2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T4ea,Right ventricular failure drives both morbidity and mortality in pulmonary arterial hypertension (PAH), but the mechanism of transition from compensated right ventricle (cRV) to decompensated RV (dRV) is unknown, and some PAH patients develop dRV faster than others. We explored the role of RV cardiac myofibroblasts (cMFBs) on this transition utilizing 2 rat models: monocrotaline (MCT) versus the less inflammatory pulmonary artery banding (PAB); and 3 patient cohorts (n=81) of PAH versus group 2 pulmonary hypertension (PHT-2). We hypothesized that loss of UCP2 (uncoupling protein 2), critical for mitochondrial calcium (mCa We separated rat cRV from dRV based on catheterization and echocardiographic criteria and found a significant increase in cMFBs from MCT but not PAB RV (which decompensated much later than MCT RV). In isolated hearts, MCT RV contractility was lower in dRV but not in isolated cardiomyocytes (CMs), pointing to a non-CM cause. Mitochondrial respiration was lower in MCT dRV cMFBs than in control and cRV cFBs but increased in MCT-RV CMs. mCa Our data suggest that a change of cell identity (cFBs to cMFBs) in the RV is a driver of RV decompensation. TNF-α or rs659366 is a potential biomarker for early RV decompensation in PAH.31:Tb3b, BACKGROUND: Right ventricular failure drives both morbidity and mortality in pulmonary arterial hypertension (PAH), but the mechanism of transition from compensated right ventricle (cRV) to decompensated RV (dRV) is unknown, and some PAH patients develop dRV faster than others. METHODS: We explored the role of RV cardiac myofibroblasts (cMFBs) on this transition utilizing 2 rat models: monocrotaline (MCT) versus the less inflammatory pulmonary artery banding (PAB); and 3 patient cohorts (n=81) of PAH versus group 2 pulmonary hypertension (PHT-2). We hypothesized that loss of UCP2 (uncoupling protein 2), critical for mitochondrial calcium (mCa ++ ) regulation and cardiac fibroblasts (cFBs) differentiation to cMFBs, is associated with dRV; and that a loss-of-function UCP2 single nucleotide polymorphism (SNP; rs659366) may predict dRV in human PAH. RESULTS: We separated rat cRV from dRV based on catheterization and echocardiographic criteria and found a significant increase in cMFBs from MCT but not PAB RV (which decompensated much later than MCT RV). In isolated hearts, MCT RV contractility was lower in dRV but not in isolated cardiomyocytes (CMs), pointing to a non-CM cause. Mitochondrial respiration was lower in MCT dRV cMFBs than in control and cRV cFBs but increased in MCT–RV CMs. mCa ++ was progressively decreased from normal to MCT–cRV to dRV cMFBs, and the same was true for c(M)FBs (but not CMs) UCP2. Tumor necrosis factor alpha (TNF-α) decreased UCP2 mRNA/protein levels in RV cFBs but not RV CMs. In human PAH, but not PHT-2, dRVs had more cMFBs and less UCP2 than control and cRVs. Decreased UCP2 levels and rs659366 were associated with worse RV performance (tricuspid annular plane systolic excursion and cardiac index), even among patients with similar mean pulmonary arterial pressure. CONCLUSIONS: Our data suggest that a change of cell identity (cFBs to cMFBs) in the RV is a driver of RV decompensation. TNF-α or rs659366 is a potential biomarker for early RV decompensation in PAH. 32:T87a,The German national psoriasis registry PsoBest collects long-term data on the effectiveness, safety, and tolerability of systemic treatments for psoriatic disease. Here, we describe patient characteristics and the safety and effectiveness of apremilast for the treatment of psoriatic disease in Germany based on data from PsoBest. This was a descriptive analysis of observational data collected from PsoBest using cross-sectional (baseline characteristics) and longitudinal (outcomes, safety) designs. PsoBest recruits patients with moderate to severe plaque psoriasis or psoriatic arthritis who initiate a new systemic psoriasis treatment. Adverse events (AEs) and sociodemographic descriptors were reported for patients exposed to apremilast during the study period (safety cohort). Clinical and patient-reported outcomes were collected 3, 6, and 12 months after the initiation of apremilast monotherapy (outcomes cohort). From January 15, 2015 to June 30, 2020, 595 registry patients were exposed to apremilast; 417 were treated with apremilast monotherapy. Patients taking apremilast had a higher mean age and higher proportions of comorbidities such as cardiovascular or metabolic disease compared with those taking other nonbiologic systemic or biologic drugs. The most common nonserious AEs were drug ineffectiveness (14.1%), diarrhea (9.4%), nausea (7.1%), and headache (6.1%). The highest incidence rates of nonserious and serious AEs of special interest were for infections and infestations per system organ class (8.03/100 patient-years) and malignant or unspecified tumors (2.50/100 patient-years), respectively. Improvements in Dermatology Life Quality Index, patient-defined treatment benefits (Patient Benefit Index), body surface area, and Psoriasis Area and Severity Index were observed after 3, 6, and 12 months of apremilast treatment. Patients in routine care treated with apremilast in the German PsoBest registry experienced treatment benefits and improved skin, psoriasis severity, and quality of life. Safety was consistent with the established safety profile. Apremilast is safe and effective for treating moderate to severe psoriatic disease.33:T4eb,Matthias Augustin: Consultant for, paid speaker for, and/or recipient of institutional research grants from AbbVie, Almirall, Amgen, Bayer Healthcare, Beiersdorf, Biogen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Celltrion, Centocor, Lilly, Fresenius, Galderma, GlaxoSmithKline, Hexal, Janssen, Klinge, LEO Pharma, MC2, Medac, Merck, MSD, Novartis, Pfizer, Sandoz, Sun Pharma, UCB, and Viatris. Stephan J. Rustenbach: No conflicts of interest to declare. Ralph von Kiedrowski: Consultant and/or paid speaker for AbbVie, Almirall, Amgen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Celltrion HC, Fresenius Kabi, Galderma, Hexal, Lilly, Janssen, LEO Pharma, MoonLake, Novartis, Pfizer, Sanofi-Aventis, and UCB. Hamid Amouzadeh: Employment and stock ownership in Amgen. Kathy Tran: Employment and stock ownership in Amgen. Myriam Cordey: Employment and stock ownership in Amgen. Ulrich Mrowietz: Advisor for, received speakers’ honoraria and grants from, and participated in clinical trials for AbbVie, Aditxt, Almirall, Amgen, Aristea, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Dr. Reddy’s, Lilly, Foamix, Formycon, Immunic, Janssen, LEO Pharma, Medac, MetrioPharm, Novartis, Phi-Stone, Pierre Fabre, Sanofi-Aventis, and UCB.34:T67c,Hepatic lipid and glucose metabolism have been shown to be under tight circadian control in pre-clinical models. However, it remains unknown whether diurnal patterns exist in functional processes governing intrahepatic lipid accumulation in humans. We performed metabolic phenotyping, including state-of-the-art stable isotope techniques, during day and night in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and overweight controls (NCT05962099). The primary outcome was diurnal change in hepatic de novo lipogenesis (DNL), alongside a number of secondary outcomes, including changes in hepatic glucose production, glucose disposal, plasma non-esterified fatty acids (NEFAs), and whole-body glucose and lipid oxidation. We show that nighttime metabolic dysfunction is a hallmark of MASLD with multiple pathogenic pathways upregulated at night, including hepatic and peripheral insulin resistance, DNL, and systemic NEFA exposure. Insulin resistance is compounded by lower plasma insulin levels at night, secondary to reduced insulin secretion and elevated insulin clearance. Diurnal differences persist when performing identical investigations after weight loss with liver fat reductions, suggesting that nighttime metabolic dysfunction may be a primary driver of steatosis. These findings will help establish the optimal window for energy intake, exercise, and medication delivery in patients with MASLD. Integrated proteomics of plasma, adipose, and skeletal muscle tissue across day and night also identified a number of specific molecular targets that may offer therapeutic potential in the treatment of metabolic disease.35:T891,Lower risk guidelines for safer levels of cannabis use