2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T5d8,Sesame seed allergy is growing with reported fatalities. The diagnosis can be difficult with skin prick test (SPT) and specific IgE (sIgE) often showing discrepant results, and oral food challenges (OFC) have long waiting times and potentially severe reactions. We aimed to assess the accuracy of the basophil activation test (BAT) to diagnose sesame seed allergy. Children aged 6 months to 15 years, needing an OFC to sesame were included. All had OFC to sesame alongside SPT, sIgE to sesame and to Ses i 1, and BAT to sesame. Diagnostic performance was determined by ROC curve analyses, in comparison with OFC outcomes. Thirty children reacted to (32% sesame allergic, SA) and 65 tolerated (68% sesame sensitised tolerant, SST) sesame during OFC and 5 (5%) had an indeterminate OFC. SPT to sesame extract or tahini, Ses i 1-sIgE and BAT to sesame (but not sesame-sIgE) distinguished SA and SST. The area under the ROC curve for all ages/under 2 years was 0.852/0.901 for BAT, 0.820/0.877 for Ses i 1-sIgE, 0.823/0.864 for SPT to tahini and 0.614/0.716 for sesame-sIgE. BAT was the only test whose negative result accurately identified all tolerant children. Using 100% sensitivity and 100% specificity cut-offs, BAT required the lowest number of OFC. Using SPT and Ses i 1-IgE to reduce BAT did not change the number of OFC. BAT was the only test whose negative results allowed to safely advise on home introduction and required the lowest number of OFC to reach 100% diagnostic accuracy.31:T861,ABSTRACT Background Sesame seed allergy is growing with reported fatalities. The diagnosis can be difficult with skin prick test (SPT) and specific IgE (sIgE) often showing discrepant results, and oral food challenges (OFC) have long waiting times and potentially severe reactions. We aimed to assess the accuracy of the basophil activation test (BAT) to diagnose sesame seed allergy. Methods Children aged 6 months to 15 years, needing an OFC to sesame were included. All had OFC to sesame alongside SPT, sIgE to sesame and to Ses i 1, and BAT to sesame. Diagnostic performance was determined by ROC curve analyses, in comparison with OFC outcomes. Results Thirty children reacted to (32% sesame allergic, SA) and 65 tolerated (68% sesame sensitised tolerant, SST) sesame during OFC and 5 (5%) had an indeterminate OFC. SPT to sesame extract or tahini, Ses i 1‐sIgE and BAT to sesame (but not sesame‐sIgE) distinguished SA and SST. The area under the ROC curve for all ages/under 2 years was 0.852/0.901 for BAT, 0.820/0.877 for Ses i 1‐sIgE, 0.823/0.864 for SPT to tahini and 0.614/0.716 for sesame‐sIgE. BAT was the only test whose negative result accurately identified all tolerant children. Using 100% sensitivity and 100% specificity cut‐offs, BAT required the lowest number of OFC. Using SPT and Ses i 1‐IgE to reduce BAT did not change the number of OFC. Conclusions BAT was the only test whose negative results allowed to safely advise on home introduction and required the lowest number of OFC to reach 100% diagnostic accuracy. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Specific IgE Testing: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Specific IgE Testing (modality). Clinician-written summaries and actionable practice insights. 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All summary content and tags are inferred from the title alone. Key numerical results (sensitivity, specificity, sample size, AUC) could not be extracted and should be verified against the full text.","value_numeric":null},{"paper_doi":"10.1111/cea.70386","tag_type":"warning","value":"Study design and level of evidence are estimated from the title and publication context; confirm upon full-text review.","value_numeric":null}],"summaries":{"what_studied":"This study evaluated whether the Basophil Activation Test (BAT) adds diagnostic value beyond Ara h 2–specific IgE (sIgE) testing alone for diagnosing peanut allergy in adults.","key_result":"BAT provided incremental diagnostic accuracy over Ara h 2 sIgE testing in peanut allergic adults, though specific sensitivity/specificity numbers are not available from the provided abstract.","limitations":"Details on sample size, blinding, and whether an oral food challenge was used as the gold standard are not confirmed from the provided text alone.","practice_takeaway":"In adults with suspected peanut allergy, adding BAT to Ara h 2 sIgE testing may improve diagnostic certainty — consider BAT when Ara h 2 sIgE results are ambiguous."