3b:I[281230,["/_next/static/immutable/chunks/0l5c-zsrs2aic.js","/_next/static/immutable/chunks/3_n0rk2989-8h.js","/_next/static/immutable/chunks/3ofw495lt1gr1.js","/_next/static/immutable/chunks/3tofdpg99uc12.js","/_next/static/immutable/chunks/2rzojj6zgb9d9.js","/_next/static/immutable/chunks/42jxjvozn2thc.js","/_next/static/immutable/chunks/1jp6nkbajpbfs.js","/_next/static/immutable/chunks/3jn_lf7v27x-6.js","/_next/static/immutable/chunks/33qq2-hg37d0b.js","/_next/static/immutable/chunks/15isb0svrppbz.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/0asz50g5_lfq9.js","/_next/static/immutable/chunks/30ia-cxa0yoyc.js","/_next/static/immutable/chunks/3ghibkczd0agr.js","/_next/static/immutable/chunks/20mjl75wrar8n.js","/_next/static/immutable/chunks/3nxreg9fiyt2y.js","/_next/static/immutable/chunks/0c04lgvo3p78i.js","/_next/static/immutable/chunks/1u78gf_avpn77.js"],"PaperListPageClient"] 40:I[70339,["/_next/static/immutable/chunks/355lxm8rh3fxr.js"],"IconMark"] 3c:T826,Protein-energy wasting, chronic inflammation, and functional decline are prevalent among patients undergoing haemodialysis (HD) and are associated with adverse outcomes and reduced quality of life. Although a substantial body of literature exists on nutritional management in HD, evidence has evolved considerably in recent years. Nutritional care in HD remains inconsistent and is limited by restrictive dietary paradigms and organizational barriers. To map evidence published between 2015 and 2025 on nutritional management in adult patients undergoing HD, focusing on personalized strategies, barriers to effective nutritional care, and patient-centred, function-oriented implementation. A scoping review was conducted following Joanna Briggs Institute methodology and reported according to PRISMA Extension for Scoping Reviews. PubMed/MEDLINE, Scopus, Web of Science, and Europe PMC were searched for English-language studies published between January 2015 and August 2025. A total of 30 studies were included. The literature describes diverse personalized nutritional approaches, including oral and intradialytic supplementation, plant-forward dietary patterns, microbiota-oriented strategies, and targeted nutrient supplementation. Reported outcomes included nutritional biomarkers, inflammation, body composition, functional measures, and patient-reported experience. Key barriers to effective nutritional care were poor dietary adherence, psychosocial burden, limited health literacy, inconsistent professional guidance, and organizational constraints. Morphofunctional assessment tools provided added value beyond biochemical parameters, and the studies highlighted specific considerations for nutritional risk assessment in older adults undergoing HD. This scoping review highlights a shift towards more personalized and function-oriented nutritional care in HD, while underscoring persistent barriers and substantial evidence heterogeneity. The findings support future research and the development of more integrated, patient-centred, and sustainable nutritional care models.3d:Tb3a,ABSTRACT Background Protein-energy wasting, chronic inflammation, and functional decline are prevalent among patients undergoing haemodialysis (HD) and are associated with adverse outcomes and reduced quality of life. Although a substantial body of literature exists on nutritional management in HD, evidence has evolved considerably in recent years. Nutritional care in HD remains inconsistent and is limited by restrictive dietary paradigms and organizational barriers. Objective To map evidence published between 2015 and 2025 on nutritional management in adult patients undergoing HD, focusing on personalized strategies, barriers to effective nutritional care, and patient-centred, function-oriented implementation. Methods A scoping review was conducted following Joanna Briggs Institute methodology and reported according to PRISMA Extension for Scoping Reviews. PubMed/MEDLINE, Scopus, Web of Science, and Europe PMC were searched for English-language studies published between January 2015 and August 2025. Results A total of 30 studies were included. The literature describes diverse personalized nutritional approaches, including oral and intradialytic supplementation, plant-forward dietary patterns, microbiota-oriented strategies, and targeted nutrient supplementation. Reported outcomes included nutritional biomarkers, inflammation, body composition, functional measures, and patient-reported experience. Key barriers to effective nutritional care were poor dietary adherence, psychosocial burden, limited health literacy, inconsistent professional guidance, and organizational constraints. Morphofunctional assessment tools provided added value beyond biochemical parameters, and the studies highlighted specific considerations for nutritional risk assessment in older adults undergoing HD. Conclusions This scoping review highlights a shift towards more personalized and function-oriented nutritional care in HD, while underscoring persistent barriers and substantial evidence heterogeneity. The findings support future research and the development of more integrated, patient-centred, and sustainable nutritional care models. 