2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T4ee,Ablative fractional CO The study aimed to evaluate the post-procedure reparative effects of a combination of vitamin C, E, and ferulic acid (CE Ferulic) in Chinese patients with atrophic acne scars. In this randomized, investigator-blinded, split-face, controlled trial, patients aged 18-50 with moderate-to-severe atrophic acne scars were randomly assigned to apply CE Ferulic to intervention-side face and normal saline (NS) to control-side face, immediately after ablative CO Sixty-four patients were included in the analysis. On Day 7, the intervention side showed a higher complete scab detachment rate than the control side (60.9% vs. 34.4%, p = 0.0026). EI and MI reduced significantly greater on the intervention side compared to the control side (Days 3, 7, and 14; p < 0.0001). On Day 14, the intervention side also demonstrated significantly better capability of maintaining skin hydration (p = 0.0367) and preventing TEWL (p = 0.0246) than the control side. This study found that CE Ferulic led to enhanced wound healing, reduced erythema and melanin levels, and improved skin hydration following laser treatment, suggesting its beneficial application in combination with laser treatment to accelerate skin recovery. ChiCTR2300078214.31:Td0a,ABSTRACT Background Ablative fractional CO 2 laser is effective for acne scar treatment but is often associated with side effects such as erythema and dyspigmentation, along with prolonged recovery time. Aims The study aimed to evaluate the post‐procedure reparative effects of a combination of vitamin C, E, and ferulic acid (CE Ferulic) in Chinese patients with atrophic acne scars. Methods In this randomized, investigator‐blinded, split‐face, controlled trial, patients aged 18–50 with moderate‐to‐severe atrophic acne scars were randomly assigned to apply CE Ferulic to intervention‐side face and normal saline (NS) to control‐side face, immediately after ablative CO 2 laser treatment for 14 days. Patients were further divided into once‐daily and twice‐daily application subgroups. During the 14‐day follow‐up, the wound healing (measured by scabbing stage on Day 7), erythema index (EI), melanin index (MI), skin hydration, and transepidermal water loss (TEWL) were evaluated. Direct assessment of scar improvement was not within the scope of this study. Results Sixty‐four patients were included in the analysis. On Day 7, the intervention side showed a higher complete scab detachment rate than the control side (60.9% vs. 34.4%, p = 0.0026). EI and MI reduced significantly greater on the intervention side compared to the control side (Days 3, 7, and 14; p < 0.0001). On Day 14, the intervention side also demonstrated significantly better capability of maintaining skin hydration ( p = 0.0367) and preventing TEWL ( p = 0.0246) than the control side. Conclusions This study found that CE Ferulic led to enhanced wound healing, reduced erythema and melanin levels, and improved skin hydration following laser treatment, suggesting its beneficial application in combination with laser treatment to accelerate skin recovery. Trial Registration ChiCTR2300078214 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Topical Antioxidant: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Topical Antioxidant (modality). Clinician-written summaries and actionable practice insights. 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Clinicians recommending vitamin C for anti-aging or brightening can point to this in vivo trial as supporting evidence, noting the use of a dual-chamber powder/vehicle system to maintain stability."}},{"doi":"10.1111/jocd.70634","pmid":"41521693","title":"Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fractional\n CO\n ₂\n Laser Treatment for Atrophic Acne Scars: A Randomized, Investigator‐Blinded, Split‐Face, Controlled Trial","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2026-01-12T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70634","source_score":19,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-15","doi":"10.1111/jocd.70634","days":"7","issn":"1473-2130","rank":"2","field":"Clinical Medicine","score":"19","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70634","title":"Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fractional CO","journal":"Journal of cosmetic dermatology","methods":"","results":"Sixty-four patients were included in the analysis. On Day 7, the intervention side showed a higher complete scab detachment rate than the control side (60.9% vs. 34.4%, p = 0.0026). EI and MI reduced significantly greater on the intervention side compared to the control side (Days 3, 7, and 14; p < 0.0001). On Day 14, the intervention side also demonstrated significantly better capability of maintaining skin hydration (p = 0.0367) and preventing TEWL (p = 0.0246) than the control side.","abstract":"$30","keywords":["CE Ferulic serum","ablative fractional CO2 laser","aesthetic dermatology","atrophic acne scars","cosmetic dermatology","evidence‐based medicine","integrated skincare"],"pubmed_id":"41521693","conclusions":"","publication_date":"2026-01-12T00:00:00"},"crossref":{"DOI":"10.1111/jocd.70634","URL":"https://doi.org/10.1111/jocd.70634","ISSN":["1473-2130","1473-2165"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70634","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jocd.70634","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"1","score":1,"title":["Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fractional\n CO\n ₂\n Laser Treatment for Atrophic Acne Scars: A Randomized, Investigator‐Blinded, Split‐Face, Controlled Trial"],"author":[{"given":"Yu","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Medical Cosmetology, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]},{"given":"Sijia","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}]}],"issued":{"date-parts":[[2026,1]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":"25","archive":["Portico"],"created":{"date-time":"2026-01-12T07:35:49Z","timestamp":1768203349000,"date-parts":[[2026,1,12]]},"indexed":{"date-time":"2026-01-12T10:42:11Z","timestamp":1768214531236,"date-parts":[[2026,1,12]]},"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000,"date-parts":[[2026,1,11]]},"delay-in-days":10,"content-version":"vor"},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70634"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-06-12"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-12-18"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-01-11"}],"deposited":{"date-time":"2026-01-12T07:35:51Z","timestamp":1768203351000,"date-parts":[[2026,1,12]]},"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"published":{"date-parts":[[2026,1]]},"publisher":"Wiley","reference":[{"DOI":"10.1155/2010/893080","key":"e_1_2_13_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1055/s‐0037‐1606096","key":"e_1_2_13_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/01.prs.0000299380.83221.a8","key":"e_1_2_13_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/s41038‐018‐0129‐9","key":"e_1_2_13_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/lsm.20512","key":"e_1_2_13_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.5978/islsm.16‐OR‐13","key":"e_1_2_13_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_13_8_1","year":"2012","issue":null,"author":"Elford E. 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Erythema Index and Melanin Index decreased more on Days 3, 7, and 14 with the serum (all p<0.0001), and on Day 14 the serum side had better skin hydration (p=0.0367) and lower TEWL (p=0.0246).","practice_takeaway":"Applying a vitamin C/E plus ferulic acid serum immediately after ablative fractional CO2 treatment for atrophic acne scars improved crust clearance, reduced erythema and pigmentation, and supported barrier recovery versus saline during the first two weeks."}}],"initialOffset":2,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Topical Antioxidant"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Topical Antioxidant"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Topical Antioxidant"}}}]]

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