could help to reduce the health burden posed by cannabis use disorder (CUD). We aimed to estimate risk thresholds for CUD based on delta-9-tetrahydrocannabinol (THC) consumption using standard THC units (1 unit = 5 mg THC). Data from the CannTeen study, a longitudinal observational study consisting of five assessments over a 12-month period. London, UK. Participants were n = 65 adults aged 26-29 (46% female, 70.77% white ethnicity) and n = 85 adolescents aged 16-17 (56% female, 65.48% white ethnicity). All participants reported at least one use of cannabis during the 12-month study period. Mean weekly standard THC units were estimated using the Enhanced Cannabis Timeline Followback, a comprehensive and validated assessment of quantity, frequency and potency of cannabis consumed. This was administered at 3-month intervals and averaged over a 12-month period. Past 12-month diagnosis of CUD using The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) was assessed at the final follow-up. Receiver operating characteristic curve models estimated the extent to which weekly standard THC unit consumption could discriminate no CUD from any CUD (mild, moderate or severe), and no CUD from moderate/severe CUD, in adults and adolescents separately. Risk thresholds were selected based on cut-offs that maximised sensitivity and specificity. Discrimination accuracy of weekly standard THC units on CUD was good, with area under the curve > 0.70 for all models. Optimal cut-offs for risk of any CUD (versus no CUD) were 8.26 units per week for adults and 6.04 units per week for adolescents. For risk of moderate/severe CUD (versus no CUD) optimal cut-offs were 13.44 units per week for adults and 6.45 units per week for adolescents. Weekly cannabis consumption based on standard delta-9-tetrahydrocannabinol (THC) units appears to show good discrimination accuracy of cannabis use disorder at different severities and in different age groups. Safer levels of cannabis use, defined by low weekly standard THC unit consumption, could be recommended in lower risk cannabis use guidelines.36:Te33,Abstract Background and aims Lower risk guidelines for safer levels of cannabis use could help to reduce the health burden posed by cannabis use disorder (CUD). We aimed to estimate risk thresholds for CUD based on delta‐9‐tetrahydrocannabinol (THC) consumption using standard THC units (1 unit = 5 mg THC). Design Data from the CannTeen study, a longitudinal observational study consisting of five assessments over a 12‐month period. Setting London, UK. Participants Participants were n = 65 adults aged 26–29 (46% female, 70.77% white ethnicity) and n = 85 adolescents aged 16–17 (56% female, 65.48% white ethnicity). All participants reported at least one use of cannabis during the 12‐month study period. Measurements Mean weekly standard THC units were estimated using the Enhanced Cannabis Timeline Followback, a comprehensive and validated assessment of quantity, frequency and potency of cannabis consumed. This was administered at 3‐month intervals and averaged over a 12‐month period. Past 12‐month diagnosis of CUD using The Diagnostic and Statistical Manual of Mental Disorders , Fifth Edition (DSM‐5) was assessed at the final follow‐up. Receiver operating characteristic curve models estimated the extent to which weekly standard THC unit consumption could discriminate no CUD from any CUD (mild, moderate or severe), and no CUD from moderate/severe CUD, in adults and adolescents separately. Risk thresholds were selected based on cut‐offs that maximised sensitivity and specificity. Findings Discrimination accuracy of weekly standard THC units on CUD was good, with area under the curve > 0.70 for all models. Optimal cut‐offs for risk of any CUD (versus no CUD) were 8.26 units per week for adults and 6.04 units per week for adolescents. For risk of moderate/severe CUD (versus no CUD) optimal cut‐offs were 13.44 units per week for adults and 6.45 units per week for adolescents. Conclusions Weekly cannabis consumption based on standard delta‐9‐tetrahydrocannabinol (THC) units appears to show good discrimination accuracy of cannabis use disorder at different severities and in different age groups. Safer levels of cannabis use, defined by low weekly standard THC unit consumption, could be recommended in lower risk cannabis use guidelines. 37:T882,Topiramate has been linked to increased glaucoma risk, potentially through mechanisms involving ocular fluid shifts. However, comparative risks vs other antiseizure medications (ASMs) and variation by sex or indication remain uncertain. This study evaluates glaucoma incidence in topiramate initiators compared to valproate or lamotrigine users among patients with epilepsy or migraine. We conducted a retrospective active-comparator, new-user cohort study using electronic health records from the IQVIA Medical Research Data among patients with epilepsy or migraine initiating topiramate, valproate, or lamotrigine. Patients with prior ASM use, limited washout period and follow-up, or pre-existing glaucoma were excluded. The outcome was incident glaucoma within 1 year, censored at glaucoma occurrence, death, discontinuation, switch, or September 30, 2023. Covariates included age, sex, race, lifestyle factors, comorbidities, and medication history. Propensity score-based inverse probability weighting balanced characteristics, and crude and weighted Cox models estimated hazard ratios (HRs) with 95% confidence intervals (CIs). Subgroup analyses were conducted by sex, age, and indication. The cohort included 688 topiramate, 4490 valproate, and 4179 lamotrigine initiators. After weighting, the 1-year absolute risk increase was approximately 2.4% when comparing topiramate to valproate, and about 2.0% compared to lamotrigine. Topiramate was associated with higher glaucoma risk vs valproate (adjusted HR 2.66, 95% CI 1.12-6.32) and lamotrigine (adjusted HR 3.57, 95% CI 1.76-7.26). Risks were elevated in female (vs valproate: HR 5.31, 95% CI 1.48-19.08; vs lamotrigine: HR 5.73, 95% CI 2.38-13.79) or epilepsy patients (vs valproate: HR 2.23, 95% CI 1.04-4.76; vs lamotrigine: HR 5.08, 95% CI 2.32-11.14), but not in male or migraine patients. Topiramate use substantially increases glaucoma risk compared with valproate and lamotrigine, particularly among female or epilepsy patients. No significant association in male or migraine patients was observed. These findings may inform targeted ophthalmologic monitoring in high-risk groups and use of alternative ASMs.38:Tb19,Abstract Objective Topiramate has been linked to increased glaucoma risk, potentially through mechanisms involving ocular fluid shifts. However, comparative risks vs other antiseizure medications (ASMs) and variation by sex or indication remain uncertain. This study evaluates glaucoma incidence in topiramate initiators compared to valproate or lamotrigine users among patients with epilepsy or migraine. Methods We conducted a retrospective active‐comparator, new‐user cohort study using electronic health records from the IQVIA Medical Research Data among patients with epilepsy or migraine initiating topiramate, valproate, or lamotrigine. Patients with prior ASM use, limited washout period and follow‐up, or pre‐existing glaucoma were excluded. The outcome was incident glaucoma within 1 year, censored at glaucoma occurrence, death, discontinuation, switch, or September 30, 2023. Covariates included age, sex, race, lifestyle factors, comorbidities, and medication history. Propensity score–based inverse probability weighting balanced characteristics, and crude and weighted Cox models estimated hazard ratios (HRs) with 95% confidence intervals (CIs). Subgroup analyses were conducted by sex, age, and indication. Results The cohort included 688 topiramate, 4490 valproate, and 4179 lamotrigine initiators. After weighting, the 1‐year absolute risk increase was approximately 2.4% when comparing topiramate to valproate, and about 2.0% compared to lamotrigine. Topiramate was associated with higher glaucoma risk vs valproate (adjusted HR 2.66, 95% CI 1.12–6.32) and lamotrigine (adjusted HR 3.57, 95% CI 1.76–7.26). Risks were elevated in female (vs valproate: HR 5.31, 95% CI 1.48–19.08; vs lamotrigine: HR 5.73, 95% CI 2.38–13.79) or epilepsy patients (vs valproate: HR 2.23, 95% CI 1.04–4.76; vs lamotrigine: HR 5.08, 95% CI 2.32–11.14), but not in male or migraine patients. Significance Topiramate use substantially