2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T6ed,Society values a full head of hair. Therefore, androgenetic hair loss (AGA), though medically benign, can cause significant emotional distress. There is strong demand for alternative (nonconventional, over-the-counter) AGA treatments. It is important to have evidence on the efficacy of these treatments for AGA-especially in comparison with treatments that are approved by the United States Food and Drug Administration (FDA), such as oral finasteride and topical minoxidil. Following a systematic review, we conducted a network meta-analysis (NMA) to determine the relative efficacy of conventional monotherapies and selected alternative (nonconventional, over-the-counter) products for male AGA. We conducted a Bayesian NMA under a fixed effect model with uniform priors; the NMA estimated relative effects-as per mean difference (MD), along with the 95% credible interval (CI)-and surface under the cumulative ranking curve (SUCRA) values. We also assessed study-level evidence quality. Eligible studies were identified through systematic searches (without date restrictions) in PubMed and Scopus on April 30, 2025. The main outcome measure was change in total hair density at 24 weeks from baseline (in hairs/cm We found 24 eligible trials-where the relative efficacy of eight conventional monotherapies and seven alternative (nonconventional, over-the-counter) products was determined. The current NMA study confirms the efficacy of conventional monotherapies such as oral dutasteride, topical/oral minoxidil, and oral/topical finasteride for male AGA. We have provided guidance regarding the relative efficacy of some alternative (nonconventional, over-the-counter) agents (e.g., melatonin (topical) and rosemary oil (topical)) compared to conventional treatments.31:T866,ABSTRACTBackgroundSociety values a full head of hair. Therefore, androgenetic hair loss (AGA), though medically benign, can cause significant emotional distress. There is strong demand for alternative (nonconventional, over‐the‐counter) AGA treatments. It is important to have evidence on the efficacy of these treatments for AGA—especially in comparison with treatments that are approved by the United States Food and Drug Administration (FDA), such as oral finasteride and topical minoxidil.AimsFollowing a systematic review, we conducted a network meta‐analysis (NMA) to determine the relative efficacy of conventional monotherapies and selected alternative (nonconventional, over‐the‐counter) products for male AGA.MethodsWe conducted a Bayesian NMA under a fixed effect model with uniform priors; the NMA estimated relative effects—as per mean difference (MD), along with the 95% credible interval (CI)—and surface under the cumulative ranking curve (SUCRA) values. We also assessed study‐level evidence quality. Eligible studies were identified through systematic searches (without date restrictions) in PubMed and Scopus on April 30, 2025. The main outcome measure was change in total hair density at 24 weeks from baseline (in hairs/cm2).Results and ConclusionWe found 24 eligible trials—where the relative efficacy of eight conventional monotherapies and seven alternative (nonconventional, over‐the‐counter) products was determined. The current NMA study confirms the efficacy of conventional monotherapies such as oral dutasteride, topical/oral minoxidil, and oral/topical finasteride for male AGA. We have provided guidance regarding the relative efficacy of some alternative (nonconventional, over‐the‐counter) agents (e.g., melatonin (topical) and rosemary oil (topical)) compared to conventional treatments.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Topical Minoxidil: modality Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Topical Minoxidil (modality). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/modality/Topical%20Minoxidil\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Modalities\",\"item\":\"https://www.reachrx.ai/hub/tag/modality\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Topical Minoxidil\",\"item\":\"https://www.reachrx.ai/hub/tag/modality/Topical%20Minoxidil\"}]}}"}}]],["$","$L2f",null,{"title":"Topical Minoxidil: Research & Clinical Takeaways","description":"Review evidence by treatment modality: Topical Minoxidil — concise summaries and practical next