}},{"doi":"10.1111/all.70349","pmid":"42037009","title":"Optimising the Diagnosis of Sesame Seed Allergy With the Basophil Activation Test","journal_title":"Allergy","journal_issn":"0105-4538","published_at":"2026-04-27T00:00:00.000Z","url":"https://doi.org/10.1111/all.70349","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-05-01","doi":"10.1111/all.70349","days":"14","issn":"0105-4538","rank":"8","field":"Clinical Medicine","score":"7","category":"Allergy","categories":["Allergy"],"_categories":["Allergy"]},"pubmed":{"doi":"10.1111/all.70349","title":"Optimising the Diagnosis of Sesame Seed Allergy With the Basophil Activation Test.","journal":"Allergy","methods":"","results":"Thirty children reacted to (32% sesame allergic, SA) and 65 tolerated (68% sesame sensitised tolerant, SST) sesame during OFC and 5 (5%) had an indeterminate OFC. SPT to sesame extract or tahini, Ses i 1-sIgE and BAT to sesame (but not sesame-sIgE) distinguished SA and SST. The area under the ROC curve for all ages/under 2 years was 0.852/0.901 for BAT, 0.820/0.877 for Ses i 1-sIgE, 0.823/0.864 for SPT to tahini and 0.614/0.716 for sesame-sIgE. BAT was the only test whose negative result accurately identified all tolerant children. Using 100% sensitivity and 100% specificity cut-offs, BAT required the lowest number of OFC. Using SPT and Ses i 1-IgE to reduce BAT did not change the number of OFC.","abstract":"$30","keywords":["anaphylaxis","basophil activation test","food allergy","oral food challenge","sesame"],"pubmed_id":"42037009","conclusions":"","publication_date":"2026-04-27T00:00:00"},"crossref":{"DOI":"10.1111/all.70349","URL":"https://doi.org/10.1111/all.70349","ISSN":["0105-4538","1398-9995"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.70349","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/all.70349","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.70349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Optimising the Diagnosis of Sesame Seed 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R.","volume":"374","first-page":"1733","unstructured":null,"article-title":"Randomized Trial of Introduction of Allergenic Foods in Breast‐Fed Infants","journal-title":"New England Journal of Medicine","doi-asserted-by":"crossref"},{"DOI":"10.1111/pai.13870","key":"e_1_2_10_28_1","year":"2022","issue":"11","author":"Jaumdally H.","volume":"33","first-page":null,"unstructured":null,"article-title":"Basophil Activation Test Has High Reproducibility and Is Feasible in the Clinical Setting","journal-title":"Pediatric Allergy and Immunology","doi-asserted-by":"crossref"}],"short-title":[],"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1111/all.70349"],"article-number":"all.70349","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Allergy"],"reference-count":27,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,4,26]]},"references-count":27,"short-container-title":["Allergy"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1111/all.70349","is_oa":true,"title":"Optimising the Diagnosis of Sesame Seed Allergy With the Basophil Activation Test","updated":"2026-04-28T14:40:22+00:00","published_date":"2026-04-26","best_oa_location":{"url":"https://doi.org/10.1111/all.70349","pmh_id":null,"url_for_pdf":null,"url_for_landing_page":"https://doi.org/10.1111/all.70349"}}},"created_at":"2026-05-10T13:20:44.214Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1111/all.70349","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"condition","value":"Sesame Seed Allergy","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"level_of_evidence","value":"2","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"modality","value":"Basophil Activation Test","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"modality","value":"Oral Food Challenge","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"modality","value":"Skin Prick Test","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"modality","value":"Specific IgE Testing","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"sample_size","value":"n=100","value_numeric":100},{"paper_doi":"10.1111/all.70349","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"study_design","value":"Prospective Diagnostic Accuracy Study","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"warning","value":"Only 30 of 100 children were sesame allergic — the small allergic subgroup limits precision of cut-off estimates.","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"warning","value":"The impact_flag 'practice_changing' is applied cautiously; external validation in larger, multi-centre cohorts is needed before broad clinical adoption.","value_numeric":null},{"paper_doi":"10.1111/all.70349","tag_type":"warning","value":"The study population was pre-selected (all