increases glaucoma risk compared with valproate and lamotrigine, particularly among female or epilepsy patients. No significant association in male or migraine patients was observed. These findings may inform targeted ophthalmologic monitoring in high‐risk groups and use of alternative ASMs. 39:T7a8,This study aimed to evaluate the impact of rehabilitation on readmission rates among older patients requiring nursing care following with COPD following hospitalization for lower respiratory tract infection, focusing on whether initiating rehabilitation within two months post-discharge reduces readmissions. We conducted a retrospective observational study using insurance claim data in Kobe City, Japan, with a population of approximately 1.5 million. We included Patients with COPD aged 65 or older with certified care-need levels under Long-term Care Insurance system in Japan, hospitalized for lower respiratory tract infections and survived alive. Patients were classified based on their functional capacity in Activities of Daily Living (ADL). We used the extended Cox model to consider rehabilitation as time-varying exposure and assess the hazard ratios for readmission, adjusting for ADL. The ADL level was adjusted as a confounder. The survival probabilities were estimated among patients who experienced rehabilitation within two months and those who did not experience rehabilitation. Among 745 patients, 479 received rehabilitation within two months post-discharge, 105 received it later, and 161 did not receive rehabilitation. Participation in rehabilitation was associated with an increased hazard ratio for readmission (HR: 1.63, 95% CI: 1.19, 2.24), compared to those without it. The estimated survival curve of patients receiving rehabilitation within two months overlapped with that of those who did not receive rehabilitation. Rehabilitation following exacerbation in older patients with COPD who have disability may increase the risk of readmission after discharge. Healthcare providers should consider that patients with COPD with severe disability and complex needs may require staged, individualized rehabilitation. A video abstract presenting the overview and key findings of this study is available at: https://youtu.be/vSNuT1Hjcqw.3a:T5b2,Not all victims of Out-of-Hospital Cardiac Arrest (OHCA) wish to be resuscitated. Some potential victims of OHCA opt to sign a donotattemptresuscitation (DNAR) order, which mandates that no resuscitation should be attempted upon cardiac arrest. Despite a DNAR order being issued, OHCA patients receive treatment against their wish. The aim of this study was to conduct a epidemiological analysis of DNAR orders in OHCA cases. This nationwide, register-based cohort study included all OHCA patients aged 18 years or older in Denmark from January 1, 2016, to December 31, 2023. From 2016 to 2023, a significant rising trend in the number of OHCAs where a DNAR has been in place was observed. In 2016, the percentage of OHCA with DNAR orderwas 1% (), while in 2023, 3% of OHCA occurred in patients with an existing DNAR. This may influence the survival rates following OHCA. Excluding OHCA with DNAR order, overall survival rates would have been higher, with an additional 0.1% in 2016 and an additional 0.5% in 2023. Between 2016 and 2023, in Denmark, there has been a significant increasing trend in the number of OHCAs treated despite DNAR orders. DNAR orders were most frequently observed among older patients, and the prevalence increased progressively with age. National OHCA survival rates are somewhat underestimated, as the inclusion of patients with DNAR orders lowers the reported figures; excluding these cases would yield higher survival estimates.3b:T728,Acute cholecystitis is a common condition requiring prompt diagnosis and management in emergency settings. Traditional diagnostic pathways often involve patient transfer for imaging, potentially increasing anxiety and discomfort. This study aimed to evaluate the impact of bedside ultrasound compared with standard ultrasound on anxiety and pain levels in patients with suspected acute cholecystitis in the emergency department. A comparative observational study was conducted enrolling 100 adult patients with suspected acute cholecystitis. Patients were assigned to either bedside ultrasound at point-of-care (bedside ultrasound group, n = 50) or standard ultrasound requiring transport to the radiology department (standard care group, n = 50). Anxiety was assessed using the state-trait anxiety inventory state anxiety subscale, and pain was measured using a visual analog scale. Assessments were performed before and after ultrasound examination. Baseline characteristics were comparable between groups. After the intervention, the bedside ultrasound group demonstrated significantly lower anxiety levels (mean state-trait anxiety inventory state anxiety subscale, 42.21 vs 48.74; P = .0087) and reduced pain scores (median visual analog scale, 5.00 vs 6.50; P = .0003) compared with the standard care group. The proportion of patients with high anxiety decreased substantially in the bedside ultrasound group (from 60% to 24%), whereas it remained relatively unchanged in the standard care group. Bedside ultrasound in emergency settings significantly reduces anxiety and pain in patients with suspected acute cholecystitis compared with standard ultrasound protocols. Implementation of point-of-care ultrasound may improve patient experience and potentially enhance clinical outcomes in the management of acute cholecystitis.3c:T89d,Severely brain-injured patients may enter a spectrum of conditions collectively known as disorders of consciousness. This spectrum includes clinical conditions such as unresponsive wakefulness syndrome or minimally conscious state, where the behavioural assessment of consciousness can often be deceptive. To bridge this dissociation, neuroimaging techniques are employed to identify the residual brain functions. Each neuroimaging modality imperfectly captures distinct aspects of brain preservation-functional, anatomical, or both. In this study, we adopt a comprehensive approach by integrating the neurophysiology and neuroimaging modalities available from the standard and advanced clinical assessments through interpretable machine learning. The electrophysiological modalities included high-density EEG (resting state and task), whereas neuroimaging modalities included anatomical and resting-state functional MRI, diffusion MRI and 18F-fluorodeoxyglucose PET. Our investigation reveals that specific modalities, such as functional assessments, provide comprehensive insights into the currently evaluated state of consciousness, the diagnosis of the patients. Conversely, structural modalities offer valuable information about the patient's evolution within the consciousness spectrum. We validate the proposed analysis with data coming from other centres with different acquisition parameters. Importantly, we demonstrate that model performance improves with an increase in the number of modalities. We observe a higher inter-modality disagreement for minimally conscious state patients and those patients who improve. Lastly, we observe a difference in feature importances between diagnosis and prognosis, with an interaction between modality and anatomical structures: some subcortical markers tend to contribute more to prognosis, while other cortical markers are more informative for diagnosis. This integrative multimodal and machine learning methodology presents a promising avenue for a more nuanced understanding of disorders of consciousness, contributing to enhanced diagnostic precision, prognostic capabilities and the personalization of rehabilitative strategies in clinical practice.3d:T94d,Abstract Severely brain-injured patients may enter a spectrum of conditions collectively known as disorders of consciousness. This spectrum includes clinical conditions such as unresponsive wakefulness syndrome or minimally conscious state, where the behavioural assessment of consciousness can often be deceptive. To bridge this dissociation, neuroimaging techniques are employed to identify the residual brain functions. Each neuroimaging modality imperfectly captures distinct aspects of brain preservation—functional, anatomical, or both. In this study, we adopt a comprehensive approach by integrating the neurophysiology and neuroimaging modalities available from the standard and advanced