steps.","papers":[{"doi":"10.1111/jocd.70483","pmid":"41051009","title":"Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2025-10-06T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70483","source_score":11,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-10-12","doi":"10.1111/jocd.70483","days":"14","issn":"1473-2130","rank":"7","field":"Clinical Medicine","score":"11","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70483","title":"Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over-the-Counter Products for Male Androgenetic Alopecia: A Network Meta-Analysis Study.","journal":"Journal of cosmetic dermatology","methods":"","results":"","abstract":"$30","keywords":[],"pubmed_id":"41051009","conclusions":"","publication_date":"2025-10-06T00:00:00"},"crossref":{"DOI":"10.1111/jocd.70483","URL":"https://doi.org/10.1111/jocd.70483","ISSN":["1473-2130","1473-2165"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"10","score":1,"title":["Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study"],"author":[{"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Mediprobe Research Inc. London Ontario Canada"},{"name":"Division of Dermatology, Department of Medicine University of Toronto School of Medicine Toronto Ontario Canada"}]},{"given":"Mary A.","family":"Bamimore","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc. London Ontario Canada"}]},{"given":"Mesbah","family":"Talukder","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University Dhaka Bangladesh"}]}],"issued":{"date-parts":[[2025,10]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":"24","archive":["Portico"],"created":{"date-time":"2025-10-06T23:33:55Z","timestamp":1759793635000,"date-parts":[[2025,10,6]]},"indexed":{"date-time":"2025-10-07T00:56:00Z","timestamp":1759798560404,"date-parts":[[2025,10,7]]},"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000,"date-parts":[[2025,10,6]]},"delay-in-days":5,"content-version":"vor"}],"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70483"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-07-29"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-09-26"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2025-10-06"}],"deposited":{"date-time":"2025-10-06T23:34:06Z","timestamp":1759793646000,"date-parts":[[2025,10,6]]},"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"published":{"date-parts":[[2025,10]]},"publisher":"Wiley","reference":[{"DOI":"10.1111/dth.12390","key":"e_1_2_11_2_1","year":"2016","issue":"6","author":"Rossi A.","volume":"29","first-page":"424","unstructured":null,"article-title":"Multi‐Therapies in Androgenetic Alopecia: Review and Clinical Experiences","journal-title":"Dermatologic Therapy","doi-asserted-by":"crossref"},{"DOI":"10.1111/bjd.12443","key":"e_1_2_11_3_1","year":"2013","issue":"4","author":"Heilmann S.","volume":"169","first-page":"927","unstructured":null,"article-title":"Evidence for a Polygenic Contribution to Androgenetic Alopecia","journal-title":"British Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1067/mjd.2001.117426","key":"e_1_2_11_4_1","year":"2001","issue":"3","author":"Olsen E. A.","volume":"45","first-page":"S70","unstructured":null,"article-title":"Female Pattern Hair Loss","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.2147/CCID.S271013","key":"e_1_2_11_5_1","year":"2020","issue":null,"author":"Majeed M.","volume":"13","first-page":"691","unstructured":null,"article-title":"Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers With Hair Fall","journal-title":"Clinical, Cosmetic and Investigational Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1046/j.1365-2133.1999.03030.x","key":"e_1_2_11_6_1","year":"1999","issue":"3","author":"Cash T. F.","volume":"141","first-page":"398","unstructured":null,"article-title":"The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature","journal-title":"British Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1080/13548506.2023.2242049","key":"e_1_2_11_7_1","year":"2024","issue":"4","author":"Frith H.","volume":"29","first-page":"822","unstructured":null,"article-title":"Psychosocial Impact of Androgenetic Alopecia on Men: A Systematic Review and Meta‐Analysis","journal-title":"Psychology, Health & Medicine","doi-asserted-by":"crossref"},{"DOI":"10.1080/13543784.2017.1353598","key":"e_1_2_11_8_1","year":"2017","issue":"8","author":"Guo H.","volume":"26","first-page":"917","unstructured":null,"article-title":"Experimental and Early Investigational Drugs for Androgenetic Alopecia","journal-title":"Expert Opinion on Investigational Drugs","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_9_1","year":"2022","issue":"3","author":"Ring