3b:I[281230,["/_next/static/immutable/chunks/0l5c-zsrs2aic.js","/_next/static/immutable/chunks/3_n0rk2989-8h.js","/_next/static/immutable/chunks/3ofw495lt1gr1.js","/_next/static/immutable/chunks/3tofdpg99uc12.js","/_next/static/immutable/chunks/2rzojj6zgb9d9.js","/_next/static/immutable/chunks/42jxjvozn2thc.js","/_next/static/immutable/chunks/1jp6nkbajpbfs.js","/_next/static/immutable/chunks/3jn_lf7v27x-6.js","/_next/static/immutable/chunks/33qq2-hg37d0b.js","/_next/static/immutable/chunks/15isb0svrppbz.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/0asz50g5_lfq9.js","/_next/static/immutable/chunks/30ia-cxa0yoyc.js","/_next/static/immutable/chunks/3ghibkczd0agr.js","/_next/static/immutable/chunks/20mjl75wrar8n.js","/_next/static/immutable/chunks/3nxreg9fiyt2y.js","/_next/static/immutable/chunks/0c04lgvo3p78i.js","/_next/static/immutable/chunks/1u78gf_avpn77.js"],"PaperListPageClient"] 3e:I[70339,["/_next/static/immutable/chunks/355lxm8rh3fxr.js"],"IconMark"] 3c:T9e5,The cardiovascular impact of biologics used in psoriasis is not fully understood. Several studies have suggested that the inhibition of the T-helper 17 cell pathway could lead to the destabilization of atherosclerotic plaques, leading to major adverse cardiovascular events (MACEs). To assess whether the initiation of interleukin (IL)-17(R)A inhibitors triggers MACEs. In this case-time-control study using the French National Health Insurance database, all individuals who received IL-17(R)A inhibitors (secukinumab, ixekizumab, and brodalumab) from 2016 to 2021, were included and classified according to their cardiovascular risk level. The risk period was defined as the 6 months before the MACE, and the reference period as the 6 months before the risk period. The same design for patients who received tumor necrosis factor (TNF)-α inhibitors (adalimumab or etanercept) for similar indications (psoriasis, psoriatic arthritis, ankylosing spondylitis, or juvenile arthritis), as an active comparator. The data analysis was conducted between April 2023 and August 2024. The initiation of the biologic was screened in both periods. The odds ratios (ORs) for the risk of MACEs were assessed following the initiation of IL-17(R)A inhibitors and TNF-α inhibitors independently. Subsequently, the OR for the risk of MACE associated with IL-17(R)A inhibitors was estimated using TNF-α inhibitors as the comparator. Among the 34 241 individuals who received an IL-17(R)A inhibitor, 381 MACEs were analyzed, including 176 acute coronary syndromes and 84 ischemic strokes in the main analysis. Initiation of IL-17(R)A inhibitors was not significantly associated with MACEs (OR, 1.25 [95% CI, 0.75-2.08] vs TNF-α inhibitor initiation and MACEs: OR, 0.90 [95% CI, 0.65-1.24]). Overall, the initiation of an IL-17(R)A inhibitor was not significantly associated with MACEs in the following 6 months, using TNF-α inhibitor as a comparator (OR, 1.40 [95% CI, 0.77-2.54]), regardless of the individual cardiovascular risk (P for homogeneity = .29). The definition of MACE was broadened in a first sensitivity analysis, and the risk period was shortened to 3 months in a second sensitivity analysis. The results did not change. In this case-time-control study based on a national insurance database, there was no evidence of a significant association between MACEs and the initiation of IL-17(R)A inhibitors, regardless of the individual cardiovascular risk of the patient. However, a modest risk increase cannot be entirely excluded.3d:Tf24, Importance The cardiovascular impact of biologics used in psoriasis is not fully understood. Several studies have suggested that the inhibition of the T-helper 17 cell pathway could lead to the destabilization of atherosclerotic plaques, leading to major adverse cardiovascular events (MACEs). Objective To assess whether the initiation of interleukin (IL)-17(R)A inhibitors triggers MACEs. Design, Setting, and Participants In this case–time-control study using the French National Health Insurance database, all individuals who received IL-17(R)A inhibitors (secukinumab, ixekizumab, and brodalumab) from 2016 to 2021, were included and classified according to their cardiovascular risk level. The risk period was defined as the 6 months before the MACE, and the reference period as the 6 months before the risk period. The same design for patients who received tumor necrosis factor (TNF)–α inhibitors (adalimumab or etanercept) for similar indications (psoriasis, psoriatic arthritis, ankylosing spondylitis, or juvenile arthritis), as an active comparator. The data analysis was conducted between April 2023 and August 2024. Exposure The initiation of the biologic was screened in both periods. Main Outcomes and Measures The odds ratios (ORs) for the risk of MACEs were assessed following the initiation of IL-17(R)A inhibitors and TNF-α inhibitors independently. Subsequently, the OR for the risk of MACE associated with IL-17(R)A inhibitors was estimated using TNF-α inhibitors as the comparator. Results Among the 34 241 individuals who received an IL-17(R)A inhibitor, 381 MACEs were analyzed, including 176 acute coronary syndromes and 84 ischemic strokes in the main analysis. Initiation of IL-17(R)A inhibitors was not significantly associated with MACEs (OR, 1.25 [95% CI, 0.75-2.08] vs TNF-α inhibitor initiation and MACEs: OR, 0.90 [95% CI, 0.65-1.24]). Overall, the initiation of an IL-17(R)A inhibitor was not significantly associated with MACEs in the following 6 months, using TNF-α inhibitor as a comparator (OR, 1.40 [95% CI, 0.77-2.54]), regardless of the individual cardiovascular risk ( P for homogeneity = .29). The definition of MACE was broadened in a first sensitivity analysis, and the risk period was shortened to 3 months in a second sensitivity analysis. The results did not change. Conclusions In this case–time-control study based on a national insurance database, there was no evidence of a significant association between MACEs and the initiation of IL-17(R)A inhibitors, regardless of the individual cardiovascular risk of the patient. However, a modest risk increase cannot be entirely excluded. 28:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"TNF-Alpha Inhibitor: Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on TNF-Alpha Inhibitor (modality). Clinician-written summaries and actionable practice insights. 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findings may not fully generalize to male-predominant populations at risk for POAG","value_numeric":null}],"summaries":{"what_studied":"This retrospective multicenter cohort study evaluated whether systemic TNF-α inhibitor use (adalimumab, infliximab, etanercept, certolizumab pegol, or golimumab) was associated with reduced risk of primary open-angle glaucoma (POAG) over 10 years in patients ≥40 years, using propensity-matched data from 70 U.S. health care organizations (2006–2026).","key_result":"Among 11,915 matched pairs, TNF-α inhibitor users had a significantly lower 10-year POAG risk vs. controls (2.0% vs. 3.3%; HR 0.70, 95% CI 0.59–0.82; P<.001); agent-specific reductions were seen with adalimumab (HR 0.74, 95% CI 0.57–0.96) and infliximab (HR 0.68, 95% CI 0.47–0.97), but no significant differences were found between individual agents.","limitations":"Retrospective design limits causal inference; POAG diagnosis relied on ICD-10 codes rather than clinical confirmation, risking misclassification; patients with uveitis were excluded, which may limit generalizability to the broader rheumatologic population.","practice_takeaway":"Clinicians managing patients on systemic TNF-α inhibitors (particularly adalimumab or infliximab) may note a modest associated reduction in POAG risk, though this is observational and should not yet change glaucoma screening practice. These findings support further investigation into TNF-α-mediated neuroinflammation as a pathway in glaucoma development."}},{"doi":"10.2340/actadv.v106.adv-2026-0499","pmid":"42775869","title":"The Use of Systemic Immunomodulating Drugs and Management Practices in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis among Dermatologists in the Philippines: A Cross-sectional Survey Study","journal_title":"Acta Dermato-Venereologica","journal_issn":"1651-2057","published_at":"2026-09-23T00:00:00.000Z","url":"https://doi.org/10.2340/actadv.v106.adv-2026-0499","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-10-02T13:52:47.603Z","updated_at":"2026-10-02T13:52:47.603Z","tags":[{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"condition","value":"Stevens-Johnson Syndrome","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"condition","value":"Toxic Epidermal Necrolysis","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"generic","value":"cyclophosphamide","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"generic","value":"cyclosporine","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"generic","value":"immune globulin intravenous","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"generic","value":"thalidomide","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"modality","value":"Calcineurin Inhibitor","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"modality","value":"Corticosteroid","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"modality","value":"Intravenous Immunoglobulin","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"modality","value":"Plasmapheresis","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"modality","value":"TNF-Alpha Inhibitor","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"sample_size","value":"n=48","value_numeric":48},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"study_design","value":"Cross-Sectional Survey","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"warning","value":"Findings reflect practice patterns of a small, convenience sample of Filipino dermatologists, predominantly from Metro Manila training institutions, and may not represent all Philippine dermatologists or other regions","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"warning","value":"Thalidomide appeared in survey rankings despite no longer being recommended for SJS/TEN management, suggesting some respondents may not be aligned with current evidence","value_numeric":null},{"paper_doi":"10.2340/actadv.v106.adv-2026-0499","tag_type":"warning","value":"The survey relies on self-reported clinical decisions using hypothetical vignettes; actual bedside decision-making may differ, and past diagnoses could not be verified","value_numeric":null}],"summaries":{"what_studied":"A cross-sectional survey of 48 Philippine board-certified dermatologists assessed management practices and treatment preferences for SJS/TEN across 6 standardized clinical vignettes, from January to June 2025.","key_result":"Corticosteroids were the most used systemic therapy (85.4%), followed by IVIG (37.5%) and cyclosporine (33.3%); 35.4% reported using supportive care alone for selected cases. Inter-physician agreement was large for simple SJS (W=0.516) but fell to small for TEN with suspected bacteremia (W=0.236), revealing major variability in complex scenarios.","limitations":"Small convenience sample (n=48) limits generalizability; self-reported practices are subject to recall bias; clinical vignettes may not fully reflect real-world complexity, and prior diagnoses could not be independently verified.","practice_takeaway":"In resource-limited settings like the Philippines, corticosteroids and IVIG dominate SJS/TEN treatment, but there is no shared treatment standard—especially for complex cases like TEN with sepsis. Clinicians should recognize that current practice is highly variable and that stratified, evidence-based local guidelines are urgently needed."