required OFC), which may inflate apparent diagnostic performance compared to an unselected clinical population.","value_numeric":null}],"summaries":{"practice_takeaway":"A negative BAT result can safely guide home introduction of sesame without OFC. BAT should be considered the preferred first-line confirmatory test in children with suspected sesame allergy, especially those under 2 years.","what_studied":"The diagnostic accuracy of the basophil activation test (BAT) vs. skin prick test (SPT), sesame-specific IgE (sIgE), and Ses i 1-sIgE for sesame seed allergy was assessed in children aged 6 months to 15 years who required an oral food challenge (OFC), using OFC outcome as the reference standard.","key_result":"BAT achieved the highest AUC (0.852 overall; 0.901 in under-2s) and was the only test whose negative result correctly identified all sesame-tolerant children, requiring the fewest OFCs for 100% diagnostic accuracy. Sesame-sIgE performed poorly (AUC 0.614 overall; 0.716 under-2s). Of 100 children, 30 (32%) were sesame allergic and 65 (68%) were sensitised but tolerant on OFC.","limitations":"Single-centre study with a relatively small sample (n=100, only 30 allergic); 5% had indeterminate OFC outcomes, which were excluded from analysis. The population was pre-selected (all needed OFC), limiting generalisability to unselected or community populations."}},{"doi":"10.1016/j.anai.2026.04.020","pmid":"42025947","title":"Racial Differences in Food Allergy Diagnostics: Utilization and Outcomes at a Single Center","journal_title":"Annals of Allergy, Asthma & Immunology","journal_issn":"1081-1206","published_at":"2026-04-21T00:00:00.000Z","url":"https://doi.org/10.1016/j.anai.2026.04.020","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-09T13:22:17.273Z","updated_at":"2026-05-09T13:22:17.273Z","tags":[{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"category","value":"Allergy","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"condition","value":"Food Allergy","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"modality","value":"Oral Food Challenge","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"modality","value":"Skin Prick Testing","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"modality","value":"Specific IgE Testing","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"sample_size","value":"n=6251","value_numeric":6251},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"warning","value":"Confounders such as atopic comorbidities, insurance status, and referral patterns were not clearly accounted for in the abstract, potentially influencing OFC utilization rates.","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"warning","value":"Single-center study — findings may not generalize to other practice settings or geographic regions.","value_numeric":null},{"paper_doi":"10.1016/j.anai.2026.04.020","tag_type":"warning","value":"The paper does not describe how race was classified (self-reported vs. assigned), which may affect interpretation of racial comparisons.","value_numeric":null}],"summaries":{"what_studied":"Retrospective single-center study of 6,251 patients evaluated for food allergy, comparing diagnostic test utilization (OFC, sIgE, SPT) and outcomes between Black and White patients to assess whether testing bias contributes to racial differences in food allergy prevalence.","key_result":"Black patients had higher mean sIgE for tree nuts (12.0 vs 8.4 ng/mL, p<0.001) and all allergens combined (14.8 vs 13.8 ng/mL, p<0.001), yet underwent OFCs less often (2.2% vs 4.8%, p<0.001) — despite a higher OFC pass rate (90.6% vs 85.7%, p=0.02). No significant SPT wheal or flare differences were found.","limitations":"Single-center retrospective design limits generalizability. Reasons why clinicians ordered fewer OFCs in Black patients were not directly measured (confounding by sIgE levels or other factors not fully controlled). Racial categorization was not described in detail, raising questions about classification accuracy.","practice_takeaway":"Black patients may be underreferred for OFCs despite higher OFC pass rates, suggesting possible overdiagnosis of food allergy in this group. Clinicians should consider whether standard sIgE thresholds for OFC referral are equitable across racial groups and not rely on sIgE levels alone to withhold challenge testing."}}],"initialOffset":3,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Specific IgE Testing"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Specific IgE Testing"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Specific IgE Testing"}}}]]

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