C.","volume":"15","first-page":"26","unstructured":null,"article-title":"Nutraceuticals for Androgenetic Alopecia","journal-title":"Journal of Clinical and Aesthetic Dermatology","doi-asserted-by":null},{"DOI":"10.1016/j.jaad.2008.07.001","key":"e_1_2_11_10_1","year":"2008","issue":"4","author":"Rogers N. E.","volume":"59","first-page":"547","unstructured":null,"article-title":"Medical Treatments for Male and Female Pattern Hair Loss","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_11_1","year":"2022","issue":null,"author":"Anastassakis K.","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1111/dth.12647","key":"e_1_2_11_12_1","year":"2019","issue":"2","author":"Andy G.","volume":"32","first-page":null,"unstructured":null,"article-title":"Controversies in the Treatment of Androgenetic Alopecia: The History of Finasteride","journal-title":"Dermatologic Therapy","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.tibtech.2022.12.020","key":"e_1_2_11_13_1","year":"2023","issue":"6","author":"Castro A. R.","volume":"41","first-page":"731","unstructured":null,"article-title":"The Booming Business of Hair Loss","journal-title":"Trends in Biotechnology","doi-asserted-by":"crossref"},{"DOI":"10.2147/CCID.S470989","key":"e_1_2_11_14_1","year":"2024","issue":null,"author":"Bin Rubaian N. F.","volume":"17","first-page":"2495","unstructured":null,"article-title":"An Overview of Commonly Used Natural Alternatives for the Treatment of Androgenetic Alopecia, With Special Emphasis on Rosemary Oil","journal-title":"Clinical, Cosmetic and Investigational Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.37766/inplasy2025.6.0102","key":"e_1_2_11_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"A.GuptaandM.Bamimore “The Comparative Effectiveness of Prescription and Selected Alternative Therapies for Pattern Hair Loss: Protocol for a Multiple Treatment Comparison Meta‐Analysis ” (2025).","article-title":null,"journal-title":null,"doi-asserted-by":"crossref"},{"DOI":"10.7326/M14-2385","key":"e_1_2_11_16_1","year":"2015","issue":"11","author":"Hutton B.","volume":"162","first-page":"777","unstructured":null,"article-title":"The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta‐Analyses of Health Care Interventions: Checklist and Explanations","journal-title":"Annals of Internal Medicine","doi-asserted-by":"crossref"},{"DOI":"10.1186/s13643-024-02619-9","key":"e_1_2_11_17_1","year":"2024","issue":"1","author":"Forbes C.","volume":"13","first-page":"206","unstructured":null,"article-title":"Automation of Duplicate Record Detection for Systematic Reviews: Deduplicator","journal-title":"Systematic Reviews","doi-asserted-by":"crossref"},{"DOI":"10.1002/jrsm.1411","key":"e_1_2_11_18_1","year":"2021","issue":"1","author":"McGuinness L. A.","volume":"12","first-page":"55","unstructured":null,"article-title":"Risk‐Of‐Bias VISualization (Robvis): An R Package and Shiny Web App for Visualizing Risk‐Of‐Bias Assessments","journal-title":"Research Synthesis Methods","doi-asserted-by":"crossref"},{"DOI":"10.1002/jrsm.1167","key":"e_1_2_11_19_1","year":"2016","issue":"1","author":"Valkenhoef G.","volume":"7","first-page":"80","unstructured":null,"article-title":"Automated Generation of Node‐Splitting Models for Assessment of Inconsistency in Network Meta‐Analysis","journal-title":"Research Synthesis Methods","doi-asserted-by":"crossref"},{"DOI":"10.1002/jrsm.1428","key":"e_1_2_11_20_1","year":"2021","issue":"1","author":"Seo M.","volume":"12","first-page":"86","unstructured":null,"article-title":"The Kilim Plot: A Tool for Visualizing Network Meta‐Analysis Results for Multiple Outcomes","journal-title":"Research Synthesis Methods","doi-asserted-by":"crossref"},{"DOI":"10.4103/ijt.ijt_72_22","key":"e_1_2_11_21_1","year":"2023","issue":"2","author":"Bharadwaj A. V.","volume":"15","first-page":"56","unstructured":null,"article-title":"Comparative Efficacy of Topical Finasteride (0.25%) in Combination With Minoxidil (5%) Against 5% Minoxidil or 0.25% Finasteride Alone in Male Androgenetic Alopecia: A Pilot, Randomized Open‐Label Study","journal-title":"International Journal of Trichology","doi-asserted-by":"crossref"},{"DOI":"10.1111/jocd.15953","key":"e_1_2_11_22_1","year":"2024","issue":"2","author":"Rossi A.","volume":"23","first-page":"502","unstructured":null,"article-title":"Efficacy of the Association of Topical Minoxidil and Topical Finasteride Compared to Their Use in Monotherapy in Men With Androgenetic Alopecia: A Prospective, Randomized, Controlled, Assessor Blinded, 