}},{"doi":"10.1093/ced/llag322","pmid":"42487627","title":"Cutaneous leishmaniasis in patients in treatment with anti-TNF-α drugs. Study of 20 cases from a single institution","journal_title":"Clinical and Experimental Dermatology","journal_issn":"0307-6938","published_at":"2026-07-23T00:00:00.000Z","url":"https://doi.org/10.1093/ced/llag322","source_score":1,"is_retracted":false,"is_open_access":null,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":false},"created_at":"2026-07-26T13:44:49.302Z","updated_at":"2026-07-26T13:44:49.302Z","tags":[{"paper_doi":"10.1093/ced/llag322","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1093/ced/llag322","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1093/ced/llag322","tag_type":"condition","value":"Cutaneous Leishmaniasis","value_numeric":null},{"paper_doi":"10.1093/ced/llag322","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1093/ced/llag322","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1093/ced/llag322","tag_type":"modality","value":"TNF-Alpha Inhibitor","value_numeric":null},{"paper_doi":"10.1093/ced/llag322","tag_type":"sample_size","value":"n=20","value_numeric":20},{"paper_doi":"10.1093/ced/llag322","tag_type":"study_design","value":"Case Series","value_numeric":null},{"paper_doi":"10.1093/ced/llag322","tag_type":"warning","value":"Age group inferred as 'adult' based on typical anti-TNF-α prescribing patterns; pediatric cases cannot be excluded.","value_numeric":null},{"paper_doi":"10.1093/ced/llag322","tag_type":"warning","value":"Full text was not available — summary is based solely on the paper title, journal, and metadata. Key results such as specific outcome rates, treatment used, and Leishmania species are not confirmed from source text.","value_numeric":null},{"paper_doi":"10.1093/ced/llag322","tag_type":"warning","value":"Sex of the study population was not reported in the available metadata and has been omitted.","value_numeric":null}],"summaries":{"what_studied":"This single-institution case series examined 20 patients who developed cutaneous leishmaniasis (CL) while receiving anti-TNF-α therapy, evaluating clinical presentation, management, and outcomes in this immunocompromised population.","key_result":"20 cases of CL were identified in patients on anti-TNF-α treatment; specific outcome rates and treatment response numbers are not available from the provided abstract alone.","limitations":"Single-institution retrospective case series with a small sample (n=20), limiting generalizability; no control group for comparison with immunocompetent CL patients.","practice_takeaway":"Clinicians should consider cutaneous leishmaniasis in patients on anti-TNF-α biologics who present with atypical or non-healing skin lesions, particularly in or with travel history to endemic areas. Prompt recognition is key, as immunosuppression may alter the clinical course."}},{"doi":"10.1080/09273948.2026.2696517","pmid":"42367087","title":"Efficacy of infliximab therapy in the treatment of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome","journal_title":"Ocular Immunology and Inflammation","journal_issn":"0927-3948","published_at":"2026-06-29T00:00:00.000Z","url":"https://doi.org/10.1080/09273948.2026.2696517","source_score":4,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-05T13:38:39.224Z","updated_at":"2026-07-05T13:38:39.224Z","tags":[{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"brand","value":"Remicade","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"condition","value":"Idiopathic Retinal Vasculitis, Aneurysms, And Neuroretinitis Syndrome","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"condition","value":"Retinal Vasculitis","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"generic","value":"infliximab","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"modality","value":"TNF-Alpha Inhibitor","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"sample_size","value":"n=3","value_numeric":3},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"study_design","value":"Case Series","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"warning","value":"Brand name 'Remicade' assigned as the canonical infliximab brand; biosimilar use was not specified in the abstract.","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"warning","value":"Extremely small sample (n=3); findings are hypothesis-generating only and should not guide broad practice changes without larger studies.","value_numeric":null},{"paper_doi":"10.1080/09273948.2026.2696517","tag_type":"warning","value":"One patient was 17 years old; the age_group tag is set to 'adult' reflecting the mean, but the sample spans adolescent to adult — findings may not be uniform across age groups.","value_numeric":null}],"summaries":{"limitations":"Very small sample size (n=3) limits generalizability. No control group or comparator arm. Short mean follow-up of 14 months may not capture late relapses or delayed adverse effects.","practice_takeaway":"Infliximab appears safe and effective for IRVAN syndrome in this small series. Early initiation after diagnosis may help preserve vision and prevent irreversible structural damage.","what_studied":"Prospective case series evaluating systemic infliximab therapy in 3 patients (mean age 32.3 years) with IRVAN syndrome, with multimodal imaging follow-up over a mean of 14 months (range 6–24 months).","key_result":"All 3 patients showed favorable response: regression of retinal and optic nerve head aneurysms, resolution of vascular leakage, resorption of macular exudates, and stable or improved BCVA. No serious systemic adverse events were recorded."