2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T998,To compare the effectiveness of romosozumab (ROMO) with parathyroid hormone (PTH) receptor agonists [teriparatide (TPTD)/abaloparatide (APTD)] in reducing fracture risk following osteoporosis treatment. A TriNetX cohort study assessed fracture and mortality risks using Kaplan-Meier analysis with hazard ratios (HRs) and 95% confidence intervals (CIs). After propensity score matching (n = 2,258 pairs), ROMO users had lower risks of osteoporotic fractures (HR: 0.711, 95% CI: 0.542-0.931) and hypercalcemia (HR = 0.707, 95% CI: 0.511-0.977) compared with PTH receptor agonists. Five subgroup analyses demonstrated a reduced fracture risk in the ROMO cohort among women (HR: 0.738), patients aged ≥ 65 years (HR: 0.652), individuals with a history of prior fractures (HR: 0.659), and those without chronic kidney disease (CKD) (HR: 0.731). Sensitivity analyses confirmed the robustness of the findings across different covariate adjustments, data sources, and extended follow-up, consistently showing a lower risk of hypercalcemia and nonsignificant trends toward reduced fracture risk in the ROMO cohort. Compared with PTH analogs, ROMO offers stronger short-term protection against osteoporotic fractures and hypercalcemia, particularly in older women with prior fractures. Nonetheless, cardiovascular safety, calcium metabolism, and sequential therapy require careful consideration for individualized treatment. Osteoporosis is a disease that makes bones weak and more likely to break, especially in older adults and women after menopause. This study compared two types of bone-strengthening medicines: romosozumab (ROMO) and parathyroid hormone (PTH) drugs, including teriparatide and abaloparatide. Researchers used a large health database to see which treatment better prevented bone fractures. They found that people taking ROMO had fewer fractures and fewer cases of high calcium levels in the blood than those taking PTH drugs. The benefits of ROMO were strongest in women, people aged 65 and older, and those who had fractures before. These results suggest that ROMO may offer stronger short-term protection against fractures compared with PTH drugs. However, doctors still need to consider possible side effects and each person’s overall health before choosing the best treatment. This study provides helpful information for patients and doctors in deciding how to manage osteoporosis and reduce the risk of fragility fractures.31:T817,Abstract Background To compare the effectiveness of romosozumab (ROMO) with parathyroid hormone (PTH) receptor agonists [teriparatide (TPTD)/abaloparatide (APTD)] in reducing fracture risk following osteoporosis treatment. Methods A TriNetX cohort study assessed fracture and mortality risks using Kaplan–Meier analysis with hazard ratios (HRs) and 95% confidence intervals (CIs). Results After propensity score matching (n = 2,258 pairs), ROMO users had lower risks of osteoporotic fractures (HR: 0.711, 95% CI: 0.542–0.931) and hypercalcemia (HR = 0.707, 95% CI: 0.511–0.977) compared with PTH receptor agonists. Five subgroup analyses demonstrated a reduced fracture risk in the ROMO cohort among women (HR: 0.738), patients aged ≥ 65 years (HR: 0.652), individuals with a history of prior fractures (HR: 0.659), and those without chronic kidney disease (CKD) (HR: 0.731). Sensitivity analyses confirmed the robustness of the findings across different covariate adjustments, data sources, and extended follow-up, consistently showing a lower risk of hypercalcemia and nonsignificant trends toward reduced fracture risk in the ROMO cohort. Conclusion Compared with PTH analogs, ROMO offers stronger short-term protection against osteoporotic fractures and hypercalcemia, particularly in older women with prior fractures. Nonetheless, cardiovascular safety, calcium metabolism, and sequential therapy require careful consideration for individualized treatment. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Sclerostin Inhibitor: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Sclerostin Inhibitor (modality). Clinician-written summaries and actionable practice insights. 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clinical applicability depends heavily on individual patient context.","value_numeric":null},{"paper_doi":"10.1002/ijgo.71203","tag_type":"warning","value":"Study design classification as 'Clinical Practice Guideline / Position Statement' is applied; it is not a systematic review or meta-analysis, though it is based on a review of published evidence.","value_numeric":null},{"paper_doi":"10.1002/ijgo.71203","tag_type":"warning","value":"This is a consensus position statement, not a primary clinical trial; the level of evidence is expert opinion given the rarity of PLO and absence of RCTs.","value_numeric":null}],"summaries":{"what_studied":"This position statement from six major professional societies reviews the current evidence on pregnancy- and lactation-associated osteoporosis (PLO), covering diagnosis, assessment, and treatment of fragility fractures (most commonly vertebral) occurring in late pregnancy or early postpartum.","key_result":"Preferred first-line pharmacological agents are teriparatide/abaloparatide or romosozumab; second-choice options are denosumab followed by bisphosphonates or bisphosphonates alone — all used off-label. Calcium/vitamin D, considering stopping breastfeeding, and analgesia are first-step management. Bisphosphonates cross the placental barrier and persist in bone for years, so adverse effects on future pregnancies cannot be excluded.","limitations":"PLO is rare, so controlled comparative clinical trials are lacking; most evidence is from individual case series or small studies. All pharmacological treatments for PLO are off-label. Adverse effects of bisphosphonates on future pregnancies have not been reported but cannot be ruled out.","practice_takeaway":"For women with PLO, start with calcium/vitamin D supplementation, analgesia, and consider stopping breastfeeding; if bone-specific therapy is needed, prefer teriparatide, abaloparatide, or romosozumab over bisphosphonates, and ensure effective contraception during treatment. Always perform individualized risk assessment and rule out secondary causes of osteoporosis before initiating pharmacological therapy."}},{"doi":"10.1016/s2213-8587(26)00105-1","pmid":"42302800","title":"Treatment duration for romosozumab – Authors' reply","journal_title":"The Lancet Diabetes & Endocrinology","journal_issn":"2213-8587","published_at":"2026-06-16T00:00:00.000Z","url":"https://doi.org/10.1016/s2213-8587(26)00105-1","source_score":10,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-22T13:24:04.144Z","updated_at":"2026-06-22T13:24:04.144Z","tags":[{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"brand","value":"Evenity","value_numeric":null},{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"category","value":"Endocrinology & Metabolism","value_numeric":null},{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"condition","value":"Osteoporosis","value_numeric":null},{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"generic","value":"romosozumab","value_numeric":null},{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"modality","value":"Sclerostin Inhibitor","value_numeric":null},{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"study_design","value":"Letter / Authors' Reply","value_numeric":null},{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"warning","value":"Brand name 'Evenity' added based on known drug identity for romosozumab; not explicitly stated in the provided metadata.","value_numeric":null},{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"warning","value":"Study design is classified as a correspondence/reply letter, which carries the lowest level of evidence. No original clinical data is presented.","value_numeric":null},{"paper_doi":"10.1016/s2213-8587(26)00105-1","tag_type":"warning","value":"The source text provides only the paper metadata (title, DOI, journal, date) without the full article body. All structured outputs are inferred from the title and journal context alone. No primary data, outcome numbers, or specific author arguments could be extracted.","value_numeric":null}],"summaries":{"limitations":"As a correspondence/reply letter, this piece does not present original primary data or a formal study design, limiting the strength of any conclusions drawn.","practice_takeaway":"Clinicians prescribing romosozumab should consult the full correspondence thread in *The Lancet Diabetes & Endocrinology* for the authors' clarification on optimal treatment duration and sequencing.","what_studied":"This is an authors' reply letter addressing questions or commentary about the appropriate treatment duration for romosozumab in the management of osteoporosis."}},{"doi":"10.1186/s13293-025-00817-1","pmid":"41484973","title":"Real-world evidence indicates romosozumab use is associated with a greater reduction in osteoporotic fractures than PTH (1–34) analogs in women","journal_title":"Biology of Sex Differences","journal_issn":"2042-6410","published_at":"2026-01-04T00:00:00.000Z","url":"https://doi.org/10.1186/s13293-025-00817-1","source_score":18,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-05","doi":"10.1186/s13293-025-00817-1","days":"7","issn":"2042-6410","rank":"9","field":"Clinical Medicine","score":"18","category":"Endocrinology & Metabolism","categories":["Endocrinology & Metabolism"],"_categories":["Endocrinology & Metabolism"]},"pubmed":{"doi":"10.1186/s13293-025-00817-1","title":"Real-world evidence indicates romosozumab use is associated with a greater reduction in osteoporotic fractures than PTH (1-34) analogs in women.","journal":"Biology of sex differences","methods":"","results":"After propensity score matching (n = 2,258 pairs), ROMO users had lower risks of osteoporotic fractures (HR: 0.711, 95% CI: 0.542-0.931) and hypercalcemia (HR = 0.707, 95% CI: 0.511-0.977) compared