3‐Arm, Pilot Trial","journal-title":"Journal of Cosmetic Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/ics.12764","key":"e_1_2_11_23_1","year":"2022","issue":"2","author":"Hashimoto M.","volume":"44","first-page":"154","unstructured":null,"article-title":"Effects of Watercress Extract Fraction on R‐Spondin 1‐Mediated Growth of Human Hair","journal-title":"International Journal of Cosmetic Science","doi-asserted-by":"crossref"},{"DOI":"10.1111/jdv.17738","key":"e_1_2_11_24_1","year":"2022","issue":"2","author":"Piraccini B. M.","volume":"36","first-page":"286","unstructured":null,"article-title":"Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomised, Controlled Clinical Trial","journal-title":"Journal of the European Academy of Dermatology and Venereology","doi-asserted-by":"crossref"},{"DOI":"10.1007/s13555-020-00448-x","key":"e_1_2_11_25_1","year":"2020","issue":"6","author":"Panchaprateep R.","volume":"10","first-page":"1345","unstructured":null,"article-title":"Efficacy and Safety of Oral Minoxidil 5 Mg Once Daily in the Treatment of Male Patients With Androgenetic Alopecia: An Open‐Label and Global Photographic Assessment","journal-title":"Dermatology and Therapy (Heidelberg)","doi-asserted-by":"crossref"},{"DOI":"10.4103/ijdvl.IJDVL_589_18","key":"e_1_2_11_26_1","year":"2020","issue":"2","author":"Singh S. K.","volume":"86","first-page":"150","unstructured":null,"article-title":"Comparison of Efficacy of Platelet‐Rich Plasma Therapy With or Without Topical 5% Minoxidil in Male‐Type Baldness: A Randomized, Double‐Blind Placebo Control Trial","journal-title":"Indian Journal of Dermatology, Venereology and Leprology","doi-asserted-by":"crossref"},{"DOI":"10.4103/0378-6323.188652","key":"e_1_2_11_27_1","year":"2017","issue":"1","author":"Shanshanwal S. J.","volume":"83","first-page":"47","unstructured":null,"article-title":"Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open‐Label, Evaluator‐Blinded Study","journal-title":"Indian Journal of Dermatology, Venereology and Leprology","doi-asserted-by":"crossref"},{"DOI":"10.1111/jocd.12265","key":"e_1_2_11_28_1","year":"2016","issue":"4","author":"Ablon G.","volume":"15","first-page":"358","unstructured":null,"article-title":"A 6‐Month, Randomized, Double‐Blind, Placebo‐Controlled Study Evaluating the Ability of a Marine Complex Supplement to Promote Hair Growth in Men With Thinning Hair","journal-title":"Journal of Cosmetic Dermatology","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_29_1","year":"2015","issue":"1","author":"Panahi Y.","volume":"13","first-page":"15","unstructured":null,"article-title":"Rosemary Oil vs Minoxidil 2% for the Treatment of Androgenetic Alopecia: A Randomized Comparative Trial","journal-title":"Skinmed","doi-asserted-by":null},{"DOI":"10.1016/j.jaad.2013.10.049","key":"e_1_2_11_30_1","year":"2014","issue":"3","author":"Gubelin Harcha W.","volume":"70","first-page":"489","unstructured":null,"article-title":"A Randomized, Active‐ and Placebo‐Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects With Androgenetic Alopecia","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaad.2009.09.018","key":"e_1_2_11_31_1","year":"2010","issue":"2","author":"Eun H. C.","volume":"63","first-page":"252","unstructured":null,"article-title":"Efficacy, Safety, and Tolerability of Dutasteride 0.5 Mg Once Daily in Male Patients With Male Pattern Hair Loss: A Randomized, Double‐Blind, Placebo‐Controlled, Phase III Study","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.4103/0378-6323.45220","key":"e_1_2_11_32_1","year":"2009","issue":"1","author":"Hajheydari Z.","volume":"75","first-page":"47","unstructured":null,"article-title":"Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of the Androgenetic Alopecia","journal-title":"Indian Journal of Dermatology, Venereology and Leprology","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1473-2165.2005.00199.x","key":"e_1_2_11_33_1","year":"2005","issue":"4","author":"Takahashi T.","volume":"4","first-page":"245","unstructured":null,"article-title":"Investigation of the Topical Application of Procyanidin Oligomers From Apples to Identify Their Potential Use as a Hair‐Growing Agent","journal-title":"Journal of Cosmetic Dermatology","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_34_1","year":"1999","issue":"4","author":"Roberts J. L.","volume":"41","first-page":"555","unstructured":null,"article-title":"Clinical Dose Ranging Studies With Finasteride, a Type 2 5α‐Reductase Inhibitor, in Men With Male