}},{"doi":"10.1002/jpn3.70484","pmid":"42299734","title":"Chronic nonbacterial osteomyelitis and inflammatory bowel disease in children: A French national cohort","journal_title":"Journal of Pediatric Gastroenterology and Nutrition","journal_issn":"0277-2116","published_at":"2026-06-16T00:00:00.000Z","url":"https://doi.org/10.1002/jpn3.70484","source_score":11,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-25T13:25:16.556Z","updated_at":"2026-06-25T13:25:16.556Z","tags":[{"paper_doi":"10.1002/jpn3.70484","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"category","value":"Gastroenterology & Hepatology","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"category","value":"Pediatrics","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"condition","value":"Chronic Nonbacterial Osteomyelitis","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"condition","value":"Crohn's Disease","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"condition","value":"Inflammatory Bowel Disease","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"condition","value":"Ulcerative Colitis","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"generic","value":"anti-TNF-alpha antibodies","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"modality","value":"TNF-Alpha Inhibitor","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"sample_size","value":"n=37","value_numeric":37},{"paper_doi":"10.1002/jpn3.70484","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"warning","value":"Incidence estimate of 1/20,000 patient-years is derived from regional (EPIMAD) data extrapolated to the French national pediatric IBD population — generalizability to other countries is uncertain.","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"warning","value":"Small sample size (n=37) limits precision of all subgroup analyses, including remission and relapse rates by treatment.","value_numeric":null},{"paper_doi":"10.1002/jpn3.70484","tag_type":"warning","value":"The specific anti-TNF-α agents used are not named in the abstract; generic and brand tags could not be specified beyond drug class.","value_numeric":null}],"summaries":{"what_studied":"This retrospective French national cohort study described the clinical features and outcomes of pediatric patients with both inflammatory bowel disease (IBD) and chronic nonbacterial osteomyelitis (CNO), enrolled from gastroenterological and rheumatological units between 2000 and 2024, and estimated the incidence of IBD-CNO among pediatric IBD patients.","key_result":"37 pediatric patients were identified (median age 13.5 years); Crohn's disease was most common (25/37). At median 3-year follow-up, 75.7% achieved IBD-CNO remission, with anti-TNF-α therapy associated with the highest remission rate (82.1%, p=0.041). Incidence was estimated at 1 case per 20,000 patient-years among French pediatric IBD.","limitations":"Retrospective design with potential underreporting due to low clinical awareness; reliance on voluntary case reports from participating units may miss cases; incidence estimate depends on EPIMAD regional cohort data extrapolated nationally.","practice_takeaway":"Order whole-body MRI in IBD children with chronic bone pain to screen for CNO. Anti-TNF-α monotherapy appears effective for both conditions and may prevent bone complications; multidisciplinary involvement of rheumatology and dermatology is recommended."}},{"doi":"10.1038/s41433-026-04460-x","pmid":"42215634","title":"Clinical outcomes of weekly adalimumab in refractory non-infectious paediatric uveitis and the role of serum drug levels and anti-adalimumab antibodies","journal_title":"Eye","journal_issn":"0950-222X","published_at":"2026-05-29T00:00:00.000Z","url":"https://doi.org/10.1038/s41433-026-04460-x","source_score":3,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-01T13:39:30.001Z","updated_at":"2026-06-01T13:39:30.001Z","tags":[{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"brand","value":"Humira","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"condition","value":"Juvenile Idiopathic Arthritis-Associated Uveitis","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"condition","value":"Paediatric Chronic Anterior Uveitis","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"generic","value":"adalimumab","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"modality","value":"TNF-Alpha Inhibitor","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"sample_size","value":"n=15","value_numeric":15},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"warning","value":"Sample size of 15 is very small; all subgroup analyses and statistical comparisons are substantially underpowered — results should be treated as hypothesis-generating only.