3b:I[281230,["/_next/static/immutable/chunks/0l5c-zsrs2aic.js","/_next/static/immutable/chunks/3_n0rk2989-8h.js","/_next/static/immutable/chunks/3ofw495lt1gr1.js","/_next/static/immutable/chunks/3tofdpg99uc12.js","/_next/static/immutable/chunks/2rzojj6zgb9d9.js","/_next/static/immutable/chunks/42jxjvozn2thc.js","/_next/static/immutable/chunks/1jp6nkbajpbfs.js","/_next/static/immutable/chunks/3jn_lf7v27x-6.js","/_next/static/immutable/chunks/33qq2-hg37d0b.js","/_next/static/immutable/chunks/15isb0svrppbz.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/0asz50g5_lfq9.js","/_next/static/immutable/chunks/30ia-cxa0yoyc.js","/_next/static/immutable/chunks/3ghibkczd0agr.js","/_next/static/immutable/chunks/20mjl75wrar8n.js","/_next/static/immutable/chunks/3nxreg9fiyt2y.js","/_next/static/immutable/chunks/0c04lgvo3p78i.js","/_next/static/immutable/chunks/1u78gf_avpn77.js"],"PaperListPageClient"] 3e:I[70339,["/_next/static/immutable/chunks/355lxm8rh3fxr.js"],"IconMark"] 3c:T58c,Lips are prone to dehydration and aging. Effective noninvasive hyaluronic acid (HA) delivery remains challenging. To evaluate topical Replenishing Lip Filler-Tiered Release Vesicles (RLF-TRV) in filler-naïve and previously-augmented lips. Two single-center trials evaluated efficacy and tolerability of RLF-TRV Serum. Study 1 included filler-naïve subjects or those without lip filler for 12 months. Study 2 enrolled subjects with prior HA lip augmentation (3-9 months earlier) in a double-blind, placebo-controlled design. Participants applied RLF-TRV or placebo twice daily for 3 weeks, followed by a 2-week regression period. Outcomes included grading of shine, texture, and vermilion border, Investigator and Subject Global Aesthetic Improvement Scale (I-GAIS, S-GAIS), and satisfaction. Imaging and tolerability assessments were conducted throughout the study. RLF-TRV significantly improved lip aesthetics (shine, texture, and vermilion border), with high satisfaction across both studies. In Study 1, 94% of treated participants were "Improved" on I-GAIS (p < 0.001), and 81% were "Much-Improved" on S-GAIS (p < 0.05). In Study 2, 88% of treated participants were "Improved" on both I-GAIS and S-GAIS. RLF-TRV was well tolerated, with no recorded adverse events. RLF-TRV significantly improved lip aesthetics, offering a noninvasive alternative or complementary treatment to injectable procedures.3d:T996,ABSTRACT Background Lips are prone to dehydration and aging. Effective noninvasive hyaluronic acid (HA) delivery remains challenging. Aim To evaluate topical Replenishing Lip Filler‐Tiered Release Vesicles (RLF‐TRV) in filler‐naïve and previously‐augmented lips. Methods Two single‐center trials evaluated efficacy and tolerability of RLF‐TRV Serum. Study 1 included filler‐naïve subjects or those without lip filler for 12 months. Study 2 enrolled subjects with prior HA lip augmentation (3–9 months earlier) in a double‐blind, placebo‐controlled design. Participants applied RLF‐TRV or placebo twice daily for 3 weeks, followed by a 2‐week regression period. Outcomes included grading of shine, texture, and vermilion border, Investigator and Subject Global Aesthetic Improvement Scale (I‐GAIS, S‐GAIS), and satisfaction. Imaging and tolerability assessments were conducted throughout the study. Results RLF‐TRV significantly improved lip aesthetics (shine, texture, and vermilion border), with high satisfaction across both studies. In Study 1, 94% of treated participants were “Improved” on I‐GAIS ( p < 0.001), and 81% were “Much‐Improved” on S‐GAIS ( p < 0.05). In Study 2, 88% of treated participants were “Improved” on both I‐GAIS and S‐GAIS. RLF‐TRV was well tolerated, with no recorded adverse events. Conclusions RLF‐TRV significantly improved lip aesthetics, offering a noninvasive alternative or complementary treatment to injectable procedures. 28:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Topical Hyaluronic Acid: Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Topical Hyaluronic Acid (modality). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/modality/Topical%20Hyaluronic%20Acid\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Modalities\",\"item\":\"https://www.reachrx.ai/hub/tag/modality\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Topical Hyaluronic Acid\",\"item\":\"https://www.reachrx.ai/hub/tag/modality/Topical%20Hyaluronic%20Acid\"}]}}"}}]],["$","$L3b",null,{"title":"Topical Hyaluronic Acid: Research & Clinical Takeaways","description":"Review evidence by treatment modality: Topical Hyaluronic Acid — concise summaries and practical next steps.","papers":[{"doi":"10.1111/jocd.70563","pmid":"41273141","title":"Efficacy and Tolerability of a Topical Peptide‐Hyaluronic Acid Lip Treatment Using a Novel Delivery System in Subjects With and Without Prior Lip Augmentation","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2025-11-22T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70563","source_score":8,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-11-26","doi":"10.1111/jocd.70563","days":"7","issn":"1473-2130","rank":"5","field":"Clinical Medicine","score":"8","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70563","title":"Efficacy and Tolerability of a Topical Peptide-Hyaluronic Acid Lip Treatment Using a Novel Delivery System in Subjects With and Without Prior Lip Augmentation.","journal":"Journal of cosmetic dermatology","methods":"","results":"RLF-TRV significantly improved lip aesthetics (shine, texture, and vermilion border), with high satisfaction across both studies. In Study 1, 94% of treated participants were \"Improved\" on I-GAIS (p < 0.001), and 81% were \"Much-Improved\" on S-GAIS (p < 0.05). In Study 2, 88% of treated participants were \"Improved\" on both I-GAIS and S-GAIS. RLF-TRV was well tolerated, with no recorded adverse events.","abstract":"$3c","keywords":[],"pubmed_id":"41273141","conclusions":"","publication_date":"2025-11-22T00:00:00"},"crossref":{"DOI":"10.1111/jocd.70563","URL":"https://doi.org/10.1111/jocd.70563","ISSN":["1473-2130","1473-2165"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"12","score":1,"title":["Efficacy and Tolerability of a Topical Peptide‐Hyaluronic Acid Lip Treatment Using a Novel Delivery System in Subjects With and Without Prior Lip Augmentation"],"author":[{"given":"Amir","family":"Moradi","sequence":"first","affiliation":[{"name":"Moradi MD Vista California USA"},{"name":"Pacific Clinical Innovations Vista California USA"}]},{"given":"Carolyn","family":"Jacob","sequence":"additional","affiliation":[{"name":"Chicago Cosmetic Surgery and Dermatology Chicago Illinois USA"},{"name":"Northwestern Feinberg School of Medicine Chicago Illinois USA"}]},{"given":"Joy","family":"Tao","sequence":"additional","affiliation":[{"name":"Modern Skin Dermatology Hinsdale Illinois USA"}]},{"given":"Robert","family":"Love","sequence":"additional","affiliation":[{"name":"Ourself Carlsbad California USA"}]},{"given":"Stacy","family":"Osborne","sequence":"additional","affiliation":[{"name":"Ourself Carlsbad California USA"}]},{"given":"Tina","family":"Fleck","sequence":"additional","affiliation":[{"name":"Ourself Carlsbad California USA"}]}],"issued":{"date-parts":[[2025,11,22]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":"24","archive":["Portico"],"created":{"date-time":"2025-11-22T08:50:58Z","timestamp":1763801458000,"date-parts":[[2025,11,22]]},"indexed":{"date-time":"2025-11-22T08:53:08Z","timestamp":1763801588781,"date-parts":[[2025,11,22]]},"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000,"date-parts":[[2025,11,22]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$3d","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70563"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-06-07"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-11-05"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2025-11-22"}],"deposited":{"date-time":"2025-11-22T08:50:59Z","timestamp":1763801459000,"date-parts":[[2025,11,22]]},"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"published":{"date-parts":[[2025,11,22]]},"publisher":"Wiley","reference":[{"DOI":"10.14639/0392‐100X‐1511","key":"e_1_2_12_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/j.1468‐2494.2008.00459.x","key":"e_1_2_12_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1046/j.1365‐2133.2003.05741.x","key":"e_1_2_12_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/ics.12692","key":"e_1_2_12_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/PRS.0000000000005190","key":"e_1_2_12_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_12_7_1","year":"2015","issue":null,"author":"Smejkalova