Pattern Hair Loss","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":null},{"DOI":"10.1016/S0190-9622(98)70007-6","key":"e_1_2_11_35_1","year":"1998","issue":"4","author":"Kaufman K. D.","volume":"39","first-page":"578","unstructured":null,"article-title":"Finasteride in the Treatment of Men With Androgenetic Alopecia. Finasteride Male Pattern Hair Loss Study Group","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1159/000017954","key":"e_1_2_11_36_1","year":"1998","issue":"4","author":"Pierard‐Franchimont C.","volume":"196","first-page":"474","unstructured":null,"article-title":"Ketoconazole Shampoo: Effect of Long‐Term Use in Androgenic Alopecia","journal-title":"Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1742-1241.1999.tb11660.x","key":"e_1_2_11_37_1","year":"1999","issue":"1","author":"Rushton D. H.","volume":"53","first-page":"50","unstructured":null,"article-title":"Androgenetic Alopecia in Men: The Scale of the Problem and Prospects for Treatment","journal-title":"International Journal of Clinical Practice","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1365-4362.1988.tb00006.x","key":"e_1_2_11_38_1","year":"1988","issue":null,"author":"Anderson C.","volume":"27","first-page":"447","unstructured":null,"article-title":"Topical Minoxidil in Androgenetic Alopecia Scandinavian and Middle East Experience","journal-title":"International Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1365-4362.1988.tb00004.x","key":"e_1_2_11_39_1","year":"1988","issue":null,"author":"Dutrée‐Meulenberg R.","volume":"27","first-page":"435","unstructured":null,"article-title":"Treatment of Male Pattern Alopecia Using Topical Minoxidil in The Netherlands","journal-title":"International Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1365-4362.1988.tb00003.x","key":"e_1_2_11_40_1","year":"1988","issue":null,"author":"Petzoldt D.","volume":"27","first-page":"430","unstructured":null,"article-title":"The German Double‐Blind Placebo‐Controlled Evaluation of Topical Minoxidil Solution in the Treatment of Early Male Pattern Baldness","journal-title":"International Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1159/000248902","key":"e_1_2_11_41_1","year":"1987","issue":"2","author":"Civatte J.","volume":"175","first-page":"42","unstructured":null,"article-title":"2% Topical Minoxidil Solution in Male‐Pattern Baldness: Preliminary European Results","journal-title":"Dermatologica","doi-asserted-by":"crossref"},{"DOI":"10.1016/S0190-9622(86)70138-2","key":"e_1_2_11_42_1","year":"1986","issue":"1","author":"Olsen E. A.","volume":"15","first-page":"30","unstructured":null,"article-title":"Dose‐Response Study of Topical Minoxidil in Male Pattern Baldness","journal-title":"Journal of the American Academy of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/ajd.12352","key":"e_1_2_11_43_1","year":"2016","issue":"3","author":"Wessagowit V.","volume":"57","first-page":"e76","unstructured":null,"article-title":"Treatment of Male Androgenetic Alopecia With Topical Products Containing S Erenoa Repens Extract","journal-title":"Australasian Journal of Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.4103/0974-7753.111199","key":"e_1_2_11_44_1","year":"2012","issue":"4","author":"Fischer T. W.","volume":"4","first-page":"236","unstructured":null,"article-title":"Topical Melatonin for Treatment of Androgenetic Alopecia","journal-title":"International Journal of Trichology","doi-asserted-by":"crossref"},{"DOI":"10.18549/PharmPract.2017.01.943","key":"e_1_2_11_45_1","year":"2017","issue":"1","author":"Tonin F. S.","volume":"15","first-page":"943","unstructured":null,"article-title":"Network Meta‐Analysis: A Technique to Gather Evidence From Direct and Indirect Comparisons","journal-title":"Pharmacy Practice (Granada)","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_46_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"FDA “FDA Alerts Health Care Providers Compounders and Consumers of Potential Risks Associated With Compounded Topical Finasteride Products ” (2025) https://www.drugs.com/fda/fda‐alerts‐health‐care‐providers‐compounders‐consumers‐potential‐risks‐associated‐compounded‐14740.html.