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"warning","value":"Serum adalimumab levels were measured at random time points, not standardised trough levels, which limits direct comparison with published therapeutic drug monitoring thresholds.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"warning","value":"The brand tag 'Humira' is inferred as the most common adalimumab brand in UK NHS practice; the paper does not specify the brand used.","value_numeric":null},{"paper_doi":"10.1038/s41433-026-04460-x","tag_type":"warning","value":"Weekly adalimumab remains off-label for uveitis in this population; the study reflects real-world UK tertiary practice and may not generalise to other healthcare settings.","value_numeric":null}],"summaries":{"what_studied":"Retrospective review of 15 children (mean age 11 years, range 3–17) with refractory non-infectious paediatric chronic anterior uveitis at two UK tertiary centres, evaluating escalation from standard biweekly to weekly adalimumab, including the predictive value of serum drug levels and anti-adalimumab antibodies (AAA) over a mean follow-up of 230 days.","key_result":"67% (10/15) achieved treatment success (≤0.5+ anterior chamber cells, <2 steroid drops/day) at 3 months. Median serum adalimumab rose from 10.1 mg/L pre-escalation to 18.1 mg/L post-escalation. AAAs were present in 47% pre-escalation and fell to 13% post-escalation, with 57% of AAA-positive patients seroconverting. Visual acuity improved or stayed stable in 93% of affected eyes. No serious adverse events occurred.","limitations":"- Very small sample (n=15); all findings are underpowered and statistically non-significant.\n- Serum ADA levels were random (not trough), limiting pharmacokinetic comparability and potentially inflating post-escalation concentrations.\n- Retrospective single-arm design with variable follow-up duration and no control group.","practice_takeaway":"Weekly adalimumab appears safe and effective as a next step for children with refractory uveitis failing biweekly dosing, including those with detectable anti-drug antibodies. However, neither serum drug level nor antibody status reliably predicted response, so clinical judgement rather than biomarker thresholds should guide escalation decisions until larger prospective data are available."}},{"doi":"10.1007/s13555-026-01761-7","pmid":"42068460","title":"A Narrative Review: Do Systemic Drugs Used in the Treatment of Psoriatic Disease Affect Alzheimer’s Disease?","journal_title":"Dermatology and Therapy","journal_issn":"2193-8210","published_at":"2026-05-02T00:00:00.000Z","url":"https://doi.org/10.1007/s13555-026-01761-7","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-10T13:20:36.620Z","updated_at":"2026-05-10T13:20:36.620Z","tags":[{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"brand","value":"Cosentyx","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"brand","value":"Enbrel","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"brand","value":"Humira","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"brand","value":"Otezla","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"brand","value":"Remicade","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"brand","value":"Sotyktu","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"brand","value":"Stelara","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"condition","value":"Alzheimer's Disease","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"condition","value":"Dementia","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"condition","value":"Psoriasis","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"condition","value":"Psoriatic Arthritis","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"acitretin","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"adalimumab","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"apremilast","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"cyclosporine","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"deucravacitinib","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"etanercept","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"infliximab","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"methotrexate","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"roflumilast","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"secukinumab","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"tofacitinib","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"upadacitinib","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"generic","value":"ustekinumab","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"modality","value":"Conventional Synthetic DMARD","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"modality","value":"IL-12/23 Inhibitor","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"modality","value":"IL-17 Inhibitor","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"modality","value":"IL-23 Inhibitor","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"modality","value":"JAK Inhibitor","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"modality","value":"NSAID","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"modality","value":"PDE4 Inhibitor","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"modality","value":"Retinoid","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"modality","value":"TNF-Alpha Inhibitor","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"modality","value":"TYK2 Inhibitor","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"study_design","value":"Narrative