clinical assessments through interpretable machine learning. The electrophysiological modalities included high-density EEG (resting state and task), whereas neuroimaging modalities included anatomical and resting-state functional MRI, diffusion MRI and 18F-fluorodeoxyglucose PET. Our investigation reveals that specific modalities, such as functional assessments, provide comprehensive insights into the currently evaluated state of consciousness, the diagnosis of the patients. Conversely, structural modalities offer valuable information about the patient's evolution within the consciousness spectrum. We validate the proposed analysis with data coming from other centres with different acquisition parameters. Importantly, we demonstrate that model performance improves with an increase in the number of modalities. We observe a higher inter-modality disagreement for minimally conscious state patients and those patients who improve. Lastly, we observe a difference in feature importances between diagnosis and prognosis, with an interaction between modality and anatomical structures: some subcortical markers tend to contribute more to prognosis, while other cortical markers are more informative for diagnosis. This integrative multimodal and machine learning methodology presents a promising avenue for a more nuanced understanding of disorders of consciousness, contributing to enhanced diagnostic precision, prognostic capabilities and the personalization of rehabilitative strategies in clinical practice.3e:T59b,Muscular function is essential for healthy aging. This study examined the relationship between baseline muscle condition and changes in cognitive performance over 2 years. We conducted an observational analysis of longitudinal data from the control arm of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomized controlled trial (n = 583). Baseline physical performance was assessed using gait speed, grip strength, and Short Physical Performance Battery (SPPB). Logistic regression models analyzed associations between baseline physical performance and changes in standardized cognitive scores after 2 years. Mean age was 68.6 years. Higher baseline chair stand performance, SPPB scores, and grip strength were significantly associated with more favorable 2-year trajectories in global cognition, memory, and executive function (p < 0.05), particularly for memory. Gait speed showed no significant associations. Better initial physical condition is linked to more favorable cognitive evolution, independent of other factors. This highlights the connection between physical and cognitive health, supporting comprehensive preventive strategies for older adults. Stronger muscles are linked to slower cognitive decline before it begins. Better performance of muscular function protects against cognitive impairment in aging. Intervening muscle health impacts brain health in aging.3f:Tb88,Abstract INTRODUCTION Muscular function is essential for healthy aging. This study examined the relationship between baseline muscle condition and changes in cognitive performance over 2 years. METHODS We conducted an observational analysis of longitudinal data from the control arm of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomized controlled trial ( n = 583). Baseline physical performance was assessed using gait speed, grip strength, and Short Physical Performance Battery (SPPB). Logistic regression models analyzed associations between baseline physical performance and changes in standardized cognitive scores after 2 years. RESULTS Mean age was 68.6 years. Higher baseline chair stand performance, SPPB scores, and grip strength were significantly associated with more favorable 2‐year trajectories in global cognition, memory, and executive function ( p < 0.05), particularly for memory. Gait speed showed no significant associations. CONCLUSION Better initial physical condition is linked to more favorable cognitive evolution, independent of other factors. This highlights the connection between physical and cognitive health, supporting comprehensive preventive strategies for older adults. Highlights

Stronger muscles are linked to slower cognitive decline before it begins.

Better performance of muscular function protects against cognitive impairment in aging.

Intervening muscle health impacts brain health in aging.

40:T501,We included a total of 206 eyes (201 patients); 46 eyes treated with FSIP and 160 eyes treated with standard ILM peeling. Of the 206 eyes, postoperative ERM developed in 16 eyes (7.8%) at 12 months: 8 eyes (17.4%) in the FSIP group and 8 eyes (5.0%) in the standard ILM peeling group. The incidence of postoperative ERM was significantly higher in the FSIP group than in the standard ILM peeling group (P= 0.014), and univariable logistic regression analysis revealed that FSIP was significantly associated with postoperative ERM at 12 months (OR=4.00, 95% CI=1.39-11.55, P=0.009). Of the 8 eyes with postoperative ERM after FSIP, 6 eyes showed stage 1 ERM and 2 eyes showed stage 2 ERM. Of the 8 eyes with postoperative ERM after standard ILM peeling, 7 eyes showed stage 1 ERM and 1 eye showed stage 2 ERM. No additional surgery was required for postoperative ERM during 12 months. Postoperative logarithm of minimum angle of resolution visual acuity at 12 months did not differ significantly between eyes with (0.50 ± 0.43) and without ERM (0.42 ± 0.52; P= 0.517). The incidence of postoperative macular hole (MH) was lower in the FSIP group (2.2%) than in the standard ILM peeling group (12.8%), although the difference was not statistically significant (P= 0.071).41:T8cb,To compare the incidence and outcomes of postoperative epiretinal membrane (ERM) formation after fovea-sparing internal limiting membrane peeling (FSIP) and standard internal limiting membrane (ILM) peeling in eyes with myopic traction maculopathy (MTM). Multicenter, retrospective clinical cohort study. Patients with MTM who underwent pars plana vitrectomy (PPV) at 10 institutions between June 2008 and July 2024, with at least 12 months of follow-up, were included. Postoperative ERM was identified on optical coherence tomography (OCT) and graded using the Govetto classification. The main outcomes were the 12-month incidence of postoperative ERM and postoperative visual outcomes. We included a total of 206 eyes (201 patients); 46 eyes treated with FSIP and 160 eyes treated with standard ILM peeling. Of the 206 eyes, postoperative ERM developed in 16 eyes (7.8%) at 12 months: 8 eyes (17.4%) in the FSIP group and 8 eyes (5.0%) in the standard ILM peeling group. The incidence of postoperative ERM was significantly higher in the FSIP group than in the standard ILM peeling group (P= 0.014), and univariable logistic regression analysis revealed that FSIP was significantly associated with postoperative ERM at 12 months (OR=4.00, 95% CI=1.39-11.55, P=0.009). Of the 8 eyes with postoperative ERM after FSIP, 6 eyes showed stage 1 ERM and 2 eyes showed stage 2 ERM. Of the 8 eyes with postoperative ERM after standard ILM peeling, 7 eyes showed stage 1 ERM and 1 eye showed stage 2 ERM. No additional surgery was required for postoperative ERM during 12 months. Postoperative logarithm of minimum angle of resolution visual acuity at 12 months did not differ significantly between eyes with (0.50 ± 0.43) and without ERM (0.42 ± 0.52; P= 0.517). The incidence of postoperative macular hole (MH) was lower in the FSIP group (2.2%) than in the standard ILM peeling group (12.8%), although the difference was not statistically significant (P= 0.071). FSIP increased the incidence of postoperative ERM compared with standard ILM peeling, but most ERMs were subclinical and did not affect vision. Despite the elevated ERM risk, the potential benefit of FSIP in reducing postoperative macular hole formation may outweigh its drawbacks.42:Tb8d, Introduction Despite extensive research on COVID-19 vaccines, comparative data on the long-term humoral response across multiple vaccine platforms and heterologous regimens remain limited. SARS-CoV-2 continues to circulate and cause infections globally, highlighting the need to monitor the durability of vaccine-induced immunity. To better understand how different COVID-19 vaccination strategies shape long-term humoral immunity, we conducted a longitudinal study of the vaccines used on the European continent. Methods The present study investigated the humoral immune response in 