D.","volume":null,"first-page":"612","unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.4161/derm.21923","key":"e_1_2_12_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/DSS.0000000000004504","key":"e_1_2_12_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.engreg.2020.10.001","key":"e_1_2_12_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/asj/sjab358","key":"e_1_2_12_11_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3389/fsurg.2021.681028","key":"e_1_2_12_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1074/jbc.M003642200","key":"e_1_2_12_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/S0021-9258(18)82153-6","key":"e_1_2_12_14_1","year":"1993","issue":"14","author":"Katayama K.","volume":"268","first-page":"9941","unstructured":null,"article-title":"A Pentapeptide From Type I Procollagen Promotes Extracellular Matrix Production","journal-title":"Journal of Biological Chemistry","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.bbrc.2018.10.044","key":"e_1_2_12_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/antiox11071346","key":"e_1_2_12_16_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3389/fnut.2024.1280100","key":"e_1_2_12_17_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/molecules29174174","key":"e_1_2_12_18_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/ijms17060955","key":"e_1_2_12_19_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s00403‐009‐0932‐z","key":"e_1_2_12_20_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_12_21_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"M. H.Sung C.Park J. C.Choi H.Uyama andS. L.Park “Hyaluronidase Inhibitor Containing Poly‐Gamma‐Glutamic Acid as an Effective Component”(2008) US Patent Application 2008/0247986 A1.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.36849/JDD.2020.10.36849/JDD.2020.5139","key":"e_1_2_12_22_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1046/j.1524‐4725.2003.29150.x","key":"e_1_2_12_23_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.20517/2347‐9264.2019.73","key":"e_1_2_12_24_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1159/000363380","key":"e_1_2_12_25_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/ijms19010070","key":"e_1_2_12_26_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1111/jocd.70563"],"article-number":"e70563","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Journal of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,12]]},"reference-count":25,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2025,11,22]]},"references-count":25,"short-container-title":["J of Cosmetic Dermatology"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1111/jocd.70563","is_oa":true,"title":"Efficacy and Tolerability of a Topical Peptide‐Hyaluronic Acid Lip Treatment Using a Novel Delivery System in Subjects With and Without Prior Lip Augmentation","updated":"2025-11-25T15:53:31+00:00","published_date":"2025-11-22","best_oa_location":{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.70563","pmh_id":null,"url_for_pdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.70563","url_for_landing_page":"https://doi.org/10.1111/jocd.70563"}}},"created_at":"2025-11-29T07:06:31.192Z","updated_at":"2025-12-02T07:03:10.886Z","tags":[{"paper_doi":"10.1111/jocd.70563","tag_type":"brand","value":"RLF-TRV","value_numeric":null},{"paper_doi":"10.1111/jocd.70563","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jocd.70563","tag_type":"condition","value":"Skin Aging","value_numeric":null},{"paper_doi":"10.1111/jocd.70563","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/jocd.70563","tag_type":"modality","value":"Peptide-Based Topical","value_numeric":null},{"paper_doi":"10.1111/jocd.70563","tag_type":"modality","value":"Topical Hyaluronic Acid","value_numeric":null},{"paper_doi":"10.1111/jocd.70563","tag_type":"study_design","value":"Randomized Controlled Trial","value_numeric":null},{"paper_doi":"10.1111/jocd.70563","tag_type":"warning","value":"Mixed study designs: one trial was double‑blind, placebo‑controlled while the other single‑center study’s design details are