Review","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"warning","value":"Corresponding author (Tsen-Fang Tsai) has disclosed extensive consultant relationships with manufacturers of many drugs discussed in the review.","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"warning","value":"Level of evidence assigned as 5 (narrative review/expert opinion) due to absence of PRISMA methodology, risk-of-bias tools, or meta-analytic synthesis, even though individual cited studies range from Level 1 to Level 5.","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"warning","value":"Several drug-AD associations cited are from studies in rheumatoid arthritis populations, not specifically psoriasis patients; generalizability to psoriatic disease may be limited.","value_numeric":null},{"paper_doi":"10.1007/s13555-026-01761-7","tag_type":"warning","value":"This is a narrative review without formal systematic methods; findings are hypothesis-generating and subject to selection bias in included studies.","value_numeric":null}],"summaries":{"what_studied":"This narrative review examined whether systemic drugs used for psoriatic disease (NSAIDs, methotrexate, cyclosporin, retinoids, PDE4 inhibitors, JAK inhibitors, TYK2 inhibitors, and biologics targeting TNF-α, IL-12/23, IL-17, and IL-23) influence the risk or progression of Alzheimer's disease (AD), using AD as a model for dementia. Literature from PubMed (2015–2025) was synthesized across preclinical, observational, and RCT-level evidence.","key_result":"Most preclinical and observational data suggest antipsoriatic therapies may reduce AD risk. The strongest clinical signal comes from a propensity score–matched cohort (n=1,766) showing biologic therapy for psoriasis was associated with a **53% lower risk of incident dementia** vs. conventional systemic therapy alone. In a large EHR-based study (56 million records), TNF inhibitors (etanercept, adalimumab, infliximab) were linked to markedly reduced AD odds (ORs 0.34, 0.28, and 0.52, respectively; all P<0.0001). However, several large observational studies found the psoriasis–dementia association attenuated or disappeared after adjusting for comorbidities.","limitations":"- Narrative (not systematic) review with no PRISMA flow, risk-of-bias assessment, or quantitative synthesis, limiting reproducibility.\n- Most mechanistic evidence comes from preclinical models (Level 5), with very few adequately powered RCTs in humans.\n- Residual confounding by disease severity, metabolic comorbidities, and medication use cannot be excluded in observational studies.","practice_takeaway":"For older patients with psoriasis, consider early cognitive screening, as shared inflammatory mechanisms may raise dementia risk—especially in those with metabolic comorbidities. Biologic therapy, particularly TNF inhibitors, shows the most consistent signal for possible neuroprotection, but current evidence is hypothesis-generating and should not yet change prescribing solely for dementia prevention."}},{"doi":"10.1182/bloodadvances.2025018853","pmid":"41961998","title":"Diagnosis and management of immune effector cell–associated enterocolitis after ciltacabtagene autoleucel","journal_title":"Blood Advances","journal_issn":"2473-9529","published_at":"2026-04-10T00:00:00.000Z","url":"https://doi.org/10.1182/bloodadvances.2025018853","source_score":8,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-03T13:39:00.566Z","updated_at":"2026-07-03T13:39:00.566Z","tags":[{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"brand","value":"Carvykti","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"brand","value":"Remicade","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"brand","value":"Vedolizumab","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"category","value":"Hematology","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"condition","value":"Immune Effector Cell-Associated Enterocolitis","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"condition","value":"Multiple Myeloma","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"generic","value":"ciltacabtagene autoleucel","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"generic","value":"infliximab","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"generic","value":"vedolizumab","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"modality","value":"Anti-Integrin Monoclonal Antibody","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"modality","value":"CAR-T Cell Therapy","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"modality","value":"TNF-Alpha Inhibitor","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"sample_size","value":"n=229","value_numeric":229},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"study_design","value":"Retrospective Case Series","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"warning","value":"GI coinfection was present in 5 of 9 cases and appeared to predict non-response to biologic therapy, but the small numbers preclude firm conclusions about causality.","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"warning","value":"Only 9 IEC-EC cases were identified, making multivariable risk factor estimates (especially wide confidence intervals) highly uncertain and difficult to generalize.","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"warning","value":"The distinction between IEC-EC and T-cell lymphoproliferative disorder (T-LPD) is not yet fully standardized; 2 of 9 cases showed T-LPD patterns, which may have different optimal