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.25259/jcas_44_23","key":"e_1_2_11_47_1","year":"2024","issue":"3","author":"Nirmal B.","volume":"17","first-page":"189","unstructured":null,"article-title":"Efficacy and Safety of Microneedling Radiofrequency in Patterned Hair Loss","journal-title":"Journal of Cutaneous and Aesthetic Surgery","doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_2_11_48_1","year":"2016","issue":null,"author":"Koyama T.","volume":"16","first-page":null,"unstructured":null,"article-title":"Standardized Scalp Massage Results in Increased Hair Thickness by Inducing Stretching Forces to Dermal Papilla Cells in the Subcutaneous Tissue","journal-title":"Eplasty","doi-asserted-by":null},{"DOI":null,"key":"e_1_2_11_49_1","year":"2021","issue":"11","author":"Lueangarun S.","volume":"14","first-page":"E64","unstructured":null,"article-title":"A Systematic Review and Meta‐Analysis of Randomized Controlled Trials of United States Food and Drug Administration‐Approved, Home‐Use, Low‐Level Light/Laser Therapy Devices for Pattern Hair Loss: Device Design and Technology","journal-title":"Journal of Clinical and Aesthetic Dermatology","doi-asserted-by":null},{"DOI":"10.1111/dth.15323","key":"e_1_2_11_50_1","year":"2022","issue":"4","author":"Gupta A. K.","volume":"35","first-page":null,"unstructured":null,"article-title":"Natural Products for Male Androgenetic Alopecia","journal-title":"Dermatologic Therapy","doi-asserted-by":"crossref"},{"DOI":"10.1016/S0944-7113(00)80040-9","key":"e_1_2_11_51_1","year":"2000","issue":"6","author":"Kamimura A.","volume":"7","first-page":"529","unstructured":null,"article-title":"Investigation of Topical Application of Procyanidin B‐2 From Apple to Identify Its Potential Use as a Hair Growing Agent","journal-title":"Phytomedicine","doi-asserted-by":"crossref"},{"DOI":"10.1111/jocd.14299","key":"e_1_2_11_52_1","year":"2022","issue":"1","author":"Dhurat R.","volume":"21","first-page":"343","unstructured":null,"article-title":"SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth","journal-title":"Journal of Cosmetic Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1111/jdv.16765","key":"e_1_2_11_53_1","year":"2021","issue":"1","author":"Ramos P. M.","volume":"35","first-page":"e24","unstructured":null,"article-title":"Minoxidil Sulfotransferase Enzyme (SULT1A1) Genetic Variants Predicts Response to Oral Minoxidil Treatment for Female Pattern Hair Loss","journal-title":"Journal of the European Academy of Dermatology and Venereology","doi-asserted-by":"crossref"},{"DOI":"10.5114/ada.2020.99947","key":"e_1_2_11_54_1","year":"2022","issue":"3","author":"Pietrauszka K.","volume":"39","first-page":"472","unstructured":null,"article-title":"Sulfotransferase SULT1A1 Activity in Hair Follicle, a Prognostic Marker of Response to the Minoxidil Treatment in Patients With Androgenetic Alopecia: A Review","journal-title":"Postepy Dermatologii I Alergologii","doi-asserted-by":"crossref"},{"DOI":"10.1001/jamadermatol.2021.5743","key":"e_1_2_11_55_1","year":"2022","issue":"3","author":"Gupta A. K.","volume":"158","first-page":"266","unstructured":null,"article-title":"Relative Efficacy of Minoxidil and the 5‐Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients: A Network Meta‐Analysis","journal-title":"JAMA Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1159/000538621","key":"e_1_2_11_56_1","year":"2024","issue":"4","author":"Starace M. V. R.","volume":"10","first-page":"293","unstructured":null,"article-title":"The Comparative Effects of Monotherapy With Topical Minoxidil, Oral Finasteride, and Topical Finasteride in Postmenopausal Women With Pattern Hair Loss: A Retrospective Cohort Study","journal-title":"Skin Appendage Disorders","doi-asserted-by":"crossref"},{"DOI":"10.1111/jocd.13976","key":"e_1_2_11_57_1","year":"2021","issue":"9","author":"Ibrahim I. M.","volume":"20","first-page":"2867","unstructured":null,"article-title":"Pumpkin Seed Oil vs. Minoxidil 5% Topical Foam for the Treatment of Female Pattern Hair Loss: A Randomized Comparative Trial","journal-title":"Journal of Cosmetic Dermatology","doi-asserted-by":"crossref"},{"DOI":"10.1248/bpb.b15-00387","key":"e_1_2_11_58_1","year":"2015","issue":"12","author":"Choi J. S.","volume":"38","first-page":"1856","unstructured":null,"article-title":"Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16‐Week Double‐Blind Randomized Controlled Trial","journal-title":"Biological & Pharmaceutical Bulletin","doi-asserted-by":"crossref"},{"DOI":"10.1007/978-3-031-74314-6","key":"e_1_2_11_59_1","year":"2024","issue":null,"author":"Panagotacos P. J.","volume":null,"first-page":"1","unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"crossref"}],"short-title":[],"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1111/jocd.70483"],"article-number":"e70483","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Journal