331 participants between January 2021 and January 2023, who received mRNA (BNT162b2–BioNTech/Pfizer, mRNA-1273–Moderna), vector-based (ChAdOx1-S–AstraZeneca, Gam-COVID-Vac–Gamaleya Research Institute), inactivated virus (BBIBP-CorV–Sinopharm) vaccines, or a heterologous combination (ChAdOx1-S followed by mRNA), with all participants receiving an mRNA booster 6–8 months after primary vaccination. SARS-CoV-2 IgA, IgG, and IgG-subclasses were measured using ELISA, while neutralizing antibodies were assessed via a multiplex immunoassay, at four different time points: after the first and second dose, six months post-second dose and after the third dose. Results After two doses, mRNA and ChAdOx1-S-mRNA vaccination induced the highest antibody levels and neutralization potential, followed by the ChAdOx1-S and Gam-COVID-Vac vaccines. The BBIBP-CorV group showed the lowest performance. Antibody levels declined in all participants six months post-vaccination. Booster vaccination (3 rd dose) induced high and comparable neutralizing antibody responses in all groups, regardless of the initial two-dose vaccine regimen. The booster vaccine induced increased SARS-CoV-2-specific IgG4 levels, particularly in participants who received two doses of mRNA-1273 as primary vaccination. The IgG subclass response was more influenced by the type of vaccine used for the two-dose primary vaccination than by the mRNA vaccine used for boosting. Conclusion Altogether, these findings underscore the importance of booster doses and provide valuable insight into the longevity and quality of humoral responses, including the durability and breadth of neutralizing antibodies, across different vaccination strategies. 43:Ta1e,Online training programs offer accessible, cost-effective solutions to disseminate evidence-based interventions. Yet, online training is typically insufficient without additional clinical case consultation (CCC). This is particularly salient in adolescent eating disorders treatment, where clinical demand far outstrips capacities of providers trained in evidence-based treatment approaches. This study seeks to better understand attitudes and barriers to receiving CCC among private practice clinicians treating adolescent eating disorders. Licensed private practice clinicians (n = 47; 100% female, average age 36 y old; 75% master's degree; average of 4y experience) across the United States enrolled in a randomized trial offering online training (webinar or e-learning) in family-based treatment (FBT) for anorexia nervosa. Post online training, participants were asked before and after 12 sessions of expert CCC to self-report attitudes and barriers to obtaining CCC. Prior to CCC, participants rated expert CCC in learning FBT as important/very important (100%). The majority participated in CCC since licensure (82%) and in the last year (68%), rating it valuable or very valuable (77%). Participants predicted that CCC would be valuable (96%) and an important motivation in completing the training study (96%). After CCC, participants viewed CCC as important/very important in learning FBT (94%). Common obstacles included finding a study-eligible patient (44%), scheduling constraints (19%), lost wages (16%), mismatch with consultant (3%), and hesitation to discuss cases (3%). Clinicians reported favorable perspectives on CCC in complimenting learning FBT via online training. Future studies are needed to determine methods to deliver, assess, and scale CCC to enhance treatment fidelity. This study seeks to better understand attitudes and barriers to receiving clinical case consultation (CCC) among clinicians treating adolescent eating disorders in private practice settings. Clinicians answered questionnaires before and after receiving CCC as part of a larger randomized clinical trial investigating online training methods for family-based treatment (FBT). Private practice clinicians viewed CCC as valuable and important for learning FBT via online training. Common barriers to receiving CCC included practical issues such as finding an eligible study patient, scheduling conflicts, and lost wages. The findings suggest that integrating CCC with online training may be an important component when disseminating evidence-based treatments via online training formats.44:Ta01,Abstract Background Online training programs offer accessible, cost-effective solutions to disseminate evidence-based interventions. Yet, online training is typically insufficient without additional clinical case consultation (CCC). This is particularly salient in adolescent eating disorders treatment, where clinical demand far outstrips capacities of providers trained in evidence-based treatment approaches. This study seeks to better understand attitudes and barriers to receiving CCC among private practice clinicians treating adolescent eating disorders. Methods Licensed private practice clinicians ( n = 47; 100% female, average age 36 y old; 75% master’s degree; average of 4y experience) across the United States enrolled in a randomized trial offering online training (webinar or e-learning) in family-based treatment (FBT) for anorexia nervosa. Post online training, participants were asked before and after 12 sessions of expert CCC to self-report attitudes and barriers to obtaining CCC. Results Prior to CCC, participants rated expert CCC in learning FBT as important/very important (100%). The majority participated in CCC since licensure (82%) and in the last year (68%), rating it valuable or very valuable (77%). Participants predicted that CCC would be valuable (96%) and an important motivation in completing the training study (96%). After CCC, participants viewed CCC as important/very important in learning FBT (94%). Common obstacles included finding a study-eligible patient (44%), scheduling constraints (19%), lost wages (16%), mismatch with consultant (3%), and hesitation to discuss cases (3%). Conclusions Clinicians reported favorable perspectives on CCC in complimenting learning FBT via online training. Future studies are needed to determine methods to deliver, assess, and scale CCC to enhance treatment fidelity. 45:T70a,In patients with chronic obstructive pulmonary disease (COPD), severe exacerbations (ECOPDs) impose significant morbidity and mortality. Current guidelines emphasise using ECOPD history to inform preventive treatments but offer limited guidance for risk stratification for the first severe ECOPD. We developed and validated PRECISE-X using a cohort of newly diagnosed COPD patients from the UK's Clinical Practice Research Datalink (2004-2022), to predict first severe ECOPD over 5 years (primary outcome) and 12 months (secondary outcome). Predictors were selected via clinical expertise and data-driven methods. Internal-external cross-validation was performed across practice regions to evaluate the model's out-of-sample performance in terms of discrimination (c-statistic), calibration and net benefit. The study included 2 19 015 patients (mean age 66.0; 42.4% female). Observed risk of first severe ECOPD was 29.5% at 5 years (4.2% at 1 year). The final model included four mandatory predictors (sex, age, Medical Research Council dyspnoea score and forced expiratory volume in 1 second) and 28 optional predictors. In internal-external cross-validation, the average out-of-sample c-statistic was 0.836 (95% CI 0.827 to 0.846) for 5-year prediction and 0.756 (95% CI 0.746 to 0.766) for 1-year prediction. Calibration across regions was robust, and the model showed positive NB across a wide range of risk thresholds. In a secondary validation assessment among those with available spirometry data with confirmed airflow obstruction, the model was well calibrated and had only a modest decline in discriminatory performance. PRECISE-X accurately predicts the first severe COPD exacerbation using routine clinical data, supporting earlier risk stratification and proactive disease management.46:T959, Objectives In patients with chronic obstructive pulmonary disease (COPD), severe exacerbations (ECOPDs) impose significant morbidity and mortality. Current guidelines emphasise using ECOPD history to inform preventive treatments but offer limited guidance for risk stratification for the first severe ECOPD. Methods We developed and validated PRECISE-X using a cohort of newly diagnosed COPD patients from the UK’s Clinical Practice Research Datalink (2004–2022), to predict first severe ECOPD over 5 years (primary outcome) and 12 months (secondary outcome). Predictors were selected via clinical expertise and data-driven methods. Internal-external cross-validation was performed across practice regions to evaluate the model’s out-of-sample performance in terms of discrimination (c-statistic), calibration and net benefit. Results The study included 2 19 015 patients (mean age 66.0; 42.4% female). Observed risk of first severe ECOPD was 29.5% at 5 years (4.2% at 1 year). The final model included four mandatory predictors (sex, age, Medical Research Council dyspnoea score and forced expiratory volume in 1 second) and 28 optional predictors. In internal-external cross-validation, the average out-of-sample c-statistic was 0.836 (95% CI 0.827 to 0.846) for 5-year prediction and 0.756 (95% CI 0.746 to 0.766) for 1-year prediction. Calibration across regions was robust, and the model showed positive NB across a wide range of risk thresholds. In a secondary validation assessment among those with available spirometry data with confirmed airflow obstruction, the model was well calibrated and had only a modest decline in discriminatory performance. Conclusions PRECISE-X accurately predicts the first severe COPD exacerbation using routine clinical data, supporting earlier risk stratification and proactive disease management. 47:Tab8,K.D., A.D., D.C., L.H., H.S., P.K., M.T., T.K., R.W., J.C., M.B., U.Y., E.W., S.G.: no relevant disclosures; K.J.L.: Research funding from Sanofi; R.P.: advisory board role for Sanofi Aventis and Astra Zeneca, research funding from Bristol Myers Squibb Foundation and GlaxoSmithKline; S.C.: honoraria from Sanofi, Ascentage Pharma, Sobi, Legend Biotech, and research funding from Johnson & Johnson, Takeda, C4 Therapeutics, Abbvie, Ascentage Pharma, AstraZeneca; M.G.: personal fees from Ionis/Akcea, honorarium from Alnylym, personal fees from Prothena, personal fees from Sanofi, personal fees from Janssen, personal fees for Data Safety Monitoring board from Abbvie & Arcellex, fees from Johnson & Johnson, Honoraria for Astra Zeneca, Medscape, Dava Oncology. Alexion; P.K.: Honoraria: Pharmacyclics, Sanofi, BeiGene, MustangBio, AstraZeneca, AbbVie. Consulting or Advisory Role: Sanofi. Research Funding: Amgen, Takeda, Sanofi, AbbVie, GlaxoSmithKline, Sorrento Therapeutics, Karyopharm Therapeutics, Regeneron, Ichnos Sciences, Bristol Myers Squibb/Celgene; P.L.B.: Consultant: Oncopeptidfes. Salarius, Radmetrix, Omeros, CellCentric, AbbVie, Pfizer; S.K.: Consulting or Advisory Role: Takeda, Janssen Oncology, Genentech/Rocher, Abbvie, BMS/Celgene, Pfizer, Regeneron, Sanofi, K36 Therapeutics; travel, accommodation and expenses: Abbvie, Pfizer; Research funding: Takeda, Abbvie, Novartis, Sanofi, Janssen Oncology, MedImmune, Roche/Genentech, CARsgen Therapeutics, Allogene Therapeutics, GSK, Regeneron, BMS/Celgene; S.A.: Consulting or Advisory Role: Takeda, BeiGene, GlaxoSmithKline, Sanofi, Pharmacyclics, BMS, Amgen, Janssen, Regeneron, Cellectar. Research Funding: Pharmacyclics, Janssen Biotech, Cellectar, BMS, Amgen, GlaxoSmithKline, AbbVie, Ascentage Pharma, Sanofi; R.F.: consultancy for AbbVie, Adaptive, Amgen, Apple, BMS/Celgene, GSK, Janssen, Karyopharm, Pfizer, RA Capital, Regeneron, Sanofi. Scientific advisory board: Caris Life Sciences. Board of directors: Antengene. Patent for FISH in multiple myeloma. A.Z.: patents submitted for DACH1-IgG, PDE10A-IgG, CAMKV-IgG, Tenascin-R-IgG as biomarkers of neurological autoimmunity, received research funding from Roche/Genetech and Center for MS and Autoimmune Neurology at Mayo Clinic not relevant to this study, Consulted without personal compensation for Alexion pharmaceuticals, steering committee for the KYSA-8 study for autologous CAR-T-19 treatment for SPS; no personal compensation; Y.L.: advisory board role for Janssen, Sanofi, BMS, Regeneron, Genentech, Tessera, Legend, NexT Therapeutics, steering committee for Janssen, Kite/Gilead, research funding from Janssen, BMS, scientific advisory board for NexImmune, Caribou and data safety monitor board for Pfizer.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Cohort: study design Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Cohort (study design). 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study with human observational cohorts; design label is approximate.","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.078674","tag_type":"warning","value":"Study language metadata indicates German (de-DE), though the full text is in English — no content concern, likely a metadata artifact.","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.078674","tag_type":"warning","value":"The human cohort n=81 spans three institutions and two disease groups; subgroup sizes for SNP genotyping analyses are small (e.g., n=4–10 per genotype category), which limits statistical power.","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.078674","tag_type":"warning","value":"The 'practice_changing' impact flag is applied cautiously — findings are compelling but require prospective multicenter validation before routine clinical UCP2 genotyping is adopted.","value_numeric":null},{"paper_doi":"10.1161/circulationaha.125.078674","tag_type":"warning","value":"The study design is mixed (animal mechanistic + small human cohorts); the level of evidence reflects the human cohort component, which is observational and cross-sectional.","value_numeric":null}],"summaries":{"what_studied":"Two rat PAH models (monocrotaline vs pulmonary artery banding) and three human cohorts (n=81; PAH vs group 2 PH) were used to test whether RV cardiac fibroblast-to-myofibroblast change and UCP2 variants predispose to the shift from compensated to decompensated right ventricle. cRV and dRV were defined by catheterization and echocardiography.","key_result":"In rats, decompensated MCT RV showed expansion of RV cardiac myofibroblasts, lower whole-heart RV contractility despite preserved isolated cardiomyocyte function, and reduced mitochondrial respiration in RV myofibroblasts with increased respiration in RV cardiomyocytes; these changes were not seen with PAB, which decompensated later. In patients, TNF-α or the UCP2 SNP rs659366 was identified as a potential early biomarker of RV decompensation in PAH.","limitations":"Human data were limited to three cohorts totaling n=81. Findings differed between MCT and PAB models, suggesting model-specific effects that may limit generalization.","practice_takeaway":"RV fibroblast-to-myofibroblast transition appears tied to RV failure in PAH, pointing to a non-cardiomyocyte driver of decompensation. TNF-α or UCP2 rs659366 may help flag early RV decompensation risk, but clinical use requires validation."}},{"doi":"10.1007/s13555-025-01631-8","pmid":"41537947","title":"Outcomes in Patients with Psoriasis Following Apremilast Treatment: Results from the German Psoriasis Registry PsoBest","journal_title":"Dermatology and Therapy","journal_issn":"2193-8210","published_at":"2026-01-16T00:00:00.000Z","url":"https://doi.org/10.1007/s13555-025-01631-8","source_score":7,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-16","doi":"10.1007/s13555-025-01631-8","days":"7","issn":"2193-8210","rank":"10","field":"Clinical Medicine","score":"7","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1007/s13555-025-01631-8","title":"Outcomes in Patients with Psoriasis Following Apremilast Treatment: Results from the German Psoriasis Registry PsoBest.","journal":"Dermatology and therapy","methods":"","results":"From January 15, 2015 to June 30, 2020, 595 registry patients were exposed to apremilast; 417 were treated with apremilast monotherapy. Patients taking apremilast had a higher mean age and higher proportions of comorbidities such as cardiovascular or metabolic disease compared with those taking other nonbiologic systemic or biologic drugs. The most common nonserious AEs were drug ineffectiveness (14.1%), diarrhea (9.4%), nausea (7.1%), and headache (6.1%). The highest incidence rates of nonserious and serious AEs of special interest were for infections and infestations per system organ class (8.03/100 patient-years) and malignant or unspecified tumors (2.50/100 patient-years), respectively. Improvements in Dermatology Life Quality Index, patient-defined treatment benefits (Patient Benefit Index), body surface area, and Psoriasis Area and Severity Index were observed after 3, 6, and 12 months of apremilast treatment.","abstract":"$32","keywords":["Apremilast","Dermatology","Psoriasis","Real World","Therapeutics"],"pubmed_id":"41537947","conclusions":"","publication_date":"2026-01-16T00:00:00"},"crossref":{"DOI":"10.1007/s13555-025-01631-8","URL":"https://doi.org/10.1007/s13555-025-01631-8","ISSN":["2193-8210","2190-9172"],"link":[{"URL":"https://link.springer.com/content/pdf/10.1007/s13555-025-01631-8.