management.","value_numeric":null},{"paper_doi":"10.1182/bloodadvances.2025018853","tag_type":"warning","value":"Vedolizumab brand tag added for clarity, though 'Entyvio' is the marketed brand name; 'Vedolizumab' used here as noted in the paper.","value_numeric":null}],"summaries":{"what_studied":"This retrospective case series examined the incidence, clinical features, risk factors, and management outcomes of immune effector cell–associated enterocolitis (IEC-EC) in 229 consecutive patients who received cilta-cel (ciltacabtagene autoleucel) for relapsed/refractory multiple myeloma at three Mayo Clinic sites between February 2022 and November 2024.","key_result":"IEC-EC occurred in 9 of 229 patients (3.9%), presenting as persistent grade ≥3 nonbloody diarrhea at a median of 85 days post-infusion. First-line corticosteroids and supportive care produced no durable responses. Biologic therapy yielded durable responses in 3 of 5 patients who received it (2/2 with vedolizumab; 1/3 with infliximab); all 3 responders had no concurrent GI infection. Independent risk factors were IMS/IMWG high-risk disease (OR 6.1; 95% CI, 1.2–30), prolonged CRS ≥3 days, and antecedent delayed neurotoxicity (OR 10.6; 95% CI, 2.0–69.3).","limitations":"- Very small case series (n=9 IEC-EC) limits statistical power and generalizability.\n- Retrospective design with missing data and likely selection bias toward more severe cases.\n- Single-institution (multi-site) experience may not reflect treatment-access disparities elsewhere.","practice_takeaway":"In cilta-cel recipients with persistent grade ≥2 diarrhea—especially those with prior delayed neurotoxicity or high-risk myeloma—pursue early endoscopy with duodenal biopsy (highest histopathological yield) and rule out GI infection. If first-line corticosteroids fail within one week, escalate promptly to biologic therapy (vedolizumab or infliximab), as prolonged steroid courses appear ineffective and durable responses are tied to early biologic use in patients without concurrent GI infection."}},{"doi":"10.1016/j.jaad.2026.01.043","pmid":"41616932","title":"Skin and soft tissue infections in pediatric patients with inflammatory bowel disease treated with tumor necrosis factor-α inhibitors","journal_title":"Journal of the American Academy of Dermatology","journal_issn":"0190-9622","published_at":"2026-01-29T00:00:00.000Z","url":"https://doi.org/10.1016/j.jaad.2026.01.043","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-05-30T13:22:42.824Z","updated_at":"2026-05-30T13:22:42.824Z","tags":[{"paper_doi":"10.1016/j.jaad.2026.01.043","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.01.043","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.01.043","tag_type":"condition","value":"Inflammatory Bowel Disease","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.01.043","tag_type":"condition","value":"Skin and Soft Tissue Infections","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.01.043","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.01.043","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.01.043","tag_type":"modality","value":"TNF-Alpha Inhibitor","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.01.043","tag_type":"warning","value":"Impact flag 'safety_signal' is inferred from the topic (infection risk with immunosuppression in children) but may not reflect the authors' conclusions.","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.01.043","tag_type":"warning","value":"Level of evidence is estimated as 4 (case series or retrospective cohort) based on typical study designs for this research question, but cannot be confirmed without full text.","value_numeric":null},{"paper_doi":"10.1016/j.jaad.2026.01.043","tag_type":"warning","value":"Only the paper citation metadata was provided — no abstract, methods, results, or full text were available. Key fields such as key_result, sample_size, sex, and study_design could not be reliably extracted and have been omitted or estimated conservatively.","value_numeric":null}],"summaries":{"what_studied":"This study evaluated the incidence and characteristics of skin and soft tissue infections (SSTIs) in pediatric patients with inflammatory bowel disease (IBD) who were treated with tumor necrosis factor-α (TNF-α) inhibitors.","limitations":"The paper abstract provides insufficient detail to extract specific outcome data, sample size, or comparator arms.","practice_takeaway":"Clinicians managing pediatric IBD patients on TNF-α inhibitors should maintain heightened vigilance for skin and soft tissue infections as a potential treatment-related complication."}},{"doi":"10.1001/jamadermatol.2025.2972","pmid":"40900466","title":"Interleukin-17 Inhibitors and Early Major Adverse Cardiovascular Events","journal_title":"JAMA Dermatology","journal_issn":"2168-6068","published_at":"2025-09-03T00:00:00.000Z","url":"https://doi.org/10.1001/jamadermatol.2025.2972","source_score":13,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2025-11-21","doi":"10.1001/jamadermatol.2025.2972","days":"7","issn":"2168-6068","rank":"10","field":"Clinical Medicine","score":"13","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1001/jamadermatol.2025.2972","title":"Interleukin-17 Inhibitors and Early Major Adverse Cardiovascular Events.","journal":"JAMA dermatology","methods":"","results":"Among the 34 241 individuals who received an IL-17(R)A inhibitor, 381 MACEs were analyzed, including 176 acute coronary syndromes and 84 ischemic strokes in the main analysis. Initiation of IL-17(R)A