of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,10]]},"reference-count":58,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2025,10,6]]},"references-count":58,"short-container-title":["J of Cosmetic Dermatology"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1111/jocd.70483","is_oa":true,"title":"Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study","updated":"2025-10-11T00:07:04+00:00","published_date":"2025-10-01","best_oa_location":{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.70483","pmh_id":null,"url_for_pdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.70483","url_for_landing_page":"https://doi.org/10.1111/jocd.70483"}}},"created_at":"2025-10-13T07:32:37.233Z","updated_at":"2025-10-19T07:07:31.491Z","tags":[{"paper_doi":"10.1111/jocd.70483","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"condition","value":"Androgenetic Alopecia","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"dutasteride","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"finasteride","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"ketoconazole","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"melatonin","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"minoxidil","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"procyanidin","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"rosemary oil","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"saw palmetto","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"generic","value":"watercress extract","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"modality","value":"5-Alpha Reductase Inhibitor","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"modality","value":"Botanical","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"modality","value":"Nutraceutical","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"modality","value":"Topical Minoxidil","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"sex","value":"male","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"study_design","value":"Network Meta-Analysis","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"warning","value":"A fixed‑effect model was used; between‑study heterogeneity was not modeled.","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"warning","value":"Some node‑splitting comparisons showed p<0.05 (inconsistency) despite the statement that most comparisons were consistent.","value_numeric":null},{"paper_doi":"10.1111/jocd.70483","tag_type":"warning","value":"The manuscript alternately cites 24 vs 25 included trials, creating uncertainty about the exact study count.","value_numeric":null}],"summaries":{"what_studied":"A Bayesian fixed‑effect network meta‑analysis compared eight conventional monotherapies with seven over‑the‑counter alternatives for male androgenetic alopecia, using 24‑week change in total hair density (hairs/cm²) as the outcome after searches of PubMed and Scopus on April 30, 2025.","key_result":"Dutasteride 0.5 mg (oral) ranked highest (SUCRA 95.8% base; 94% severity‑adjusted). Versus control, network estimates showed mean hair density gains at 24 weeks for minoxidil 5% topical: +20.0 hairs/cm² (95% CrI 3.7 to 41.0), dutasteride 0.5 mg oral: +19.0 (9.5 to 28.0), finasteride 0.25% topical: +15.0 (0.85 to 30.0), and finasteride 1 mg oral: +12.0 (4.20 to 19.0); OTC agents ranked mid to low (e.g., rosemary topical SUCRA 53.6%; melatonin topical 55.4%; saw palmetto topical 14.1%).","limitations":"Efficacy was assessed only at 24 weeks; baseline disease duration was not accounted for. Many alternative‑agent trials enrolled relatively small numbers, and several studies showed risk‑of‑bias concerns. Network geometry limited some node‑splitting inconsistency assessments.","practice_takeaway":"At 6 months, dutasteride 0.5 mg daily ranks highest for increasing hair density, with finasteride (oral/topical) and topical minoxidil also outperforming control by clinically meaningful margins. OTC options like topical rosemary and melatonin show modest relative efficacy, while saw palmetto ranks low—use these data to set expectations when discussing nonprescription alternatives."}}],"initialOffset":1,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"modality","value":"Topical Minoxidil"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Modalities","href":"/hub/tag/modality"},{"name":"Topical Minoxidil"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"modality","hub_tag_value":"Topical Minoxidil"}}}]]

Papers