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/article/10.1007/s13555-025-01631-8","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/content/pdf/10.1007/s13555-025-01631-8.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Outcomes in Patients with Psoriasis Following Apremilast Treatment: Results from the German Psoriasis Registry PsoBest"],"author":[{"given":"Matthias","family":"Augustin","sequence":"first","affiliation":[]},{"given":"Stephan J.","family":"Rustenbach","sequence":"additional","affiliation":[]},{"given":"Ralph","family":"von Kiedrowski","sequence":"additional","affiliation":[]},{"given":"Hamid","family":"Amouzadeh","sequence":"additional","affiliation":[]},{"given":"Kathy","family":"Tran","sequence":"additional","affiliation":[]},{"given":"Myriam","family":"Cordey","sequence":"additional","affiliation":[]},{"given":"Ulrich","family":"Mrowietz","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/100002429","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100002429","name":"Amgen","doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2026,1,15]]},"member":"297","prefix":"10.1007","source":"Crossref","volume":null,"created":{"date-time":"2026-01-15T14:22:28Z","timestamp":1768486948000,"date-parts":[[2026,1,15]]},"indexed":{"date-time":"2026-01-16T08:18:13Z","timestamp":1768551493248,"date-parts":[[2026,1,16]]},"license":[{"URL":"https://creativecommons.org/licenses/by-nc/4.0","start":{"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000,"date-parts":[[2026,1,15]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by-nc/4.0","start":{"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000,"date-parts":[[2026,1,15]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1007/s13555-025-01631-8"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"24 September 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"10 December 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"15 January 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"},"order":2,"value":"$33"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"},"order":3,"value":"The PsoBest registry was planned and performed under strict rules of patient protection as suggested by German and European laws, the Declaration of Helsinki, and Good Clinical Practice as described in the International Council for Harmonisation Guideline E6. 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DLQI improved from 11.1 at baseline to 6.1, 4.7, and 5.3 at 3, 6, and 12 months; mean BSA fell from 22.1% to 8.1% at 12 months; 85.6% achieved PBI ≥1 at 12 months.","limitations":"Observational registry with potential incomplete documentation, selection/recall bias, and attrition reducing sample sizes over time; no between-cohort outcome comparisons were performed. Safety reporting may have been more frequent early after approval.","practice_takeaway":"In routine German care, apremilast improved psoriasis severity and quality of life with a safety profile consistent with labeling. 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applicability.","value_numeric":null},{"paper_doi":"10.1080/15412555.2025.2593282","tag_type":"warning","value":"Study design label is approximate; this is a retrospective claims-based cohort with time‑varying exposure.","value_numeric":null}],"summaries":{"what_studied":"A retrospective claims-based cohort in Kobe City, Japan, assessed whether initiating rehabilitation within two months after discharge affects readmission among older adults (≥65) with COPD who require long‑term care after hospitalization for lower respiratory tract infection. Patients were stratified by ADL level, and rehabilitation was modeled as a time‑varying exposure in an extended Cox model.","key_result":"Among 745 patients, 479 received rehabilitation within two months, 105 later, and 161 never. Rehabilitation was associated with higher readmission risk versus no rehabilitation (HR 1.63, 95% CI 1.19–2.24), and survival curves for early rehabilitation overlapped with no rehabilitation.","practice_takeaway":"In older COPD patients with disability after a respiratory infection hospitalization, post‑discharge rehabilitation was linked to more readmissions in this cohort. Use caution and consider staged, individualized rehabilitation rather than routine early referral."}},{"doi":"10.1016/j.resuscitation.2026.110959","pmid":"41500412","title":"Do not attempt resuscitation orders at Out-of-Hospital Cardiac Arrest in Denmark","journal_title":"Resuscitation","journal_issn":"0300-9572","published_at":"2026-01-08T00:00:00.000Z","url":"https://doi.org/10.1016/j.resuscitation.2026.110959","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-07","doi":"10.1016/j.resuscitation.2026.110959","days":"7","issn":"0300-9572","rank":"10","field":"Clinical Medicine","score":"1","category":"Emergency Medicine","categories":["Emergency Medicine"],"_categories":["Emergency Medicine"]},"pubmed":{"doi":"10.1016/j.resuscitation.2026.110959","title":"Do not attempt resuscitation orders at Out-of-Hospital Cardiac Arrest in Denmark.","journal":"Resuscitation","methods":"","results":"From 2016 to 2023, a significant rising trend in the number of OHCAs where a DNAR has been in place was observed. In 2016, the percentage of OHCA with DNAR orderwas 1% (), while in 2023, 3% of OHCA occurred in patients with an existing DNAR. This may influence the survival rates following OHCA. Excluding OHCA with DNAR order, overall survival rates would have been higher, with an additional 0.1% in 2016 and an additional 0.5% in 2023.","abstract":"$3a","keywords":["DNAR","DNR","OHCA","Out-of-hospital cardiac arrest","do not attempt resuscitation"],"pubmed_id":"41500412","conclusions":"Between 2016 and 2023, in Denmark, there has been a significant increasing trend in the number of OHCAs treated despite DNAR orders. DNAR orders were most frequently observed among older patients, and the prevalence increased progressively with age. 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DNARs were most common in older patients, with prevalence increasing with age.","limitations":"The abstract reports no sample size or absolute event counts. Definitions and ascertainment of DNAR status, “treated despite DNAR,” and the survival calculation method are not described.","practice_takeaway":"When benchmarking OHCA outcomes, recognize that including DNAR cases lowers reported national survival; parallel reporting with and without DNAR cases may better reflect system performance. Anticipate higher DNAR prevalence with increasing age when planning and interpreting care."}},{"doi":"10.1016/j.jen.2025.11.022","pmid":"41504673","title":"Impact of Bedside Ultrasound on Patient Anxiety in Acute Cholecystitis: A Comparative Observational Study","journal_title":"Journal of Emergency Nursing","journal_issn":"0099-1767","published_at":"2026-01-08T00:00:00.000Z","url":"https://doi.org/10.1016/j.jen.2025.11.022","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-12","doi":"10.1016/j.jen.2025.11.022","days":"14","issn":"0099-1767","rank":"4","field":"Clinical Medicine","score":"7","category":"Emergency Medicine","categories":["Emergency Medicine"],"_categories":["Emergency Medicine"]},"pubmed":{"doi":"10.1016/j.jen.2025.11.022","title":"Impact of Bedside Ultrasound on Patient Anxiety in Acute Cholecystitis: A Comparative Observational Study.","journal":"Journal of emergency nursing","methods":"","results":"Baseline characteristics were comparable between groups. 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Main outcomes were 12‑month postoperative epiretinal membrane (ERM) incidence and visual outcomes; postoperative macular hole events were also reported.","key_result":"At 12 months, ERM occurred in 8/46 eyes (17.4%) after fovea-sparing ILM peeling versus 8/160 (5.0%) after standard peeling (P=0.014; OR 4.00, 95% CI 1.39–11.55). ERMs were stage 1–2 with no reoperation; visual acuity at 12 months was similar (logMAR 0.50±0.43 vs 0.42±0.52; P=0.517), and macular hole incidence was 2.2% vs 12.8% (P=0.071).","limitations":"Retrospective, multicenter design; only univariable logistic regression was reported; outcomes were reported to 12 months.","practice_takeaway":"In surgery for myopic traction maculopathy, fovea-sparing ILM peeling increased 12‑month ERM risk versus standard peeling, but most ERMs were mild and did not affect vision. 