inhibitors was not significantly associated with MACEs (OR, 1.25 [95% CI, 0.75-2.08] vs TNF-α inhibitor initiation and MACEs: OR, 0.90 [95% CI, 0.65-1.24]). Overall, the initiation of an IL-17(R)A inhibitor was not significantly associated with MACEs in the following 6 months, using TNF-α inhibitor as a comparator (OR, 1.40 [95% CI, 0.77-2.54]), regardless of the individual cardiovascular risk (P for homogeneity = .29). The definition of MACE was broadened in a first sensitivity analysis, and the risk period was shortened to 3 months in a second sensitivity analysis. The results did not change.","abstract":"$3c","keywords":[],"pubmed_id":"40900466","conclusions":"","publication_date":"2025-09-03T00:00:00"},"crossref":{"DOI":"10.1001/jamadermatol.2025.2972","URL":"https://doi.org/10.1001/jamadermatol.2025.2972","ISSN":["2168-6068"],"link":[{"URL":"https://jamanetwork.com/journals/jamadermatology/articlepdf/2838219/jamadermatology_raby_2025_oi_250041_1762976601.59148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"1107","type":"journal-article","issue":"11","score":1,"title":["Interleukin-17 Inhibitors and Early Major Adverse Cardiovascular Events"],"author":[{"given":"Maxime","family":"Raby","sequence":"first","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"},{"name":"Department of Dermatology, Université de Rennes, CHU Rennes, Rennes, France"}]},{"given":"Frederic","family":"Balusson","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"},{"name":"Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, Department of Clinical Pharmacology, Rennes Hospital, France"}]},{"given":"Emmanuel","family":"Oger","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"},{"name":"Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, Department of Clinical Pharmacology, Rennes Hospital, France"}]},{"given":"Marion","family":"Gundelwein","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"}]},{"given":"Alain","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"},{"name":"Department of Dermatology, Université de Rennes, CHU Rennes, Rennes, France"}]},{"given":"Florence","family":"Poizeau","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)—UMR_S 1085, Rennes, France"},{"name":"Department of Dermatology, Université de Rennes, CHU Rennes, Rennes, 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Dermatol","doi-asserted-by":"publisher"}],"short-title":[],"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,1]]}},"content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["JAMA Dermatology"],"published-print":{"date-parts":[[2025,11,1]]},"reference-count":64,"published-online":null,"references-count":64,"short-container-title":["JAMA Dermatol"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1001/jamadermatol.2025.2972","is_oa":false,"title":"Interleukin-17 Inhibitors and Early Major Adverse Cardiovascular 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Inhibitor","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2025.2972","tag_type":"sample_size","value":"n=34,241","value_numeric":34241},{"paper_doi":"10.1001/jamadermatol.2025.2972","tag_type":"study_design","value":"Case-Time-Control Study","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2025.2972","tag_type":"warning","value":"Abstract reports odds ratios without absolute event rates by exposure group.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2025.2972","tag_type":"warning","value":"Design labeled as case–time–control; classification may be unfamiliar to some readers.","value_numeric":null},{"paper_doi":"10.1001/jamadermatol.2025.2972","tag_type":"warning","value":"Only early (3–6 month) risk windows were evaluated; longer-term risk remains uncertain.","value_numeric":null}],"summaries":{"what_studied":"A national case–time–control study of the French health insurance database (2016–2021) assessed whether initiating IL‑17(R)A inhibitors (secukinumab, ixekizumab, brodalumab) triggers major adverse cardiovascular events (MACEs) within 6 months, using TNF‑α inhibitors (adalimumab, etanercept) as an active comparator. Among 34,241 IL‑17(R)A recipients, 381 MACEs were analyzed; risk and reference windows were the 6 months before the MACE and the preceding 6 months.","key_result":"Initiation of IL‑17(R)A inhibitors was not significantly associated with MACEs (OR 1.25, 95% CI 0.75–2.08); TNF‑α inhibitor initiation also showed no association (OR 0.90, 95% CI 0.65–1.24). Compared with TNF‑α inhibitors, IL‑17(R)A initiation had an OR of 1.40 (95% CI 0.77–2.54) over 6 months, with similar findings across cardiovascular risk strata (P for homogeneity = .29) and unchanged results in sensitivity analyses (broader MACE definition; 3‑month risk window).","limitations":"Only early risk windows (3–6 months) were evaluated, so longer‑term risk was not assessed. Precision was limited by 381 MACEs, yielding wide confidence intervals that do not exclude a modest risk increase.","practice_takeaway":"In this large real‑world analysis, starting an IL‑17(R)A inhibitor did not show a significant increase in 6‑month MACEs versus TNF‑α inhibitors, across cardiovascular risk levels. Continue standard cardiovascular risk management; a small increase in early events cannot be ruled out."}}],"initialOffset":10,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"TNF-Alpha Inhibitor"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"TNF-Alpha Inhibitor"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"TNF-Alpha Inhibitor"}}}]] 2b:null

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