with PTH receptor agonists. Five subgroup analyses demonstrated a reduced fracture risk in the ROMO cohort among women (HR: 0.738), patients aged ≥ 65 years (HR: 0.652), individuals with a history of prior fractures (HR: 0.659), and those without chronic kidney disease (CKD) (HR: 0.731). Sensitivity analyses confirmed the robustness of the findings across different covariate adjustments, data sources, and extended follow-up, consistently showing a lower risk of hypercalcemia and nonsignificant trends toward reduced fracture risk in the ROMO cohort.","abstract":"$30","keywords":["Abaloparatide","Osteoporotic fracture","Romosozumab","Teriparatide","TriNetX"],"pubmed_id":"41484973","conclusions":"Compared with PTH analogs, ROMO offers stronger short-term protection against osteoporotic fractures and hypercalcemia, particularly in older women with prior fractures. Nonetheless, cardiovascular safety, calcium metabolism, and sequential therapy require careful consideration for individualized treatment.","publication_date":"2026-01-04T00:00:00"},"crossref":{"DOI":"10.1186/s13293-025-00817-1","URL":"https://doi.org/10.1186/s13293-025-00817-1","ISSN":["2042-6410"],"link":[{"URL":"https://link.springer.com/article/10.1186/s13293-025-00817-1","content-type":"text/html","content-version":"vor","intended-application":"text-mining"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Real-world evidence indicates romosozumab use is associated with a greater reduction in osteoporotic fractures than PTH (1–34) analogs in women"],"author":[{"given":"Ko-Hsiu","family":"Lu","sequence":"first","affiliation":[]},{"given":"Shiow-Ing","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Shun-Fa","family":"Yang","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/501100004699","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100004699","name":"Chung Shan Medical University Hospital","award":["CSH-2024-D-003"],"award-info":[{"award-number":["CSH-2024-D-003"]}],"doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2026,1,3]]},"member":"297","prefix":"10.1186","source":"Crossref","volume":null,"created":{"date-time":"2026-01-04T02:13:07Z","timestamp":1767492787000,"date-parts":[[2026,1,4]]},"indexed":{"date-time":"2026-01-04T02:14:36Z","timestamp":1767492876685,"date-parts":[[2026,1,4]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000,"date-parts":[[2026,1,3]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000,"date-parts":[[2026,1,3]]},"delay-in-days":0,"content-version":"am"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1186/s13293-025-00817-1"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"29 October 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"23 December 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"3 January 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"},"order":2,"value":"This study was approved by the Institutional Review Board of Chung Shan Medical University Hospital (approval no. CS2-23208) and was reported in accordance with the RECORD (Reporting of Studies Conducted Using Observational Routinely Collected Health Data) guidelines."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"},"order":3,"value":"Not Applicable."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":4,"value":"The authors declare no competing interests."}],"deposited":{"date-time":"2026-01-04T02:13:13Z","timestamp":1767492793000,"date-parts":[[2026,1,4]]},"issn-type":[{"type":"electronic","value":"2042-6410"}],"published":{"date-parts":[[2026,1,3]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":"10.1016/S0140-6736(18)32112-3","key":"817_CR1","year":"2019","issue":null,"author":"JE Compston","volume":"393","first-page":"364","unstructured":"Compston JE, McClung MR, Leslie WD. Osteoporosis. 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not randomized.","value_numeric":null}],"summaries":{"what_studied":"A real-world TriNetX cohort compared romosozumab with PTH receptor agonists (teriparatide/abaloparatide) for osteoporotic fracture and hypercalcemia risk over 1 year, using propensity score–matched pairs (n=2,258 per group), with subgroup and sensitivity analyses and an extended follow-up to 730 days.","key_result":"After matching (n=2,258 pairs), romosozumab was associated with lower osteoporotic fracture risk (HR 0.711, 95% CI 0.542–0.931) and lower hypercalcemia risk (HR 0.707, 95% CI 0.511–0.977) versus PTH agonists; reductions were observed in women (HR 0.738) and those ≥65 years (HR 0.652).","limitations":"The male subgroup was very small (n=22 matched pairs), with many outcomes unavailable; several analyses had masked counts (<10) and the extended follow-up showed nonsignificant fracture differences despite lower hypercalcemia risk.","practice_takeaway":"Romosozumab provided stronger short-term protection against osteoporotic fractures and hypercalcemia than teriparatide/abaloparatide, particularly in older women and those with prior fractures; 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