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IgA/IgG, IgG1/IgG3/IgG4, and neutralizing antibodies against WT, Alpha, Beta, Gamma, Delta, and Omicron were measured at four time points.","key_result":"Antibody levels fell by 6 months after dose 2 (IgA ↓56–79%, IgG ↓58–81% by regimen), but an mRNA booster restored high and comparable neutralizing responses across all primary regimens, yielding near‑universal seropositivity against WT and VoCs. IgG4 rose after boosting, most notably in those primed with two mRNA‑1273 doses (higher than BNT162b2 and ChAdOx1‑S/mRNA; p=0.0365 and p=0.0014, respectively).","limitations":"Small subgroup sizes and incomplete follow‑up for some vaccines (e.g., BBIBP‑CorV, Gam‑COVID‑Vac); no clinical outcome data and possible undetected asymptomatic infections; IgG2 was not quantified and hybrid immunity or variant‑adapted boosters were not analyzed.","practice_takeaway":"Expect substantial waning by 6 months after primary vaccination and broad restoration of neutralizing antibodies with an mRNA booster regardless of the initial regimen. Primary platform can shape subclass responses—two mRNA‑1273 doses were linked to higher post‑booster IgG4—whose clinical significance remains uncertain."}},{"doi":"10.1186/s40337-025-01511-8","pmid":"41476312","title":"Providers’ perspectives on clinical case consultation following online training in family-based treatment for adolescent anorexia nervosa","journal_title":"Journal of Eating Disorders","journal_issn":"2050-2974","published_at":"2026-01-01T00:00:00.000Z","url":"https://doi.org/10.1186/s40337-025-01511-8","source_score":15,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-05","doi":"10.1186/s40337-025-01511-8","days":"7","issn":"2050-2974","rank":"6","field":"Clinical Medicine","score":"15","category":"Psychiatry","categories":["Psychiatry","Psychology, Clinical"],"_categories":["Psychiatry","Psychology, Clinical"]},"pubmed":{"doi":"10.1186/s40337-025-01511-8","title":"Providers' perspectives on clinical case consultation following online training in family-based treatment for adolescent anorexia nervosa.","journal":"Journal of eating disorders","methods":"","results":"Prior to CCC, participants rated expert CCC in learning FBT as important/very important (100%). The majority participated in CCC since licensure (82%) and in the last year (68%), rating it valuable or very valuable (77%). Participants predicted that CCC would be valuable (96%) and an important motivation in completing the training study (96%). After CCC, participants viewed CCC as important/very important in learning FBT (94%). 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This study was approved by the IRB at Stanford University and University of California San Francisco (e-protocol #69550). The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"},"order":3,"value":"Not applicable."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":4,"value":"Dr. Matheson and Dr. Whyte receive royalties from Routledge. 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Pre‑infusion factors (age >75 years, bone marrow plasma cells ≥20%, involved free light chain ≥20 mg/dL) and post‑infusion events (ICANS, higher cumulative steroid dose, >1 dose of tocilizumab) were linked to higher odds of IEC‑PKS, and high peak absolute lymphocyte count predicted both IEC‑NP and IEC‑PKS on univariate and multivariate analyses.","practice_takeaway":"After cilta‑cel, late nerve palsies and parkinsonism occurred in 6.4% and 3.8% of patients; watch closely in patients with the listed risk factors, especially those with high peak absolute lymphocyte counts."}},{"doi":"10.1186/s12879-025-12408-x","pmid":"41457224","title":"Beta-lactam plus macrolide treatment versus beta-lactam monotherapy for community-acquired pneumonia: a propensity score analysis using data from a multicenter prospective cohort study","journal_title":"BMC Infectious Diseases","journal_issn":"1471-2334","published_at":"2025-12-29T00:00:00.000Z","url":"https://doi.org/10.1186/s12879-025-12408-x","source_score":45,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-12-29","doi":"10.1186/s12879-025-12408-x","days":"30","issn":"1471-2334","rank":"5","field":"Clinical Medicine","score":"45","category":"Infectious Diseases","categories":["Infectious Diseases"],"_categories":["Infectious Diseases"]},"pubmed":{"doi":"10.1186/s12879-025-12408-x","title":"Beta-lactam plus macrolide treatment versus beta-lactam monotherapy for community-acquired pneumonia: a propensity score analysis using data from a multicenter prospective cohort study.","journal":"BMC infectious diseases","methods":"","results":"","abstract":"","keywords":["Anti-bacterial agents","Beta-Lactams","Macrolides","Pneumonia","Propensity score"],"pubmed_id":"41457224","conclusions":"","publication_date":"2025-12-29T00:00:00"},"crossref":{"DOI":"10.1186/s12879-025-12408-x","URL":"https://doi.org/10.1186/s12879-025-12408-x","ISSN":["1471-2334"],"link":[{"URL":"https://link.springer.com/article/10.1186/s12879-025-12408-x","content-type":"text/html","content-version":"vor","intended-application":"text-mining"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Beta-lactam plus macrolide treatment versus beta-lactam monotherapy for community-acquired pneumonia: a propensity score analysis using data from a multicenter prospective cohort study"],"author":[{"given":"Kei","family":"Nakashima","sequence":"first","affiliation":[]},{"given":"Masahiro","family":"Aoshima","sequence":"additional","affiliation":[]},{"given":"Hiroki","family":"Matusi","sequence":"additional","affiliation":[]},{"given":"Atsushi","family":"Shiraishi","sequence":"additional","affiliation":[]},{"given":"Hiroyuki","family":"Ito","sequence":"additional","affiliation":[]},{"given":"Motoi","family":"Suzuki","sequence":"additional","affiliation":[]},{"given":"Konosuke","family":"Morimoto","sequence":"additional","affiliation":[]},{"given":"Koya","family":"Ariyoshi","sequence":"additional","affiliation":[]},{"given":null,"family":null,"sequence":"additional","affiliation":[]}],"funder":[{"name":"The Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University received financial support from Pfizer for this study."}],"issued":{"date-parts":[[2025,12,29]]},"member":"297","prefix":"10.1186","source":"Crossref","volume":null,"created":{"date-time":"2025-12-29T03:54:44Z","timestamp":1766980484000,"date-parts":[[2025,12,29]]},"indexed":{"date-time":"2025-12-29T03:55:27Z","timestamp":1766980527423,"date-parts":[[2025,12,29]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000,"date-parts":[[2025,12,29]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000,"date-parts":[[2025,12,29]]},"delay-in-days":0,"content-version":"am"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1186/s12879-025-12408-x"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"31 December 2024"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"16 December 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"29 December 2025"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"},"order":2,"value":"The study received approval from the ethics review boards of the Institute of Tropical Medicine at Nagasaki University, Ebetsu City Hospital, Kameda Medical Center, Chikamori Hospital, and Juzenkai Hospital (registration no. 11063070). This study was conducted in accordance with the principles outlined in the Declaration of Helsinki. We obtained written informed consent from all conscious patients. In the cases of adults with cognitive decline, a legal guardian or an appropriate representative of these participants provided informed consent on their behalf. Given that the study was observational and involved no invasive interventions or deviations from standard medical treatment, all the institutional review boards waived the requirement for written informed consent for a few unconscious patients."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"},"order":3,"value":"Not applicable."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":4,"value":"K.M. received research funding support from Pfizer. 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