limited.","value_numeric":null},{"paper_doi":"10.1111/jocd.70563","tag_type":"warning","value":"Sample size is not reported in the abstract.","value_numeric":null},{"paper_doi":"10.1111/jocd.70563","tag_type":"warning","value":"Short (3‑week) treatment with a 2‑week regression limits conclusions about durability.","value_numeric":null}],"summaries":{"what_studied":"Two single-center trials tested a topical peptide–hyaluronic acid lip serum (RLF‑TRV), applied twice daily for 3 weeks with a 2‑week regression period, in filler‑naïve lips and in lips 3–9 months after HA augmentation; one trial (Study 2) was double‑blind and placebo‑controlled.","key_result":"Study 1: 94% were “Improved” on I‑GAIS (p<0.001) and 81% were “Much‑Improved” on S‑GAIS (p<0.05). Study 2: 88% were “Improved” on both I‑GAIS and S‑GAIS; no adverse events were recorded.","limitations":"Single‑center setting for both trials; short treatment and follow‑up (3 weeks on treatment plus a 2‑week regression period); outcomes relied on aesthetic rating scales (I‑GAIS, S‑GAIS) rather than objective functional measures.","practice_takeaway":"In both filler‑naïve and previously HA‑augmented lips, short‑term twice‑daily RLF‑TRV improved clinician‑ and patient‑rated lip aesthetics and was well tolerated; durability beyond the brief off‑treatment period was not assessed."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Topical Hyaluronic Acid"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Topical Hyaluronic Acid"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Topical Hyaluronic Acid"}}}]] 2b:null 2f:[["$","title","0",{"children":"Topical Hyaluronic Acid: Research & Clinical Takeaways | ReachRx"}],["$","meta","1",{"name":"description","content":"Explore peer-reviewed papers on Topical Hyaluronic Acid (modality). Clinician-written summaries and actionable practice insights. Updated daily."}],["$","meta","2",{"name":"apple-mobile-web-app-capable","content":"yes"}],["$","meta","3",{"name":"msapplication-config","content":"/browserconfig.xml"}],["$","meta","4",{"name":"msapplication-tap-highlight","content":"no"}],["$","link","5",{"rel":"canonical","href":"https://www.reachrx.ai/hub/tag/modality/Topical%20Hyaluronic%20Acid"}],["$","meta","6",{"name":"format-detection","content":"telephone=no"}],["$","meta","7",{"name":"mobile-web-app-capable","content":"yes"}],["$","meta","8",{"name":"apple-mobile-web-app-status-bar-style","content":"black-translucent"}],["$","meta","9",{"property":"og:title","content":"Topical Hyaluronic Acid: Research & Clinical Takeaways | ReachRx"}],["$","meta","10",{"property":"og:description","content":"Explore peer-reviewed papers on Topical Hyaluronic Acid (modality). Clinician-written summaries and actionable practice insights. Updated daily."}],["$","meta","11",{"property":"og:url","content":"https://www.reachrx.ai/hub/tag/modality/Topical%20Hyaluronic%20Acid"}],["$","meta","12",{"property":"og:site_name","content":"ReachRx"}],["$","meta","13",{"property":"og:locale","content":"en_US"}],["$","meta","14",{"property":"og:image","content":"https://www.reachrx.ai/reachrx_branding/reachrx-logo-metaimage.png"}],["$","meta","15",{"property":"og:image:type","content":"image/png"}],["$","meta","16",{"property":"og:image:width","content":"1200"}],["$","meta","17",{"property":"og:image:height","content":"630"}],["$","meta","18",{"property":"og:type","content":"website"}],["$","meta","19",{"name":"twitter:card","content":"summary_large_image"}],["$","meta","20",{"name":"twitter:creator","content":"@Reach_Rx"}],["$","meta","21",{"name":"twitter:title","content":"Topical Hyaluronic Acid: Research & Clinical Takeaways | ReachRx"}],["$","meta","22",{"name":"twitter:description","content":"Explore peer-reviewed papers on Topical Hyaluronic Acid (modality). Clinician-written summaries and actionable practice insights. Updated daily."}],["$","meta","23",{"name":"twitter:image","content":"https://www.reachrx.ai/reachrx_branding/reachrx-logo-metaimage.png"}],["$","link","24",{"rel":"shortcut icon","href":"/favicon.ico"}],["$","link","25",{"rel":"apple-touch-icon","href":"/apple-touch-icon.png","sizes":"180x180"}],["$","link","26",{"rel":"mask-icon","href":"/safari-pinned-tab.svg","color":"#000000"}],["$","$L3e","27",{}]]

Papers

Papers