3e:T6f6,Coronary microvascular dysfunction (CMD) is associated with adverse cardiovascular outcomes. CMD is driven by endothelial and vascular smooth muscle cell (VSMC) dysfunction. We aimed to test whether CMD could be mitigated by a plant-based diet (PBD) in an animal model of hypertension. We compared 28- and 40-week-old female normotensive Wistar-Kyoto and spontaneously hypertensive rats (SHRs), maintained, from age 4 weeks, on a control refined diet or a PBD, composed of 28% fruits, vegetables, nuts, and legumes. A subset of control SHRs was switched to the PBD at 28 weeks. CMD was assessed by coronary flow reserve via echocardiogram. Cardiac microvascular endothelial function was assessed via cardiac magnetic resonance imaging. Endothelial and VSMC function were assessed in the left ventricle or in isolated VSMCs. The role of gut microbiota was probed via 16S sequencing and antibiotics. Cardiac inflammation, oxidative stress, and fibrosis were also explored. SHRs exhibited endothelial dysfunction and likely VSMC dysfunction. A PBD did not ameliorate their hypertension but, nonetheless, prevented and reversed CMD. The PBD's mitigation of CMD was associated with improved endothelial nitric oxide synthase function and nitric oxide-mediated VSMC signaling, as well as reductions in left ventricular oxidative stress, inflammatory signaling, and fibrosis. A PBD altered the gut microbiota, although antibiotic studies failed to establish its importance in ameliorating CMD. A PBD prevented CMD development and reversed established CMD in SHRs. Such benefits of PBD, which occurred without alleviating hypertension, were possibly due to improved endothelial function and likely improved VSMC function. These results support clinical trials to test PBDs in human CMD.3f:T9bd, Background Coronary microvascular dysfunction (CMD) is associated with adverse cardiovascular outcomes. CMD is driven by endothelial and vascular smooth muscle cell (VSMC) dysfunction. We aimed to test whether CMD could be mitigated by a plant‐based diet (PBD) in an animal model of hypertension. Methods We compared 28‐ and 40‐week‐old female normotensive Wistar–Kyoto and spontaneously hypertensive rats (SHRs), maintained, from age 4 weeks, on a control refined diet or a PBD, composed of 28% fruits, vegetables, nuts, and legumes. A subset of control SHRs was switched to the PBD at 28 weeks. CMD was assessed by coronary flow reserve via echocardiogram. Cardiac microvascular endothelial function was assessed via cardiac magnetic resonance imaging. Endothelial and VSMC function were assessed in the left ventricle or in isolated VSMCs. The role of gut microbiota was probed via 16S sequencing and antibiotics. Cardiac inflammation, oxidative stress, and fibrosis were also explored. Results SHRs exhibited endothelial dysfunction and likely VSMC dysfunction. A PBD did not ameliorate their hypertension but, nonetheless, prevented and reversed CMD. The PBD’s mitigation of CMD was associated with improved endothelial nitric oxide synthase function and nitric oxide–mediated VSMC signaling, as well as reductions in left ventricular oxidative stress, inflammatory signaling, and fibrosis. A PBD altered the gut microbiota, although antibiotic studies failed to establish its importance in ameliorating CMD. Conclusions A PBD prevented CMD development and reversed established CMD in SHRs. Such benefits of PBD, which occurred without alleviating hypertension, were possibly due to improved endothelial function and likely improved VSMC function. These results support clinical trials to test PBDs in human CMD. 28:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Plant-Based Diet: Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Plant-Based Diet (modality). 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Primary endpoints were feasibility and tolerability; secondary endpoints included gut microbiome composition (shotgun metagenomics) and fecal short-chain fatty acid (SCFA) levels.","key_result":"All 22 enrolled participants consumed study meals to some degree (17/22 completed the full study). Higher meal intake was dose-dependently associated with enrichment of SCFA-producing taxa (e.g., Blautia, Lachnospiraceae) and fiber-responsive microbiome shifts. Fecal SCFA concentrations increased from baseline to end of study. Fiber was the most prominent differentially consumed nutrient in high vs. low consumers.","limitations":"- Single-arm design with no control group limits causal inference about microbiome or clinical outcomes.\n- Small sample size (n=22) limits statistical power; nutrient-microbiome correlations did not survive multiple-testing correction.\n- Study meals were commercially prepared ('Thistle'), limiting generalizability to other plant-based approaches or settings.","practice_takeaway":"A structured plant-based meal delivery program appears feasible and well tolerated during auto-HCT for multiple myeloma, with adherence supporting measurable microbiome changes. Clinicians may consider dietary fiber optimization as a low-risk adjunct strategy during transplant, pending controlled trial data."}},{"doi":"10.1093/ckj/sfag117","pmid":"42094027","title":"Personalized nutrition in haemodialysis: a scoping review of studies published between 2015 and 2025","journal_title":"Clinical Kidney Journal","journal_issn":"2048-8505","published_at":"2026-05-07T00:00:00.000Z","url":"https://doi.org/10.1093/ckj/sfag117","source_score":42,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-04-19","doi":"10.1093/ckj/sfag117","days":"30","issn":"2048-8505","rank":"5","field":"Clinical Medicine","score":"42","category":"Urology & Nephrology","categories":["Urology & Nephrology"],"_categories":["Urology & Nephrology"]},"pubmed":{"doi":"10.1093/ckj/sfag117","title":"Personalized nutrition in haemodialysis: a scoping review of studies published between 2015 and 2025.","journal":"Clinical kidney journal","methods":"","results":"A total of 30 studies were included. 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