-08T00:00:00"},"crossref":{"DOI":"10.1161/strokeaha.125.052311","URL":"https://doi.org/10.1161/strokeaha.125.052311","ISSN":["0039-2499","1524-4628"],"link":[{"URL":"https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.125.052311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Sarcopenia, Grip Strength, Walking Pace, and New-Onset Stroke Risk: A UK Biobank Study"],"author":[{"given":"Li-Li","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}]},{"given":"Yu-Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China (Y.-H.H., C.Y.)."}]},{"given":"Yu-Jia","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}]},{"given":"Kai-Cheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}]},{"given":"Qing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Taizhou First People’s Hospital, China (Q.L.)."}]},{"given":"Zien","family":"Zhou","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (Z.Z.)."},{"name":"Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China (Z.Z.)."}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (L.-L.T., Y.-J.J., K.-C.Y., F.G., L.-S.T.)."}]},{"given":"Bing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (B.X.)."}]},{"given":"Changzheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China (Y.-H.H., C.Y.)."},{"name":"Department of Nutrition, Harvard T.H. 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only.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"warning","value":"'Practice_changing' flag applied cautiously — findings support adding physical function screening to stroke prevention, but formal guideline changes are pending.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"warning","value":"Relative grip strength metric is truncated in the provided text, limiting interpretability of that effect size.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"warning","value":"Study includes a Mendelian randomization component in addition to the cohort; design label reflects the primary cohort analysis.","value_numeric":null},{"paper_doi":"10.1161/strokeaha.125.052311","tag_type":"warning","value":"The reported cohort size in the abstract is inconsistent: the full cohort is stated as 482,699 but the results section cites n=219,015 (men only, 45.37%). The full analytic sample size should be verified in the methods.","value_numeric":null}],"summaries":{"limitations":"- Sarcopenia confirmed in only 0.4% of participants, limiting power for that subgroup.\n- UK Biobank is a volunteer cohort with known healthy-volunteer bias, which may underestimate true effect sizes.\n- Sarcopenia and muscle metrics were measured at baseline only, so changes over time are not captured.","what_studied":"A prospective UK Biobank cohort (n=482,699) assessed whether sarcopenia (EWGSOP2), grip strength, and walking pace are associated with incident stroke (any, ischemic, hemorrhagic) and poststroke all-cause mortality using multivariable Cox models and Kaplan-Meier analyses. A 2-sample Mendelian randomization was also conducted to explore causal associations.","key_result":"Probable sarcopenia (prevalence 4.7%) was associated with higher risk of any stroke (aHR 1.30, 95% CI 1.21–1.39), ischemic stroke (aHR 1.31, 95% CI 1.22–1.42), and hemorrhagic stroke (aHR 1.41, 95% CI 1.20–1.67). 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